• Journal of Korean Society of Water and Wastewater
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• v.28 no.1
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• pp.125-134
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• 2014

6 sigma is a management innovation strategy which improves most of all managerial processes including transactional and project based operations such as marketing, purchasing, accounting, and construction. Even though 6 sigma is trying to solve problems from the customer's viewpoint in the scientific manner, project leader feels some difficulties in implementation because of several reasons. Especially the difficulties are prevalent in construction site. This paper investigates the cause of the difficulties through questionnaires, analyzes the investigation results, and verifies the critical success factors of 6 sigma implementation. Factor analysis has been usually employed in reducing quantity of data and summarizing information chaos. In this study, several variables from questionnaires are grouped into just only four factors by the process of factor analysis. The critical success factors are extracted as project management system, implementation mechanism, site condition, and project ownership. Some ideas for each individual success factor are suggested, which are expected to be useful in successful implementation of 6 Sigma in construction site.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.11
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• pp.42-49
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• 1997

The extent of absorption and transmitance of the light that passes through some material is changed as the wavelength of the light varies, and which makdes it possible to estimate characteristics of the material. Spectrometer is a measurement system that can analyze the characteristics of material by using this principle. Its application field is so wide that it can be applied to all the arease that are concerned with analyzing materials : biological, environmental, medical and chemical area etc. This study is focused on developing precision sine drive mechanism for grating monochromator which is the most important part of the spectrometers. It is designed to be simple in struicture. It is achieved to derive basic principles to manipu- late precision sine drive mechanism : it should be aligned with a condition that .beta. , the angle between grat- ing normal and grating rod should be the same as .gamma. , the one between moving nut's normal and sliding guide. And also, it's found that the mis-alignments of the grating and mirrors are not the main factor in guaranteeing the linearity of sine drive mechanism. Performance evaluation is achieved by a standard sample by comparing experimental results with standard values. It results in wavelength accuracy of .+-. 0.5nm and resolution of 1nm. Conclusively, it can be verified that the sine drive mechanism developed in this study is not only simple in structure, but also stable and excellent in performanes.

• Journal of Applied Reliability
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• v.17 no.3
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• pp.224-235
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• 2017

Purpose: Reliability is the most important factor to detect defects as wind turbines are deployed in large blades. The methods of detecting defects are various, such as non-destructive inspection and thermal imaging inspection. We propose the phased array ultrasonic testing method of non-destructive testing. Methods: We propose the active pressure mechanism for wind power blade. The phase array ultrasonic inspection method is used for fault detection inner blade surface. Controlled pressure of mechanism with respect to z-axis is important for guarantee the result of phase array ultrasonic inspection. The model based control and proposed mechanism are utilized for overall system stability and effectiveness of system. Result: The result of proposed pressure mechanism B is more stable than A. Convergence speed is also faster than A. Conclusion: We confirmed the performance of the proposed constant pressure mechanism through experiments. Non-destructive testing was applied to the specimen to confirm the reliability of detecting defects.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.363.1-363
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• 1998

No Abstract, See Full Text

• The Plant Pathology Journal
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• v.19 no.1
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• pp.9-12
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• 2003

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.70-70
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• 2003

Estrogen receptor is a ligand-activated transcription factor. Its action depends on the receptor, its ligand, and its coactivator proteins. As a consequence, the concentration of the receptor is a major component that governs the magnitude of the estrogen response. Despite the extensive knowledge on mechanism of estrogen receptor action, regulation of estrogen receptor itself is not very well understood. Estrogen receptor is known to be downregulated under hypoxia leading to inhibition of estrogen receptor mediated transcription activation. We have studied mechanism of loss of estrogen responsiveness under hypoxia. We found that Hif-l${\alpha}$, a major transcription factor regulating hypoxic response, inhibited transcription of estrogen response element driven luciferase gene by expression of HIF-l${\alpha}$/vp16 construct designed to contain transcription activity under normoxia. This loss of estrogen responsiveness appears to be the result of ER${\alpha}$ downregulation. ER${\alpha}$was downregulated at the levels of ligand-biding and protein within l2-24h, and the response was blocked by the proteasome inhibitor MG132, protein synthesis inhibitor cyclohexamide, and tyrosine kinase inhibitor Genistein. These results demonstrate that Hif-l${\alpha}$ downregulates ER${\alpha}$ by proteasome dependent pathway.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4879-4881
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• 2012

Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage induced by ionizing radiation, and non-homologous end joining is the predominant pathway for repair of radiation-induced DSBs. Some cell signaling pathways that respond to normal growth factors are abnormally activated in human cancer. These pathways also invoke the cell survival mechanisms that lead to resistance to radiation. The molecular connection between the EGFR and its control over DNA repair capacity appears to be mediated by one or more signaling pathways downstream of this receptor. The purpose of this mini-review was not only to highlight the relation of the EGFR signal as a regulatory mechanism to DNA repair and radiation resistance, but also to provide clues to improving existing radiation resistance through novel therapies based on the above-mentioned mechanism.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.1
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• pp.511-535
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• 2017

Internet banking is one of many services provided by financial institutions that have become very popular with an increasing trend. Due to the increased amount of usage of the service, Internet banking has become a target from adversaries. One of the points that are at risk of an attack is the login process. Therefore, it is necessary to have a security mechanism that can reduce this risk. This research designs and develops a multi-factor authentication protocol, starting from a registration system, which generates authentication factors, to an actual authentication mechanism. These factors can be categorised into two groups: short term and long term. For the authentication protocol, only three messages need to be exchanged between a client and a financial institution's server. Many cryptographic processes are incorporated into the protocol, such as symmetric and asymmetric cryptography, a symmetric key generation process, a method for generating and verifying digital signatures. All of the authentication messages have been proved and analysed by the logic of GNY and the criteria of OWASP-AT-009. Even though there are additional factors of authentication, users do not really feel any extra load on their part, as shown by the satisfactory survey.

• Journal of Korean Academy of Nursing
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• v.26 no.3
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• pp.678-687
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• 1996

Smoking is considered to be one of the important risk factors associated with various health problems. Thirty seven million people in America quit smoking in the past decade, with 90% quitting on their own(Americal Heart Association, 1986). According to McAlister(1975), 70% of smokers reported that they adopted a self-help smoking cessation approach rather than a formal treatment program. In our country, although, auccessful exsmokers have used, are not available, concerns about smoking cessation have increased, recently, due to changes in social and political attitudes to health promotion. This study was conducted to help smokers who had made a decision to adopt a self-helf smoking cessation approach instead of depending on a formal treatment program. It provided a structurd way for sucessful smoking cessation by identifying change mechanism factors which have been commonly used by smokers. The subjects selected for this study were 155 university students between 20 and 29. Years of age the results from the analysis of the collected data showed that seven factors in the self-help change processes significant, and they are named, Stimulus Control, Self-Determination, Information Management, Reinforcement Management, Helpful Relationships, Dramatic Relief, and Cognitive Restructuring. All of the factors except Self-Determination represent the same change mechanisms which are proposed by Prochaska et at.(1988). Self-Determination uniformly includes items belonging to various change processes. Therefore, it might be an transitional factor including strategies related to both cognitive and behavioral dimensions. In spite of this, noted that one item which gives meaning of Self-Determination shows the highest factor loading, it is named Self-Determination.

• Biomolecules & Therapeutics
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• v.25 no.3
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• pp.337-343
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• 2017

Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic effect of kahweol is not known. Activating transcription factor 3 (ATF3) has been reported to be associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which kahweol stimulates ATF3 expression and apoptosis in human colorectal cancer cells. Kahweol increased apoptosis in human colorectal cancer cells. It also increased ATF3 expression through the transcriptional activity. The responsible cis-element for ATF3 transcriptional activation by kahweol was CREB located between -147 to -85 of ATF3 promoter. ATF3 overexpression increased kahweol-mediated cleaved PARP, while ATF3 knockdown attenuated the cleavage of PARP by kahweol. Inhibition of ERK1/2 and $GSK3{\beta}$ blocked kahweol-mediated ATF3 expression. The results suggest that kahweol induces apoptosis through ATF3-mediated pathway in human colorectal cancer cells.