• Journal of the Optical Society of Korea
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• v.8 no.1
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• pp.21-28
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• 2004

When femtosecond laser pulses are focused inside the bulk of transparent materials, the intensity in the focal volume becomes high enough to produce permanent structural modifications. This technique has been applied to fabricate three-dimensional photonic structures such as optical memory, waveguides, gratings, and couplers inside a wide variety of transparent materials. In this paper, we review the fabrication of optical elements in glasses with femtosecond laser pulses, including the fabrication of waveguides, couplers, Bragg gratings, zone plates, holographic memory, and micro holes.

• Proceedings of the KAIS Fall Conference
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• 2001.05a
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• pp.277-280
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• 2001

We proposed a novel fractal-space multiplexing holographic memory system using moving window and double-focusing lens, which can eliminate crosstalk due to two neighboring moving window rows in the vertical direction of the conventional moving window holographic memory system, and demonstrated its feasibility through optical experiments.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.11a
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• pp.41-42
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• 2009

현재 많은 임베디드 SoC(System-On-Chip)에는 캐시 메모리의 단점을 보완하기 위해 온-칩(On-Chip) SRAM, 즉, SPM(Scratchpad Memory)를 내장하고 있으며 SPM은 그 특성상 캐시 메모리와 달리 소프트웨어가 직접 관리해야 한다. 본 논문에서는 NUMA를 지원하는 Linux 상에서 이식성이 높으면서 단순하게 구현할 수 있는 SPM 관리 방법을 제안한다.

• Journal of Broadcast Engineering
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• v.16 no.2
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• pp.339-349
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• 2011

IBDI (Internal Bit Depth Increase) is able to significantly improve the coding efficiency of high definition video compression by increasing the bit depth (or precision) of internal arithmetic operation. However the scheme also increases required internal memory for storing decoded reference frames and this can be significant for higher definition of video contents. So, the reference frame memory compression method is proposed to reduce such internal memory requirement. The reference memory compression is performed on 4x4 block called the processing unit to compress the decoded image using the correlation of nearby pixel values. This method has successively reduced the reference frame memory while preserving the coding efficiency of IBDI. However, additional information of each processing unit has to be stored also in internal memory, the amount of additional information could be a limitation of the effectiveness of memory compression scheme. To relax this limitation of previous memory compression scheme, we propose a selective merging-based reference frame memory compression algorithm, dramatically reducing the amount of additional information. Simulation results show that the proposed algorithm provides much smaller overhead than that of the previous algorithm while keeping the coding efficiency of IBDI.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1543-1548
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• 2007

Recent experiments investigating the analgesic or anti-stress effects of electro-acupuncture provide extensive evidence that opioid or stress hormone system is involved in those effects, respectively. It has been also suggested that opioid or stress hormones modulate long-term memory consolidation or retrieval in animals and human subjects. This article reviews the possibilitythat electroacupuncture can modulate memory consolidation or retrieval. The release of serum cortisol is enhanced or reduced by high-frequency or low-frequency electroacupuncture, respectively. Also the release of beta endorphin and enkephalin is enhanced by low-frequency electroacupuncture and the release of dynorphin is enhanced by high-frequency electroacupunture. The memory consolidation is enhanced by post-training injection of Glucocorticoids, Naloxone or Dynorphin. So this review suggests strongly that memory consolidation can be modulated by electroacupuncture.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1487-1494
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• 2008

This study was conducted to determine the effect of Gagamjeongji-hwan (JJH)(Jiajiandingzhi-wan) and Evoidae Fructus (EF) on learning and memory disturbance and neuronal damage induced by focal ischemia in the rat. Rats were used for testing in the following three. Morris Water Maze, Cholineacetyltransferase (ChAT) immunohistochemistry, acetylcholine esterase (AchE) histochemistry. JJH+ISCH group (ischemia-induced rats pretreated with JJH) and EF+ISCH group (ischemia-induced rats pretreated with EF) significantly reduced the latency of swimming time, compared with those of ISCH group (ischemia-induced rats) in morris water maze acquisition test. JJH+ISCH group attenuated ischemia.induced learning and memory damage in morris water maze retention test. The density of ChAT neurons of the JJH+ISCH and EF+ISCH group in the hippocampal CA1 area was increased, compared to that of SAL+ISCH group (ischemia-induced rats pretreated with SAL). The density of AchE neurons of the JJH+ISCH and EF+ISCH group in the hippocampal CA1 and CA3 area was increased, compared to that of SAL+ISCH group. These results suggest that Gagamjeongji-hwan (JJH) and Evodiae Fructus (EF) may have significant protective effects on ischemia-induced brain damage and memory impairments.

• The Korea Journal of Herbology
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• v.21 no.4
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• pp.189-195
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• 2006

Objectives : It has been reported previously that the roots of Scutellaria baicalensis (known as Huang-Gum in Korean, henceforth referred to as S. baicalensis) could prevent neuronal cell death after global cerebral ischemia. In Genuine Korean medicine, S. baicalensis is known to relieve fever in upper body, and it was thus thought to be able to alleviate deteriorations in brain function. Methods : The protective effects of S. baicalensis against post-stroke memory retardation using 4-vessel occlusion model were examined in the present study. Results : S. baicalensis was shown to significantly alleviate the deficits in learning and memory by increasing the fraction of time spent in the quadrant in which the platform was initially placed ($34.9\;{\pm}\;3.2%$, p < 0.05) compared to that of the ischemia group ($28.0\;{\pm}\;2.5%$). The cytoprotective effect of S. baicalensis on CA1 hippocampal neurons was evaluated by measuring the neuronal cell density. Neuronal cell density in S. baicalensis extracts-treated ischemia group ($138.0\;{\pm}\;13.6\;cells/mm^2$) was significantly increased compared to saline-treated ischemia group ($22.1 \;{\pm}\;9.3\;cells/mm^2$, p < 0.05). In the study of OX-42 immunohistochemistry, S. baicalensis could decrease the micrgial activation in hippocampus after brain ischemia. Conclusion : These results may provide experimental support for the use of S. baicalensis in treating post-stroke memory impairment.

• Journal of IKEEE
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• v.17 no.2
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• pp.168-175
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• 2013

The delay times due to the propagating of data on PCB depend on the shape and length of interconnection lines when memory controllers and high speed memories are soldered on the PCB. The dependency on the placement and routing on the PCB requires redesign of I/O logic or reconfiguration of the memory controller after the delay time is measured if the controller is programmable. In this paper, we propose architecture of configuring logic for the delay time estimation by writing and reading test patterns while initializing the memories. The configuration logic writes test patterns to the memory and reads them by changing timing until the correct patterns are read. The timing information is stored and the configuration logic configures the memory controller at the end of initialization. The proposed method enables easy design of systems using PCB by solving the problem of the mismatching caused by the variation of placement and routing of components including memories and memory controllers. The proposed method can be applied to high speed SRAM, DRAM, and flash memory.

• Biomolecules & Therapeutics
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• v.22 no.1
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• pp.17-26
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• 2014

${\alpha}$-Asarone exhibits a number of pharmacological actions including neuroprotective, anti-oxidative, anticonvulsive, and cognitive enhancing action. The present study investigated the effects of ${\alpha}$-asarone on pro-inflammatory cytokines mRNA, microglial activation, and neuronal damage in the hippocampus and on learning and memory deficits in systemic lipopolysaccharide (LPS)-treated C57BL/6 mice. Varying doses of ${\alpha}$-asarone was orally administered (7.5, 15, or 30 mg/kg) once a day for 3 days before the LPS (3 mg/kg) injection. ${\alpha}$-Asarone significantly reduced TNF-${\alpha}$ and IL-$1{\beta}$ mRNA at 4 and 24 hours after the LPS injection at dose of 30 mg/kg. At 24 hours after the LPS injection, the loss of CA1 neurons, the increase of TUNEL-labeled cells, and the up-regulation of BACE1 expression in the hippocampus were attenuated by 30 mg/kg of ${\alpha}$-asarone treatment. ${\alpha}$-Asarone significantly reduced Iba1 protein expression in the hippocampal tissue at a dose of 30 mg/kg. ${\alpha}$-Asarone did not reduce the number of Iba1-expressing microglia on immunohistochemistry but the average cell size and percentage areas of Iba1-expressing microglia in the hippocampus were significantly decreased by 30 mg/kg of ${\alpha}$-asarone treatment. In the Morris water maze test, ${\alpha}$-asarone significantly prolonged the swimming time spent in the target and peri-target zones. ${\alpha}$-Asarone also significantly increased the number of target heading and memory score in the Morris water maze. The results suggest that inhibition of pro-inflammatory cytokines and microglial activation in the hippocampus by ${\alpha}$-asarone may be one of the mechanisms for the ${\alpha}$-asarone-mediated ameliorating effect on memory deficits.

• Proceedings of the Korean Information Science Society Conference
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• 2006.06a
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• pp.34-36
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• 2006

본 연구는 특정 사물을 계속 접하면서 그 사물에 대한 기억 강도가 의식적 노력 없이도 점점 강화되는 암묵적 기억 인출과정 associative memory retrieval의 DNA 연산 가능성을 논한다. 예를 들어 한 표적 단어에 대한 노출이 이를 관찰하는 시스템에게 그 단어의 기억 강도를 강화시키는 반면, 그와 유사한 다른 단어는 천천히 감소되고 나머지 가장 다른 단어는 일찍 잊혀지는 현상을 생각할 수 있다. 이들 단어들과 알파벳 철자들을 DNA 염기서열로 표현하고 simulated annealing을 통하여 결합 결과를 얻는다. Ridge regression 형태의 supervised 학습을 통하여 한 가지 표적 단어가 많이 생성되도록 DNA 조각들의 개수 분포를 변화시켜 진행한다. 실험 예로 'tic' 'tac' 'toe' 세 가지 단어를 그 아이템으로 정하여 계속 자극받는 표적 단어의 갯수가 증가함을 DNA annealing 시뮬레이션을 통하여 확인할 수 있다. 또한 'tac' 과 't' 와 'c'를 공유하는 'tic' 의 감소 점도가 't'만을 공유하는 'toe' 보다 느림을 확인할 수 있다. 위의 실험들을 통해 연합기억associative memory의 암묵적 인출과정을 분자 층위에서 표현할 수 있음을 확인 할 수 있다.