• 한국어병학회지
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• 제7권2호
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• pp.161-171
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• 1994

뱀장어의 울혈증 발병 원인구명을 위하여 서해안 지역 5 개 양만장을 대상으로 아가미 울혈증 발병현황과 수질등 역학조사를 실시하였고, 한편으로는 스트레스(handling 과 수온차) 및 병어에서 분리한 아가미 마쇄액을 건강어의 복강에 주사하여 울혈증 발병률과 CHSE-214 에 접종하여 세포변성을 조사하였다. 조사한 양만장의 아가미 울혈증 발병률은 30-80%로서 사육시의 수온과 선별시의 수온차가 클수록 발병률이 높았으며, 수질환경과 본증의 발병과는 뚜렷한 상관관계가 없었다. 또한 발병률이 높은 양만장의 뱀장어는 Ht, Hb, Tp, Alb, Mg 및 Glu 치등이 낮은 반면 GOT, GPT, Ca 및 Met-Hb 치등은 높게 나타나는 경향을 보였으나, 반드시 아가미 울혈증에 비례하여 증감되지는 않았다. 스트레스(handling 과 수온차)를 가함에 따라 아가미 울혈증이 실험적으로 유발되어졌으며, 발병률은 50-70% 이었다. 이러한 스트레스 조건하의 어류의 혈액학적인 성상은 울혈증 발병빈도에 비례하여 Ht, GOT, GPT, Met-Hb, Alb 및 Glu 치등은 증가되었으나, Tp, Hb 및 Mg 은 감소하는 경향을 보였으며, 온도차가 클수록 cortisol 량이 증가되는 경향을 보였다. 그러나, 병어의 아가미 마쇄액을 복강주사 및 CHSE-214 에 접종하였던 바 각각 울혈증의 발병 및 세포변성이 전혀 관찰되지 않았다. 이러한 결과는 선별시 handling 과 수온의 급변이 혈중 cortisol을 상승시켜 혈액의 전해질 변화를 초래케하므로써 혈액의 흐름을 완만하게 되고 동정맥계로의 혈액유입량이 증가하게 되어 중심정맥동이 확장되므로써 울혈이 형성되는 것임을 시사한다.

• 한국임상수의학회지
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• 제18권2호
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• pp.111-115
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• 2001

The water celery, Oenanthe javanica DC., is widely distributed in Korea and the other South East Asian countries. From ancient times, the water celery has widely been used for food or medicine. In herbal medicine, the water celery has a medical actions which are defervescence, diuresis, hypotensor, appetizer. Recently, studies on the water celery are briskly being conducted. For example, studies on the morphologic property and classifications of origin of the water celery, studies on the chemical constituents of the Water celery, studies on the bio activities of the water celery which contains flavonoids. However, there is not studies of hematological changes in dogs administrated the water celery until now. Consicontly, this study was conducted to observe the hematological changes in dogs administrated excessive amount of the water celery concentrated extract for a long period. In this studies, all dogs showed significantly decrease of the RBC, PCV, Hb and MCHC, and increase of the WBC, MCV, GSH and reticulocytes, but did not significantly change in the Met-Hb.

• Journal of Preventive Medicine and Public Health
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• 제18권1호
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• pp.129-136
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• 1985

도시인(都市人)과 농촌인(農村人)간의 혈중(血中) 가스 및 중금속(重金屬) 농도(濃度)를 비교(比較)하기 위하며 1985년 5월에 대구지역(大邱地域)에서 15년이상 거주(居住)한 모(某) 고등학교(高等學校) 3학년(學年) 재학생중(在學生中) 34명(名)과 대조군(對照群)으로서 의성군(義城郡) 소재(所在) 동급(同級) 학생(學生) 37명(名)을 대상(對象)으로 하였다. 다만 흡연(吸煙)한 경험(經驗)이 있는 학생(學生)은 포함되지 않았다. 시료(試料)는 Heparin으로 처리된 1회용 주사기로 정맥혈액(靜脈血液)을 채혈(採血)했다. 혈액(血液)가스는 CO-Oximeter(IL. 282)가 부착(附着)된 Blood Gas Analyzer(IL. 1301)로 분석(分析)하였으며, 연(鉛)은 원자화(原子化) 무염광여(無焰光廬)(flameless furance atomizer, IL. 655)가 부착(附着)된 원자(原子) 흡광(吸光) 광도계(光度計)(atomic absorption spectrophotometer, IL. 551)로 분석(分析)하였고 카드뮴과 동(銅)은 염광(焰光) 원자(原子) 흡광(吸光) 광도계(光度計)(flame atomic absorption spectrophotometer)로 분석(分析)하였다. $PO_2$와 $O_2-Hb$은 농촌(農村) 거주군(居住群)에서 각각 $29.34{\pm}7.37mmng,\;48.30{\pm}15.23%$로 도시(都市) 거주군(居住群) 보다 높았다(각각, p<0.01, p<0.03). ${HCO_3}^-$와 $TCO_2$는 도시(都市) 거주군(居注群)에서 각각 $28.01{\pm}1.58mM/L\;29.66{\pm}1.69mmHg$로 농촌(農村) 거주군(居住群) 보다 높았다(각각, p<0.01, p<0.01). CO-Hb는 도시(都市) 거주군(居住群) 보다 농촌(農村) 거주군(居住群)에서 $1.82{\pm}0.36%$로 높았다(p<0.03). Met-Hb은 도시(都市) 거주군(居住群)에서 $0.36{\pm}0.24%$로 농촌(農村) 거주군(居住群)보다 높았다(p<0.01). 도시(都市) 거주군(居住群)의 혈중(血中) 연(鉛)과 카드뮴 함량(含量)은 각각 $0.142{\pm}0.084ppm,\;0.029{\pm}0.007ppm$으로 농촌(農村) 거주군(居住群)의 $0.099{\pm}0.082\;ppm,\;0.025{\pm}0.006\;ppm$보다 높았다(각각, p<0.03, p<0.02). 이상의 결과(結果)로 보아 도시(都市) 거주자(居住者)는 각종 차량(車輛)의 배기(排氣)가스로 인한 대기오염(大氣汚染)의 영향(影響)을 크게 받고 있다는 것을 알 수 있으며, 농촌(農村)에서는 주택(住宅) 구조(構造)가 개선(改善) 되지 않은 상태(狀態)에서 연탄(煉炭) 난방시설(煖房施設)이 보급(普及)된 관계(關係)로 실내(室內) 일산화탄소오염(一酸化炭素汚染)이 문제(問題)가 된다고 추측(推測)되는 바이다.

• BMB Reports
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• 제31권2호
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• pp.161-169
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• 1998

TThe reactive oxygen species oxidatively modify the biological macromolecules, including proteins, lipids, and nucleic acids. Iron- and heme-mediated Fenton-like reactions produce different pro-oxidants. However, these reactive products have not been clearly characterized. We examined the nature of the oxidizing species from the different iron sources by measuring oxidative protein modification and spectroscopic study. Hemoglobin (Hb) and methemoglobin (metHb) were oxidatively modified in $O{\array-\\\dot{2}}$ and $H_{2}O_{2}$ generating systems. Globin and bovine serum albumin (BSA) were also modified by iron, iron-EDTA, hematin, and Hb in an $O{\array-\\\dot{2}}$ generating system. In a $H_{2}O_{2}$ generating system, the iron- and iron-EDTA-mediated protein modifications were markedly reduced while the Hb-and hematin-mediated modifications were slightly increased. In the $O{\array-\\\dot{2}}$ generating system, the iron- and iron-EDTA-mediated protein modifications were strongly inhibited by superoxide dismutase (SOD) or catalase, but heme- and Hb-mediated protein modifications were inhibited only by catalase and slightly increased by SOD. Mannitol, 5,5-dimethyl-l-pyrroline-N-oxide (DMPO), deoxyribose, and thiourea inhibited the iron-EDTA-mediated protein modification. Mannitol and DMPO, however, did not exhibit significant inhibition in the hematin-mediated modification. Desferrioxamine (DFO) inhibited protein modification mediated by iron, but cyanide and azide did not, while the hematin-mediated protein modification was inhibited by cyanide and azide, but not significantly by DFO. The protein-modified products by iron and heme were different. ESR and UV-visible spectroscopy detected the DMPO spin adduct of the hydroxyl radical and ferryl ion generated from iron-EDTA and metHb, respectively. These results led us to conclude that the main oxidizing species are hydroxyl radical in the iron-EDTA type and the ferry I ion in the hematin type, the latter being more effective for protein modification.

• 약학회지
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• 제58권1호
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• pp.71-79
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• 2014

Although Korean patients with type 2 diabetes mellitus (T2DM) are generally treated by western medicine, many of them strongly believe in the traditional oriental Sasang constitutional classification and depend on it for food, health supplements, and oriental medicines decision making. Sasang constitutional classification is a part of traditional Korean medicine that divides people into four constitutional types (Tae-Yang: TY, Tae-Eum: TE, So-Yang: SY, and So-Eum: SE), which differ in inherited characteristics such as appearance, personality traits, susceptibility to diseases, and drug responses. It is recommended for T2DM patients to control their blood glucose very well from early stages with drugs and diet. However, many T2DM patients respond differently to their drugs, even though they receive the same medicine. Therefore, the present study investigated whether Sasang constitutional type can explain the therapeutic differences between oral hypoglycemic agents (OHAs) therapy (mono, dual and triple drug therapy). Patients of 618 with T2DM diagnosis and Sasang constitutional type known who received both western and oriental medicine treatment in a hospital between April 2006 and April 2013 retrospectively studied. HbA1c (%) and blood glucose (mg/dl) levels before OHAs therapy and 3 month after were collected for metformin (MET) or sulfonylurea (SU) monotherapy, MET+SU dual therapy, MET+except SU (where was either alpha-glucosidase inhibitor, dipeptidyl peptidase-4 inhibitor, meglitinide or thiazolidinedione) dual therapy, and triple therapy, according to Sasang constitutional type. For statistical analysis, ANOVA was used and paired t-test by SPSS 19.0 where P values less than 0.05 were considered statistically significant. Pattern was similar levels of HbA1c and blood glucose and which was decreased in order of mono, MET+SU dual, MET+except SU dual and triple therapy. In all patients comparison, for the So-yang (SY) constitutional type, either monotherapy was less effective; for Te-eum (TE) type, MET+SU dual therapy was less effective while MET+except SU dual therapy was more effective and the triple therapy was less effective; and for So-eum (SE) type, the triple therapy was more effective. For the management of TE type it is recommended to use drugs except SU when dual therapy is needed, restrict triple therapy and consider dual and insulin therapy; for SY type it is recommended to follow current guidelines; and for SE type it is advisable to skip dual therapy and start the triple therapy early. Finally, the therapeutic response to OHAs is different among Korean T2DM patients with different Sasang constitutional types. Taken together, the choice of effective OHAs therapy for each type is necessary in order to minimize the poor control of blood glucose level, the risk of complications, and the costs from a failure of therapy.

• 한국콘텐츠학회논문지
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• 제15권11호
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• pp.338-346
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• 2015

본 연구는 동기강화면담이 공복혈당장애 환자의 건강증진생활양식, 행동변화단계, 당화혈색소값에 미치는 효과를 확인하기위해 시도되었다. 2011년 12월부터 2012년 3월까지 U시 동구보건소에 내소하는 공복혈당장애를 가진 대상자로 실험군 27명 과 대조군 33명으로 무작위 배정하여 실험군에게 연구자가 개발한 동기강화면담 프로그램을 실시하였다. 면담프로그램은 1대1 면담 1회와 전화상담 1회로 이루어졌으며 MET I, II 프로그램을 응용하여 연구자가 개발한 후 전문가 내용타당도를 검증받았다..프로그램 적용후 효과검정을 위해 실험전후 대상자의 건강증진생활양식, 변화단계는 설문지 조사하였고 채혈을 통해 당화혈색소를 측정하였다. 수집된 자료는 SPSS WIN 20.0을 이용하여 빈도와 백분율, 평균과 표준편차, $x^2$ test, t-test로 분석하였다. 연구결과, 변화단계점수는 두 집단 간 유의한차이가 있어(t=-20.224, p=.000) 동기강화면담의 긍정적인 효과를 확인하였고, 건강증진생활양식(t=-1.297, p=.200)과 당화혈색소값(t=.794, p=.431)에 대해서는 두집단간 유의한 차이가 없었다. 따라서, 본 연구의 동기강화면담프로그램은 공복혈당장애 환자의 행위변화단계를 인식전단계에서 인식단계로 변화되는데 효과가 있었으므로 간호현장에서 건강관리 중재프로그램을 시행하기위한 준비단계에 효과적으로 적용되기를 기대한다.

• 한국임상약학회지
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• 제20권3호
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• pp.183-192
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• 2010

While Self-monitoring of blood glucose (SMBG) has been recommended in some diabetes mellitus (DM) patients population according to the 2010 American Diabetes Association (ADA), 2007 Korean Diabetes Association (KDA), 2005 International Diabetes Federation guideline, it is excluded from a routine insurance coverage for outpatients in Korea. The objective of this study is to meta-analyze the impact of SMBG on HbA1c in non insulin-treated diabetes mellitus (NIT) DM patients. Published clinical literatures were identified through electronic database searches from inception and until May 2010. Studies were selected if they met the following inclusion criteria: 1) randomized controlled trials (RCTs), 2) comparing SMBG with non-SMBG in NIT type 2 diabetes, 3) measuring HbA1c as an outcome. Literature qualities were assessed by the Scottish Intercollegiate Guidelines Network Checklist. The mean difference of HbA1c between the 2 groups was pooled from non-heterogeneous 6 RCTs by meta-analysis using Review Manger (RevMan) Version 5.0 program. Pooled results demonstrated that SMBG is associated with a statistically significant improvement in glycemic control (mean HbA1c difference -0.23, 95%CI -0.32, -0.13). Sensitivity analysis showed that glycemic controls were significantly improved in patients with shorter study duration, more frequent self-monitoring, higher baseline HbA1c value, and without prior SMBG experiences. Conclusively SMBG is effective in improving glycemic control in NIT DM patients, but additional evidences from further researches in Korean patients and cost-effectiveness analysis would be necessary to make a suggestion for coverage expansion.

• 한국임상수의학회지
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• 제18권2호
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• pp.105-110
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• 2001

The water celery, Oenanthe Javanica DC., is a perennial herb which mostly grows on a damp ground or a streamside. The water celery is widely distributed in Korea, Japan, china, Taiwan, Indonesia, Malaysia and the other countries. From ancient times, the water celery has widely been used for food or medicine. In herbal medicine, the water celery has a medical actions which are defervescence, diuresis, jaundice, edema, hypotensor, haematic, angiostasis, sthenia, appetizer. Recently, studies on the water celery are briskly being conducted. For example, studies on the morphologic property and classifications of origin of the water celery, studies on the chemical constituents of the water celery which contains vitamins, proteins and amino acids, studies on the bio activities of the water celery which contains flavonoids. However, there is not studies of hematological changes in dogs administrated the water celery until now. Consicontly, this study was conducted to observed the hematological changes in dogs administrated excessive amount of the water celery crude juice for a long period. In this studies, all dogs showed significantly decrease of the PCV and Hb, and increase of the WBC, GSH and reticulocytes, but did not significantly change in the RBC, MCV, MCHC and Met-Hb.

• Nutrition Research and Practice
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• 제16권1호
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• pp.60-73
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• 2022

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized trial included a total of 74 adults, and they were assigned to the placebo group (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS components. Safety was assessed by monitoring adverse events (AEs). RESULTS: After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly decreased in the D. morbifera group compared to that of the placebo group (difference: -0.13 ± 0.20% vs. 0.00 ± 0.28%, P = 0.031; % of change: -2.27 ± 3.63% vs. 0.10 ± 5.10%, P = 0.025). The homeostatic model assessment for insulin resistance level also decreased significantly from its baseline in the D. morbifera group. The systolic BP of D. morbifera group decreased significantly than that of placebo group (difference: -3.9 ± 9.8 mmHg vs. 3.3 ± 11.7 mmHg, P = 0.005; % of change: -2.8 ± 7.7% vs. 3.3 ± 10.2%, P = 0.005). However, the lipid parameters and body composition including body weight did not differ between the groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. morbifera group than it was in the placebo group. No serious AEs occurred in either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 12-week period improved metabolic parameters such as HbA1c and BP and reduced the prevalence of MetS.

• 한국임상수의학회지
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• 제20권1호
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• pp.110-114
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• 2003

The Korean Chinese Chives(Allium tuberosum Rottler) are a perennial herb and have been used from ancient as food and medical purpose in Korea. They are known to posses diuresis, sthemia activities and used for the treatment or anemia, haematemesis, and eczema. Recently the Korean Chinese Chives have been studied on the morphologic property, the classification of origin and chemical constituent. However there has not been studied on kg) (or 6 days and observed the hematological effects in dogs. The results are as follows, 1. The red blood cell count was significantly (P < 0.05) decreased on day 2. 2. The reduced glutathion(GSH) concentration was significantly (P< 0.05) increased on day 4 and Met-hemoglobin concentration was significantly (P< 0.05) increased on 3 hrs after administration. 3. Packed cell volume(PCV) and hemoglobin concentration were not showed significant difference during experimental periods. 4. The mean corpuscular volume(MCV) was significantly(P < 0.05) increased on 3 hours after administration.