• BMB Reports
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• v.51 no.8
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• pp.388-393
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• 2018

The activating transcription factor (ATF) 4 belongs to the ATF/CREB (cAMP Response Element Binding bZIP [Basic Leucine Zipper]) transcription factor family, and plays a central role in the UPR (Unfolded Protein Response) process in cells. The induction of ATF4 expression has previously been shown to increase the replication of HIV-1. However, the detailed mechanism underlying this effect and the factors involved in the regulation of ATF4 function are still unknown. Here, we demonstrate first that knocking out ATF4 using siRNA shows a strong negative effect on HIV-1 production, indicating that ATF4 is a functional positive cellular factor in HIV-1 production. To determine the mechanism by which ATF4 regulates the HIV-1 life cycle, we assessed the effect of the overexpression of wild type ATF4 and its various derivatives on HIV-1 LTR-mediated transcriptional activation and the production of HIV-1 particles. This effect was studied through co-transfection experiments with either reporter vectors or proviral DNA. We found that the N-terminal domains of ATF4 are involved in HIV-1 LTR-mediated transcriptional activation, and thus in HIV-1 production.

• Nuclear Engineering and Technology
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• v.55 no.7
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• pp.2613-2620
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• 2023

Excellent thermal neutron absorption performance of boron expands the potential use of boron rich slag to prepare epoxy resin matrix nuclear shielding composites. However, shielding attenuation behaviors and mechanism of the composites against gamma rays are unclear. Based on the radiation protection theory, Phy-X/PSD, XCOM, and ⁶⁰Co gamma ray source were integrated to obtain the shielding parameters of boron rich slag/epoxy resin composites at 0.015-15 MeV, which include mass attenuation coefficient (µ_t), linear attenuation coefficient (µ), half value thickness layer (HVL), electron density (N_eff), effective atomic number (Z_eff), exposure buildup factor (EBF) and exposure absorption buildup factor (EABF).µ_t, µ, HVL, N_eff, Z_eff, EBF and EABF are 0.02-7 cm²/g, 0.04-17 cm^-1, 0.045-20 cm, 5-14, 3 × 10²³-8 × 10²³ electron/g, 0-2000, and 0-3500. Shielding performance is BS4, BS3, BS3, BS1 in descending order, but worse than ordinary concrete. µ and HVL of BS1-BS4 for ⁶⁰Co gamma ray is 0.095-0.110 cm^-1 and 6.3-7.2 cm. Shielding mechanism is main interactions for attenuation gamma ray by BS1-BS4 are elements with higher content or higher atomic number via Photoelectric Absorption at low energy range, and elements with higher content via Compton Scattering and Pair Production in Nuclear Field at middle and higher energy range.

• Current Applied Physics
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• v.18 no.11
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• pp.1388-1392
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• 2018

Metal thin films are used widely to solve the vibration problem. However, damping mechanism is still not clear, which limits the further improvement of the damping properties for film and the development of multi-functional damping coating. In this paper, Damping microscopic mechanism of porous metal films was investigated at both macroscopically and microscopically mixed levels. Molecular dynamics simulation method was used to model and simulate the loading-unloading numerical experiment on the micro-pore and vacancy model to get the stress-strain curve and the microstructure diagram of different defects. And damping factor was calculated by the stress-strain curve. The results show that dislocations and new vacancies appear in the micro-pores when metal film is stretched. The energetic consumption from the motion of dislocation is the main reason for the damping properties of materials. Micro-mechanism of damping properties is discussed with the results of in-situ experiment.

• Archives of design research
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• v.16 no.3
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• pp.221-230
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• 2003

In product design, many designers incorporate psychological aspects to express the "fun" factor. If so, is it possible to apply the fun inducing mechanism utilized in psychology to product design and are there any problems in the application\ulcorner Psychology defines the sense of fun as the result of relief to a situation that causes a mental accumulation through the discovery of a due. The psychological extraction of fun inducing mechanism tends to lean too much to the cognitive aspect. Therefore, when dealing with product design, psychology's particular disposition is inadequate in explaining the important perceptive factor of fun. This study hypothesizes that perceptive aspect of should be induced along with the cognitive aspect in order to rationalize fun in product design. In order to understand the perception of fun, this study will introduce the amusement aspect within Kitsch products. Methods of developing a humorous form will be studied and these methods will be applicable to perceptive aspects. This paper hypothesizes that through the theoretical basis of internal characteristic of cognitive factors and external characteristic of perceptive factors, the mechanism of fun can be determined.etermined.

• Journal of Educational Research in Mathematics
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• v.14 no.3
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• pp.239-266
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• 2004

This article presents new perspectives for analysing and diagnosing students' mathematical errors on the basis of Pascaul-Leone's neo-Piagetian theory. Although Pascaul-Leone's theory is a cognitive developmental theory, its psychological mechanism gives us new insights on mathematical errors. We analyze mathematical errors in the domain of proof problem solving comparing Pascaul-Leone's psychological mechanism with mathematical errors and diagnose misleading factors using Schoenfeld's levels of analysis and structure and fuzzy cognitive map(FCM). FCM can present with cause and effect among preconceptions or misconceptions that students have about prerequisite proof knowledge and problem solving. Conclusions could be summarized as follows: 1) Students' mathematical errors on proof problem solving and LC learning structures have the same nature. 2) Structures in items of students' mathematical errors and misleading factor structures in cognitive tasks affect mental processes with the same activation mechanism. 3) LC learning structures were activated preferentially in knowledge structures by F operator. With the same activation mechanism, the process students' mathematical errors were activated firstly among conceptions could be explained.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.5 s.236
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• pp.689-697
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• 2005

This paper presents the reliability estimation of door hinge for home appliances, which consists of bushing and shaft. The predominant failure mechanism of bushing made of polyoxymethylene(POM) is brittle fracture due to decrease of strength caused by voids existing, and that of shaft made of acrylonitrile-butadiene-styrene(ABS) is creep due to plastic deformation caused by excessive temperature and lowering of glass transition temperature by absorbed moisture. Since the brittle fracture of bushing is overstress failure mechanism, the load-strength interference model is used to estimate the failure rate of it along with failure analysis. By the way, the creep of shaft is wearout failure mechanism, and an accelerated life test is then planned and implemented to estimate its lifetime. Through the technical review about failure mechanism, temperature and humidity are selected as accelerating variables. Assuming Weibull lifetime distribution and Eyring model, the life-stress relationship and acceleration factor, $B_{10}$ life and its lower bound with $90\%$ confidence at worst case use condition are estimated by analyzing the accelerated life test data.

• Proceedings of the Korean Reliability Society Conference
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• 2004.07a
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• pp.303-311
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• 2004

This paper presents the reliability estimation of door hinge for home appliances, which consists of bushing and shaft. The predominant failure mechanism of bushing made of polyoxymethylene(POM) is brittle fracture due to decrease of strength caused by voids existing, and that of shaft made of acrylonitrile-butadiene-styrene(ABS) is creep due to plastic deformation caused by excessive temperature and lowering of glass transition temperature by absorbed moisture. Since the brittle fracture of bushing is overstress failure mechanism, the load-strength interference model is used to estimate the failure rate of it along with failure analysis. By the way, the creep of shaft is wearout failure mechanism, and an accelerated life test is then planned and implemented to estimate its lifetime. Through the technical review about failure mechanism, temperature and humidity are selected as accelerating variables. Assuming Weibull lifetime distribution and Eyring model, the life-stress relationship and acceleration factor, B$_{10}$ life and its lower bound with 90% confidence at worst case use condition are estimated by analyzing the accelerated life test data.a.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.4
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• pp.250-256
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• 2016

The prevalence of renal disease is increased with the overweight and obesity. High fat diet-associated oxidative stress increases production of reactive oxygen species (ROS) and induces apoptosis. There are two types of antioxidant defense mechanisms for oxidative stress. One is the enzyme defense mechanism by antioxidant enzymes such as superoxide dismutase (SOD), and catalase (CAT). The other is non-enzyme defense mechanism by signaling molecules such as nuclear factor-like 2 (Nrf-2), HO-1. In this study, we induced obesity in mice with high fat diet for six weeks and thereafter administered orally Viola mandshurica for 4 weeks. V. mandshurica is known to clear heat, detoxify and cool blood, and subside a swelling effect. In the V. mandshurica administered group, the immunoreactive signal of the Tunel staining was weaker than that of obesity group. Proapoptotic Bax, caspase 3 immunoreactives of the V. mandshurica administered group was lower than those of obesity group, whereas anti-apoptotic Bcl-2 immunoreactity was higher in the V. mandshurica administered group. Antioxidant enzyme mechanism such as superoxide dismutase 2 (SOD2), catalase (CAT) immunoreactives of the V. mandshurica administered group and Antioxidant non-enzyme mechanism such as Nuclear factor-like 2 (Nrf2), Heme Oxygenase 1 (HO-1) immunoreactives of the V. mandshurica administered group was higher than those of obesity group. These results demonstrate that V. mandshurica had the antioxidant and anti-apoptosis effects on obese mice.

• Journal of Welding and Joining
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• v.31 no.5
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• pp.59-63
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• 2013

A bendable electronic module has been developed for a mobile application by using a low-cost roll-to-roll manufacturing process. In flexible embedded electronic module, a thin silicon chip was embedded in a polymer-based encapsulating adhesive between flexible copper clad polyimide layers. To confirm reliability and durability of prototype bendable module, the following tests were conducted: Moisture sensitivity level, thermal shock test, high temperature & high humidity storage test, and pressure cooker tester. Those experiments to induce failure of the module due to temperature variations and moisture are the experiment to verify the reliability. Failure criterion was 20% increase in bump resistance from the initial value. The mechanism of the increase of the bump resistance was analyzed by using non-destructive X-ray analysis and scanning acoustic microscopy. During the pressure cooker test (PCT), delamination occurred at the various interfaces of the bendable embedded modules. To investigate the failure mechanism, moisture diffusion analysis was conducted to the pressure cooker's test. The hygroscopic characteristics of the encapsulating polymeric materials were experimentally determined. Analysis results have shown moisture saturation process of flexible module under high temperature/high humidity and high atmosphere conditions. Based on these results, stress factor and failure mechanism/mode of bendable embedded electronic module were obtained.

• International Journal of Computer Science & Network Security
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• v.23 no.12
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• pp.81-90
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• 2023

Cloud computing is an emerging business model popularized during the last few years by the IT industry. Providing "Everything as a Service" has shifted many organizations to choose cloud-based services. However, some companies still fear shifting their data to the cloud due to issues related to the security and privacy. The paper suggests a novel Trust based Mutual Authentication Mechanism using Secret P-box based Mutual Authentication Mechanism (TbMAM-SPb) on the criticality of information. It uses a particular passcodes from one of the secret P-box to act as challenge to one party. The response is another passcode from other P-box. The mechanism is designed in a way that the response given by a party to a challenge is itself a new challenge for the other party. Access to data is provided after ensuring certain number of correct challenge-responses. The complexity can be dynamically updated on basis of criticality of the information and trust factor between the two parties. The communication is encrypted and time-stamped to avoid interceptions and reuse. Overall, it is good authentication mechanism without the use of expensive devices and participation of a trusted third party.