• Journal of Sasang Constitutional Medicine
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• v.15 no.1
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• pp.12-26
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• 2003

1. Purpose This study is intend to catch DongMu(東武)'s viewpoint of Chobongeun Soyangin prescription. 2. Method Through Comparing Chongeun Soyangin prescriptions and medications on those of DongEuiBoGam(東醫寶鑑), DongyiSooseBowon Gabobon and DongyiSooseBowon Sinchukbon, we can find DongMu(東武)'s viewpoint of Sasang Constitutional Medicine. 3. Results 1) The same Hi prescriptions between DongEuiBoGam(東醫寶鑑) and Chobongeun Soyangin are not entirely identical. 2) GamCho(甘草), GaengMi(粳米) and Sagunja(使君子) were used in the Chobongeun Soyangin prescriptions. that means DongMu(東武)'s viewpoint of Sasang Constitutional Medicine was not entirely established. 3) PaedockSan(敗毒散), VukmijihwangTang(六味地黃湯) and BaekhoTang(白虎湯) were representative prescriptions in the Chobongeun Soyangin prescriptions. And that prescriptions were connected to DongyiSooseBowon Sinchukbon. 4) The same kind medications which were record on DongEuiBoGam(東醫寶鑑) and Chobongeun Soyangin are eighteen. And that medications are the structural principle of Chobongeun Soyangin prescriptions.

• Journal of Sasang Constitutional Medicine
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• v.14 no.3
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• pp.33-51
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• 2002

1. Purpose This study is intended to catch the expasion of theory of Sasang Constitutional Medicine through comparision DongyiSooseBowon Chopanbon with DongyiSooseBowon Chobonguen and DongyiSooseBowon Gabobon. 2. Method I compared the Soyangin's prescription and medications of DongyiSooseBowon Chopanbon with those of DongyiSooseBowon Chobonguen and Dongyisoosebowon Gabobon. 3. Result and conclusion 1) Soyangin's Medications of the same kind in Chobonguen's prescriptions and Gabobon's and Chopann's are thirty-two; like Bangpoong(防風), Hyeunggye(荊芥), Sangjihwang(生地黃), sukgo(石膏), etc. And these medications are the principle in Soyangin's disease. 2) Soyangin's Prescriptions of the same name in Chobonguen's prescriptions and Gabobon's and Chopanbon's are Yangdokbackhotang(陽毒白虎湯). Chopanbon's Yangdokbackhotang(陽毒白虎湯) is more rational and effective prescription. 3) Soyangin's Prescriptions of the same name in Chobonguen's prescriptions and Gabobon's are eleven; Bangpoongtongseungsan(防風通聖散), chengumdojuksan(千金導赤散), etc. These prescriptions are similar in the structure. 4) Soyangin's Prescriptions of the same name in Gabobon's prescriptions and Chopanbon's are five; Hyungbangpaedoksan(荊防敗毒散), Yangdokbackhotang(陽毒白虎湯). etc. These Prescriptions make a change in the structure from Gabobon's to Chopanbon's. As this we know that Dongmu(東武) selected Sasang Constitutional prescription and medication in detail as he has the more experience of treatment.

• Korean Journal of Clinical Pharmacy
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• v.29 no.1
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• pp.25-32
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• 2019

Objective: South Korea made a list of potentially inappropriate medications (PIMs) for elderly patients in 2015 and has prompted medical professionals to prescribe proper medication by using the drug utilization review (DUR) system. It has been three years since the system was introduced, but related studies have rarely been conducted. This study aimed to evaluate the effect of the DUR system on the prescription of PIMs for elderly patients. Methods: The data on the prescription of PIMs for elderly patients (${\geq}65$ years) who received medical treatment between March 1st and May 31st in 2015 (before introduction of the DUR system) and who received medical treatment between March 1st and May 31st in 2018 (after introduction of the DUR system) were retrospectively collected from electronic medical records. Results: The prescriptions of PIMs decreased from 3,716 (7.7%) to 3,857 (6.9%) (p < 0.001). The prescription of escitalopram and paroxetine, among selective serotonin reuptake inhibitors, increased significantly, and that of short-acting benzodiazepines also increased significantly from 454 (0.93%) to 624 (1.2%). Conclusion: Prescription of PIMs for elderly patients significantly decreased (p < 0.001) after the DUR system was introduced. Further expanded studies of PIMs need to be conducted for the safety of elderly patients.

• Journal of the Korean Medical Association
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• v.61 no.12
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• pp.758-764
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• 2018

Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in activities of daily living. As a result of worldwide trends of population aging, dementia has had a huge impact on public health in almost all countries. Disease modification therapies for dementia have not yet been developed. However, pharmacotherapy is essential in patients with dementia to combat delays in their cognitive and functional decline. In this article, we review the current pharmacotherapy for dementia. Three acetylcholinesterase inhibitors-donepezil, rivastigmine, galantamine-and memantine are the only medications that have been approved for the treatment of dementia. We present the indications, dose recommendations, side effects, and criteria for National Health Insurance coverage in Korea of these medications for dementia treatment. Although the Ministry of Food and Drug Safety in Korea has not approved any medications for managing the behavioral and psychological symptoms of dementia, some antipsychotics and antidepressants have been studied and used clinically for those purposes. Clinicians may consider vitamin E, Ginkgo biloba extract, choline alfoscerate, or omega-3 fatty acids as additional treatment options. Non-steroid anti-inflammatory drugs, estrogen hormone therapy, and statins are not generally recommended for dementia treatment. We believe that our findings will aid clinicians in the treatment of patients with cognitive decline.

• Journal of Korean society of Dental Hygiene
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• v.22 no.4
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• pp.225-230
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• 2022

Objectives: Patients with excessive tooth wear should first be diagnosed for the etiology of the tooth wear. Causes of tooth wear include bruxism, clenching, and taking medications for systemic diseases. After identifying the cause of tooth attrition, the final prosthesis should be restored with an appropriate vertical dimension. Methods: A 79-year-old man with worn out teeth desired a whole dental treatment. He was on medications for high blood pressure and asthma. The treatment proceeded with a consultation with a medical doctor. The medications for asthma evoked multiple teeth wear and a loss of the vertical dimension. After recovery of 3 mm of vertical dimension, 2 months of evaluation was followed by an interim prosthesis. Results: The increased vertical dimension caused no problem in function and esthetics, and the final restoration was performed with a full monolithic zirconia crown. Group function, adequate anterior guidance, and the occlusal plane were determined. Conclusions: After the final restoration, the patient was both esthetically and functionally satisfied, and a night guard splint was delivered to prevent prosthesis fracture. The patient was informed about the potential tooth wear associated with asthma drugs and educated to visit the clinic regularly.

• Childhood Kidney Diseases
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• v.28 no.2
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• pp.51-58
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• 2024

Patients with chronic kidney disease (CKD) bear a significant financial burden and face numerous complications and higher mortality rates. The progression of CKD is associated with glomerular injury caused by glomerular hyperfiltration and oxidative stress. Factors such as uncontrolled hypertension, elevated urine protein levels, anemia, and underlying glomerular disease, contribute to CKD progression. In addition to conservative treatment, several medications are available to combat the progression of CKD to end-stage kidney disease. Renin-angiotensin-aldosterone system blockers could slow the progression of CKD by reducing glomerular hyperfiltration, lowering blood pressure, and decreasing inflammation. Mineralocorticoid receptor antagonists inhibit the mineralocorticoid receptor signaling pathway, thereby attenuating inflammation and fibrosis. Sodium-glucose cotransporter 2 inhibitors exhibit protective effects on the kidneys and against cardiovascular events. Tolvaptan, a selective vasopressin V2-receptor antagonist, decelerates the rate of increase in total kidney volume and deterioration of kidney function in patients with rapidly progressive autosomal dominant polycystic kidney disease. The protective effects of AST-120 remain controversial. Due to a lack of evidence regarding the efficacy and safety of these medications in children, it is imperative to weigh the benefits and adverse effects carefully. Further research is essential to establish the efficacy and safety profiles in pediatric populations.

• Hip & pelvis
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• v.34 no.4
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• pp.191-202
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• 2022

The aim of this study was to provide helpful information for use in selection of an appropriate medication after osteoporotic fractures through conduct of a literature review. In addition, a review of the recommendations of several societies for prevention of subsequent fractures was performed and the appropriate choice of medication for treatment of atypical femur fractures was examined. Clinical perspective was obtained and an updated search of literature was conducted across PubMed and MEDLINE and relevant articles were selected. The articles were selected manually according to relevance, and the references for identified articles and reviews were also evaluated for relevance. The following areas are reviewed: Commonly prescribed osteoporosis medications: BPs (bisphosphonates), denosumab, and SERMs (selective estrogen receptor modulators) in antiresorptive medications and recombinant human parathyroid hormone teriparatide, recently approved Romosuzumab in anabolic agents, clinical practice guidelines for the management of osteoporosis, osteoporotic fracture, and atypical femur fracture. Most medications for treatment of osteoporosis do not delay fracture healing and the positive effect of teriparatide on fracture healing has been confirmed. In cases where an osteoporotic fracture is diagnosed, risk assessment should be performed for selection of very high-risk patients in order to prevent subsequent fractures, and administration of anabolic agents is recommended.

• Journal of agricultural medicine and community health
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• v.40 no.1
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• pp.9-20
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• 2015

Objectives: This study aimed to explore the persistence and adherence to secondary preventive medication of stroke patients after discharge and to assess the reasons for persistence and nonadherence. Methods: Four hundred twenty-nine patients with stroke were surveyed to determine their behaviors from discharge. Reasons for stopping medications were ascertained. Persistence was defined as continuation of all secondary preventive medications prescribed at hospital discharge, and adherence as continuation of prescribed medications according to health care provider instructions. Results: Of the 429 patients, 86.5% were treatment persistent and 41.2%(non-intentional nonadherence=39.4%, intentional nonadherence=19.4%) were adherent. Independent predictors of persistence included having experience about health education. Independent predictors of non-intentional nonadherence were modified Rankin Scale(mRS) (Exp(B)=2.858, p=0.001) and health education experience (Exp(B)=0.472, p=0.032), and independent predictors of intentional nonadherence were mRS (Exp(B)=2.533, p=0.006), depressive symptoms (Exp(B)=1.113, p=0.016), beliefs about medications questionnaire(necessity, Exp(B)=0.879, p=0.011, concern, Exp(B)=1.098, p=0.019). Conclusions: Although up to one-ninth of stroke patients continued secondary prevention medications, nonadherence is common. Several potentially modifiable patient, provider, and system-level factors associated with persistence and adherence may be targets for future interventions. Specially, interventions to improve adherence should target patients' beliefs about their medication.

• Journal of fish pathology
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• v.27 no.1
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• pp.77-83
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• 2014

The monitoring was performed to survey the mortalities and medications occurred in the inland aquaculture farms of olive flounder in South Korea from May to October, 2012. Both of the indirect inquiry for entire inland farms and the sample survey for selected farms were carried out. The aquatic organism disease inspectors, who have the national licenses for the diagnosis and prevention of aquatic organism diseases and have close relationship with the farms, investigated the rates and causes of mortalities according to the standard manual. The cumulative mortalities rate by the indirect inquiry on 565 farms, was calculated to 27.18%, and the mortalities rate by infectious diseases was 22.64%. Otherwise, the mortalities rate by sample survey on 60 farms was 25.50%, 19.33% of them were caused by infectious diseases. The high mortality rates were recorded by scuticociliatosis, non-infectious loss, streptococcosis, VHS, artificial eliminations, vibriosis and gliding bacterial disease. Streptococcosis and non-infectious mortality caused to serious loss in productivity and economy of the farms, because of their outbreaks in the flounder groups over 600 g. The monitoring of medications in the selected farms revealed that formalin for the treatment of external parasites, such as scuticociliates, was the most commonly used drugs in the farms. As the antibiotic medications, amoxicillin and florfenicol for streptococcosis, and oxytetracycline and neomycin expecting wide antibacterial spectrum, were frequently prescribed.

• Journal of Sasang Constitutional Medicine
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• v.13 no.2
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• pp.74-93
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• 2001

1. Background and Purpose At the year of 2000, the society of Sasang Constitutional Medicine acquired ${\ulcorner}$HamsanSachon DongyiSooseBowon GaboGubon${\lrcorner}$ which is seen as a written copy of ${\ulcorner}$GaboBon${\lrcorner}$. According to Lee Sung-su who is the great-grandson of DongMu's older brother, ${\ulcorner}$HamsanSachon DongyiSooseBowon GaboGubon${\lrcorner}$ was worked by Lee Jin-yoon who is the grandson of DongMu's older brother, and it was copied by Han Min-gab and now is owned by Lee Sung-su who is son of Lee Jin-yoon. 2. Methods This paper was written in order to understand of the character of the discourse on the medications and prescriptions of the ${\ulcorner}$HamsanSachon DongyiSooseBowon GaboGubon${\lrcorner}$. 3. Result and Conclusion 1) Newly created prescriptions of ${\ulcorner}$GaboBon${\lrcorner}$ is composed of the 125 medications of Soeumin 46, Soyangin 36, Taeumin 29, Taeyangin 14. Regarding with that prescriptions, the average number of the medications per prescription is 9.3 and the average capacity of that is 42.6gram. 2) The experimental prescription is from ${\ulcorner}$GaboBon${\lrcorner}$. All the 37 prescriptions of ${\ulcorner}$Sanghanlon${\lrcorner}$ is found at the text of ${\ulcorner}$GaboBon${\lrcorner}$, and only 12 of 37 prescriptions of Traditional Medicine excepting ${\ulcorner}$Sanghanlon${\lrcorner}$ is described at the text of it. Hardly any case of treatment by Traditional Prescription can be found at the discourse on constitunal symptoms and diseases. 3) Only 13 of 69 newly created prescriptions is not prescribed at ${\ulcorner}$GaboBon${\lrcorner}$, and 7 of the 13 prescriptions don't have the symptom of charge also. 4) 6 prescriptions which are supposed to newly created prescriptions of ${\ulcorner}$The Discourse on Constitutional Symptoms and Diseases${\lrcorner}$ are not describe to the composition of medications. 5) All the newly created prescriptions of ${\ulcorner}$The General Remarks on the Soeumin${\lrcorner}$ of ${\ulcorner}$SinChucBon${\lrcorner}$ are to be regarded as GaboBon's.