• Title/Summary/Keyword: Mechanical stretch

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Stretch-activated $K^+$ Channels in Rat Atrial Myocytes

  • Youm, Jae-Boum
    • The Korean Journal of Physiology and Pharmacology
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    • v.7 no.6
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    • pp.341-348
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    • 2003
  • Mechanical stimuli to the cardiac myocytes initiate many biochemical and physiological events. Stretch-activated cation channels have been suggested to mediate these events. In this study, cell-attached and inside-out excised-patch clamp methods were used to identify stretch-activated cation channels in adult rat atrial myocytes. Channel openings were increased in cell-attached configuration when negative pressure was applied to the pipette, and also in inside-out excised patches by negative pressure. The channel was not permeable to $Cl^-$, $Na^+$ and $Cs^+$, but selectively permeable to $K^+$, and the degree of activation was dependent on the magnitude of negative pressure (full activation at ${\sim} -50 mmHg). In symmetrical 140 mM KCl, the slope conductance was $51.2{\pm}3$ pS between the potentials of -80 and 0 mV and $55{\pm}6$ pS between 0 and +80 mV (n=5). Glibenclamide ($100{mu}M$) or ATP (2 mM) failed to block the channel openings, indicating that it is not ATP-sensitive $K^+$ channel. Arachidonic acid ($30{mu}M$), which has been shown to activate a $K^+$ channel cooperatively with membrane stretch, did not affect the channel activity. $GdCl_3$ ($100{mu}M$) also did not alter the activity. These results demonstrate that the mechanical stretch in rat atrial myocytes activates a novel $K^+$-selective cation channel, which is not associated with other $K^+$ channels such as ATP-sensitive and arachidonic acid-activated $K^+$ channel.

Evaluation of Tailorability and Mechanical Properties of Stretch Fabrics (스트레치 직물의 역학적 특성 및 봉제성능 평가)

  • Lee, Hwan-Deok;Sung, Su-Kwang;Kwon, Hyun-Sun
    • Fashion & Textile Research Journal
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    • v.2 no.2
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    • pp.150-158
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    • 2000
  • This study investigated mechanical properties, drape coefficients and node indices of stretch fabrics. We applied mechanical properties to exhibited tailorability control in HESC and evaluated making-up. The mechanical properties such as tensile, bending, shearing, compression, surface characteristic values, thickness and weight were measured by the KES-F system and drape coefficient by drape tester. The summarized results of this study were as follows; First, stretch fabrics, almost, shown high stretch in weft inserted polyurethane yarn fabric and had a ${\pm}2{\sigma}$(sigma) range of shearing, compression, surface and thickness, except bending and weight, as compared with Japanese women's thin dress fabrics. Second, bending had a positive correlation in stiffness, anti-drape and flexibility & softness. Shearing had a negative correlation in crispness and scroop. Surface properties had a high contribution in fullness & softness. Third, The drape coefficient was found by measuring the mechanical properties according to the obtained regression equation. Forth, many problems are expected in overfeed and cutting operations in sewing process. In the decision of the good external appearance using TVA, only 26 of 55 samples are included in the range of the good external appearance. Fifth, in the regard of the result for sewing control, warp values are not necessary to control in the all kind of items. But weft value in the RT and EM are out of non-control zone. So we need a special management during sewing process.

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Study on Influence of Process Parameter on Stretch Flangeability of Steel Sheet (판재 신장플랜지성에 미치는 전단 공정 인자의 영향 연구)

  • S.S. Han;H.Y. Lee
    • Transactions of Materials Processing
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    • v.32 no.2
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    • pp.61-66
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    • 2023
  • The quality of the sheared surface affects the stretch flangeability of steel sheet. The quality of sheared surface is influenced by several process factors such as die clearance, shape of cutting edge, use of counter punch, and shear. In this paper, the influence of these shearing process factors on the stretch flangeability of the HSS (DP980) was analyzed through a shearing and a stretch flangeability test. When the die clearance was 10%, the effect of these shearing process factors on the stretch flangeability was the greatest, and the use of an acute angle blade was found to be more advantageous in the stretch flangeability than a right angle blade. It was found that the stretch flangeability was improved when active bending was applied during shearing.

Hyposmotic Cell Stretch Increases L-type Calcium Current in Smooth Muscle Cells of the Human Stomach

  • Kang, Tong-Mook;Kim, Chun-Hee;Kim, Min-Jung;Park, Myoung-Kyu;Uhm, Dae-Yong;Rhee, Jong-Chul;Rhee, Poong-Lyul
    • Proceedings of the Korean Biophysical Society Conference
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    • 1998.06a
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    • pp.39-39
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    • 1998
  • Stretch-activated ion channel that is open by mechanical stress applied on the cell membrane is one of the classes of ion channels. Other than stretch-activated channel itself, it has been also reported that a variety of ion channels could be modulated by a mechanical cell stretch.(omitted)

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Effects of Polymerization and Spinning Conditions on Mechanical Properties of PAN Precursor Fibers

  • Qin, Qi-Feng;Dai, Yong-Qiang;Yi, Kai;Zhang, Li;Ryu, Seung-Kon;Jin, Ri-Guang
    • Carbon letters
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    • v.11 no.3
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    • pp.176-183
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    • 2010
  • PAN precursor fibers were produced via wet-spinning process, and effects of polymerization and spinning processes, especially the stretching process, were investigated on mechanical properties and micro-morphologies of precursor fibers. An increase in molecular weight, dope solid and densification and a decrease in surface defects were possible by controlling polymerization temperature, the number of heating rollers for densification and the jet stretch ratio, which improved the mechanical properties of precursor fibers. The curves for strength, modulus, tensile power and diameter as a function of stretch ratio can be divided into three stages: steady change area, little change area and sudden change area. With the increase of stretch ratio, the fiber diameter became smaller, the degree of crystallization increased and the structure of precursor fibers became compact and homogeneous, which resulted in the increase of strength, modulus and tensile power of precursor fibers. Empirical relationship between fiber strength and stretch ratio was studied by using the sub-cluster statistical theory. It was successfully predicted when the strengths were 0.8 GPa and 1.0 GPa under a certain technical condition, the corresponding stretch ratio of the fiber were 11.16 and 12.83 respectively.

Dynamic Properties of Outwardly Propagating Spherical Hydrogen-Air Flames at High Temperatures and Pressures

  • Kwon, Oh-Chae
    • Journal of Mechanical Science and Technology
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    • v.18 no.2
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    • pp.325-334
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    • 2004
  • Computational experiments on fundamental un stretched laminar burning velocities and flame response to stretch (represented by the Markstein number) of hydrogen-air flames at high temperatures and pressures were conducted in order to understand the dynamics of the flames including hydrogen as an attractive energy carrier in conditions encountered in practical applications such as internal combustion engines. Outwardly propagating spherical premixed flames were considered for a fuel-equivalence ratio of 0.6, pressures of 5 to 50 atm, and temperatures of 298 to 1000 K. For these conditions, ratios of unstretched-to-stretched laminar burning velocities varied linearly with flame stretch (represented by the Karlovitz number), similar to the flames at normal temperature and normal to moderately elevated pressures, implying that the "local conditions" hypothesis can be extended to the practical conditions. Increasing temperatures tended to reduce tendencies toward preferential-diffusion instability behavior (increasing the Markstein number) whereas increasing pressures tended to increase tendencies toward preferential-diffusion instability behavior (decreasing the Markstein number).

Mechanotransduction in Cardiac Myocytes

  • Earm, Yung-E
    • Proceedings of the Korean Biophysical Society Conference
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    • 2001.06a
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    • pp.17-17
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    • 2001
  • It is well known that myocardial stretch causes changes in electrical signalling and contractility of the heart. For example, mechanical stretch depolarises the membrane potential of cardiac cells and alters the shape of action potentials. As a result, these effects either accelerate the frequency of heart rate or induce arrhythmias of the heart.(omitted)

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A Finite Element Analysis for a Rotating Cantilever Beam (회전 외팔보의 유한요소 해석)

  • Jeong, Jin-Tae;Yu, Hong-Hui;Kim, Gang-Seong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.25 no.11
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    • pp.1730-1736
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    • 2001
  • A finite element analysis for a rotating cantilever beam is presented in this study. Based on a dynamic modeling method using the stretch deformation instead of the conventional axial deformation, three linear partial differential equations are (derived from Hamilton's principle. Two of the linear differential equations show the coupling effect between stretch and chordwise deformations. The other equation is an uncoupled one for the flapwise deformation. From these partial differential equations and the associated boundary conditions, two weak forms are derived: one is for the chordwise motion and the other is fur the flptwise motion. The weak farms are spatially discretized with newly defined two-node beam elements. With the discretized equations or the matrix-vector equations, the behaviors of the natural frequencies are investigated for the variation of the rotating speed.

On the Extinction Characteristics of the Interacting Lean-Lean Premixed Flames (상호작용을 하는 희박-희박 예혼합화염의 소화특성에 관한 연구)

  • 정석호;김종수
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.10 no.2
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    • pp.232-240
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    • 1986
  • Extinction characteristics of the two interacting premixed flames are analyzed for the effects of flame stretch and preferential diffusion using large activation energy asymptotic analysis by adopting counterflow system as a model problem. Results show that the flammable limit of the thermally interacting premixed flames is extended compared to the single flame, and the extinction mechanism is classified into weak and strong interactions. As the lewis number of the deficient species increases, the region of strong interaction diminishes which can explain the different characteristics of the extinction boundaries of the lean (rich) methane/air and butane/air flames. The influence of the flame stretch to the interaction boundaries is also studied.

On the interaction of rich-lean premixed flames (과농-희박 예혼합화염의 상호작용에 관한 연구)

  • 이충훈;정석호
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.11 no.6
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    • pp.991-1000
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    • 1987
  • Existence of triple flames in a lean-rich concentration field is studied both experimentally and theoretically using large activation energy asymptotic technique adopting counterflow system as a model problem. Experiment shows that in triplet system of a lean and a rich premixed flame separated by a diffusion flame, either lean or rich premixed flame merges with diffusion flame as stretch is increased, such that transition boundary between 3-flame and 2-flame exists. The region in which 3-flame can exist forms an island within rich-lean concentration fields for large stretch, where as it is extends to the line of (.OMEGA.$_{0}$/.OMEGA.$_{F}$)$_{R}$=0 or (.OMEGA.$_{F/}$.OMEGA.$_{0}$)$_{L}$=0 for small stretch. Theoretical results show the qualitative agreement with experiment and the existence of limiting stretch over which 3-flame can not exist.t.t.t.t.t.t.