• 소음진동
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• 제9권6호
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• pp.1123-1130
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• 1999

A system which is composed of a membrane and an air cavity is studied. To analyze the low frequency characteristics of a single membrane-cavity system, a plane wave model is derived. The relations among system variables, such as tension, density and stiffness, are investigated. Absorption coefficient has a maximum value at a peak frequency. In addition, a membrane-cavity system absorbs the low frequency noise with a band around peak frequency. This band is primarily determined by damping effect of the system. Furthermore, a multiple membrane-cavity system is investigated by using the transfer matrix method. To show the practical applicability of the proposed model, extensive experiments were conducted. Results show that a multiple membrane-cavity system can have broader noise reduction in the low frequency range than single.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.1036-1039
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• 2004

This paper is to experimentally study on the sound absorption of a membrane resonance type system. Membrane resonance type system improves the weak point of a perforated plate system. The experimental results for a membrane resonance type system are explained in comparison with those of a perforated plate system. From the experimental results, it is found that there is an influence of the membrane on the absorption performance. The sound absorbing performances of a membrane resonance system are similar to those of a perforated plate system.

• Applied Microscopy
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• 제27권2호
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• pp.165-175
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• 1997

This paper aims to prove the effects of Squalene (SQ) on the cellular toxicity of 5-FU to the mouse which pretreated with SQ and then treated with 5-FU. The results of the group A (treated with only 5-FU) are as follows. The nucleus was destroyed at 24 hours and 48 hours group, however, somewhat repaired at 72 hours group. The dilated inner cavity and the irregular lamellae of the rough surfaced endoplasmic reticulum (RER) were observed continually until 72 hours group. The inner cavity of the smooth surfaced endoplasmic reticulum (SER) were dilated in all groups. However, the destroyed and the normal membrane were observed simultaneously at 72 hours group. The inner membrane of the mitochondria were almost repaired at 96 hours group. The results of the group B (treated with 5-FU and squalene) are as follows. The nucleus was a little influenced by the toxicity of 5-FU at 24 hours and 48 hours, RER were observed to keep the typical lamella structure of cisternae from 24 to 72 hours group, but inner cavity kept on dilating. In SER, inner cavity were also observed to flatten from 24 to 72 hours group. Mitochnodria were always shown normal. All cell organelles were simillar to those of normal groups at 96 hours. Accordingly, it can be said that the treatment of 50 prevents the cytotoxicity of 5-FU on cell organelles of liver cell and that is concerned with the formation of membrane system of cell organelles.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 춘계학술대회논문집
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• pp.298-302
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• 2002

Equivalent volume estimation of the coupler and two coupled microphones has a key role in standard microphone pressure calibration. The equivalent volume of the microphone is determined by the dynamic characteristics of the diaphragm system and front cavity. Therefore the modal parameters of diaphragm system - natural frequency and damping fatter - should be measured explicitly for the estimation of the equivalent volume. The diaphragm system is composed of the vibrating diaphragm, back slit behind diaphragm, pressure equalization vent, and front cavity which are acoustically coupled. In the measurement, the electrostatic actuator was used to excite the system with the swept sine, and the frequency response was obtained. The close actuator in front of the diaphragm must influence the radiation impedance of the system, and then the modal parameters. From the measured frequency response, the natural frequency and the damping factor could be estimated with the Complex exponential method based on the Prony model and the zero crossing real and imaginary plot.

• 대한한방내과학회지
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• 제35권3호
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• pp.274-287
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• 2014

Objectives: This study was aimed to figure out an agreement between the diagnosis of nasal endoscopy and a preexisting questionnaire focusing on Cold-Heat pattern. Methods: 52 patients with cough who met the criteria filled out a pattern questionnaire and the examiner looked at their nasal cavities through nasal endoscopy. According to the checked questionnaire results, the subjects were identified by 6 patterns. After examining subject's mucous membrane of oropharynx and nasal cavity through nasal endoscopy, we classified each to the Cold or Heat group. Correlation between questionnaire and nasal endoscopy results was analyzed. Results: In diagnosing Cold-Heat, there was no significant difference by McNemar test (p=0.227) between nasal endoscopy and the questionnaire, and the two methods agreed moderately (${\kappa}=0.428$). The color of mucous membrane of oropharynx and the Cold-Heat pattern on questionnaire agreed slightly (${\kappa}=0.133$). The color of mucous membrane of nasal cavity and the Cold-Heat pattern on questionnaire agreed fairly (${\kappa}=0.384$). In the patients with cough related to upper respiratory tract, they got higher diagnosis accuracy than the patients with cough related to lower respiratory tract did. Similarly, external cough patients got higher diagnosis accuracy than internal cough patients did. Conclusions: To identify Cold or Heat, examining oropharynx and nasal cavity using nasal endoscopy is a meaningful method in patients with cough, showing that two diagnosis methods which use nasal endoscopy and questionnaire agreed moderately. Especially, it is more useful diagnosing patients with cough related to the upper respiratory tract than diagnosing the patients with cough related to the lower respiratory tract.

• 한국지반공학회논문집
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• 제19권6호
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• pp.335-342
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• 2003

엄밀한 변형해석을 위해서는 전체변형률 범위에서 신뢰성 있는 변형특성 평가가 가능한 현장시험 기법이 개발되어야 한다. 공내재하시험은 현장지반의 변형률 크기에 따른 전단탄성계수를 직접 평가할 수 있는 유일한 시험기법이다. 본 연구에서는 $10^{-5}$% ∼20%의 전체변형률 범위에 대하여 적용 가능한 공동변형 측정방법을 고안하였다. 개발된 장비의 순응성 검증을 위하여 검증토조에 대한 시험과 현장시험을 수행하였다. 개발된 장비는 $5\times 10^{-2}$% 이상의 변형률 범위에서 신뢰성 있는 전단탄성계수 측정이 가능하였다. 미소한 공동변형을 측정하는데 발생하는 주요 오차의 원인은 공동변형 측정 시스템 자체보다는 측정봉과 멤브레인 사이에서 역재하-재재하 과정에 발생하는 마찰인 것으로 판단된다.

• Journal of Pharmaceutical Investigation
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• 제25권4호
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• pp.353-363
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• 1995

The purpose of this study was to investigate the intestinal and nasal absorption enhancement of cefotaxime (CTX) by ion-pairing with counterions and to design an effective oral and intranasal drug delivery system for antibiotics. Counterions for absorption promotion were cationic surfactants [cetylpyridinium chloride (CP), cetrimide (CT) and benzalkonium chloride (BA)]. In the presence of counterions, the apparent partition coefficient of cefotaxime was increased depending on the molar concentration of the counterions. Anion interference was observed for ion-pairing of cefotaxime with counterions because of the counterbalance between an anion and counterions. The present study employed the in situ simultaneous nasal and intestinal perfusion technique in rats. The apparent permeabilities $(P_{app})$ of cefotaxime were $1.43{\pm}0.04{\times}10^{-5}\;cm/sec(mean{\pm}S.E)$ in the nasal cavity and 0 in the jejunum, respectively, which indicated that the intrinsic absorptivity of cefotaxime was greater in the nasal cavity than in the jejunum. When ionupairing formers were used, the decreasing order of apparent cefotaxime permeability $(P_{app},\;10^{-5}\;cm/sec)$, corrected for surface area of absorption, was as followings: $BA\;(7.50{\pm}0.36)\;>\;CT\;(4.92{\pm}0.24)\;>\;CP\;(3.01{\pm}0.17)$ in the jejunum and $BA\;(22.31{\pm}1.36)\;>\;CP\;(18.24{\pm}0.81)\;>\;CT \;(16.22{\pm}1.87)$ in the nasal cavity. The increase in permeability of cefotaxime was about 13-fold in the rat nasal cavity and was marked in the rat jejunum for ion-pairing with counterions as compared to those without ion-pairing. The damages of jejunal and nasal mucosal membrane by counterions were observed within approximately 2hrs after removal of ion-pair of cefotaxime with counterions from the nasal cavity and jejunum. These results suggest that CP can be used as an ion-pairing former in the jejunum and CP and CT can be used as ion-pairing formers in the nasal cavity for cefotaxime, as well as for poorly absorbed drugs with a negative charge due to ionization.

• 한국정밀공학회지
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• 제16권7호
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• pp.24-31
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• 1999

Bulging is a forming method to shape of die cavity by using hydraulic pressure in tube or vessel. Bulging machine and die were developed in order to produce vessel for keeping warm. Bulging machine is a double type with two horizontal cylinders for bulging of two pieces at the same time. The developed die system has one bulging die and two drawing dies for necking at the both ends of tube. The diameter of tube expands by hydraulic pressure in tube. at the same time, thrust at the both ends of tube. pushes tube in the direction of expansion to obtain high expanding rate with no crack. In this study, the bulging properties were investigated to solve tube crack and necking in manufacturing vessel by the combination method of bulging and drawing. As a result, high expanding rate of tube radius without crack, precision necking and high productivity were obtained.

• International Journal of Precision Engineering and Manufacturing
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• 제2권4호
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• pp.40-46
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• 2001

Bulging is a forming method to shape die cavity by using hydraulic pressure in tube or vessel. Bulging machine and die were developed in order to produce vessel for keeping warm. Bulging machine is a double type with two horizontal cylinders for bulging of two pieces at the same time. The developed die system has one bulging die and two drawing dies for necking at both ends of the tube. The diameter of tube expands by hydraulic pressure in tube. At the same time, thrust at both ends of the tube pushes tube in the direction of expansion to obtain high expansion rate with no crack. In this study, the bulging properties were investigated to solve tube crack and necking in manufacturing vessel by combining bulging and drawing. As a result, high expanding rate of tube radius without crack, precision necking and high productivity were obtained.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1976년도 제10차 학술대회연제 순서 및 초록
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• pp.87.1-87
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• 1976

Bekesy measured the sound transformation system of the middle ear 49 years ago. According to his reports, a ratio between the size of ear drum and the size of oval window is 17 : 1, and the lever function of the ossicles is physiologically 1.3 : 1. Therefore, the hearing might be aggravated to 27.5㏈ in the case of the vanishment of 3 ossicles. In 1952, Wullstein reported 5 types of tympanop-lasty and the fourth type among them was especially named for the sound-protection. The oval window is only exposed by the sound pressure and the round window is not exposed. According to the application by this idea, the post-operative hearing might be improved until 27.5㏈. Mean while, in 1942, Onchi verified through his experiment that the results of Bekesy's measurement was not completely conformed to Onchi result. Bekesy measured the sound pressure on the stapes plate of the oval window, on the other hand, Onchi measured the sound pressure on the surface of the perilymph of the oval window after removing the stapes plate(Fig. 1).(Figure omitted) The difference of their experiment is recognized that the impedance of the stapes plate exists or not (Fig. 1). Both Audiogrums are compared as Fig. 2. The result of IV type of tympanoplasty is success ful in 54% as the Table 1. (Table Omitted) The reason of unsatisfactory is caused by the thick and unmovable window-membrane and by the closing of air passage to the round window. The closing of the air passage to the round window is occurred by the adhesion between the grafting membrane and the surface of promontorium. In order to preserve this adhesion, I produce to transplantate the mucous membrane of the lip to the bone surface of tympanic cavity after removing the granulation tissue of the tympanic cavity and to form a membranous canal for the sake of air passage (Fig. 3). (Figure Omitted) The post-operative hearing by this method is shown as Fig. 4, 5. In other words, the post-operative sound pressure entered into the cochlea directly, by way of the oval window only, not by way of the round window, as a theorie of the sound protection. (Figure omitted)