• Earthquakes and Structures
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• v.27 no.1
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• pp.1-15
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• 2024

In order to enhance the seismic performance of base-isolated structures on soft foundations, the hybrid system of base-isolated system (BIS) and shape memory alloy inerter (SMAI), referred to as BIS+SMAI, is for the first time here proposed. Considering the nonlinear hysteretic relationships of both the isolation layer and SMA, and soil-structure interaction (SSI), the equivalent linearized state space equation is established of the structure-BIS+SMAI system. The displacement variance based on the H₂ norm is then formulated for the structure with BIS+SMAI. Employing the particle swarm optimization, the optimization design methodology of BIS+SMAI is presented in the frequency domain. The evolvement rules of BIS+SMAI in the effectiveness, robustness, SMA driving force, inertia force, stroke, and damping enhancement effect are revealed in the frequency domain through changing the inerter-mass ratio, structural height, aspect ratio, and relative stiffness ratio between the soil and structure. Meanwhile, the validation of BIS+SMAI is conducted using real earthquake records. Results demonstrate that BIS+SMAI can effectively reduce the isolation layer displacement. The inerter can significantly increase the hysteretic displacement of SMA and thus enhance its energy dissipation capacity, implying that BIS+SMAI has better effectiveness than BIS+SMA. Although BIS+SMAI and BIS+ tuned inerter damper (TID) have practically the same effectiveness, BIS+SMAI has the lower optimum damping, significantly smaller inertia force, and higher robustness to perturbations of the optimum parameters. Therefore, BIS+SMAI can be used as a more engineering realizable hybrid system for enhancing the performance of base-isolated structures in soft soil areas.

• Biomolecules & Therapeutics
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• v.15 no.2
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• pp.83-88
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• 2007

The roots of Liriope platyphylla (Liliaceae) are widely used in traditional Chinese medicine. In the present study, we investigated the effects of ethanol (70%) extract of the roots of Liriope platyphylla (ELP70) on learning and memory using behavioral and immunohistochemical methods in mice. Control animals were treated with vehicle (10% Tween 80). With sub-chronic treatments of ELP70 (p.o.) for 14 days, the latency time was significantly increased compared with that of the vehicle-treated control group (50, 100 and 200 mg/kg; P<0.05). Moreover, immunopositive cells for brain derived neurotrophic factor (BDNF) were significantly increased in the hippocapmpal dentate gyrus and CA1 regions after ELP70 treatments for 14 days (50, 100 and 200 mg/kg; P < 0.05). In addition, those cells for nerve growth factor (NGF) were also increased in the hippocapmpal dentate gyrus region (50, 100 and 200 mg/kg; P<0.05). These results suggest that the sub-chronic administration of ELP70 improves learning and memory, and that their beneficial effects are mediated, in part, by the enhancement of BDNF or NGF expression.

• Journal of Ginseng Research
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• v.40 no.1
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• pp.55-61
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• 2016

Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of $K^+$ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated. Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used. Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus. Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.1
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• pp.183-189
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• 2018

This paper proposes distributed file placement and coverage expansion techniques for mitigating the traffic bottleneck in backhaul for small-cell networks. In order to minimize the backhaul load with limited memory space, the proposed scheme controls the coverage and file placement of base station according to file popularity distribution and memory space of base stations. In other words, since the cache hit ratio is low when there is small memory capacity or widespread file popularity distribution, the base stations expand its coverage and cache different set of files for the user located in overlapped area to exploit multiple cached file sets of base stations. Our simulation results show that the proposed scheme outperforms the conventional cache strategy in terms of network throughput when there is small memory capacity or widespread file popularity distribution.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.102-108
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• 2016

Objectives : The deficit of recognition memory has been found as one of the common neurocognitive impairments in patients with schizophrenia. In addition, they were reported to fail to enhance the memory about emotional stimuli. Previous studies have shown that bilateral eye movements enhance the memory retrieval. Therefore, this study was conducted in order to investigate the memory enhancement of bilaterally alternating eye movements in schizophrenic patients. Methods : Twenty one patients with schizophrenia participated in this study. The participants learned faces (angry or neutral faces), and then performed a recognition memory task in relation to the faces after bilateral eye movements and central fixation. Recognition accuracy, response bias, and mean response time to hits were compared and analysed. Two-way repeated measure analysis of variance was performed for statistical analysis. Results : There was a significant effect of bilateral eye movements condition in mean response time(F=5.812, p<0.05) and response bias(F=10.366, p<0.01). Statistically significant interaction effects were not observed between eye movement condition and face emotion type. Conclusions : Irrespective of the emotional difference of facial stimuli, recognition memory processing was more enhanced after bilateral eye movements in patients with schizophrenia. Further study will be needed to investigate the underlying neural mechanism of bilateral eye movements-induced memory enhancement in patients with schizophrenia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.2192-2200
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• 2015

In this paper, we propose an efficient vehicle image compensation algorithm based on Histogram Equalization. The proposed a vehicle image compensation algorithm was elimination to the vehicle image shake using motion compensation and motion estimation. And, algorithm was calculated the histogram of pixel values from each sub-image by dividing the image as the constant size areas in order to image enhancement. Also, it had enhancement to the image by adjusting the gradient. The proposed algorithm was evaluate the difference between of performance and time, image by applied to the IP, and were confirmed the image enhancement with removing of vehicle camera image shake. In this paper, the proposed vehicle image enhancement algorithm was demonstrated effectiveness when compared to existing vehicle image stabilization, because the elimination of shake for the vehicle images used real-time processing without using a memory. And it was obtained the reduction effect of the computation time by the calculated through block matching, and obtained the better restoration result for naturalness of the image with the lowest noise.

• Journal of the Korean Applied Science and Technology
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• v.40 no.3
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• pp.402-411
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• 2023

The purpose of this study was to investigate the effects of a cognitive enhancement program combined Silbot on cognitive function, depression, and dementia prevention behavior in the elderly complaining of subjective memory decline. The subjects were 170 elderly people living in Seongnam-si, Gyeonggi-do, and the study was performed at a welfare center. A total of 20 sessions program using Silbot and physical activity was developed and applied, and were evaluated using the Korean version of Montreal Cognitive Assessment (K-MoCA), Geriatric depression Scale(GDS) , and Dementia Prevention Behavior before and after intervention. As a result of the study, the cognitive enhancement program combined Silbot showed statistically significant changes in cognitive function (t=-4.49, p<.001) and depression (t=2.58, p=.023) in the elderly. Therefore, it is expected that the cognitive enhancement program using Silbot will be a useful program that can enhance the cognitive function of the elderly and reduce depression.

• Journal of the Korean Society of Radiology
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• v.83 no.4
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• pp.945-950
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• 2022

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a common autoimmune encephalitis that is noted to be a severe but treatable disease entity. Patients with anti-NMDAR encephalitis often develop psychotic symptoms, including delusions, hallucinations, and paranoia, as well as memory impairment and persistent loss of attention. However, MRI findings in such patients show no abnormalities in most cases. Although typical brain abnormality features, known as T2 hyperintensities, involve the brain parenchyma and contrast enhancement at the cerebral cortex or overlying meninges, isolated leptomeningeal enhancement has been rarely reported in anti-NMDAR encephalitis. Herein, we report a patient with anti-NMDAR encephalitis who presented with isolated leptomeningeal enhancement, additionally showing the diagnostic value of contrast-enhanced fluid-attenuated inversion recovery imaging.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.10
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• pp.111-121
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• 2012

In this paper, a poly-Si thin film transistor with ${\sim}0.5{\mu}m$ gate length was fabricated and its electrical characteristics are optimized. From the results, it was verified that making active region with larger grain size using low temperature annealing is an efficient way to enhance the subthreshold swing, drain-induced barrier lowering and on-current characteristics. A SONOS flash memory was fabricated using this poly-Si channel process and its performances are analyzed. It was necessary to optimize O/N/O thickness for the reduction of electron back tunneling and the enhancement of its memory operation. The optimized device showed 2.24 V of threshold voltage memory windows which coincided with a well operating flash memory.

• Journal of Life Science
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• v.19 no.5
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• pp.688-691
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• 2009

The methanol extract of muskmelon (Cucumis melo) has been investigated for its cognition enhancing effects by evaluation of inhibitory activities on acetylcholinesterase, a degrading enzyme of acetylcholine, a brain neurotransmitter, and ${\beta}$- secretase, which forms the ${\beta}$-amyloid toxic protein from its precursor protein. A passive avoidance task, one of the animal model experiments for learning and memory, was also performed. As a result, the melon extract showed 15.8% and 35.3% inhibition on acetylcholinesterase and ${\beta}$-secretase, respectively, with a final concentration of 100 mg/ml. In the animal model test, melon extract significantly (p<0.05) lengthened the step-through latency time by 22.7% compared to the control group, suggesting that melon extract has, indeed, an effect on cognition enhancement.