• 약학회지
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• 제51권1호
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• pp.13-34
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• 2007

Traditional Medicine (TM) is called as philosophical medicine in Korea. An unified theory named as Sihnsang-hanron (SSHR) was hypothesized through studies of scientific analyses on various theories of TM. SSHR has extracted seven concepts which are six common ones from the great three books (三大原典) and the Logic of Laotzu & Chuangtzu (老莊思想). Six common concepts are the affecting by cold (傷寒), qi (氣), cold or heat (寒熱), exterior & interior of body (表裏), deficiency or excessiveness (虛實), and yin & yang (陰陽). We have tried to apply these seven concepts to Physics and Life Science. The affecting by cold means anti-sunlight and the origin of all diseases. The difference between TM and modern medical science would be in diagnostic methods as well as their theoretical analyses for various diseases. The modern science follows Haeckel's positive dialectics applied by the biological monism, and oriental one(SSHR) does Yin-Yang monism from the studies of Logic of Laotzu (老子) & Chuangtzu (莊子). SSHR would make the theory of exterior & interior of body (表裏論) and six channels (六經) develope scientifically as a diagnostic technique of disease. This theory is an excellent one that can't be found out in modern medical science, and so it should be developed as a scientific theory by using modern mechanic instrument. Chuangtzu asserted that ai was the basic substance of the universe. It is hypothesized that qi (氣) is like small particles -higgs, with dynamic power in modern Physics. We consider cautiously qi could be calculated by mathematics through higgs' bosons in near future.

• 융합신호처리학회논문지
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• 제21권4호
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• pp.183-194
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• 2020

최근 영유아 성장기에 발생하는 고관절 이형성증(Developmental Dysplasia of Hip, DDH)의 숫자가 늘어나고 있다. DDH는 영유아 성장을 방해하고 다른 부작용도 많이 발생시키기 때문에 최대한 조기에 발견하여 치료해야 한다. 최근 들어 Convolutional Neural Networks (CNN) 및 개선된 Resnet50을 활용한 머신러닝 기법이 초음파 영상 분석에 많이 활용되고 있다. 연구 결과를 보면 컴퓨터 보조 이미지 분석이 의료현장에서 객관성과 생산성을 크게 향상시키고 있다. 본 연구의 결과는 정형외과에서의 난제인 초음파 영상을 통한 DDH 컴퓨터 보조 진단 알고리즘에도 충분히 활용될 수 있다는 것을 보여주고 있다. 본 논문에서는 CNN을 활용하여 DDH를 자동으로 측정하고 진단할 수 있는 컴퓨터 보조 진단 알고리즘을 제안하였다. DDH 측정을 위해 유아 고관절의 정상/비정상 판독을 위해 Acetabulum-Femoral head의 angle을 자동으로 계산하였으며 기존 영상을 딥 러닝하여 진단을 자동으로 하는 알고리즘을 설계하였다. 실험 결과 의사와 비교하여 진단의 속도와 정확도가 향상된다는 것을 확인하였다.

• Parasites, Hosts and Diseases
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• 제60권6호
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• pp.401-407
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• 2022

Antimalarial drugs play an important role in the control and treatment of malaria, a deadly disease caused by the protozoan parasite Plasmodium spp. The development of novel antimalarial agents effective against drug-resistant malarial parasites is urgently needed. The novel derivatives, SKM13-MeO and SKM13-F, were designed based on an SKM13 template by replacing the phenyl group with electron-donating (-OMe) or electron-withdrawing groups (-F), respectively, to reverse the electron density. A colorimetric assay was used to quantify cytotoxicity, and in vitro inhibition assays were performed on 3 different blood stages (ring, trophozoite, and schizonts) of P. falciparum 3D7 and the ring/mixed stage of D6 strain after synchronization. The in vitro cytotoxicity analysis showed that 2 new SKM13 derivatives reduced the cytotoxicity of the SKM13 template. SKM13 maintained the IC₅₀ at the ring and trophozoite stages but not at the schizont stage. The IC₅₀ values for both the trophozoite stage of P. falciparum 3D7 and ring/mixed stages of D6 demonstrated that 2 SKM13 derivatives had decreased antimalarial efficacy, particularly for the SKM13-F derivative. SKM13 may be comparably effective in ring and trophozoite, and electron-donating groups (-OMe) may be better maintain the antimalarial activity than electron-withdrawing groups (-F) in SKM13 modification.

• 문화기술의 융합
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• 제9권3호
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• pp.647-654
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• 2023

딥러닝은 이미지, 텍스트와 같이 복잡한 데이터를 분류 및 인식하는데 유용한 방법으로 딥러닝 기법의 정확도는 딥러닝이 인터넷상의 AI 기반의 서비스를 유용하게 하는데 기초가 되었다. 그러나 딥러닝에서 훈련에 사용되는 방대한 양의 사용자 데이터는 사생활 침해 문제를 야기하였고 사진이나 보이스와 같이 사용자이 개인적이고 민감한 데이터를 수집한 기업들이 데이터들을 무기한으로 소유한다. 사용자들은 자신의 데이터를 삭제할 수 없고 사용되는 목적도 제한할 수 없다. 예를 들면, 환자 진료기록에 대한 딥러닝 기술을 적용하기 원하는 의료기관들과 같은 데이터소유자들은 사생활과 기밀유지 문제로 환자의 데이터를 공유할 수 없고 딥러닝 기술의 혜택을 받기 어렵다. 우리는 멀티 파티 시스템에서 다수의 작업자들이 입력 데이터집합을 공유하지 않고 신경망 모델을 공동으로 사용할 수 있는 프라이버시 보존 기술을 적용한 딥러닝 방법을 설계한다. 변형된 확률적 경사 하강에 기초한 최적화 알고리즘을 이용하여 하위 집합을 선택적으로 공유할 수 있는 방법을 이용하였고 결과적으로 개인정보를 보호하면서 학습 정확도를 증가시킨 학습을 할 수 있도록 하였다.

• 보건의료생명과학 논문지
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• 제11권1호
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• pp.67-77
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• 2023

본 논문은 인공지능 기술을 활용한 헬스케어 서비스 및 기술 등을 분석함으로써 향후 전문대학 수준의 인공지능 전문인력을 양성하기 위한 선행연구로서의 목적이 있다. 인공지능 기술은 국가 경쟁력 및 부가가치를 창출할 미래 핵심 동력 또는 핵심 기술로 인식되면서, 선진 국가들은 국가 차원에서 기술 개발은 물론 인력양성에 많은 관심과 지원을 투입하고 있다. 우리나라도 인공지능 대학원 프로그램 지원사업과 같은 국가 차원의 R&D 인력 양성 사업을 추진하고 있고, 대기업을 위주로 해서 자체적인 인공지능 인력 양성 및 확보에 많은 투자를 진행하고 있지만, 그럼에도 불구하고 인공지능 전문인력이 부족한 상황이다. 본 연구는 인공지능기술을 활용한 의료 서비스 및 기술, 산업 현황 및 인공지능 인력양성의 현황을 분석하고, 이를 통해 전문대학 수준의 헬스케어 인공지능 인력 양성에 대한 방향을 제안한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10475-10481
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• 2015

Forkhead-box (FOX) transcription factors comprise a large gene family that contains more than 50 members in man. Extensive studies have revealed that they not only have functions in control of growth and development, but also play important roles in different diseases, especially in cancer. However, biological functions for most of the members in the FOX family remain unknown. In the present study, the expression of 39 FOX genes in 48 kinds of cancer was mined from the Gene Expression Atlas database of European Bioinformatics Institute. The analysis results showed that some FOX genes demonstrate overlapping expression in various cancers, which suggests particular biological functions. The pleiotropic features of the FOX genes make them excellent candidates in efforts aimed to give medical treatment for cancers at the genetic level. The results also indicated that different FOX genes may have the synergy or antagonistics effects in the same cancers. The study provides clues for further functional analysis of FOX genes, especially for the pleiotropic biological functions and crosstalk of FOX genes in human cancers.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6823-6827
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• 2014

Objective: This study was conducted to investigate the efficacy of pancreatic drainage for pain relief in advanced pancreatic cancer. Method: Seventy-one patients with pancreatic carcinoma were divided into two groups: dilated and non-dilated pancreatic ducts. All patients underwent endoscopic retrograde cholangiopancreatography (ERCP), endoscopic biliary stenting and pancreatic stenting. Visual Analog Scale (VAS) scores, pain remission rates and survival time were evaluated during follow-up. Results: The post-ERCP VAS score of the dilated group was lower than that of the non-dilated group at 1 and 3 months post-ERCP. There was no difference at 6 months. The pain remission rate in the dilated duct group was significantly higher than that in non-dilated duct group in 1 and 3 months post-ERCP. The median survival times were 8.17 and 8.22 months respectively. Conclusion: Endoscopic pancreatic drainage can relieve pain of advanced pancreatic cancer accompanied by safe dilation of the pancreatic duct.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9607-9610
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• 2014

Breast cancer, a leading cause of death among women in most countries worldwide, is rapidly increasing in incidence in Vietnam. One of biomarkers is the disruption of the genetic material including epigenetic changes like DNA methylation. With the aim of finding hypermethylation at CpG islands of promoter of BRCA1 gene, belonged to the tumor suppressor gene family, as the biomarker for breast cancer in Vietnamese population, sensitive methyl specific PCR (MSP) was carried out on 115 samples including 95 breast cancer specimens and 20 normal breast tissues with other diseases which were obtained from Ho Chi Minh City Medical Hospital, Vietnam. The result indicated that the frequency of BRCA1 hypermethylation reached 82.1% in the cases (p<0.001). In addition, the DNA hypermethylation of this candidate gene increased the possibility to be breast cancer with high incidence via calculated odd ratios (p<0.05). In conclusion, hypermethylation of this candidate gene could be used as the promising biomarker application with Vietnamese breast cancer patients.

• Nuclear Engineering and Technology
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• 제52권4호
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• pp.835-840
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• 2020

A position-sensitive CsI(Tl) crystal array coupled with the multi-anode position sensitive photomultiplier tube (PS-PMT), Hamamatsu H8500C, has been developed at the Institute of Modern Physics. An effective, fast, and economical readout circuit based on discretized positioning circuit (DPC) bridge was designed for the 64-channel multi-anode flat panel PSPMT. The horizontal and vertical position resolutions are 0.58 mm and 0.63 mm respectively for the 1.0 × 1.0 × 5.0 ㎣ CsI(Tl) array, and the horizontal and vertical position resolutions are 0.86 mm and 0.80 mm respectively for the 2.0 × 2.0 × 10.0 ㎣ CsI(Tl) array. These results show that the CsI(Tl) crystal array with low cost could be applied in the fields of medical imaging and high-resolution gamma camera.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2006년도 제47회 학술심포지움 및 추계국제학술대회
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• pp.44.2-44.2
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• 2006