• Journal of Life Science
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• v.34 no.3
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• pp.170-178
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• 2024

Adipose-derived stem cells (ADSCs) are capable of differentiation into multiple lineages of cells, which has attracted attention for clinical therapy. However, ADSCs have poor proliferation capacity and a short life span in culture, which is an impediment in the application to clinical use. Previously, to overcome growth disadvantages, we had established an immortalized ADSC line (ADSC-T) by introducing the SV40 T antigen coding gene into primary human ADSC. In the present study, we evaluated the differentiation potential of this cell line and assessed the anti-inflammatory effect of its conditioned medium (CM). ADSC-T appeared to maintain the differentiation potential into adipocyte and chondrocyte. The CM of ADSC-T suppressed the NF-κB activity and its target gene expression of COX-2 and iNOS. Furthermore, the phosphorylations of MAPKs, including ERK, JNK and p38, were suppressed by the ADSC-T CM. The expressions of pro-inflammatory cytokines such as TGF-β, TNF-α, IL-6, and IL-13 were also suppressed by the CM of ADSC-T. In the Nc/Nga atopic model mice, the CM showed therapeutic effect on DNCB-induced atopic dermatitis. These results indicate that the immortalized ADSC-T maintains the beneficial properties of primary ADSC and could be a versatile cell source for not only research into ADSC but also for production of CM suitable for clinical application.

• Journal of Korean Society of Steel Construction
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• v.18 no.1
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• pp.113-122
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• 2006

The purpose of this paper is to evaluate the fire resistance of the TSC beam, a composite beam composed of a concrete beam enclosed by steel plates. Since a discrepancy was observed between the structural mechanisms of TSC and typical composite beams, the fire performances of the two beams are likewise believed to be partially dissimilar. In this experiment, small and medium-sized TSC beams were tested under given conditions in the laboratory, with/without one of the most widely used spray-on fire protections in Korea. Furthermore, based on the steel and concrete properties under elevated temperatures that were obtained from Eurocode, temperature development across the section was suggested, analyses. To determine the capacity of a modified plastic section, th e fire performance of the model was also examined.

• Journal of the Economic Geographical Society of Korea
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• v.10 no.3
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• pp.344-353
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• 2007

Business incubators (BIs) could be regarded as an effective mechanism for linking research and industry to inspire technology and knowledge based entrepreneurship and innovation of start-up SMEs. The performance of BIs for small and medium enterprises (SMEs) innovation should be differentiated in accordance with the technology capacity of SMEs, the national entrepreneurial culture and characters in each economy. Therefore, the research intended to categorize BIs in the selected 10 APEC member economies into four types by investigating the issue of member economies' strategies, functions and characteristics in various focused programs.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.278-287
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• 2000

In Korea, countermeasures against earthquake disasters such as the seismic performance evaluation and/or retrofit scheme of buildings have not been fully performed since Korea had not been experienced many destructive earthquakes in the past. However, due to more than four hundred earthquakes with slight/medium intensity occurred in the off-coastal and inland of Korea during the past 20 years, and due to the great earthquakes occurred recently in neighboring countries, such as the 1995 Hyogoken-Nambu Earthquake with more than 6,500 fatalities in Japan and the 1999 Ji-Ji Earthquake with more than 2,500 fatalities in Taiwan, the importance of the future earthquake preparedness measures in Korea is highly recognized. The main objective of this paper is to provide the basic data for development of a methodology for the future earthquake preparedness in Korea by investigating the concept and applicabilities of the Japanese Standard for Evaluation of Seismic Performance of Existing RC Buildings developed in Japan among the methodologies of all over the world. In this paper, a seismic performance evaluation method of the existing reinforced concrete buildings is proposed based on experimental data of columns and walls carried out in Korea by referring the Japanese Standard, especially focusing on the Strength Index(C) among the indices in the seismic capacity index(IS) equations. Also, the seismic capacities of two existing reinforced concrete buildings in Korea are evaluated based on the proposed methodology and the Japanese Standard, and the correlations between the seismic capacities by the proposed methodology and the Japanese Standard are discussed.

• Journal of Pharmaceutical Investigation
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• v.11 no.2
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• pp.1-10
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• 1981

Phospholipids were examined for their capacity to protect human erythrocytes against hemolysis induced by hypotonic solution, p-hydroxymercuribenzoate or hematin. The following results were obtained. 1. Phosphatidyl choline, lysophosphatidyl choline and phophatidyl ethanoleamine as well as chlorpromazine prevented the osmotic hemolysis of human erythrocytes which occurred due to water influx into erythrocytes from medium, but showed no effect on hematin-induced hemolysis which occurred without the volume change of erythrocytes. 2. Human erythrocytes were found to be most sensitive to the antihemolytic action of phospholipids among mammalian erythrocytes from sheep, rabbit, rat and mouse. 3. Phospholipids at the concentrations showing their strong antihemolytic effect on human erythrocytes against osmotic hemolysis had no influence on methylene blue uptake and volume change of erythrocytes in hypotonic solution. 4. Phospholipids increased erythrocyte deformability 2 to 3 times over control group and there was aclose relationship between their antihemolytic action and increase of deformability as a function of their concentrations. 5. The phospholipids increased the resistance to osmotic hemolysis of human erythrocytes by increasing membrane elasticity through their incorporation into lipid bilayer without altering glucose metabolism and water influx to erythrocytes.

• Journal of Information Processing Systems
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• v.9 no.2
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• pp.287-300
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• 2013

Cloud storage is provided as a service in order to keep pace with the increasing use of digital information. It can be used to store data via networks and various devices and is easy to access. Unlike existing removable storage, many users can use cloud storage because it has no storage capacity limit and does not require a storage medium. Cloud storage reliability has become a topic of importance, as many users employ it for saving great volumes of data. For protection against unethical administrators and attackers, a variety of cryptography systems, such as searchable encryption and proxy re-encryption, are being applied to cloud storage systems. However, the existing searchable encryption technology is inconvenient to use in a cloud storage environment where users upload their data. This is because this data is shared with others, as necessary, and the users with whom the data is shared change frequently. In this paper, we propose a searchable re-encryption scheme in which a user can safely share data with others by generating a searchable encryption index and then re-encrypt it.

• Journal of the Korean Institute of Educational Facilities
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• v.20 no.4
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• pp.35-43
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• 2013

Some results of experimental investigation conducted to assess the effect of cement composite strength and ductility on the shear behavior and crack-damage mitigation of stud connections between existing reinforced concrete frame in school buildings and seismic strengthening elements from cyclically direct shear tests are described. The cement composite strengths include 50 for medium strength and 70 MPa for high strength. Two types of cement composites, strain-hardening cement composite (SHCC) and non-shrinkage mortar, are used for stud shear connection specimens. The special SHCCs are reinforced with hybrid 0.2% polyethylene (PE) and 1.3% polyvinyl alcohol (PVA) fibers at the volume fraction and exhibits tensile strain capacity ranging from 0.2 to 0.5%. Test result indicates that SHCC improves the seismic performance and crack-damage mitigation of stud shear connections compared with stud connections with non-shrinkage mortar. However, the performance enhancement in SHCC stud connections with transverse and longitudinal reinforcements is less notable for those without additional reinforcement.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2131-2136
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• 2003

Since the number of user-requests increases dramatically on the Internet, the servers and networks can be swamped unexpectedly without any prior notice. Therefore, the end-users are waiting or refused for the responses of the contents from the originating servers. To solve this problem, it has been considered that a distributed web caching system efficiently utilizes structural elements of the network. Because a distributed web caching system uses the caches that are close to end-users on the network, it transmits the contents to users faster than the original network system. This paper proposes a simple client-based distributed web caching system(2HRCS) that client can directly perform object allocation and load balancing without an additional DNS for load balancing in CARP (Cache Array Routing Protocol) and GHS (Global Hosting System) that are the recent distributed web caching system protocol. The proposed system reduces the cost of setup and operation by removing DNS that needs to balance the load in the existing system. The system has clients with consistent hashing method, so it extends its environment to other distributed web caching system that has caches of different capacity. A distributed web caching system is composed and tested to evaluate the performance. As a result, it shows superior performance to consistent hashing system. Because this system can keep performance of the existing system and reduce costs, it has the advantage of constructing medium or small scale CDN (Contents Delivery Network).

• Journal of Korea Society of Industrial Information Systems
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• v.22 no.5
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• pp.9-15
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• 2017

In the Digital Age, All Data used in the Internet is Digitized and Transmitted and Received Over a Communications Network. Therefore, it is Important to Transmit Data with Confidentiality and Integrity, Since Digital Data may be Tampered with and Tampered by Illegal users. Steganography is an Efficient Method for Ensuring Confidentiality and Integrity Together with Encryption Techniques. I Propose a Hangul Steganography Method that Inserts a Secret Message based on a Changing Insertion Position and a Changing Eojeol Size in a Cover Medium. Considering the Insertion Capacity of 3.35% and the File Size Change of 0.4% in Hangul Text Steganography, Experimental Results Show that the Jaro_score Value needs to be Maintained at 0.946.

• Food Science of Animal Resources
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• v.38 no.1
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• pp.26-42
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• 2018

Today incorporation of natural ingredients as inorganic phosphate replacers has come into prominence as a novel research topic due to health concerns about phosphates. In this study, we aimed to investigate the quality of emulsified chicken meatballs produced with Jerusalem artichoke powder (JAP), either alone or in combination with sodium carbonate (SC) as sodium tripolyphosphate (STPP) replacers. The results showed that naturally dried JAP showed favorable technological properties in terms of water-oil binding and gelling. Emulsion batters formulated with JAP-SC mixture showed lower jelly and fat separation, higher water-holding capacity and higher emulsion stability than control samples with STPP. In final product, incorporation of JAP-SC mixture increased moisture and reduced lipid and energy values, and kept the pH value similar to control. Added JAP lead to increments in $b^*$ values whereas decreases $L^*$ values. Cook yield was similar to control in phosphate-free samples formulated with JAP-SC mix. Either low or medium ratios of JAP in combination with SC managed to protect most of the sensory parameters, while sensory scores tend to decrease in samples containing high levels of JAP. Addition of JAP to formulations presented samples that have equivalent behavior to phosphates in terms of lipid oxidation. In conclusion, our study confirms that utilization of JAP in combination with SC had promising effects as phosphate replacers by presenting natural solutions and providing equivalent quality to standard phosphate containing products.