• Advances in Traditional Medicine
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• 제3권3호
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• pp.123-128
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• 2003

Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S. hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid which was identified as cycleanine using spectroscopic methods (UV, IR, $^1HNMR$. $^{13}CNMR$, Mass). Cycleanine showed significant anti-inflammatory activity against carrageenin induced paw oedema, comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potent analgesic effects against chemical and thermal noxious stimuli. It was also found to possess anticonvulsive activity in the strychnine induced convulsion model.

• 동의생리병리학회지
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• 제20권4호
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• pp.902-908
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• 2006

Tetrandra is the root of Stephania tetrandra 5. Moore (family Menispermaceae), or of Aristolochia frangchi Wu (family Aristolochiaceae). It is a Differ-flavored and cold-property herb acting on the urinary bladder, kidney and spleen meridiands. Known biological effects of this herb are expelling wind to relieve pain and inducing diuresis to alleviate edema. This herb also has anti-inflammatory and anti-hypersensitivity actions. Recent studies have shown that Stephanniae Tetrandrae Radix has antimicrobial effects, namely, a protective effect on acute renal failure induce by gentamicin sulfate and a suppressive effect against clostridium perfringes. However, there is a lack of studies concerning the immunological activities of this herb. The present study was conducted to evaluate the immunological activities of Stephanniae Tetrandrae Radix on the regulatory mechanisms of cytokines and nitric oxide (NO) in Raw 264.7 cells. Cell viability was measured by MTT assay after the treatment of Stephanniae Tetrandrae Radix extract (STRE) and NO production was monitored by measuring the nitrite content in culture medium. COX-2 and iNOS were determined by immunoblot analysis, and levels of cytokine were analyzed by sandwich immunoassays. Results provided evidences that STRE inhibited the production of nitrite and nitrate (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$, $interleukin-1{\beta}(IL-1{\beta})$ and interleukin-6 (IL-6) in Raw 264.7 cells activated with lipopolysaccharide (LPS). These findings showed that STRE could produce some anti-inflammatory effects which might play a role in adjunctive therapy in Gram-negative bacterial infections.

• 화훼연구
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• 제18권2호
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• pp.98-109
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• 2010

국내에 아직 많이 이용되지 않는 식물 중 실외 정원의 화분에서 봄부터 가을까지 잘 견뎌낼 수 있는 자생식물을 조사하기 위해 2007년부터 2009년까지 한국 30여 지역을 탐사하였다. 일반적인 화분(직경 27.5 cm ${\times}$ 높이 27.5 cm) 과 걸이용 화분(직경 27.5 cm ${\times}$ 높이 13 cm)에 식물을 채취하여 심거나 파종하여 충남 성환(북위 36''56' 동경 127''09')의 정원에서 재배하여 생육이 좋은 것으로 파악된 자생식물은 일반적인 화분용으로는 13과 29속 38종(초본식물 37종류, 목본식물 1종류)이었으며, 걸이용 화분용으로는 28과 43속 46종(초본식물 29종류, 목본식물 17종류)이었다. 이 중 이용 가능성이 가장 높을 것으로 기대되는 식물은, 일반적인 화분에는 박주가리과의 박주가리, 도라지과의 염아자, 국화과의 인진쑥 사자발쑥 물쑥, 사초과의 가는그늘사초, 화본과의 수크령 강아지풀, 꿀풀과의 배초향 긴병꽃풀 꽃향유 산박하 들깨풀, 콩과의 털갈퀴나물, 후추과의 후추등, 장미과의 분홍찔레의 16종이었고, 걸이용 화분용으로는 박주가리과의 박주가리, 국화과의 좀씀바귀, 메꽃과의 메꽃 둥근잎유홍초, 마과의 마, 꿀풀과의 긴병꽃풀 백리향, 콩과의 제주달구지풀 털갈퀴나물, 방기과의 새모래덩굴, 후추과의 후추등, 미나리아재비과의 긴잎으아리, 장미과의 분홍찔레, 양지꽃, 꼭두서니과의 계요등, 꼭두서니, 포도과의 담쟁이 덩굴 18종이었다.