• Journal of Information Technology Services
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• v.15 no.2
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• pp.125-155
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• 2016

By reclassifying and reinterpreting the factor variables that were used in precedent studies on company informatization by research theme and perspective on them success factor, the present study tried to examine how different the factor variables are in frequency of use and by period, and how importantly they were considered by research theme and perspective on its success factor, combining them with the studies done on mechanism point of view. The key findings of this study are as follows. First, it was found that the frequency of using mechanism variables, which are reclassified based on SER-M perspective, has gradually increased since 1990s. While the frequency of using resource factors sharply increased in 1990s, it decreased from 2000s. It indicates that more studies were conducted of mechanism factors other than resource factors from the early 2000s. Second, when looking at those variables reclassified by research them, it was found that such theme as decision maker, environment, and resource factors were more used than other research themes in the studies on the measuring factors of informatization. Mechanism factors turned out most used among overall research themes. In particular, they were more frequently used in studies related to the performance of informatization. This result evidences that mechanism-related variables are more importantly considered in the studies than other factors. This study produces a practical implication: what factors companies have to manage and secure intensively to attain successful informatization. In addition, this study helps companies seeking informatization understand and take advantage of SER-M factors on the basis of knowledge in the transitional process of the factor variables used in studies by period. It is expected that CIO can use the key findings of this study in monitoring the factors by the stage of informatization.

• Journal of Biosystems Engineering
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• v.38 no.2
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• pp.129-137
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• 2013

Purpose: Modeling has been used for elucidating the mechanism of complex biosystems. In spite of importance and uniqueness of adolescent calcium (Ca) metabolism characterized by a threshold Ca intake, its regulatory mechanism has not been covered and even not proposed. Hence, this study aims at model-based proposing potential mechanisms regulating adolescent Ca metabolism. Methods: Two different hypothetic mechanisms were proposed. The main mechanism is conceived based on Ca-protein binding which induces renal Ca filtration, while additional mechanism assumed that active renal Ca re-absorption regulated Ca metabolism in adolescents. Mathematical models were developed to represent the proposed mechanism and simulated them whether they could produce adolescent Ca profiles in serum and urine. Results: Simulation showed that both mechanisms resulted in the unique behavior of Ca metabolism in adolescents. Based on the simulation insulin-like growth factor-1 (IGF-1) is suggested as a potential regulator because it is related to both growth, a remarkable characteristic of adolescence, and Ca metabolism including absorption and bone accretion. Then, descriptive modeling is employed to conceptualize the hypothesized mechanisms governing adolescent Ca metabolism. Conclusions: This study demonstrated that modeling is a powerful tool for elucidating an unknown mechanism by simulating potential regulatory mechanisms in adolescent Ca metabolism. It is expected that various analytic applications would be plausible in the study of biosystems, particularly with combination of experimental and modeling approaches.

• Biomedical Science Letters
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• v.29 no.3
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• pp.137-143
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• 2023

Inflammation plays an important role in immune system's response to tissue injury and biological stimuli. However, excessive inflammation can cause tissue damage. Therefore, the development of naturally derived anti-inflammatory agents have received broad attention. In this study, we investigated the anti-inflammatory mechanism of Rubi Fructus (RF) extract on the mast cell-mediated inflammatory response. To determine the regulatory mechanism of RF in inflammatory reaction, we evaluated the effects of RF on secretion of interleukin (IL)-8, IL-6 and tumor necrosis factor (TNF)-α and activation of nuclear factor-κB (NF-κB) and caspase-1 in activated human mast cells-1 (HMC-1). The results showed that RF attenuated IL-8, IL-6 and TNF-α secretion in a concentration-dependent manner. Moreover, RF significantly attenuated caspase-1and NF-κB activation in activated HMC-1. Conclusively, the present results provide evidence that RF may be a promising agent for anti-inflammatory therapy.

• Elastomers and Composites
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• v.26 no.4
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• pp.287-295
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• 1991

The mixing process with carbon black is important in the rubber industries. However, it is difficult to characterize the mixing mechanism of the carbon black. The mixing mechanism(distributive mixing and dispersive mixing) was discribed in this paper. The effect of fill factor on the mixing of the carbon black was studied. The dispersive mixing ability increases with increasing fill factor. However, the distributive mixing ability decreases with increasing fill factor. The effect of the carbon black content on the rheological property of the material was studied in this paper. The viscosity of the material increases with increasing the carbon black content. However, the elasticity of the matarial decreases with the carbon black content.

• Journal of Korea Trade
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• v.25 no.2
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• pp.95-110
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• 2021

Purpose - This paper intends to conduct theoretical analysis and empirical test on the action mechanism of South Korea-China trade and South Korea's FDI to China on green total factor productivity, so as to provide a new perspective and ideas for the improvement of China's green total factor productivity and promote the high-quality development of China's economy Design/methodology - This paper uses the data of 30 provinces, autonomous regions and municipalities in China from 2004 to 2017 as the research sample, adopts the GML index method of SBM Directional Distance Function to measure GTFP, and analyzes the influence of South Korea-China trade and FDI from South Korea on China's GTFP. Findings - Trade is conducive to promoting technological progress, which has a significant promotion effect on China's green total factor productivity. While FDI has a significant inhibitory effect on China's green total factor productivity, which verifies the "pollution haven" hypothesis. In addition, such influence has certain regional overall heterogeneity. Trade has a more significant promoting effect on GTFP in eastern coastal areas, while FDI has a more significant inhibitory effect on GTFP in central and western inland areas. The interaction between trade and FDI is conducive to the improvement of green total factor productivity, indicating that the benign mechanism of trade and FDI has been formed. Urbanization, industrial structure, human resource level and investment in science and technology are all conducive to the improvement of GTFP. Originality/value - Through theoretical analysis and empirical test on the action mechanism of South Korea-China trade and South Korea's FDI on green total factor productivity, this paper provides a solid theoretical foundation for the further development of China-South Korea economic and trade cooperation in the future.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.788-793
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• 1995

For a linkage mechanism deiven by cam, cam profile is the major design factor and is determined by the motion type od cam follower. If a cam mechanism has additional kinematic linkages besides cam and follower then the follower motion should be specified form the motion of end linkage member so that cam would be able to generate the desired end linkage motion. In this paper, a cam-linkage mechanism is constructed with the combinations of modular linkage elements including cam and follower and as a resullt, a planar cam-linkage mechanism design software with the cam profile optimization function is developed and presented.

• Journal of Marine Bioscience and Biotechnology
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• v.7 no.2
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• pp.35-41
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• 2015

Whales are marine mammals that are fully adapted to aquatic environment. Whales breathe by lungs so they require adaptive system to low oxygen concentration (hypoxia) while deep and prolonged diving. However, the study for the molecular mechanism underlying cetacean adaptation to hypoxia has been limited. Hypoxia-inducible factor (HIF) is the central transcription factor that regulates hypoxia-related gene expression. Here we identified HIF-binding sites in whale genome by phylogenetic footprinting and analyzed HIF-target genes to understand how whales cope with hypoxia. By comparison with the HIF-target genes of terrestrial mammals, it was suggested that whales may retain unique adaptation mechanisms to hypoxia.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.301-308
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• 2017

With the popularization of smart phones and the development of the Internet, many people use smart phones to conduct identity verification procedures. smart phones are easier and faster to authenticate than personal desktop computers. However, as Internet hacking technology and malicious code distribution technology rapidly evolve and attack types become more diverse, authentication methods suitable for mobile environment are required. As authentication methods, there are methods such as possessive-based authentication, knowledge-based authentication, biometric-based authentication, pattern-based authentication, and multi-element authentication. In this paper, we propose a user authentication mechanism that uses collected information as authentication factor using smart phone. Using the proposed authentication mechanism, it is possible to use the smart phone information and environment information of the user as a hidden authentication factor, so that the authentication process can be performed without being exposed to others. We implemented the user authentication system using the proposed authentication mechanism and evaluated the effectiveness based on applicability, convenience, and security.

• Biomedical Science Letters
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• v.29 no.2
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• pp.58-65
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• 2023

Pu-erh tea, a popular and traditional Chinese tea, possesses various health-promoting effects, including inhibiting tumor cell progression and preventing type II diabetes and neurodegenerative disorders. However, the precise anti-inflammatory mechanisms are not well understood. In present study, we elucidated the anti-inflammatory mechanism of Pu-erh tea in lipopolysaccharide (LPS)-activated RAW264.7 cells. We explored the effects of Pu-erh tea on the levels of inflammatory-related genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and prostaglandin E₂ (PGE₂) in LPS-activated RAW264.7 cells. Moreover, we investigated its regulatory effects on nuclear factor-kappa B (NF)-κB and hypoxia-inducible-factor (HIF)-1α activation. The findings of this study demonstrated that Pu-erh tea inhibited the LPS-increased inflammatory cytokines and PGE₂ release, as well as COX-2 and iNOS expression. Moreover, we confirmed that the anti-inflammatory mechanism of Pu-erh tea occurs via the inhibition of NF-κB and HIF-1α activation. Conclusively, these findings provide experimental evidence that Pu-erh tea may be useful candidate in the treatment of inflammatory-related diseases.

• Nutrition Research and Practice
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• v.11 no.4
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• pp.347-347
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• 2017