• Proceedings of the KSME Conference
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• 2001.11b
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• pp.622-627
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• 2001

Microjet flows are often encountered in many industrial applications of micro-electro-mechanical systems as well as in medical engineering fields such as a transdermal drug delivery system for needle-free injection of drugs into the skin. The Reynolds numbers of such microjets are usually several orders of magnitude below those of larger-scale jets. The supersonic microjet physics with these low Reynolds numbers are not yet understood to date. Computational modeling and simulation can provide an effective predictive capability for the major features of the supersonic microjets. In the present study, computations using the axisymmetic, compressible, Navier-Stokes equations are applied to understand the supersonic microjet flow physics. The pressure ratio of the microjets is changed to obtain both the under- and over-expanded flows at the exit of the micronozzle. Sonic and supersonic microjets are simulated and compared with some experimental results available. Based on computational results, two microjets are discussed in terms of total pressure, jet decay and supersonic core length.

• Proceedings of the Materials Research Society of Korea Conference
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• 2010.05a
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• pp.43.2-43.2
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• 2010

Most of previous methods for the dispersions of carbon nanotube were achieved by various chemical functionalizations. In this study, however, we generated highly water dispersed carbon nanofibers by altering intrinsic materials property only, such as crystallinity of outer layers of carbons, without chemical treatment. Although most of chemical functionalization requires acidic treatment and may degrade their chemical functions by interacting with other molecules, suggested strategy demonstrated a simple but chemically non-degradable carbon nanotube for the application of various medical applications, such as drug delivery system and implant coatings.Furthermore, protein adsorption was increased by the reducing surface crystalinity since outer activated surface induced more adsorption of oxygen and eventually greater protein adsorption than pristine carbon nanofibers.

• Journal of Biomedical Engineering Research
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• v.9 no.1
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• pp.73-78
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• 1988

The polymer electrolyte complex hydrogels consisting of poly (methacrylic acid) and poly (4-vinylpyrridine) were formed and 5-flurouracil and pilocarpine drugs were loaded on their hydrogels. Cumulative 5-FU released from PEC hydrogel was affected by the degree of loading and release rate of 5-FU was followed by the monolithic type. Cumulative pilocarpine released from PEC hydrogel increased by ionic interaction between cationic pilocarpine and anionic PMA. Release rate showed the zero order after burst effect.

• Journal of the Korean Society of Visualization
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• v.16 no.1
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• pp.42-47
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• 2018

A needle-free injector is one of the new non-invasive players in impregnating the biological barriers. It is considered as the next phase in drug delivery and therapeutic applications. One of the major fields of application is in skin remodeling procedures. Although many studies were carried out in understanding the principle in the needle-free injection procedure, fewer studies were done with the aim of therapeutic applications. In the present study, we tried to identify key parameters that affect the jet divergence and peak stagnation pressure on the skin surface in a conventional needle-free injector for skin treatment. A summary of the working principle and effect of the key parameters are presented.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2005.11a
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• pp.11-16
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• 2005

Utilization of herbal medicine has been an intrinsic part of Philippine culture for many centuries. In spite of tremendous development in the field of modern medicine, traditional and alternative medicine will continue to flourish and take an important role in meeting the basic health needs of the people. The National Integrated Research Program on Medicinal Plant (NIRPROMP), the lead government institution for herbal medicinal research had already validated ten medicinal plants and is currently studying new batch of medicinal plants. Five of the ten clinically-tested medicinal plants have been elevated to herbal medicinal drugs that are now being commercially manufactured in the different parts of the country. Research on medicinal plants takes longer time as the nature of medical research dictates it to be. It must adhere to the internationally accepted standards of medicinal research in the Philippines was observed making alternative medicine an effective health delivery system to the people.

• Journal of Korean Public Health Nursing
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• v.8 no.2
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• pp.71-82
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• 1994

The article reviewed the elderly health care management problems in policy development issue of the nation. Policy of Korean government on elderly health care has still not yet developed. The main stream of policy which is effective on elderly welfare policy is 'Elderly care are responsible by their families'. Now only those aged whose family members are not able to take care of their parents are receive custodial care at the non-profit nursing homes. This article examined the main stream policy in pro and cons aspects in relation to social changes such as: demographic changes. family structure changes. attitude changes. health care delivery system. and political settlement view points in connection with medical insurance program. Finally. a model for the elderly health care management was proposed which will provide chronic care services at the community level. such as nursing homes. day care centers. day hospitals, respite care units, and special care institute for dementia.

• Journal of The Korea Institute of Healthcare Architecture
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• v.6 no.10
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• pp.41-49
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• 2000

Today, medical system faces to two major flows of change. The first one changes to small-to-middle size special hospital from large size general hospital. The another one changes to the patient-focused hospital. In these two flows of change, women's hospital is a typical small-to-middle size special hospital. In Korea, several studies on the architectural planning of delivery-part designed with recent trends in large size general hospital have done with focusing on LDR type or LDR/P type, but few studies on the architectural planning of the recent trends in women's hospitals. Therefore, this study aims to propose improve way after analysis the developing circumstances and problems on the Architectural planning on women's hospital by case studies on Women's hospital builded recently in Korea.

• Korean Institute of Interior Design Journal
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• no.18
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• pp.44-50
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• 1999

The purpose of this study is to suggest reasonable composition and layout of a nurse station and attached spaces-which are central sector of patient caring in the inpatient department- in the view of funtional efficiency. The method of this study is examining other studies and case study of inpatient department in general hospitals. through this research we find out the plan type of inpatient department and layout of nurse station and attached spaces in the view of 'the efficiency of circulation' and 'the easiness of observation' . It is also found out that the nursing delivery system effects to the composition and layout of nurse station attached spaces. Therefore, the efficient design of inpatient department by this study can accomplish 'patient-focused' medical environment and aid to develop their health.

• Journal of mucopolysaccharidosis and rare diseases
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• v.4 no.2
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• pp.37-41
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• 2018

Mucopolysaccharidosis III (MPS III, Sanfilippo syndrome) is a rare autosomal recessive disease caused by a deficiency of one of four enzymes involved in the degradation of glycosaminoglycan (GAG). The resultant cellular accumulation of GAG causes various clinical manifestations. MPS III is divided into four subtypes depending on the deficient enzyme. All the subtypes show similar clinical features and are characterized by progressive degeneration of the central nervous system. A number of genetic and biochemical diagnostic methods have been developed. However, there is no effective therapy available for any form of MPS III, with treatment currently limited to clinical management of neurological symptoms. Main purpose of the treatment for MPS III is to prevent neurologic deterioration. Because conventional intravenous enzyme replacement therapy (ERT) has a limitation due to inability to cross the blood-brain barrier, several innovative therapeutic approaches for MPS III are being developed. This review covers the currently developing new therapeutic options for MPS III including high dose ERT, substrate reduction therapy, intrathecal or intraventricular ERT, fusion protein delivery using bioengineering technology, and gene therapy.

• Journal of agricultural medicine and community health
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• v.49 no.2
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• pp.132-145
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• 2024

Objectives: This study compares cases of Dalgubeol Health Care Project, 301 Network Project, and 3 for 1 Project based on program logic models to derive measures for promoting integrated healthcare and welfare services centered around medical institutions. Methods: From January to December 2021, information on the implementation systems and performance of each institution was collected. Data sources included prior academic research, project reports, operational guidelines, official press releases, media articles, and written surveys from project managers. A program logic model analysis framework was applied, structuring the information based on four elements: situation, input, activity, and output. Results: All three projects aimed to address the fragmentation of health and welfare services and medical blind spots. Despite similar multidisciplinary team compositions, differences existed in specific fields, recruitment scale, and employment types. Variations in funding sources led to differences in community collaboration, support methods, and future directions. There were discrepancies in the number of beneficiaries and medical treatments, with different results observed when comparing the actual number of people to input manpower and project cost per beneficiary. Conclusions: To design an integrated health and welfare service provision system centered on medical institutions, securing a stable funding mechanism and establishing an appropriate target population and service delivery system are crucial. Additionally, installing a dedicated department within the medical institution to link activities across various sectors, rather than outsourcing, is necessary. Ensuring appropriate recruitment and stable employment systems is needed. A comprehensive provision system offering services from mild to severe cases through public-private cooperation is suggested.