• Biomolecules & Therapeutics
• /
• v.27 no.2
• /
• pp.160-167
• /
• 2019

Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.

• Phonetics and Speech Sciences
• /
• v.13 no.3
• /
• pp.71-78
• /
• 2021

Most neural-network-based speech synthesis models utilize neural vocoders to convert mel-scaled spectrograms into high-quality, human-like voices. However, neural vocoders combined with mel-scaled spectrogram prediction models demand considerable computer memory and time during the training phase and are subject to slow inference speeds in an environment where GPU is not used. This problem does not arise in linear spectrogram prediction models, as they do not use neural vocoders, but these models suffer from low voice quality. As a solution, this paper proposes a Tacotron 2 and Transformer-based linear spectrogram prediction model that produces high-quality speech and does not use neural vocoders. Experiments suggest that this model can serve as the foundation of a high-quality text-to-speech model with fast inference speed.

• Journal of the Korea Convergence Society
• /
• v.12 no.4
• /
• pp.249-258
• /
• 2021

Bitcoin prices have been soaring recently as investors flock to cryptocurrency exchanges. The purpose of this study is to predict the Bitcoin price using a deep learning model and analyze whether Bitcoin is profitable through investment strategy. LSTM is utilized as Bitcoin prediction model with nonlinearity and long-term memory and the profitability of MA cross-over strategy with predicted prices as input variables is analyzed. Investment performance of Bitcoin strategy using LSTM forecast prices from 2013 to 2021 showed return improvement of 5.5% and 46% more than market price MA cross-over strategy and benchmark Buy & Hold strategy, respectively. The results of this study, which expanded to recent data, supported the inefficiency of the cryptocurrency market, as did previous studies, and showed the feasibility of using the deep learning model for Bitcoin investors. In future research, it is necessary to develop optimal prediction models and improve the profitability of Bitcoin investment strategies through performance comparison of various deep learning models.

• Journal of Convergence for Information Technology
• /
• v.10 no.12
• /
• pp.216-225
• /
• 2020

This study was conducted to qualitatively analyze the selected research through a systematic review to find out application method, outcome measures, and intervention effects of dual task. We searched for published studies from January 2010 to December 2019. Electrical database were PubMed and ProQuest. Search terms were 'dual task' OR 'multi modal' AND 'mild cognitive impairment' OR 'dementia' OR 'Alzheimer's disease'AND 'intervention' OR 'rehabilitation. There were 8 studies selected finally. The dual task was applied not as a single intervention but as a combined intervention with other exercises. The contents of dual task were consisted of motor and cognitive tasks to be independent each other. The outcome measures included general cognitive function such as MMSE and CERAD, executive function, and memory. Additionally the dual task cost was also used to identify the direct improvement of the dual task. This study could provide informations of dual task application on elderly with cognitive impairment.

• Journal of the Korea Society of Computer and Information
• /
• v.25 no.12
• /
• pp.203-210
• /
• 2020

Memory-based collaborative filtering is one of the representative types of the recommender system, but it suffers from the inherent problem of data sparsity. Although many works have been devoted to solving this problem, there is still a request for more systematic approaches to the problem. This study exploits distribution of user ratings given to items for computing similarity. All user ratings are utilized in the proposed method, compared to previous ones which use ratings for only common items between users. Moreover, for similarity computation, it takes a global view of ratings for items by reflecting other users' ratings for that item. Performance is evaluated through experiments and compared to that of other relevant methods. The results reveal that the proposed demonstrates superior performance in prediction and rank accuracies. This improvement in prediction accuracy is as high as 2.6 times more than that achieved by the state-of-the-art method over the traditional similarity measures.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.22 no.6
• /
• pp.1243-1252
• /
• 2012

Due to the widespread use of smart devices, threats of direct observation attacks such as shoulder surfing and recording attacks, by which user secrets can be stolen at user interfaces, are increasing greatly. Although formal security models are necessary to evaluate the possibility of and security against those attacks, such a model does not exist. In this paper, based on the previous work in which a HCI cognitive model was firstly utilized for analyzing security, we propose STM-GOMS model as an improvement of GOMS-based model with regard to memory limitations. We then apply STM-GOMS model for analyzing usability and security of a password entry scheme commonly used in smart devices and show the scheme is vulnerable to the shoulder-surfing attack. We finally conduct user experiments to show the results that support the validity of STM-GOMS modeling and analysis.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.30 no.6
• /
• pp.1225-1236
• /
• 2020

Fuzzing is an automated software testing methodology that dynamically tests the security of software by inputting randomly generated input values outside of the expected range. KISA is releasing open source for standard cryptographic algorithms, and many crypto module developers are developing crypto modules using this source code. If there is a vulnerability in the open source code, the cryptographic library referring to it has a potential vulnerability, which may lead to a security accident that causes enormous losses in the future. Therefore, in this study, an appropriate security policy was established to verify the safety of block cipher source codes such as SEED, HIGHT, and ARIA, and the safety was verified using differential fuzzing. Finally, a total of 45 vulnerabilities were found in the memory bug items and error handling items, and a vulnerability improvement plan to solve them is proposed.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.24 no.9
• /
• pp.1180-1186
• /
• 2020

One of the Embedded systems Tiny Processing Unit (TPU) usually acts in harsh environments like external shock or insufficient power. In these cases, data could be polluted, and cause critical problems. As a solution to data pollution, many embedded systems are using Error Correcting Code (ECC) to protect and restore data. However, ECC processing in TPU increases the overall processing time by increasing the time of instruction fetch which is the bottleneck. In this paper, we propose an architecture of parallelized ECC block to the reduce bottleneck of TPU. The proposed architecture results in the reduction of time 10% compared to the original model, although memory usage increased slightly. The test is evaluated with a matrix product that has various instructions. TPU with proposed parallelized ECC block shows 7% faster than the original TPU with ECC and was able to perform the proposed test accurately.

• Nutrition Research and Practice
• /
• v.16 no.2
• /
• pp.173-193
• /
• 2022

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD. MATERIALS/METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ_25-35-induced mouse model and conducted behavioral experiments to test cognitive ability. In addition, we evaluated the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and measured the production of lipid peroxide, nitric oxide (NO), and reactive oxygen species (ROS) in tissues. RESULTS: PT treatment improved the space perceptive ability in the T-maze test, object cognitive ability in the novel object recognition test, and spatial learning/long-term memory in the Morris water-maze test. Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show liver toxicity. Furthermore, administration of PT significantly inhibited the production of lipid peroxide, NO, and ROS in the brain, liver, and kidney, suggesting that PT protected against oxidative stress. CONCLUSIONS: Our study demonstrated that administration of PT improved Aβ_25-35-induced cognitive impairment by regulating oxidative stress. Therefore, we propose that PT could be used as a natural agent for AD improvement.

• Journal of Audiology & Otology
• /
• v.24 no.4
• /
• pp.167-173
• /
• 2020

Background and Objectives: Top-down restoration of distorted speech, tapped as phonemic restoration of speech in noise, maybe a useful tool to understand robustness of perception in adverse listening situations. However, the relationship between phonemic restoration and speech perception in noise is not empirically clear. Subjects and Methods: 20 adults (40-55 years) with normal audiometric findings were part of the study. Sentence perception in noise performance was studied with various signal-to-noise ratios (SNRs) to estimate the SNR with 50% score. Performance was also measured for sentences interrupted with silence and for those interrupted by speech noise at -10, -5, 0, and 5 dB SNRs. The performance score in the noise interruption condition was subtracted by quiet interruption condition to determine the phonemic restoration magnitude. Results: Fairly robust improvements in speech intelligibility was found when the sentences were interrupted with speech noise instead of silence. Improvement with increasing noise levels was non-monotonic and reached a maximum at -10 dB SNR. Significant correlation between speech perception in noise performance and phonemic restoration of sentences interrupted with -10 dB SNR speech noise was found. Conclusions: It is possible that perception of speech in noise is associated with top-down processing of speech, tapped as phonemic restoration of interrupted speech. More research with a larger sample size is indicated since the restoration is affected by the type of speech material and noise used, age, working memory, and linguistic proficiency, and has a large individual variability.