• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.6
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• pp.811-817
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• 2013

In this study we present a system for pulse-rate period detection and human sensibility evaluation based on the wireless medical telemetry service (WMTS) used for transmission of data from medical telemetry devices to various medical facilities and services. We develop a medical-purpose specific WMTS communication module to transmit biometric signals. From the pulse rate variability(PRV) signal, we attempt to classify positive and negative emotional states based on analysis of the ratio of LF/HF in the frequency domain. We measure the data reception rate according to distance in order to test the performance of the WMTS module and analyze the effects on human sensibility evaluation.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.1
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• pp.63-70
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• 2018

Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.

• Korea Journal of Hospital Management
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• v.20 no.2
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• pp.72-81
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• 2015

• Journal of information and communication convergence engineering
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• v.2 no.3
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• pp.167-171
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• 2004

The evolution of modern imaging modalities, followed by the rapid development of computer technology has introduced many new features in the communication networks used in medical facilities. Since it is very important to keep patient's record accurately, the ability to exchange medical data securely over the communication network is essential for any medical information. In this paper, therefore, we introduce some problems which occur from digitizing medical images such as MRI (Magnetic Resonance Imaging), CT (Computed Tomography), CR(Computed Radiography), etc., and then we propose a authentication mechanism for medical image verification using secret watermark images.

• Journal of Internet Computing and Services
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• v.18 no.6
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• pp.75-84
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• 2017

As there has been growing interests in PHR-based personalized health management project, various institutions recently explore safe methods of recording personal medical and health information. In particular, innovative medical solution can be realized when medical researchers and medical service institutes can generally get access to patient data. As EMR data is extremely sensitive, there has been no progress in clinical information exchange. Moreover, patients cannot get access to their own health data and exchange it with researchers or service institutions. It can be operated in terms of technology, yet policy environment are affected by state laws as well as Privacy and Security Policy. Blockchain technology-independent, in transaction, and under test-is introduced in the medical industry in order to settle these problems. In other words, medical organizations can grant preliminary approval on patient information exchange by using the safely encrypted and distributed Blockchain ledger and can be managed independently and completely by individuals. More apparently, medical researchers can gain access to information, thereby contributing to the scientific advance in rare diseases or minor groups in the world. In this paper, we focused on how to manage personal medical information and its protective use and proposes medical treatment exchange system for patients based on a permissioned Blockchain network for the safe PHR operation. Trusted Model for Sharing Medical Data (TMSMD), that is proposed model, is based on exchanging information as patients rely on hospitals as well as among hospitals. And introduce medical treatment exchange system for patients based on a permissioned Blockchain network. This system is a model that encrypts and records patients' medical information by using this permissioned Blockchain and further enhances the security due to its restricted counterfeit. This provides service to share medical information uploaded on the permissioned Blockchain to approved users through role-based access control. In addition, this paper presents methods with smart contracts if medical institutions request patient information complying with domestic laws by using the distributed Blockchain ledger and eventually granting preliminary approval for sharing information. This service will provide an independent information transaction and the Blockchain technology under test will be adopted in the medical industry.

• Journal of Convergence for Information Technology
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• v.9 no.4
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• pp.1-7
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• 2019

The medical environment, combined with IT technology, is changing the paradigm for medical services from treatment to prevention. In particular, as ICT convergence digital healthcare technology is applied to hospital medical systems, infrastructure technologies such as big data, Internet of Things, and artificial intelligence are being used in conjunction with the cloud. In particular, as medical services are used with IT devices, the quality of medical services is increasingly improving to make them easier for users to access. Medical institutions seeking to incorporate IoT services into cloud health care environment services are trying to reduce hospital operating costs and improve service quality, but have not yet been fully supported. In this paper, a patient information collection model from hospital IoT system, which has established a cloud environment, is proposed. The proposed model prevents third parties from illegally eavesdropping and interfering with patients' biometric information through IoT devices attached to the patient's body at hospitals in cloud environments that have established hospital IoT systems. The proposed model allows clinicians to analyze patients' disease information so that they can collect and treat diseases associated with their eating habits through IoT devices. The analyzed disease information minimizes hospital work to facilitate the handling of prescriptions and care according to the patient's degree of illness.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.8
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• pp.1424-1429
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• 2016

Segmentation is one of the first steps in most diagnosis systems for characterization of dental caries in an early stage. The purpose of automatic dental cavity detection system is helping dentist to make more precise diagnosis. We proposed the semi-automatic method for the segmentation of dental caries on digital x-ray images. Based on a manually and roughly selected ROI (Region of Interest), it calculated the contour for the dental cavity. A snake algorithm which is one of active contour models repetitively refined the initial contour and self-examination and correction on the segmentation result. Seven phantom tooth from incisor to molar were made for the evaluation of the developed algorithm. They contained a different form of cavities and each phantom tooth has two dental cavities. From 14 dental cavities, twelve cavities were accurately detected including small cavities. And two cavities were segmented partly. It demonstrates the practical feasibility of the dental lesion detection using Computer-aided Detection (CADe).

• Convergence Security Journal
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• v.19 no.4
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• pp.123-132
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• 2019

Rapid developments of IT technology has been creating new security threats. There have been more attacks to get patients' sensitive personal information, targeting medical institutions that are relatively insufficient to prevent and defend against such attacks. Although the government has required senior general hospitals to get the ISMS certification since 2016, such a requirement has been burdensome for small and medium-sized medical institutions. Therefore, this study was designed to draw measures to identify and improve the privacy status of the medical institution by dividing it into management, physical and cyber areas for small and medium-sized medical institutions. The results of this study showed that the government should provide financial support and managerial supervision for the improvement of personal information protection of small and medium-sized medical institutions. They also suggested that the government should also provide medical security specialists, continuous medical security education, disaster planning, reduction of medical information management regulations not suitable for small and medium sized institutions.

• International journal of advanced smart convergence
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• v.1 no.2
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• pp.47-51
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• 2012

In highly developed society, information and communication technologies are widely used for better medical services. These information and communication technologies should be more and more acceptable in all hospitals for exchange medical records. EMR becomes more convenient than the previously used paper charts. It will be able to record medical institutions every time and dual treatment. Each is different specifications for each medical institution to use the program or document to exchange it. The personal clinic records still does not exchange well. To solve this gap between medical alienation, this paper describes the concepts of HL7-CDA and proposes types of telemedicine system. To resolve time and space constraints, new form of treatment methods presents in future directions after described about related systems. CDA enables electronic medical records to the each medical center and gradually expanded by exchanging the patient's medical records. This paper is using XML-based CDA documents as a hierarchical for medical information exchange standards compliant HL7-CDA documents. It could be possible currently used structural variety of multimedia data. Thus It is able to send and receive HL7-CDA-based medical information and clinical information to identify the medical institutions of medical information with interchange system design and building standards, and through mutual exchange of clinical information.

• Food Science of Animal Resources
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• v.43 no.5
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• pp.859-876
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• 2023

It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae Periostracum (CP), the slough of Cryptotympana pustulata, has been frequently used for treating AD and skin affliction in traditional Korean Medicine. This study is aimed at investigating the ameliorating effects of CP on AD and its potential mechanism. The dinitrochlorobenzene sensitized mice were treated with CP for 2 weeks. The various biomarkers and the dermatitis scores presented that CP treatment can induce the visual and biological improvements of AD model. Pruritus, the most serious symptom of AD, which can cause repeated scratching behaviors and finally lead to lichenification, was reduced with CP treatment by regulating the inflammatory reactions. In addition, CP treatment diminished the number of mast cells that are known for causing inflammatory reactions. Moreover, it is proven that CP can decline secretion of interleukin-22, which means CP treatment has anti-inflammatory effects. CP treatment can correct the imbalance of helper T (Th)1 and Th2, downregulating thymic stromal lymphopoietin that leads to decrease of mRNA level of inflammatory cytokines. The crucial role of CP treatment is controlling of the Janus kinase 1/signal transducer and activator of transcription 3 pathway. In addition, CP treatment has the inhibitory effects on kallikrein related peptidase (KLK) 5 and KLK7. Taken together, CP treatment can ameliorate most symptoms and problems caused by AD disease, improving the AD patients' life quality.