• Journal of Life Science
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• v.29 no.6
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• pp.747-753
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• 2019

Cognitive decline is characterized by reduced long-/short-term memory and attention span, and increased depression and anxiety. Such decline is associated with various degenerative brain disorders, especially Alzheimer's disease (AD) and Parkinson's disease (PD). The increases in elderly populations suffering from cognitive decline create social problems and impose economic burdens, and also pose safety threats; all of these problems have been extensively researched over the past several decades. Possible causes of cognitive decline include metabolic and hormone imbalance, infection, medication abuse, and neuronal changes associated with aging. However, no treatment for cognitive decline is available. In neurodegenerative diseases, changes in the gut microbiota and gut metabolites can alter molecular expression and neurobehavioral symptoms. Changes in the gut microbiota affect memory loss in AD via the downregulation of NMDA receptor expression and increased glutamate levels. Furthermore, the use of probiotics resulted in neurological improvement in an AD model. PD and gut microbiota dysbiosis are linked directly. This interrelationship affected the development of constipation, a secondary symptom in PD. In a PD model, the administration of probiotics prevented neuron death by increasing butyrate levels. Dysfunction of the blood-brain barrier (BBB) has been identified in AD and PD. Increased BBB permeability is also associated with gut microbiota dysbiosis, which led to the destruction of microtubules via systemic inflammation. Notably, metabolites of the gut microbiota may trigger either the development or attenuation of neurodegenerative disease. Here, we discuss the correlation between cognitive decline and the gut microbiota.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.48 no.3
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• pp.82-90
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• 2011

Multi-core system is becoming more general with development of microprocessors. Due to this change in performance improvement paradigm, switching conventional single thread applications with multi thread applications. Performance monitoring tools are used to optimize application performance because of complexity in development of multi thread applications. Conventional performance monitoring tools are focused on performance itself rather than user friendliness or real-time support. Real-time performance monitor identify the problem while multi-threaded applications should be performed as well as check real-time operating status of the application. So it can be used as an effective tool compared to non-real-time performance monitor that only with simple performance indicators to find the cause of the problem. In this paper, we propose RMPM(Real-time Multi-core Performance Monitor) which is real-time performance monitoring tool for multi-core system. Observation period is optimized by comparing relation between overhead due to performance evaluation period and accuracy. Our performance monitor shows not only amount of CPU usage of whole system, memory usage, network usage but also aspect of overhead distribution per thread of an application.

• Journal of the Institute of Convergence Signal Processing
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• v.14 no.2
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• pp.136-146
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• 2013

In this paper, the residual delay compensation algorithm is proposed for FX-type KJJVC. In case of initial version as that design algorithm of KJJVC, the integer calculation and the cos/sin table for the phase compensation coefficient were introduced in order to speed up of calculation. The mismatch between data timing and residual delay phase and also between bit-jump and residual delay phase were found and fixed. In final design of KJJVC residual delay compensation algorithm, the initialization problem on the rotation memory of residual delay compensation was found when the residual delay compensated value was applied to FFT-segment, and this problem is also fixed by modifying the FPGA code. Using the proposed residual delay compensation algorithm, the band shape of cross power spectrum becomes flat, which means there is no significant loss over the whole bandwidth. To verify the effectiveness of proposed residual delay compensation algorithm, we conducted the correlation experiments for real observation data using the simulator and KJJVC. We confirmed that the designed residual delay compensation algorithm is well applied in KJJVC, and the signal to noise ratio increases by about 8%.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.12
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• pp.2469-2475
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• 2015

A structured XML has been widely used to present services on various Web-services. The XML is also used for digital documents and digital signatures and for the representation of multimedia files in email systems. The XML document should be firstly parsed to access elements in the XML. The parsing is the most compute-instensive task in the use of XML documents. Most of the previous work has focused on hardware based XML parsers in order to improve parsing performance, while a little work has studied parsing techniques. We present the high performance parsing technique which can be used all of XML parsers and design hardware based XML parser using an FPGA. The proposed parsing technique uses element analyzers instead of the state machine and performs multibyte-based element matching. As a result, our parsing technique can reduce the number of clock cycles per byte(CPB) and does not need to require any preprocessing, such as loading XML data into memory. Compared to other parsers, our parser acheives 1.33~1.82 times improvement in the system performance. Therefore, the proposed parsing technique can process XML documents in real time and is suitable for applying to all of XML parsers.

• Journal of Korea Game Society
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• v.9 no.2
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• pp.13-22
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• 2009

Recently, mobile games are developed as the various genre and form with the hardware performance improvement and communication network speed increase of the mobile phone. But it shows the limit of the game material to be developed, because the mobile game has to play by using only the keypad handing of the mobile phone. In this research, 'Flip On / Off interface' and 'Microphone interface' were developed in order to utilize the physical device of the mobile phone as the game interface. 'Flip On / Off interface' and 'Microphone interface' have the advantage that there is no need to purchase a device as an additional interface with utilizing the hardware of the mobile phone itself and the progressing of a game is smooth in comparison with the keypad method of the pre-existence mobile game because the interface waiting time for a call response is short. Moreover, by applying to a commercializing game, the developed interface tests, we confirmed an availability at the commercialization inspection standards on mobile phone without the heap memory deficiency phenomenon to be smooth of an operation. Furthermore, in the result of usability evaluation accessability, reliability, and aesthetics were rated as 'high'. The results of this research reveal that the interface environment of the mobile game limited to a keypad will be able to be made with diversification.

• Korean Journal of Food Science and Technology
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• v.52 no.5
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• pp.450-458
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• 2020

The purpose of this study was to conduct a systematic review of the current published research related to improvement in cognitive function. A systematic search was performed in three bibliographic databases (PubMed, Cochrane Library, and EMBASE) using "dementia", "memory", "food", "diet", and "nutrition" as keywords. Meal management intervention, including Dietary Approaches to Stop Hypertension (DASH) diet, Mediterranean (Med) diet, Diet Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, and other studies, was also included in the analysis. Through extensive screening, 21 articles, out of 2101 papers retrieved, were used for the final systematic review. The methodological quality of the randomized controlled clinical trials (RCTs) was assessed using the Cochrane Risk of Bias tool. These articles recommended vegetables, fruits, whole grains, olive oil, fish, berries, nuts, and beans. In conclusion, this study suggests the potential use of meal management to improve cognitive function.

• The Korean Journal of Food And Nutrition
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• v.19 no.1
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• pp.62-69
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• 2006

This study was performed to investigate the biocogical activity of the phospholipid separated and purified from duck egg yolk as functional brain food. A quantitative restriction of maternal diet was given to Sprague-Dawely rats during lactation. Animals were separated into three groups, such as control, duck egg phospholipid(PL) or pig-brain phospholipid additions groups. And ad libitum during lactation was given to control groups. All of the offsprings at 3 weeks of age fed a diet ad libitum for 4 weeks of rehabilitation. Body weight and brain weight and protein, phosphplipid, and cholesterol were determined on offsprings of each of group sacrificed at 0, 1, 2, 3, 5 and 7 weeks of age, sacrified body weight of duck egg phospholipid and pig brain phospholipid group were significantly higher than the control group. Body weight and brain weight after a recovery period were significantly at the control group. However, protein, phospholipid and cholesterol contents were significantly high than the control group. Response latency in the passive avoidance task was the lowest in the ${\beta}$-amyloid group and highest in the phospholipid group. It is consequently suggested that phospholipid supplement may be effective in memory improvement.

• Journal of KIISE:Computer Systems and Theory
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• v.27 no.2
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• pp.177-187
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• 2000

In the past several years, many systems which adopted ring topology with high-speed unidirectional point-to-point links have emerged to overcome the limit of bus for interconnection network of clustered multiprocessor system. However, rapid increase of processor speed and performance improvement of local bus and memory system limit scalability of system with point-to-point link of standard bandwidth. Therefore, necessity to extend bandwidth is emphasized. In this paper, we adopt PANDA system as base model, which is clustering-based multiprocessor system. By simulating a model adopting commercial processor and local bus specification, we show that point-to-point link is bottleneck of system performance, and bandwidth expansion by more than 200% is needed. To expand bandwidth of interconnection network, it needs excessive design cost and time to develop new point-to-point link with doubled bandwidth. As an alternative to double bandwidth, we propose several ways to implement dual ring -simple dual ring, transaction-separated dual ring, direction-separated dual ring- by using off-the-shelf point-to-point links with IEEE standard bandwidth. We analyze pros. and cons. of each model compared with doubled-bandwidth single ring by simulation.

• Journal of KIISE
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• v.42 no.3
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• pp.307-319
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• 2015

Current ontology studies use the Hadoop distributed storage framework to perform map-reduce algorithm-based reasoning for scalable ontologies. In this paper, however, we propose a novel approach for scalable Web Ontology Language (OWL) Horst Lite ontology reasoning, based on distributed cluster memories. Rule-based reasoning, which is frequently used for scalable ontologies, iteratively executes triple-format ontology rules, until the inferred data no longer exists. Therefore, when the scalable ontology reasoning is performed on computer hard drives, the ontology reasoner suffers from performance limitations. In order to overcome this drawback, we propose an approach that loads the ontologies into distributed cluster memories, using Spark (a memory-based distributed computing framework), which executes the ontology reasoning. In order to implement an appropriate OWL Horst Lite ontology reasoning system on Spark, our method divides the scalable ontologies into blocks, loads each block into the cluster nodes, and subsequently handles the data in the distributed memories. We used the Lehigh University Benchmark, which is used to evaluate ontology inference and search speed, to experimentally evaluate the methods suggested in this paper, which we applied to LUBM8000 (1.1 billion triples, 155 gigabytes). When compared with WebPIE, a representative mapreduce algorithm-based scalable ontology reasoner, the proposed approach showed a throughput improvement of 320% (62k/s) over WebPIE (19k/s).

• The Journal of Internal Korean Medicine
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• v.35 no.1
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• pp.37-49
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• 2014

Objectives & Methods : The objective of this study was to evaluate the single oral dose toxicity of Chongmyung-tang (CMT) in ICR mice. Korean traditional herbal prescription CMT has traditionally been used as a neuroprotective for treatment of learning disability and memory improvement. CMT, lyophilized aqueous extracts (yield=9.7%) were administered to female and male mice with oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for mortality, changes in body weight, clinical signs and gross observation during 14 days after administration upon necropsy; organ weight and histopathology of 14 principle organs were examined. Results : We could not find any CMT extracts treatment related mortalities, clinical signs, changes in body and organ weight, or gross and histopathological observations against 14 principle organs up to 2,000 mg/kg in both female and male mice, except for some accidental sporadic findings which did not show any obvious dose-relations and most of which also demonstrated in both the female and male vehicle control mice in this experiments. Conclusions : Based on the results of this experiment, the 50% lethal dose ($LD_{50}$) and approximate lethal dose (ALD) of CMT extracts after single oral treatment in female and male mice can be considered to be over 2,000 mg/kg, and is likely to be safe in humans.