• Nuclear Engineering and Technology
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• v.42 no.4
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• pp.450-459
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• 2010

The present paper investigates the collapse pressure of cylinders with intermediate thickness subjected to external pressure based on detailed elastic-plastic finite element (FE) analyses. The effect of the initial ovality of the tube on the collapse pressure was explicitly considered in the FE analyses. Based on the present FE results, the analytical yield locus, considering the interaction between the plastic collapse and local instability due to initial ovality, was also proposed. The collapse pressure values based on the proposed yield locus agree well with the present FE results; thus, the validity of the proposed yield locus for the thickness range of interest was verified. Moreover, the partial safety factor concept based on the structural reliability theory was also applied to the proposed collapse pressure estimation model, and, thus, the priority of importance of respective parameter constituting for the collapse of cylinders under external pressure was estimated in this study. From the application of the partial safety factor concept, the yield strength was concluded to be the most sensitive, and the initial ovality of tube was not so effective in the proposed collapse pressure estimation model. The present deterministic and probabilistic results are expected to be utilized in the design and maintenance of cylinders subjected to external pressure with initial ovality, such as the once-through type steam generator.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.396-401
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• 2019

A virtual rigid is modeled as the parallel structure of a virtual spring and a virtual damper. The reflective force from the virtual model is designed to be as large as possible to improve the realism of the virtual environment while maintaining the stable interaction. So, it is important to analyze the stability boundary of the virtual spring and damper. In the previous researches, the stability boundary is analyzed based on the zero-order-hold (ZOH) method, but it is analyzed based on the first-order-hold (FOH) method and the virtual damper in the paper. The boundary value of the stable virtual damper is inverse proportional to the sampling time and the maximum value of stable virtual stiffness is inverse proportional to the square of the sampling time. And the maximum value in the FOH method is increased to 110% of the value in the ZOH method. If the virtual damper is smaller than about 50% of the boundary value of the virtual damper in the FOH method, the stable virtual stiffness in the FOH method is several times larger than that in the ZOH method.

• Structural Engineering and Mechanics
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• v.69 no.3
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• pp.257-268
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• 2019

Infills are as important members in structural design as beams, columns and braces. They have significant effect on structural behavior. Because of lots of variables in infills like material non-linear behavior, the interaction between frames and infill, etc., the infills performance during an earthquake is complicated, so have led designers do not consider the effect of infills in designing the structure. However, the experimental studies revealed that the infills have the remarkable effect on structure behavior. As if these effects ignored, it might occur soft-story phenomena, torsion or short-column effects on the structures. One simple and appropriate method for considering the infills effects in analyzing, is replacing the infills with diagonal compression strut with the same performance of real infill, instead of designing the whole infill. Because of too many uncertainties, codes and researchers gave many expressions that were not as the same as the others. The major intent of this paper is calculation the width of this diagonal strut, which has the most characteristics of infill. This paper by comprehensive on different parameters like the modulus of young or moment of inertia of columns presents a new formula for achieving the equivalent strut width. In fact, this new formula is extracted from about 60 FEM analyses models. It can be said that this formula is very efficient and accurate in estimating the equivalent strut width, considering the large number of effective parameters relative to similar relationships provided by other researchers. In most cases, the results are so close to the values obtained by the FEM. In this formula, the effect of out of plane buckling is neglected and this formula is used just in steel structures. Also, the thickness of infill panel, and the lateral force applied to frame are constant. In addition, this new formula is just for modeling the lateral stiffness. Obtaining the nearest response in analyzing is important to the designers, so this new formula can help them to reach more accurate response among a lot of experimental equations proposed by researchers.

• Membrane Journal
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• v.28 no.6
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• pp.388-394
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• 2018

Carbon nanotube (CNT) based membranes are promising candidates for separation membranes by showing high water transport rate and ion rejection rate according to their radii. The ion selectivity is an important factor to discover the full potential of CNT membranes, and it is affected by the functionalization of CNTs. With multivalent/size ion mixtures, the ion selectivity is affected by not only ion-functional groups interaction but also ion-ion interactions and ion size exclusion in a complex manner. In this study, molecular dynamics simulations are performed to study the ion selectivity of functionalized carbon nanotubes when multivalent/size ions are contained. The permeation energy barriers are calculated by plotting potential of mean force profiles, and various factors, such as CNT size and partial charges, affecting ion selectivity are investigated. The results presented here will be useful for designing CNT membranes for ion separation, biomimetic ion channels, etc.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.10
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• pp.1427-1434
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• 2021

In this paper, we propose a psychological state estimation process that computes children's attention and tension in response to training stimuli. Joint attention was adopted as the training stimulus required for behavioral intervention, and the Discrete trial training (DTT) technique was applied as the training protocol. Three types of training stimulation contents are composed to check the user's attention and tension level and provided mounted on a character-shaped tabletop robot. Then, the gaze response to the user's training stimulus is estimated with the vision-based head pose recognition and geometrical calculation model, and the nervous system response is analyzed using the PPG and GSR bio-signals using heart rate variability(HRV) and histogram techniques. Through experiments using robots, it was confirmed that the psychological response of users to training contents on joint attention could be quantified.

• The Journal of the Acoustical Society of Korea
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• v.40 no.1
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• pp.10-17
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• 2021

The cymbal transducer is a miniaturized version of the Class V flextensional transducer. It has low resonant frequency and high output pressure characteristics compared with its size. However, since it has high quality factor and low energy conversion efficiency as well, it is often used as an array rather than single. When used as an array, a big change in the frequency characteristics occurs in comparison with that of the single transducer due to the interaction between constituent transducers. In this study, we designed a pattern of cymbal array with a view to having broadband characteristics. Three transducers having different center frequencies were designed first. The designed cymbal transducers were used to construct all possible patterns of a 3 × 3 planar array. After analyzing frequency characteristics of these patterns, based on the results, we derived the most effective pattern to achieve a higher fractional bandwidth. The derived array pattern showed an improvement of the fractional bandwidth by 24.9 % in comparison with the reference model.

• Applied Chemistry for Engineering
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• v.22 no.5
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• pp.490-494
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• 2011

Nanocomposites of blends of polyethyleneterephthalate (PET) and polyamide66 (Nylon66) containing natural and organically modified montmorillonite clays (PM, $Cloisite^{(R)}$ 25A and 15A) were prepared by melt mixing. DSC results showed that the addition of clay changed the crystallization behavior of PET/Nylon66 nanocomposites. Clay C25A was observed to most significantly change the crystallization temperature than other clays in blends of PET and Nylon66, which may be caused by the difference in interaction with matrix polymers. AFM results also showed that the lowest value of surface roughness was observed for nanocomposites containing C25A indicating the smooth and relatively homogenous surface. Mechanical properties measurement showed the similar results. Contact angle was measured to study the difference in hydrophobicity. An increase in contact angle was observed for nanocomposites with C25A or C15A due to the increased hydrophobicity.

• Membrane Journal
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• v.31 no.1
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• pp.1-15
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• 2021

The membrane-based CO2 capture is a fast-growing branch in gas separating field. Ionic liquid assisted mixed matrix membrane (MMM), which consists of organic fillers with dispersed ionic liquid, shows high potentiality as a candidate for CO2 separation medium. In MMM, various kinds of ionic liquid and inorganic filler are incorporated into polymer to enhance gas separating performance. Especially, the strong interaction between ionic liquid and organic filler gives huge influence on enhancing the separating performance by increasing affinity, selectivity and adsorption of CO2 into the framework. Also the mechanical properties of metal organic framework are positively tuned by input of ionic liquid to improve CO2 permeability and selectivity. In this review, study of various combinations of ionic liquid and metal organic framework (MOF) in the polymeric membrane for carbon dioxide separation is discussed.

• Korean Journal of Clinical Pharmacy
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• v.30 no.4
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• pp.243-249
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• 2020

Background: Despite the increased use of direct-acting oral anticoagulants, warfarin is still recommended as first-line therapy in patients with mechanical valves or moderate to severe mitral stenosis. Anticoagulation management services (AMSs) are warranted for patients receiving warfarin therapy due to the complexity of warfarin dosing and large interpatient variability. To overcome limited health care resources, we developed a messenger app-based chatbot that provides information to patients taking warfarin. Methods: We developed "WafarinTalk" as an add-on to the open-source messenger app KakaoTalk. We developed the prototype chatbot after building a database containing seven categories: 1) dosage and indications, 2) drug-drug interactions, 3) drug-food interactions, 4) drug-diet supplement interactions, 5) monitoring, 6) adverse events, and 7) precautions. We then surveyed 30 pharmacists and 10 patients on chatbot reliability and on participant satisfaction. Results: We found that 80% of the pharmacists agreed on the consistency of chatbot responses and 44% agreed on the appropriateness of chatbot. Furthermore, 47% of pharmacists said that they were willing to recommend the chatbot to patients. Of the seven categories, information on drug-food interaction was the most useful; 90% of patients said they were satisfied with the chatbot and 100% of patients said they were willing to use it when they were unable to see a pharmacist. We updated the prototype chatbot with feedback from the survey. Conclusion: This study showed that warfarin-related information could be provided to patients through a messenger application-based chatbot.

• BMB Reports
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• v.55 no.4
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• pp.192-197
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• 2022

Cell signals for growth factors depend on the mechanical properties of the extracellular matrix (ECM) surrounding the cells. Microtubule acetylation is involved in the transforming growth factor (TGF)-β-induced myofibroblast differentiation in the soft ECM. However, the mechanism of activation of α-tubulin acetyltransferase 1 (α-TAT1), a major α-tubulin acetyltransferase, in the soft ECM is not well defined. Here, we found that casein kinase 2 (CK2) is required for the TGF-β-induced activation of α-TAT1 that promotes microtubule acetylation in the soft matrix. Genetic mutation and pharmacological inhibition of CK2 catalytic activity specifically reduced microtubule acetylation in the cells cultured on a soft matrix rather than those cultured on a stiff matrix. Immunoprecipitation analysis showed that CK2α, a catalytic subunit of CK2, directly bound to the C-terminal domain of α-TAT1, and this interaction was more prominent in the cells cultured on the soft matrix. Moreover, the substitution of alanine with serine, the 236th amino acid located at the C-terminus, which contains the CK2-binding site of α-TAT1, significantly abrogated the TGF-β-induced microtubule acetylation in the soft matrix, indicating that the successful binding of CK2 and the C-terminus of α-TAT1 led to the phosphorylation of serine at the 236th position of amino acids in α-TAT1 and regulation of its catalytic activity. Taken together, our findings provide novel insights into the molecular mechanisms underlying the TGF-β-induced activation of α-TAT1 in a soft matrix.