• Korean Journal of Radiology
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• 제22권10호
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• pp.1697-1707
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• 2021

The recent introduction of various high-dimensional modeling methods, such as radiomics and deep learning, has created a much greater diversity in modeling approaches for survival prediction (or, more generally, time-to-event prediction). The newness of the recent modeling approaches and unfamiliarity with the model outputs may confuse some researchers and practitioners about the evaluation of the performance of such models. Methodological literacy to critically appraise the performance evaluation of the models and, ideally, the ability to conduct such an evaluation would be needed for those who want to develop models or apply them in practice. This article intends to provide intuitive, conceptual, and practical explanations of the statistical methods for evaluating the performance of survival prediction models with minimal usage of mathematical descriptions. It covers from conventional to deep learning methods, and emphasis has been placed on recent modeling approaches. This review article includes straightforward explanations of C indices (Harrell's C index, etc.), time-dependent receiver operating characteristic curve analysis, calibration plot, other methods for evaluating the calibration performance, and Brier score.

• Journal of Multimedia Information System
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• 제7권1호
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• pp.1-10
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• 2020

The image analysis is an important and predominant task for classifying the different parts of the image. The analysis of complex image analysis like histopathological define a crucial factor in oncology due to its ability to help pathologists for interpretation of images and therefore various feature extraction techniques have been evolved from time to time for such analysis. Although deep reinforcement learning is a new and emerging technique but very less effort has been made to compare the deep learning and deep reinforcement learning for image analysis. The paper highlights how both techniques differ in feature extraction from complex images and discusses the potential pros and cons. The use of Convolution Neural Network (CNN) in image segmentation, detection and diagnosis of tumour, feature extraction is important but there are several challenges that need to be overcome before Deep Learning can be applied to digital pathology. The one being is the availability of sufficient training examples for medical image datasets, feature extraction from whole area of the image, ground truth localized annotations, adversarial effects of input representations and extremely large size of the digital pathological slides (in gigabytes).Even though formulating Histopathological Image Analysis (HIA) as Multi Instance Learning (MIL) problem is a remarkable step where histopathological image is divided into high resolution patches to make predictions for the patch and then combining them for overall slide predictions but it suffers from loss of contextual and spatial information. In such cases the deep reinforcement learning techniques can be used to learn feature from the limited data without losing contextual and spatial information.

• 한국방사선학회논문지
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• 제15권4호
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• pp.455-461
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• 2021

심장비대증은 흉부 X선 영상에서 흔히 보이는 질병 중 하나이지만 조기에 발견을 하지 못하면 심각한 합병증을 유발할 수도 있다. 이러한 점을 고려하여 최근에는 여러 과학기술 분야의 발전으로 인공지능을 이용한 딥러닝 알고리즘을 의료에 접목시키는 영상 분석 연구들이 많이 진행되고 있다. 본 논문에서는 Inception V3 딥러닝 모델을 흉부 X선 영상을 이용하여 심장비대증의 분류에 유용한 모델인지 평가하고자 한다. 사용된 영상의 경우 총 1026장의 경북대학교병원 내 정상 심장 진단을 받은 환자와 심장비대증 진단을 받은 환자의 흉부 X선 영상을 사용하였다. 실험결과 Inception V3 딥러닝 모델의 심장비대증 유무에 따른 분류 정확도와 손실도 결과값은 각각 96.0%, 0.22%의 결과값을 나타내었다. 연구결과를 통해 Inception V3 딥러닝 모델은 흉부 영상 데이터의 특징 추출 및 분류에 있어 우수한 딥러닝 모델인 것을 알 수 있었다. Inception V3 딥러닝 모델의 경우 흉부 질환의 분류에 있어 유용한 딥러닝 모델이 될 것으로 판단되며 조금 더 다양한 의료 영상 데이터를 이용한 연구를 진행하여 이와 같은 우수한 연구결과를 얻게 된다면 향후 임상의의 진단 시 많은 도움을 줄 수 있을 것으로 사료된다.

• KEPCO Journal on Electric Power and Energy
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• 제7권2호
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• pp.323-328
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• 2021

Diagnostic models are required. Data augmentation is one of the best ways to improve deep learning performance. Traditional augmentation techniques that modify image brightness or spatial information are difficult to achieve great results. To overcome this, a generative adversarial network (GAN) technology that generates virtual data to increase deep learning performance has emerged. GAN can create realistic-looking fake images by competitive learning two networks, a generator that creates fakes and a discriminator that determines whether images are real or fake made by the generator. GAN is being used in computer vision, IT solutions, and medical imaging fields. It is essential to secure additional learning data to advance deep learning-based fault diagnosis solutions in the power industry where facilities are strictly maintained more than other industries. In this paper, we propose a method for generating power facility images using GAN and a strategy for improving performance when only used a small amount of data. Finally, we analyze the performance of the augmented image to see if it could be utilized for the deep learning-based diagnosis system or not.

• Advances in nano research
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• 제12권2호
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• pp.185-195
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• 2022

Deep learning is another field of artificial intelligence (AI) utilized for computer aided diagnosis (CAD) and image processing in scientific research. Considering numerous mechanical repetitive tasks, reading image slices need time and improper with geographical limits, so the counting of image information is hard due to its strong subjectivity that raise the error ratio in misdiagnosis. Regarding the highest mortality rate of Lung cancer, there is a need for biopsy for determining its class for additional treatment. Deep learning has recently given strong tools in diagnose of lung cancer and making therapeutic regimen. However, identifying the pathological lung cancer's class by CT images in beginning phase because of the absence of powerful AI models and public training data set is difficult. Convolutional Neural Network (CNN) was proposed with its essential function in recognizing the pathological CT images. 472 patients subjected to staging FDG-PET/CT were selected in 2 months prior to surgery or biopsy. CNN was developed and showed the accuracy of 87%, 69%, and 69% in training, validation, and test sets, respectively, for T1-T2 and T3-T4 lung cancer classification. Subsequently, CNN (or deep learning) could improve the CT images' data set, indicating that the application of classifiers is adequate to accomplish better exactness in distinguishing pathological CT images that performs better than few deep learning models, such as ResNet-34, Alex Net, and Dense Net with or without Soft max weights.

• Imaging Science in Dentistry
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• 제49권1호
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• pp.1-7
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• 2019

Purpose: Artificial intelligence (AI), represented by deep learning, can be used for real-life problems and is applied across all sectors of society including medical and dental field. The purpose of this study is to review articles about deep learning that were applied to the field of oral and maxillofacial radiology. Materials and Methods: A systematic review was performed using Pubmed, Scopus, and IEEE explore databases to identify articles using deep learning in English literature. The variables from 25 articles included network architecture, number of training data, evaluation result, pros and cons, study object and imaging modality. Results: Convolutional Neural network (CNN) was used as a main network component. The number of published paper and training datasets tended to increase, dealing with various field of dentistry. Conclusion: Dental public datasets need to be constructed and data standardization is necessary for clinical application of deep learning in dental field.

• International Journal of Advanced Culture Technology
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• 제5권2호
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• pp.82-89
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• 2017

The range of problems that can be handled by the activation of big data and the development of hardware has been rapidly expanded and machine learning such as deep learning has become a very versatile technology. In this paper, mnist data set is used as experimental data, and the Cross Entropy function is used as a loss model for evaluating the efficiency of machine learning, and the value of the loss function in the steepest descent method is We applied the GradientDescentOptimize algorithm to minimize and updated weight and bias via backpropagation. In this way we analyze optimal reliability value corresponding to the number of exercises and optimal reliability value without overfitting. And comparing the overfitting time according to the number of data changes based on the number of training times, when the training frequency was 1110 times, we obtained the result of 92%, which is the optimal reliability value without overfitting.

• 대한의용생체공학회:의공학회지
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• 제40권2호
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• pp.62-67
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• 2019

The purpose of this study was to evaluate the performance of deep neural network model in order to determine whether there is a risk factor for coronary artery disease based on the cardiac variation parameter. The study used unidentifiable 297 data to evaluate the performance of the model. Input data consists of heart rate parameters, which are SDNN (standard deviation of the N-N intervals), PSI (physical stress index), TP (total power), VLF (very low frequency), LF (low frequency), HF (high frequency), RMSSD (root mean square of successive difference) APEN (approximate entropy) and SRD (successive R-R interval difference), the age group and sex. Output data are divided into normal and patient groups, and the patient group consists of those diagnosed with diabetes, high blood pressure, and hyperlipidemia among the various risk factors that can cause coronary artery disease. Based on this, a binary classification model was applied using Deep Neural Network of deep learning techniques to classify normal and patient groups efficiently. To evaluate the effectiveness of the model used in this study, Kernel SVM (support vector machine), one of the classification models in machine learning, was compared and evaluated using same data. The results showed that the accuracy of the proposed deep neural network was train set 91.79% and test set 85.56% and the specificity was 87.04% and the sensitivity was 83.33% from the point of diagnosis. These results suggest that deep learning is more efficient when classifying these medical data because the train set accuracy in the deep neural network was 7.73% higher than the comparative model Kernel SVM.

• Korean Journal of Radiology
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• 제23권12호
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• pp.1269-1280
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• 2022

Objective: This study aimed to evaluate the usefulness of quantitative indices obtained from deep learning analysis of gadoxetic acid-enhanced hepatobiliary phase (HBP) MRI and their longitudinal changes in predicting decompensation and death in patients with advanced chronic liver disease (ACLD). Materials and Methods: We included patients who underwent baseline and 1-year follow-up MRI from a prospective cohort that underwent gadoxetic acid-enhanced MRI for hepatocellular carcinoma surveillance between November 2011 and August 2012 at a tertiary medical center. Baseline liver condition was categorized as non-ACLD, compensated ACLD, and decompensated ACLD. The liver-to-spleen signal intensity ratio (LS-SIR) and liver-to-spleen volume ratio (LS-VR) were automatically measured on the HBP images using a deep learning algorithm, and their percentage changes at the 1-year follow-up (ΔLS-SIR and ΔLS-VR) were calculated. The associations of the MRI indices with hepatic decompensation and a composite endpoint of liver-related death or transplantation were evaluated using a competing risk analysis with multivariable Fine and Gray regression models, including baseline parameters alone and both baseline and follow-up parameters. Results: Our study included 280 patients (153 male; mean age ± standard deviation, 57 ± 7.95 years) with non-ACLD, compensated ACLD, and decompensated ACLD in 32, 186, and 62 patients, respectively. Patients were followed for 11-117 months (median, 104 months). In patients with compensated ACLD, baseline LS-SIR (sub-distribution hazard ratio [sHR], 0.81; p = 0.034) and LS-VR (sHR, 0.71; p = 0.01) were independently associated with hepatic decompensation. The ΔLS-VR (sHR, 0.54; p = 0.002) was predictive of hepatic decompensation after adjusting for baseline variables. ΔLS-VR was an independent predictor of liver-related death or transplantation in patients with compensated ACLD (sHR, 0.46; p = 0.026) and decompensated ACLD (sHR, 0.61; p = 0.023). Conclusion: MRI indices automatically derived from the deep learning analysis of gadoxetic acid-enhanced HBP MRI can be used as prognostic markers in patients with ACLD.

• Journal of Multimedia Information System
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• 제6권2호
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• pp.81-86
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• 2019

Deep learning is emerging as one of the best tool in processing data related to medical imaging. In our research work, we have proposed a deep learning based framework CNN (Convolutional Neural Network) for the classification of dysplastic tissue images. The CNN has classified the given images into 4 different classes namely normal tissue, mild dysplastic tissue, moderate dysplastic tissue and severe dysplastic tissue. The dataset under taken for the study consists of 672 tissue images of epithelial squamous layer of oral cavity captured out of the biopsy samples of 52 patients. After applying the data pre-processing and augmentation on the given dataset, 2688 images were created. Further, these 2688 images were classified into 4 categories with the help of expert Oral Pathologist. The classified data was supplied to the convolutional neural network for training and testing of the proposed framework. It has been observed that training data shows 91.65% accuracy whereas the testing data achieves 89.3% accuracy. The results produced by our proposed framework are also tested and validated by comparing the manual results produced by the medical experts working in this area.