• Korean journal of medical education
• /
• v.30 no.4
• /
• pp.365-368
• /
• 2018

• BMB Reports
• /
• v.45 no.11
• /
• pp.641-646
• /
• 2012

It has been reported that ubiquitin-conjugating enzyme 9 (Ubc9), the unique enzyme2 in the sumoylation pathway, is up-regulated in many cancers. However, the expression and regulation of UBC9 in glioma remains unknown. In this study, we found that Ubc9 was up-regulated in glioma tissues and cell lines compared to a normal control. UBC9 knockdown by small interfering RNA (siRNA) affected cell proliferation and apoptosis in T98G cells. Further experiments revealed that microRNA (miR)-214 directly targeted the 3' untranslated region (UTR) of UBC9 and that there was an inverse relationship between the expression levels of miR-214 and UBC9 protein in glioma tissues and cells. miR-214 overexpression suppressed the endogenous UBC9 protein and affected T98G cell proliferation. These findings suggest that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation.

• BMB Reports
• /
• v.42 no.6
• /
• pp.361-366
• /
• 2009

It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. In this study, we showed that 20 ${\mu}M$ sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite.

• Journal of Korean Medical classics
• /
• v.29 no.1
• /
• pp.55-63
• /
• 2016

Objectives : Doctors are obviously one of the most interesting subject in medical history. Doctors are who treat patients and disease and the authors for medical records or books. Especially doctors in traditional medicine mostly tried to write medical books for new idea or their esperiences or leave their medical records for treatments, medication, prescription and so on. Therefore, many researchers have explained Korean or Chinese medical history of traditional society through those books or documents rather than doctors themselves. The Annals of the Joseon Dynasty has massive records for history, politics, society, culture, etc. Relating to medical history in traditional Korean medicine, there are ceveral researches about disease of King, disease itself, the methods of treatment and so on, through The Annals of the Joseon Dynasty. However, there are few on activities of many doctors in The Annals of the Joseon Dynasty. Methods : I tried to find out the names who had some roles of medicine in The Annals of King Sejong out of The Annals of the Joseon Dynasty. I could get 35 doctors and browsed 35 doctors in The Annals of the Joseon Dynasty again. Finally, I could have lots of articles from The Annals of the Joseon Dynasty related to 33 doctors(2 dontors had no records about medicine even they were doctors). Results : I categorized 2 ways of those articles; medical activities, non-medical activities. For medical activities, I got subcategories for medical activities; medical maltreatment, treatment for King, royal family, bureaucrat, ambassador. I also got subcategories for non-medical activities; publishing medical books, ambassador as a doctor, medical training, things related to hot spring, food therapist, veterinarian. Conclusions : Medical history of Joseon Dynasty in Korean medical history has somehow been recorded by medical books such as Hyangyakjipseongbang, Euibangyuchwi, Euilimchwalyo, Dongeuibogam, Jejungsinpyeon, Dongeuisusebowon, etc. So I have concerned that there are massive records on doctors activities in The Annals of the Joseon Dynasty and tried to focus on their various activities through this research.

• Journal of Korean Medical classics
• /
• v.25 no.2
• /
• pp.95-105
• /
• 2012

Objective : This study was conducted to examine the scope and learning objective of Medical classics in the field of the education of Korean Medicine. Method : This study was analyzed and figured out list of classes which was taken by department of medical classics in eleven College of Korean Medicine and one school of Korean Medicine. Results & Conclusions : 1. Now, 14 subjects out of 16 subjects which were taken by whole department of medical classics in Korea can be a proper area of education of medical classics. Now, Hwangjenaekyung and Nangyeong are the only aim of the lessons at the medical classics. Therefore, we present to modify the aims inclusively. 2. The subject of the class have to change as follows. 'Wonjeon' changes into 'Hwangjenaekyung', 'Medical Chinese character' changes into 'Korean medical chinese character', 'medical informatics' changes into 'korean medical informatics'. 3. As we consider the condition that 'Nangyeong' is educating in just four departments of medical classics, we have to discuss about the stature of Nangyeong and to extend education of Nangyeong. 4. In the department of medical classics, we can improve the level of understanding and reading skills by educating the class of 'Sanghanron' and 'Donguibogam'. 5. This study is actively involved in trying to include 'Korean Medical Informatics' and 'Korean medical terminology ' in the education field of the medical classics.

• Journal of Microbiology and Biotechnology
• /
• v.25 no.6
• /
• pp.936-940
• /
• 2015

Human papillomavirus (HPV) type 52 is a high-risk HPV responsible for cervical cancer. HPV type 52 is common around the world and is the most common in some Asian regions. The available prophylactic HPV vaccines protect only from HPV types 16 and 18. Supplementing economical vaccines that target HPV type 52 may satisfactorily complement available prophylactic vaccines. A codon-adapted HPV 52 L1 gene was expressed in the methylotrophic yeast Hansenula polymorpha, which is used as an industrial platform for economical hepatitis B surface antigen particle production in China. We found that the recombinant proteins produced in this expression system could form virus-like particles (VLPs) with diameters of approximately 50 nm. This study suggests that the HPV 52 VLPs produced in this platform may satisfactorily complement available prophylactic vaccines in fighting against HPVs prevalent in Asia.

• The Journal of Information Systems
• /
• v.19 no.1
• /
• pp.35-61
• /
• 2010

The Internet marketing of hospital is being considered as a strategic requirement that can satisfy the customers. Therefore, it is very important to understand the effects of the medical information on the Internet on the actual consumers. In this study, the paths through which the attitude and satisfaction of the medical information consumers that visit hospital web site are formed for the medical information through the quality of the medical information on the Internet and usability of hospital web site were examined respectively according to the medical examination and treatment subjects that respectively deal with medical acts and cosmetic acts through light metabolism recovery. The usability of hospital web site, rather than medical information quality, had positive effects on the attitudes toward the medical information distributed in the corresponding web site and the satisfaction of use of hospital web site in the case of visitors of the hospital web site for the medical examination and treatment subjects of essential medical examination and treatment and emergency medical treatment, and, on the other hand, the result of analyzing the path of the medical examination and treatment subjects of cosmetics and functional improvement revealed that the medical information quality had positive effects on the medical information attitudes and the usage satisfaction of hospital web site. Accordingly, the attitudes toward the medical information distributed through the web site by the visitors of hospital web site is formed from the quality of medical information and web site usability, and, ultimately, they become generally satisfied with the hospital web site. Such process is revealed different1y according to the medical examination and treatment subjects for which consumers desire to obtain information.

• Korea Journal of Hospital Management
• /
• v.9 no.4
• /
• pp.21-44
• /
• 2004

Toe objective of this study is to verify the factors influencing the taxation cognition of medical institutions and to verify the difference of taxation cognition among the interest groups in medical services. The factors that influence taxation cognition are supposed to be five: cognition of public benefits on medical services, cognition of profits from medical institutions, cognition of self-responsibility of medical institutions, cognition of distinction of medical institutions, and cognition of the importance of medical services. The interest groups are divided into four: medical institution employees, medical treatment consumers, taxation experts, and tax officials. As a result of this study, first, cognition of public benefits, cognition of profits, and cognition of distinction are verified to have statistical significance as factors for taxation cognition. It means that cognition of the public benefits of medical services is low, while cognition of profits is high, and taxation cognition such as tax supports and tax exemption appears low in accordance with lowness of cognition of distinction of medical institutions. Second, taxation cognition of the interest groups about medical service shows statistical significance between the group of medical institution employees and the group of tax officials, and between the group of medical institution employees and the group of taxes experts. This study is expected to contribute to tax policy, which can support medical institutions to provide medical consumers with good medical services, by analyzing the factors that influence taxation cognition on medical institutions.

• Journal of Medicine and Life Science
• /
• v.20 no.1
• /
• pp.15-20
• /
• 2023

Medical schools realize their social accountability in cultivating future doctors as decision-makers of medical care in the future society as an axis of society and carrying out communication, research, and medical service (medical care). This study summarized the social accountability status of eight medical schools in Korea, including the characteristics, activities, and programs in the sociocultural context. The data from the self-evaluation research reports of eight medical schools were classified and organized according to education, research, and medical care services. The medical schools offer related subjects, community service activities, and clinical practice, allowing active participation in local health promotion and disease prevention. Community health information research was conducted considering the difference between the local natural environment in which the medical school is located and the frequency of diseases. Medical schools and hospitals collaborated to conduct domestic and foreign health education volunteer activities. Social accountability must be prioritized, considering the importance of medical schools' functions and roles in a high knowledge-information society. Both doctors' medical capacity and competence to actively participate in developing medical care and health policies for the community should be strengthened.

• Journal of Microbiology and Biotechnology
• /
• v.33 no.2
• /
• pp.235-241
• /
• 2023

Hyaluronidase (HAase) can enhance drug diffusion and dissipate edema by degrading hyaluronic acid (HA) in the extracellular matrix into unsaturated HA oligosaccharides in mammalian tissues. Microorganisms are recognized as valuable sources of HAase. In this study, a new hyaluronate lyase (HAaseD) from Bacillus sp. CQMU-D was expressed in Escherichia coli BL21, purified, and characterized. The results showed that HAaseD belonged to the polysaccharide lyase (PL) 8 family and had a molecular weight of 123 kDa. HAaseD could degrade chondroitin sulfate (CS) -A, CS-B, CS-C, and HA, with the highest activity toward HA. The optimum temperature and pH value of HAaseD were 40℃ and 7.0, respectively. In addition, HAaseD retained stability in an alkaline environment and displayed higher activity with appropriate concentrations of metal ions. Moreover, HAaseD was an endolytic hyaluronate lyase that could degrade HA to produce unsaturated HA oligosaccharides. Together, our findings indicate that HAaseD from Bacillus sp. CQMU-D is a new hyaluronate lyase and with excellent potential for application in industrial production.