• 한국약용작물학회지
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• 제10권5호
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• pp.392-398
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• 2002

4년생 의성작약을 재료로 하여 작약의 주 이용부위인 약근 외에 뇌두, 줄기, 잎과 같은 작약 식물체 각 부위로 시료를 구분하고, 또한 작약근의 경우 관행적 법제시 박피를 통해 제거되는 코르크층과 코르크층의 유 무에 따라 유피근 및 거피근으로 구분하여 각 시료에 함유된 작약 주요 생리활성 성분의 함량 분포를 검토한 결과 작약 식물체 부위별 paeoniflorin, albiflorin 및 phenolic compounds의 각 함량은 뇌두가 뿌리보다 높은 양상을 나타내었다. 또한 기능성 물질로 평가되는 gallic acld 및 benzoic acid는 작약의 잎과 줄기에도 상당히 많은 양이 존재하였고, 특히 잎에는 paeoniflorln도 약 2.3%가 존재하는 것을 확인할 수 있었다. 따라서 현재까지 번식용으로만 이용되어온 작약의 뇌두도 약재로서의 이용 가능성을 체계적으로 검토할 필요가 있을 것이며, 작약의 잎 및 줄기도 gallic acid 및 그 유도체들의 source가 될 수 있으므로 이들 부위의 이용성도 체계적으로 검토되어야 할 것이다. 한편 작약근에 함유된 유용 생리활성 성분들은 목부와 껍질부위의 코르크층에 함께 존재하였다 특히 albiflorin, gallic acid, benzoic acid 및 (-)-epicatechin 성분은 코르크층에 많이 존재하였고, 목부에 더 많은 양이 존재하는 성분은 paeoniflorin, (+)-taxifolin $3-O-{\beta}-D-glucopyranoside$ 및 (+)-catechin이었다. 결국 작약근 이용시 코르크층을 벗기면 albiflorin을 포함한 유용성분의 손실이 발생되고, phenol 성 물질의 분비로 외면의 갈변이 유도되므로 상품의 질을 떨어뜨리는 원인이 된다. 그러므로 작약근의 이용 시 거피를 하지 않는 것이 유용성분의 활용 면에서도 유리하고, 수치작업에 대한 노력이 감소되므로 경제적 측면에서도 유리한 것으로 평가된다.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2008년도 춘계학술발표회
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• pp.122-123
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• 2008

• Biomolecules & Therapeutics
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• 제29권4호
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• pp.384-391
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• 2021

Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcement-enhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.

• 한국자원식물학회지
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• 제36권5호
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• pp.508-516
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• 2023

왜당귀[Angelica acutiloba (Siebold & Zucc.) Kitagawa]를 대상으로 종자 발아 및 유묘 생육, 유용성분 함량과 관련된 GA₃ 처리 효과를 분석하여 왜당귀 재배시 기초자료를 제공하고자 하였다. 왜당귀 종자의 수분흡수율은 침지 2시간이 경과한 시점에서 62.07%를 나타냈고, 48시간이 경과한 시점에서 122.15%로 가장 높은 값을 나타냈다. 왜당귀 종자의 적정 발아온도는 10℃에서 25℃로 확인되었으며, 5℃에서는 발아가 진행되지 않았고, 30℃에서는 GA₃ 농도가 증가함에 따라 발아율이 유의하게 증가하였다. 또한 유묘 생육은 GA₃ 처리농도가 높아질수록 양호하였으나 유용성분 함량의 경우 실험구에 따른 유의성이 확인되지 않았다. 이러한 결과는 약용 및 식용으로 활용성이 높은 왜당귀에 대한 최적 재배와 생산기술 정립에 기초자료로 활용할 수 있을 것으로 판단된다.

• 한국식품조리과학회지
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• 제18권4호
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• pp.455-460
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• 2002

This experiment was conducted to obtain basic information on the natural spice of Elsholtzia splendens, which is one of the native Korean aromatic plants for aromatic, medicinal and ornamental uses. The overall acceptability and the masking effects on the fetid smell of beef were investigated with Elsholtzia splendens-flavored oils by sensory evaluation. The ability of an electronic nose with six metal oxide sensors to classify Elsholtzia splendens flavored oils based on their odors was studied. The response by electronic nose was analyzed by principal component analysis (PCA). In EOI, EOII, and ESI, (이것들이 무엇을 의미하는지 기술할 필요가 있음). overall acceptability of French dressing showed a same level of preference during storage. Fetid smell of beef was not changed by the addition of 4 types of Elsholtzia splendens-flavored oil during storage. In EO I -flavored oil, the proportion of 1st principal component was 0.829, and the proportion of 1st principal component was 0.818 in ESI-flavored oil. The PCA plot was used to detect stored Elsholtzia splendens flavored oils.(앞 뒤 문맥이 안맞음. 뒤에 이어지는 글이 있는지\ulcorner).

• 한국의학물리학회지:의학물리
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• 제8권1호
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• pp.69-79
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• 1997

뫼스바우어 분광법을 사용해서 다목적용으로 제조된 의학용 치료 연고제내에 포함된 자성물질 입자들의 성질들이 연고제내에서 안정되게 존재하고 있는 지를 연구하였다. 자성물질 내에 들어있는 $^{57}$ Fe 동위철 핵자들에 의해 나타나는 뫼스바우어 스펙트럼에 대해 분석한 결과들과 Fe$_3$O$_4$-${\gamma}$-Fe$_2$O$_3$ 체계에 대해 잘 알려진 분석결과들을 비교 연구하여 자성입자들의 구성상태를 규명할 수 있었다. 결과적으로 나타난 연고제내에 자성물질의 합성상태는 합성되지 않은 순수한 자성물 질만의 성분 분석과는 다른 결과를 나타내었다. 한편, 자성물질 입자의 크기 (~100$\AA$)가 매우 작음에도 불구하고 이들 입자들은 95K~300K 범위에서 초 상자성 형태의 뫼스바우어 스펙트럼 특성을 나타내지 않았다. 또한, 연고제를 방사성 살균한 후에도 자성물질 성분 구성에는 변화가 없었다.

• 한국약용작물학회지
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• 제26권1호
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• pp.32-41
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• 2018

Background: To obtain useful safflower resources for breeding and research of functional materials, the present study was conducted to determine fatty acid compositions and antioxidant activities of 281 safflower accessions collected from East Asia including South Korea. Methods and Results: Lipid contents and fatty acids compositions were evaluated using soxhlet extraction and gas chromatography, respectively. A antioxidant activities were analyzed using a spectrophotometer. The evaluation range of safflower accessions showed very wide variation. In terms of lipid contents, the China accessions were higher than the collection from other regions, whereas antioxidant activities did not differ among regions. The result of the principal component analysis showed that the first and second principal component cumulatively explained 90.6% of the total variation. In clustering the safflower accessions, the tree showed four major clades. Group II (16 accessions) was high in lipid content, oleic acid and linoleic acid, whereas group III (50 accessions) exhibited higher antioxidant activities than other groups. Conclusions: It was recommended that the China collections be utilized as a useful resource for research on functional oil materials. These results provided valuable information for safflower breeders and researchers of functional food.

• 한국약용작물학회지
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• 제2권2호
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• pp.174-179
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• 1994

물쑥을 유용화하기위해 물쑥의 화학성분을 수집 종쑥과 분석비교한 결과는 다음과 같다. 1. 일반성분중 수분, 조회분 및 조섬유의 함량은 물쑥이 수집종쑥보다 높았다. 2. 비타민함량에 있어서는 thimain, riboflavin 및 ascorbic acid의 함량은 물쑥이 수집종쑥보다 약간 낮았고 niacin함량은 약간 높았다. 3. 식이섬유소함량은 물쑥이 40.91%, 수집종쑥이 38.42%이었으며 물쑥이 수집종쑥보다 hemicellusose, cellulose의 함량이 높았고 lignin함량은 낮았다. 4. 무기질함량중 K함량이 물쑥 5206.7mg%, 일반 쑥 4166.7mg%로 가장 높았고 Na, Fe 및 Mn의 함량은 물쑥이 수집종쑥보다 2배이상 높았으며 Cu함량만 물쑥이 수집종쑥보다 낮았다. 5. Phenolic compound 의 함량은 수집종쑥보다 물쑥이 약간 높았다.

• 한국약용작물학회지
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• 제23권5호
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• pp.395-399
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• 2015

Background : This study examined the effect of harvesting time on the growth, yield characteristics, and major beneficial components in Salvia miltiorrhiza. Methods and Results : Although plant height, stem diameter and branch length were not affected by harvesting time, the number of stems was highest when harvested in mid October. There were no differences in root length and thickness, however, the rhizome was thicker when it was harvested at the end of October or early November than when it was harvested in early and mid October. The dried root weight also showed a similar pattern. However, there was a statistically significant increase to 408 kg (16%) in the rhizome weight when in late October and a rise to 455 kg (29%) when harvested in early November. Harvest time had little effect on the content of the major component of S. miltiorrhiza. For example, salvianolic acid content rose from 9.42 to 9.64% with later harvest times, and tanshinone ${\prod}A$ content was tended to be slightly more increased in mid October which S. miltiorrhiza has 0.22% tanshinon ${\prod}A$ than in early October. Conclusions : According to these results, the optimum harvest time for S. miltiorrhiza is early November when plant or major component yields are hightest. There were no significant harvest time effects on the major beneficial components.

• 한국약용작물학회지
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• 제20권2호
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• pp.108-116
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• 2012

In this study, to develop hair growth agents using natural products which has excellent ability to promote hair growth effect and fewer side effect, animal experiment and clinical trials was performed to evaluate hair growth promotion effect of herbal product containing $Rosa$ $mutiflora$ roots extracts as a main component (RMHP). 4-week-old male C57BL/6 mice were removed the dorsal hair using thioglycolate, and applied 15% EtOH solution as a negative control, 5% minoxidil as a positive control and RMHP to dorsal skin. In the results of macroscopy and photo-interpretation, RMHP group recorded 100% (+++++) of hair growth was proved to significantly stimulate hair growth against 80% (++++) negative control group. 37 patients were treated with RMHP and evaluated the therapeutic effect at 16 weeks. Hair density was significantly increased at 16 weeks after applying RMHP ($125.0{\pm}4.9\;FU/cm^2$) compared to before treatment ($104.3{\pm}4.7\;FU/cm^2$, p < 0.05), and hair thickness were also significantly increased ($0.066{\pm}0.003$ mm) than before treatment ($0.055{\pm}0.002$ mm, p < 0.05). The result of clinical photo-interpretation using 7-point rating scale assessment, after 16 weeks clinical symptoms were evaluated to significantly improve with $1.23{\pm}0.05$ (p < 0.05). Therefore, the results of this study were observed that RMHP have hair loss prevention effect and hair growth promotion effect to hair loss patients.