• 한국위성정보통신학회논문지
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• 제11권3호
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• pp.28-31
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• 2016

본 연구에서는 최근 의료용으로 많이 사용되고 있는 고휘도, 고균일도의 직하광원구조를 가지는 백라이트 유닛에 대한 설계 시뮬레이션을 실시하였다. 직하형 백라이트 시스템은 기존의 Edge-Lighr 방식에 비해서 고휘도 및 고균일도를 달성할 수 있어 의료용 판독이 요구되는 고품질의 디스플레이에 사용되고 있으며, 흑백이미지를 바탕으로 진단을 실시하는 경우가 많기 때문에 휘도 및 휘도 균일도에 대한 높은 성능이 요구되는 분야이다. 본 연구에서는 복수 개의 램프를 수평으로 배열한 경우에 각 램프간의 거리 및 반사판과의 거리, 상측 확산판과의 거리에 대한 최적설계를 실시하고, 이 결과를 바탕으로 실물과 유사한 조건에서 시뮬레이션을 실시하였다. 연구 결과, Parameter 에 의존하는 변수를 최적화 할 수 있었으며, 4.5mm 의 램프와 반사판 거리 및 26mm 의 램프간 거리를 바탕으로 16개의 램프를 배치하여, 32인치 크기의 화면에서 6423nit 의 중심휘도를 갖는 고품위의 우수한 광원의 설계가 가능함을 확인할 수 있었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 신호처리소사이어티 추계학술대회 논문집
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• pp.221-224
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• 2003

Recently, TFT-LCD is widely used of medicine machine on the display devices. However, the display precision of TFT-LCD is 8 bits instead of 10 bits of CRT display. If the medical image have more than 8 bits, we must requantize the medical image. We propose an efficient method to reduce medical image from 10 bits into 8 bits by employing human visual perception. The proposed method shows good performance for the medical image display.

• Transactions on Electrical and Electronic Materials
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• 제9권1호
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• pp.16-19
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• 2008

In this study, it was investigated about optical simulation in direct-type backlight design. Direct-type backlight has been used high-brightness backlight such as medical LCD application. The key parameter in designing direct-type backlight was consists of three geometrical dimension such as the distance of two lamps, the gap of lamp and reflection plate and the number of lamps. It has many of variations in optical design and it causes the different properties in backlight system. It shows the best values of above parameters; 26 mm of the distance of two lamps, 4.5 mm of the gap of lamp and reflection plate and 16 lamps. And we produced the specimen as above condition, and acquired good result in backlight such as the value of the brightness is 6423 nit in center of emission area and less than 5 % in brightness uniformity. It shows the effective ways of designing backlight system using optical simulation method for medical LCD application.

• Korean Journal of Ophthalmology
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• 제32권6호
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• pp.470-477
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• 2018

Purpose: To investigate the relationship between the progression of visual field (VF) loss and changes in lamina cribrosa depth (LCD) as determined by spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in patients with primary open angle glaucoma (POAG). Methods: Data from 60 POAG patients (mean follow-up, $3.5{\pm}0.7$ years) were included in this retrospective study. The LCD was measured in the optic disc image using SD-OCT enhanced depth imaging scanning at each visit. Change in the LCD was considered to either 'increase' or 'decrease' when the differences between baseline and the latest two consecutive follow-up visits were greater than the corresponding reproducibility coefficient value ($23.08{\mu}m$, as determined in a preliminary reproducibility study). All participants were divided into three groups: increased LCD (ILCD), decreased LCD (DLCD), and no LCD change (NLCD). The Early Manifest Glaucoma Trial criteria were used to define VF deterioration. Kaplan-Meier survival analysis and Cox's proportional hazard models were performed to explore the relationship between VF progression and LCD change. Results: Of the 60 eyes examined, 35.0% (21 eyes), 28.3% (17 eyes), and 36.7% (22 eyes) were classified as the ILCD, DLCD, and NLCD groups, respectively. Kaplan-Meier survival analysis showed a greater cumulative probability of VF progression in the ILCD group than in the NLCD (p < 0.001) or DLCD groups (p = 0.018). Increased LCD was identified as the only risk factor for VF progression in the Cox proportional hazard models (hazard ratio, 1.008; 95% confidence interval, 1.000 to 1.015; p = 0.047). Conclusions: Increased LCD was associated with a greater possibility of VF progression. The quantitative measurement of LCD changes, determined by SD-OCT, is a potential biomarker for the prediction of VF deterioration in patients with POAG.

• 한국의학물리학회지:의학물리
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• 제17권2호
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• pp.77-82
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• 2006

영상의 표시는 PACS 및 디지털 의료 영상계에서 중요한 요소이다. 동일한 디지털 데이터에 대한 영상의 질은 디스플레이 장치의 물리적 특성, 최적화된 설정 및 교정, 주위 불빛 조건 등에 의하여 영향을 받는다. 디스플레이 장치는 사용시간에 따라서 휘도 감소 및 설정값들의 변화에 의하여 성능이 저하된다. 디스플레이 시스템의 성능이 지속적으로 저하되기 때문에 일정한 주기마다. 정도관리를 수행하여야한다. 정도관리 효과를 평가하기 위하여 진단에 사용되는 10대의 평판 LCD 디스플레이 장치를 선택하였으며, 설정값 교정 전과 후에 휘도 반응, 휘도 공간 의존도, 분해능, 그리고 색도 변화를 정량적으로 측정하여 평가하였다. 정도관리 효과는 휘도 반응과 휘도 공간 의존도 테스트에서 다소 큰 변화가 있었으나 분해능 및 디스플레이 색도에서의 영향은 크지 않았다. 디스플레이 장치의 주기적인 정도관리는 의료영상을 일관성 있게 표시하기 위하여 필수적이다. 본 연구 결과는 의료용 디스플레이 장치의 정도관리에 대한 항목 선정 및 주기를 결정하는 데 중요한 역할을 할 수 있을 것이다.

• 디지털콘텐츠학회 논문지
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• 제5권1호
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• pp.73-78
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• 2004

본 논문에서는 현재 상용중인 일반 복강경 시스템에 LCD셔터를 적용하여 시분할 입체 복강경 시스템을 구현하였다. 본 논문에서 구현한 시분할 입체 복강경 시스템은 일반 복강경 시스템의 카메라 어뎁터에 LCD셔터를 장착하여 입체 어뎁터를 구성하였다. 실험은 일반 복강경의 2차원 영상과 시분할 입체 복강경 시스템의 3차원 영상을 비교하였으며, 그 결과 입체 어뎁터를 통하여 모니터에 디스플레이 되는 3차원 영상은 아주 미소하게 픽셀 쉬프트(Pixel Shifted)된 영상임을 확인할 수 있었다. 이는 기존의 엔터테인먼트(Entertainment)를 위한 입체보다 사용자의 눈의 피로를 줄일 수 있으며, 장시간 수술을 하는 복강경 수술에 입체감을 주어 수술을 더욱더 용이하게 할 수 있다.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.115-120
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• 2011

Objectives : The purpose of this study is to develop an apparatus which can take a facial image by self-operated capturing technique. The user can obtain one's facial image immediately after adjusting facial tilt and focusing distance. The system has been designed for classifying Sasang typology based on facial image. Methods : The system is composed of a Webcam, one-way glass mirror and mini LCD. The Webcam takes a facial image which is displayed on the mini LCD. Then the user can see and adjust to the right position in the real time through the image mirror-reflected from the mini LCD. The optical sensor is used to estimate the proper focusing distance. To verify the performance of the system, 11 characteristic points on the facial image are used and compared with high performance DSLR camera(D700) by applying the coefficient of variance and Bland-Altman Plot. Results : The developed system and D700 show enough agreement with the small coefficient of variance to analyse constitutional types with a facial im mage. However, the result of Bland-Altman plot shows that the width parameters have distortions owing to short focusing distance. Conclusions : The system is expected to be utilized on u-healthcare services for home environment after improving the distortion in the width parameters.

• Clinical Nutrition Research
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• 제11권1호
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• pp.50-61
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• 2022

Resting metabolic rate (RMR) accounts for most daily energy expenditure. The low carbohydrate diet (LCD) attenuates decreases in RMR. This study aims to investigate the relationship between an LCD and RMR status among overweight and obese women. We enrolled 291 overweight and obese women in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, visceral fat, and insulin level were assessed. RMR was measured using indirect calorimetry. LCD score (LCDS) was measured using a validated semi-quantitative food frequency questionnaire. Analysis of variance, independent sample t-test, and Multinomial logistic regression tests were used. Results showed no relationship between LCDS and deviation of normal RMR (DNR) even after adjust for confounders (increased [Inc.] RMR: odds ratio [OR], 0.97; 95% confidence interval [CI], 0.92-1.01; p = 0.20; decreased [Dec.] RMR: OR, 0.97; 95% CI, 0.94-1.00; p = 0.14). Some components of LCDS had no significant association with DNR, such as carbohydrate and Dec. RMR in adjusted model (OR, 1.62; 95% CI, 0.98-1.37; p = 0.08) and monounsaturated fatty acids and Dec. RMR in adjusted model (OR, 0.48; 95% CI, 0.21-1.10, p = 0.08). However, refined grains had a significant association with Inc. RMR in crude model (OR, 0.87; 95% CI, 0.77-0.99, p = 0.04). There is no association between LCDS and RMR status.

• Journal of Microbiology and Biotechnology
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• 제32권10호
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• pp.1245-1252
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• 2022

Induced pluripotent stem cells (iPSCs) can be generated from somatic cells using Oct4, Sox2, Klf4, and c-Myc (OSKM). Small molecules can enhance reprogramming. Licochalcone D (LCD), a flavonoid compound present mainly in the roots of Glycyrrhiza inflata, acts on known signaling pathways involved in transcriptional activity and signal transduction, including the PGC1-α and MAPK families. In this study, we demonstrated that LCD improved reprogramming efficiency. LCD-treated iPSCs (LCD-iPSCs) expressed pluripotency-related genes Oct4, Sox2, Nanog, and Prdm14. Moreover, LCD-iPSCs differentiated into all three germ layers in vitro and formed chimeras. The mesenchymal-to-epithelial transition (MET) is critical for somatic cell reprogramming. We found that the expression levels of mesenchymal genes (Snail2 and Twist) decreased and those of epithelial genes (DSP, Cldn3, Crb3, and Ocln) dramatically increased in OR-MEF (OG2^+/+/ROSA26^+/+) cells treated with LCD for 3 days, indicating that MET effectively occurred in LCD-treated OR-MEF cells. Thus, LCD enhanced the generation of iPSCs from somatic cells by promoting MET at the early stages of reprogramming.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 춘계학술대회 논문집 디스플레이 광소자 분야
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• pp.121-123
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• 2002

Fast response characteristics of twisted nematic liquid crystal display (TN-LCD) cell with different nematic liquid crystals (NLCs) and cell gap on a rubbed polyimide (PI) surface were studied. High transmittance and fast response time of the TN-LCD on the rubbed PI surface were achieved by using high birefringence ($\Delta$ n) and low cell gap. It is considered that the transmittance and response time of the TN-LCD on the rubbed PI surface decreased as $\Delta$ nd decrease.