• 제목/요약/키워드: Memory disorder

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Fluoxetine 및 Sertraline으로 유도된 심한 세로토닌 증후군 1예 (A Case of Severe Serotonin Syndrome Induced by Fluoxetine and Sertraline)

  • 전진숙;이상신;김성희;조웅
    • 생물정신의학
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    • 제8권1호
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    • pp.167-174
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    • 2001
  • A 54-year old male patient who was suffering from bipolar I disorder for 19 years and was admitted to the National Bugok Mental Hospital due to a depressive episode, was referred to the Kosin University Gospel Hospital. On arrival at the emergency room, he had confused mentality with disorientation, memory impairment, hypomania, marked anxiety and hyperirritability. The change of neuromuscular activity such as ataxia, gait disturbance, tremor, shivering, myoclonus and epileptic seizures was also shown. In addition, the symptoms and signs of autonomic instability including diaphoresis, tachycardia, hypotension, fever and facial flushing were noticed. The above symptoms developed after the administration of sertraline successive to the discontinuation of fluoxetine without any washout period. The degree of severity seemed to be severe because he had epileptic seizures, fever and hypotension. He was recovered from the severe serotonin syndrome by the supportive symptomatic treatment with sodium valproate, clonazepam, lorazepam and cyproheptadine after cessation of the selective serotonin reuptake inhibitors during hospitalization. Therefore, this rare case of severe serotonin syndrome was reported and related literatures were also reviewed.

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외상후 스트레스 장애 환자의 신경인지기능 (Neurocognitive Functions in Posttraumatic Stress Disorder)

  • 김선국;이강준;이승환;남민;정영조
    • 생물정신의학
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    • 제10권2호
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    • pp.147-158
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    • 2003
  • Objective:The differences of various neurocognitive functions, including attention, memory, motor function, and higher cognitive function were compared between PTSD patients and normal control subjects. Also, correlation with PTSD symptom severity and neurocognitive functions were evaluated between PTSD patients and normal control subjects. Method:We assessed the neurocognitive functions by computerized neurocognitive test(CNT) batteries. The visual continuous performance test(CPT) and digit span test, finger tapping test and Wisconsin card sorting test(WCST) were executed. The Impact of Event Scale-Revised(IES-R) was used in the evaluation of the severity of PTSD. Result:The PTSD patients showed significantly impaired neurocognitive performance in all of the items, compared with normal control subjects. The relation between impairment in neurocognitive functions and symptom severity showed significant correlations. Conclusion:These results imply that PTSD patients have impaired neurocognitive functions concerning with specific brain areas, especially the frontal area. For the thorough evaluation of further neurocognitive functions, more detailed evaluation items of neurocognitive functions and brain imaging studies are necessary in the future study.

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전광증 환자 1례에 대한 임상적 고찰 (Clinical Report of One Patient with Schizophrenia)

  • 양재선;염승룡;권영달
    • 동의생리병리학회지
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    • 제18권5호
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    • pp.1538-1541
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    • 2004
  • Jeon-Kwang(癲狂) is a term of oriental medicine, corresponding to schizophrenia. In detail, Jeon-Kwang is divided into Jeon(癲) and Kwang(狂). The symptoms of Jeon have silence, cry and giggle alternately, muttering, and so on. And those of Kwang have quick-tempered, absurd remarks, slander, and so on. We expierenced a patient who was suffered from headache, auditory hallucination, insomnia, anxiety, delirium, memory impairment and, cognitive disorder. In this case, we gave a diagnosis of Jeon-Kwang(狂) and, treated the patient with acupuncture therapy and sa-ha(瀉下) therapy (Dangguiseunggi-tang, Hwangryunsasim-tang). Sa-ha therapy is an oriental medicine therapy about wha(火) syndrom such as constipation, hydrodipsomania, red face. After three weeks of oriental medicine treatment, the chief complaints were considerablely reduced. This suggested that sa-ha herbal treatment have an effect on psychopathy.

Development of the Computerized Mathematics Test in Korean Children and Adolescents

  • Lee, Eun Kyung;Jung, Jaesuk;Kang, Sung Hee;Park, Eun Hee;Choi, InWook;Park, Soowon;Yoo, Hanik K.
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • 제28권3호
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    • pp.174-182
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    • 2017
  • Objectives: This study was conducted in order to develop a computerized test to measure the level of mathematic achievement and related cognitive functions in children and adolescents in South Korea. Methods: The computerized Comprehensive Learning Test-Mathematic (CLT-M) consists of the whole number computation test, enumeration of dot group test, number line estimation test, numeral comparing test (magnitude/distance), rapid automatized naming test, digit span test, and working memory test. To obtain the necessary data and to investigate the reliability and validity of this test, 399 children and adolescents from kindergarten to middle school were recruited. Results: The internal consistency reliability of the CLT-M was high (Cronbach's alpha=0.76). Four factors explained 66.4% of the cumulative variances. In addition, the data for all of the CLT-M subtests were obtained. Conclusion: The computerized CLT-M can be used as a reliable and valid tool to evaluate the level of mathematical achievement and associated cognitive functions in Korean children and adolescents. This test can also be helpful to detect mathematical learning disabilities, including specific learning disorder with impairment in mathematics, in Korea.

뇌혈관성(뇌혈관성) 치매(痴?)에 대(對)한 동서의학적(東西醫學的) 고찰(考察) (The literatual study on the cerebral vascular dementia in oriental and occidental medicine)

  • 안탁원;홍석;김희철
    • 한국한의학연구원논문집
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    • 제2권1호
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    • pp.40-70
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    • 1996
  • In the literatual study on the cerebral vascular dementia, the results were as follows : 1. Cerebral vascular dementia is so called apoplectic dementia, because it almost occurs after apoplexy, the attack rate has gradually increased by increase of life, so it exert a harmful influence to geriatric diseases. 2. The etiological factors are summarized on deficiency in the heart, kidney, liver(心, 腎, 肝虛), pathogenic wind(豊) pathogenic fire(火) phlegm(痰) and stagnated blood(瘀血) in the oriental medicine, and multiple cerebral infarction, cerebral anemia, decrease of cerebral vascular flow are etiological factors in the occidental medicine. 3. The region of infarction and attack of cerebral vascular dementia have a close connection, and generally the cerebral vascular dementia easily occur in injury of white matter of brain. 4. Symptoms of cerebral vascular dementia are dysphasia, walking disorder, hemiplegia, sensory paralysis, disturbance of memory, judgement, calculation, emotion incontinence, speech impediment, silence or talkative, lower thinking ability and depersonalization, and symptoms are aggravated by stage. 5. Therapeutic herb medicines are Palpungsan(八風散), Baepungsan(排風散), Jinsaanshinhwan(辰砂安神丸), Sabacksan(四白散), Kanghwalyupungsan(姜活愈風散), Woohwangchungshimhwan(牛黃淸心丸), and they are used to dispelling pathogenic wind(祛風), soothe the nerves(安神), dispel pathogenic heat from lung, nourish the blood(淸肺養血).

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갱년기 증후군의 약침 치료에 대한 국내 연구 동향 고찰 (A Review of the Domestic Study Trends on Climacteric Syndrome Treated with Pharmacopuncture)

  • 황현지;안수연;김동철
    • 대한한방부인과학회지
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    • 제34권3호
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    • pp.79-95
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    • 2021
  • Objectives: The purpose of this review is to analyze the domestic study trends on climacteric syndrome treated with pharmacopuncture. Methods: We investigated the studies on pharmacopuncture for climacteric syndrome via searching 6 online databases. Results: 18 studies were selected. There were 2 case reports, 1 randomised controlled trial, and 15 animal experiments. There were 14 studies about osteoporosis, 1 study about hot flush and sweating, 1 study about abdominal obesity, 1 study about neck pain, and 1 study about learning disability and memory disorder. Nokyong was most frequently used for pharmacopuncture, followed by Honghwa. 陰谷 (KI10) was most frequently used for acupuncture point, followed by 腎兪 (BL23). Conclusions: This study shows that pharmacopuncture could be one of the effective treatments for climacteric syndrome. More well-designed clinical studies using pharmacopuncture for climacteric syndrome will be needed.

통합관리 프로그램이 아급성 뇌졸중 환자의 운동기능, 인지기능, 우울에 미치는 효과 (The Effects of an Integrated Management Program on Physical Function, Cognitive Function, and Depression in Patients with Subacute stroke)

  • 양근영;민혜숙
    • 중환자간호학회지
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    • 제14권1호
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    • pp.50-62
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    • 2021
  • Purpose : This study examined the effects of an integrated management program on physical function, cognitive function, and depression in patients with subacute stroke. Methods : A nonequivalent control group design was adopted. The participants were assigned to either the experimental group (n=20) or control group (n=23). The experimental group received an 8-week integrated management program and standard rehabilitation service (i.e., physical therapy and occupational therapy), while the control group received the standard rehabilitation service only. Physical function was measured as gait speed and balance ability using the Berg Balance Scale (BBS). Cognitive function was measured with neuro-behavioral cognitive status examination (NCSE), and depression was measured using the Beck Depression Inventory-II (BDI-II). Repeated measure ANOVA was used to determine changes in physical function, cognitive function, and depression over 8-weeks. Results : The interaction between group and time was significant, indicating that the experimental group showed improvement in gait speed, balance ability, cognitive function (linguistic ability, linguistic memory, reasoning), and a decrease in depression compared to the control group. Conclusion : These results indicate that the integrated management program developed herein was beneficial in restoring physical function, cognitive function, and depression in subacute stroke patients.

The effect of game-based dual-task training for executive function and repetitive behaviors in patients with autism

  • Yu, Jae-ho
    • 한국정보통신학회:학술대회논문집
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    • 한국정보통신학회 2022년도 춘계학술대회
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    • pp.394-395
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    • 2022
  • Exergames are playing an important role in healthcare/rehabilitation. It has also been used to improve motivation among patients with reduced cognition. The purpose of this pilot study was to evaluate the feasibility of using augmented reality (AR) with game-based cognitive-motor training programs for executive function, restricted and repetitive behaviors (RRBs) in children with autism spectrum disorder. Sixteen children aged 6 -16 years were randomly allocated to the experimental group and control group. Outcome measures were performed before and after the intervention and included executive function, restricted and repetitive behavior. A satisfactory survey was conducted post-intervention. A statistically significant improvement was observed in working memory and cognitive flexibility in the experimental group (P<0.05). However, despite no statistical improvements in cognitive inhibition and four subscales of RRBs, promising changes were observed in all the subscales of the executive function and the behavioral outcomes. Parents appreciated the program and children enjoyed the interaction with the AR game-based training. The findings of this preliminary feasibility study showed that AR using Kinect v2 motion with a cognitive-motor game content can be used for children with autism. However, there is a need for conducting a large-scale study to evaluate his effectiveness on executive function and restricted and repetitive behaviors.

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트레드밀 운동이 당뇨흰쥐에서 기억력과 해마 BDNF 발현에 미치는 영향 (Effects of Treadmill Exercise on Memory and Hippocampal BDNF Expression in Streptozotocin-induced Diabetic Rats)

  • 이희혁;윤진환;김승희
    • 생명과학회지
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    • 제17권11호
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    • pp.1464-1471
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    • 2007
  • 당뇨병은 만성적 대사질환으로 말초뿐만 아니라 중추신경계에서도 다양한 합병증을 유발시키는 것으로 알려져 있다. 특히, 당뇨환자는 인지기능의 손상으로 인해 치매 유병율이 높은 것으로 보고되고 있다. 규칙적인 운동은 당뇨병의 이차 합병증을 예방하기 위한 치료적 방법으로 흔히 권장된다. 이에 본 연구는 당뇨흰쥐를 대상으로 트레드밀 운동이 기억력과 해마 BDNF 발현에 미치는 효과를 조사하였다. SD계열 흰쥐를 실험동물로 하여 STZ (50 mg/kg) 투여로 유발시킨 당뇨흰쥐를 8주간 주 5회 30분씩 트레드밀에서 달리도록 하였다. 운동프로그램 종료 후, Morris water maze로 기억력을 측정하고, 해마조직을 적출하여 Western으로 brain-derived neurotrophic factor (BDNF) 발현을 정량화하였다. 본 연구결과 8주간의 당뇨는 선행연구과 유사하게 기억력 손상과 함께 해마 조직의 BDNF 발현을 유의하게 감소시키는 것으로 나타났다. 하지만 트레드밀 운동은 당뇨흰쥐에서 기억력과 해마 BDNF 발현을 유의하게 향상시키는 것으로 나타났다. 이러한 결과는 당뇨동물에서 운동이 해마 BDNF 발현의 증가를 통해 인지기능의 손상을 완화시킬 수 있음을 보여주는 것이다.

주의력결핍 과잉행동장애 환아 보호자의 삶의 질과 관련요인 (Quality of Life and Related Factors in Caregivers of Attention Deficit Hyperactivity Disorder Patients)

  • 정종현;홍승철;한진희;이성필
    • 정신신체의학
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    • 제13권2호
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    • pp.102-111
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    • 2005
  • 목적: 질병이 환자에 끼치는 주관적인 영향을 반영하고, 환자의 전반적인 경과와 예후를 나타내는 지표로써 삶의 질 개념이 널리 사용되고 있다. 이때 질병은 환자 자신뿐만 아니라 가족들의 삶에도 상당한 영향을 미치게 되고, 특히 아동이 질병에 이환 되었을 경우 이러한 영향은 더욱 커지리라고 생각된다. 이에 주의력결핍 과잉 행동장애 환아의 보호자를 대상으로 삶의 질의 정도를 알아보고, 삶의 질에 영향을 주는 다른 요인은 무엇인지를 알아보고자 하였다. 방법: DSM-IV 진단기준에 의해 주의력결핍 과잉행동장애로 진단된 아동 38명의 보호자를 대상으로 하였고, 나이와 성별을 맞춘 정상아동 16명의 보호자를 건강대조군으로 하였다. 환아 보호자군과 건강대조군에 대하여 자체 제작한 사회인구학적인 변인에 대한 설문지, 한국판 세계보건기구 삶의 질 간편형 척도(WHOQOL-BREF)를 사용하여 각각 변인의 차이를 비교하였다. 결과: 1) 한국판 WHOQOL-BREF 척도에서 전체 삶의 질 총점과 전반적인 삶의 질, 척도내의 4개의 영역인 신체적 건강 영역, 심리적 영역, 사회적 관계 영역, 환경영역에서 환아 보호자군과 대조군에서 의미 있는 차이는 없었으나, 신체적 건강 영역의 하부척도인 일상생활수행능력 척도$(3.0{\pm}0.7\;vs.\;3.6{\pm}0.7)(p=0.008)$와 심리적 영역에 해당되는 자존감척도$(2.8{\pm}0.7\;vs.\;3.3{\pm}0.7)(p=0.049)$에서 유의하게 감소되어 있었다. 2) 전체 삶의 질 총점은 교육년수가 길수록 높았다(r=0.437, p=0.007). 3) 신체적 건강 영역 (영역 1)은 교육년수가 길수록 높은 점수를 보였고(r=0.370, p=0.024), 하부 척도 중에서는 수면과 휴식 척도가 교육연수와 양의 상관관계를 보였다(r=0.429, p=0.008). 4) 심리적 영역(영역 2)과 관련 있는 요인은 없었으나, 하부 척도인 긍정적사고 척도는 교육년수가 길수록 점수가 높았으며 (r=0.346, p=0.036), 자존감 척도(r=-0.337, p=0.039)와 사고 학습 기억능력 척도(r=-.341, p=0.036)는 보호자의 나이가 많을수록 점수가 낮았다. 5) 사회적 관계 영역(영역 3)과 관련 있는 요인은 없었으나, 하부척도 중 성적활동 척도는 교육년수가 길수록 높은 점수를 보이고 있었다(r=0.344, p=0.037). 6) 환경 영역(영역 4)은 교육년수가 길수록 점수가 높았지만(r=0.482, p=0.003), 환아의 나이가 많을수록 낮은 삶의 질 수준을 보고하였다(r=0.328, p=0.044). 한편 하부 척도 중에서는 신체적 안전 척도(r=-0.414, p=0.010), 거주환경 척도(r=-0.429, p=0.007), 새로운 정보나 기술의 취득 척도(r=-0.382, p=0.018), 의료서비스 및 사회보장서비스 척도(r=-0.351, p=0.031)가 환아의 나이와 음의 상관관계를 보였으며, 신체적 안전척도는 보호자의 나이가 많을수록 삶의 질이 낮음을 보고하였다(r=-403, p=0.012). 한편, 새로운 정보나 기술의 취득척도(r=0.406, p=0.013), 여가활동 척도(r=0.464, p=0.004), 교통 척도(r=0.363, p=0.027)은 교육연수가 길수록 높은 점수를 보고하였다. 결론: 주의력결핍 과잉행동장애 환아의 보호자가 느끼는 주관적인 삶의 질은 건강대조군에 비해 나쁘지 않았다. 그러나 환아의 나이가 많을수록, 보호자의 교육연수가 낮을수록 스스로 느끼는 삶의 질의정도가 낮았으므로 이에 대한 관심이 필요할 것이다.

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