• 대한한방소아과학회지
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• 제15권1호
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• pp.77-104
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• 2001

The effects of the oriental herbal medicine Saenghyetang(SHT, 生慧湯), which consists of Rehmanniae Radix (熟地黃 九蒸: was made by 9th steam) 40g, Corni Fructus(山茱黃) 16g, Polygalae Radix(遠志) 8g, Zizyphi Spinosae Semen(酸棗仁) 2g, Biotae Semen(柏子仁 去油: oil ingredient was removed) 20g, Poria Cocos(茯笭) 12g, Ginseng Radix(人蔘) 12g, Acori Graminei Rhizoma(石菖蒲) 2g, Sinapis Semen(白芥子) 8g, on learning ability and memory were investigated. Hot water extract(HWE) and ethanol extract(EE) from SHT were used for the studies. Learning ability and memory are related to modifications of synaptic strength among neurons that interactive. Enhanced synaptic coincidence detection leads to improved learning ability and memory. If the NMDA receptor, a synaptic coincidence detector, acts as a graded switch for memory formations, enhanced signal detection by NMDA receptors should enhance learning ability and memory. It was shown that NR2B was increased in the forebrains of oriental medicine-administrated mice, leading to enhanced activation of NMDA receptors and facilitating synaptic potentiation in response to stimulation at 10-100 Hz. These HWE-SHT treated mice exhibited that superior ability in learning and memory when performing various behavioral tasks, showing that NR2B is enhanced by HWE-SHT treatment and also is critical in gating the age-dependent threshold for plasticity and memory formation. NMDA receptor-dependent modifications, which were mediated in part by HWE administration, of synaptic efficacy, therefore, represent a mechanism for associative learning ability and memory. Results suggest that oriental medical enhancement of NR2B contributes to increase intelligence and memory in mammals On the other hand, to examine the effects of EE-SHT on the learning ability and memory in experimental mice, EE-SHT was tested on passive and active avoidance responses. The EE-SHT ameliorated the memory retrieval deficit induced by ethanol in mice, but not other memory impairments. EE-SHT(10, 20mg/100 g, p.o.) did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests and the ambulatory activity of normal mice in a normal condition. However, EE-SHT at 20 mg/kg significantly decrease the spontaneous motor activity during the shuttle box test, and also to extend the sleeping time induced by pentobarbital in mice. These results suggest that SHT has an ameliorating effect on memory retrieval impairments and a weak tranquilizing action.

• The Korean Journal of Physiology and Pharmacology
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• 제24권1호
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• pp.27-37
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• 2020

Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but it has also been shown to exhibit strong antioxidative, anti-inflammatory, and neuroprotective effects. Here, we sought to investigate the effects of CAR on inflammation in the hippocampus and prefrontal cortex, as well as the molecular mechanisms underlying these effects. In our study, lipopolysaccharide was injected into the lateral ventricle of rats to induce memory impairment and neuroinflammation. Daily administration of CAR (25, 50, and 100 mg/kg) for 21 days improved recognition, discrimination, and memory impairments relative to untreated controls. CAR administration significantly attenuated expression of several inflammatory factors in the brain, including interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2. In addition, CAR significantly increased expression of brain-derived neurotrophic factor (BDNF) mRNA, and decreased expression of Toll-like receptor 4 (TLR4) mRNA. Taken together, these results show that CAR can improve memory impairment caused by neuroinflammation. This cognitive enhancement is due to the anti-inflammatory effects of CAR medicated by its regulation of BDNF and TLR4. Thus, CAR has significant potential as an inhibitor of memory degeneration in neurodegenerative diseases.

• 정보처리학회논문지A
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• 제11A권5호
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• pp.373-382
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• 2004

이 논문에서는 내장형 소프트웨어의 성능 향상을 위하여 사용될 수 있는 레지스터 프로모션의 새로운 기법을 제안한다. 레지스터 프로모션은 프로그램 내의 메모리 접근 연산(memory access)을 레지스터 접근 연산(register access)으로 바꾸어서 프로그램의 성능 향상을 꾀하는 최적화 방법 중의 하나이다. 제안된 방법에서는 프로파일링(profiling)을 통하여 주어진 소스 코드 내에서의 메모리 접근 연산에 대한 트레이스(trace)를 얻는다. 그리고 각 함수의 수행 횟수에 대한 프로파일링 결과로부터 높은 동적 호출 횟수를 가지는 대상 함수를 선정하여 제안된 레지스터 프로모션 기법을 적용한다. 이와 같이 최적화의 대상이 되는 함수의 수를 줄임으로써 컴파일 시간을 줄일 수 있다. 최적화 대상 함수의 메모리 트레이스를 탐색하여 레지스터 접근 연산으로 변경될 경우 수행 사이클을 줄일 수 있는 메모리 접근 연산을 찾는다. 찾아진 메모리 접근 연산에 대해서는 컴파일러의 중간단계 코드를 수정하여 프로모션 레지스터를 할당한다. 이와 같은 과정을 거쳐 메모리 접근 연산이 프로모션 레지스터에 대한 접근 연산으로 대체되고 이로부터 성능향상을 얻을 수 있다. 제안된 레지스터 프로모션 기법을 ARM과 MCORE 프로세서용 컴파일러에 적용한 후 MediaBench와 DSPStone 벤치마크을 이용하여 실험한 결과 ARM과 MCORE 프로세서에 대하여 각각 평균 14%와 18%의 성능향상을 얻을 수 있었다.

• 대한통합의학회지
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• 제9권4호
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• pp.91-103
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• 2021

Purpose : This study aimed to evaluate the effects of a cognitive enhancement brain yoga program on short-term memory and serum brain-derived neurotrophic factor (BDNF) levels according to the cognitive state in men aged 20-29 years. Methods : Thirty healthy volunteers aged 20-29 years were divided into four groups: brain yoga group, yoga group, combined exercise group, and control group. Seven people were assigned randomly per group. A single-session intervention was conducted over 50 min and consisted of three parts: warm-up, main exercise (brain yoga, yoga, combined exercise, or non-exercise), and cool-down. Serum BDNF levels were measured using enzyme-linked immunosorbent assay, and short-term memory was evaluated using the forward number span test before and after the intervention. Results : BDNF levels significantly increased within the brain yoga group after the intervention (from 28874.37±5185.57 to 34074.80±7321.12, p=.003), whereas there were no significant differences pre-and post-intervention in the other groups. The inter-group comparison showed a significant interaction between the brain yoga group and the combined exercise group (p=.036) but no significant interaction between any of the other groups. Forward number span scores were significantly increased in the brain yoga group (from 9.43±9.83 to 23±7.92, p=.012) and theyoga group after the intervention (from 13.43±9.41 to 24.14±8.45, p=.011), whereas there were no significant changes after the intervention in any other groups. Conclusion : Our findings showed that a single-session, 50-minute brain yoga exercise improved short-term memory and increased serum BDNF levels in healthy men aged 20-29 years and that yoga improved only short-term memory in healthy men of this age group.

• 대한한의학회지
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• 제26권4호
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• pp.87-97
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• 2005

Backgrounds: Intracerebral hemon-hage is one of the most devastating types of stroke. Ginseng radix, the root of Panax Ginseng, C. A. MEYER (Araliaceae), is one of the most famous medicinal herbs with various therapeutic applications. Objectives: In the present study, the effect of aqueous extract of Ginseng radix on intracerebral hemorrhage-induced neuronal cell death in rats was investigated. Materials and Methods: Step-down avoidance task, Nissl staining, immunohistochemistry for caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were used for this study. Results: The present results show that hemorrhage-induced lesion volume and apoptotic neuronal cell death in the striatum were significantly suppressed by treatment with Ginseng radix, resulting in enhancement of short-ten-n memory. Conclusions: We have shown that Ginseng radix has a neuroprotective effect on stroke, and aids the recovery from central nervous system sequelae following stroke.

• 대한전자공학회논문지
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• 제24권6호
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• pp.1040-1048
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• 1987

We propose a hardware architecture called Multiring which is applicable for various geometrical operations on rectilinear objects such as design rule checking in VLSI layout and many image processing operations including noise suppression and coutour extraction. It has both a fast execution speed and extremely high flexibility. The whole architecture is mainly divided into four parts` I/O between host and Multiring, ring memory, linear processor array and instruction decoder. Data transmission between host and Multiring is bit serial thereby reducing the bandwidth requirement for teh channel and the number of external pins, while each row data in the bit map stored in ring memory is processed in the corresponding processor in full parallelism. Each processor is simultaneously configured by the instruction decoder/controller to perform one of the 16 basic instructions such as Boolean (AND, OR, NOT, and Copy), geometrical(Expand and Shrink), and I/O operations each ring cycle, which gives Multiring maximal flexibility in terms of design rule change or the instruction set enhancement. Correct functional behavior of Multiring was confirmed by successfully running a software simulator having one-to-one structural correspondence to the Multiring hardware.

• 한국통신학회논문지
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• 제41권12호
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• pp.1858-1860
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• 2016

논문에서는 YARA의 스캐닝 스레드 알고리즘을 개선하여 다수의 룰 파일 패턴 매칭을 수행할 수 있는 새로운 소프트웨어 구조를 제안한다. 제안하는 방식은 기존의 YARA에 비해 매칭을 위한 룰 파일의 메모리 적재 횟수를 감소시킨다. 따라서 제안된 구조를 적용할 경우 메모리 사용량은 룰 파일의 개수에 비례하여 증가하지만 패턴 매칭 수행에 따른 시간을 감소시킬 수 있다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.657-657
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• 2013

In-situ observations of nano-scale behavior of nanomaterials are very important to understand onthe nano-scale phenomena associated with phase change, atomic movement, electrical or optical properties, and even reactions which take place in gas or liquid phases. We have developed on the in-situ experimental technologies of nano-materials (nano-cluster, nanowire, carbon nanotube, and graphene, et al.) and their interactions (percolation of metal nanoclusters, inter-diffusion, metal contacts and phase changes in nanowire devices, formation of solid nano-pores, melting behavior of isolated nano-metal in a nano-cup, et al.) by nano-discovery membrane platform [1-4]. Between two microelectrodes on a silicon nitride membrane platform, electrical percolations of metal nano-clusters are observed with nano-structures of deposited clusters. Their in-situ monitoring can make percolation devices of different conductance, nanoclusters based memory devices, and surface plasmonic enhancement devices, et al. As basic evidence on the phase change memory, phase change behaviors of nanowire devices are observed at a nano-scale.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권10호
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• pp.5035-5048
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• 2016

Nano scale networks are futuristic networks deemed as enablers for the Internet of Nano Things, Body area nano networks, target tracking, anomaly/ abnormality detection at molecular level and neuronal therapy / drug delivery applications. Molecular communication is considered the most compatible communication technology for nano devices. However, connectivity in such networks is very low due to inter-symbol interference (ISI). Few research papers have addressed the issue of ISI mitigation in molecular communication. However, many of these methods are not adaptive to dynamic environmental conditions. This paper presents an enhancement over original Memory-1 ISI cancellation scheme using maximum likelihood estimation of a channel parameter (λ) to make it adaptable to variable channel conditions. Results of the Monte Carlo simulation show that, the connectivity (P_conn) improves by 28% for given simulation parameters and environmental conditions by using enhanced Memory-1 cancellation method. Moreover, this ISI mitigation method allows reduction in symbol time (Ts) up to 50 seconds i.e. an improvement of 75% is achieved.

• Smart Structures and Systems
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• 제26권6호
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• pp.703-720
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• 2020

This paper investigates the safety of the wind turbine blade against excessive deformation. For this purpose, the performance of the blade in the along-wind direction is improved by longitudinal stiffener made of shape memory alloy. The rationale behind the selection of this smart material is due to its ability to offer excellent thermo-mechanical behaviour at low strain. Here, Liang-Roger model is adopted for vibration control, and the super-elastic effects are utilised for blade stiffening. Turbulent wind fields are generated at the hub height using TurbSim and the corresponding loads are evaluated using blade element momentum theory. An efficient switching algorithm is developed along with performance curves that enable the designer to select an optimal mode of heating depending upon the operational scenario. Numerical results presented in this paper clearly demonstrate the performance envelope of the proposed stiffener and its influence on the reliability of the blade.