• 대한약침학회지
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• 제12권4호
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• pp.33-50
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• 2009

Objectives : This study was conducted to confirm validation and stability of concentration analysis method of pure melittin (Sweet Bee Venom-Sweet BV) extracted from the bee venom by utilizing protein isolation method of gel filtration. Methods : All experiments were conducted at Biotoxtech, a non-clinical studies authorized institution, under the regulations of Good Laboratory Practice (GLP). Standard solutions of melittin (SIGMA, USA) and test substances were dispensed and were analyzed with HPLC for Sweet BV to secure the validation of analysis. Results : 1. Measurement of system suitability of Sweet BV satisfied criterion of below 3%. 2. Confirming Linearity of Sweet BV in 10-200${\mu}g/m\ell$ solution yielded correlation coefficient (r) of 0.995 and accuracy of 85-115% which satisfy criterion. 3. Measurement of Specificity of Sweet BV didn't yield any substance affecting the peak of test substances, but detected at 21.22min verified as the test substance. 4. Confirming Intra-day of Sweet BV, accuracy and precision of 0.1, 100${\mu}g/m\ell$ were 105.70, 95.81 and 0.66, 0.73, respectively, satisfying both criteria of accuracy (85-115%) and precision (within 10%). 5. To measure Stability in autosampler, all samples used in Intra-day reproducibility sat in the autosampler for five hours and were re-analyzed. Both variability and precision satisfied the criteria. 6. Homogeneity of Sweet BV (0.1, 100${\mu}g/m\ell$) at upper, middle, and lower layers all satisfied the accuracy and precision criteria. 7. Stability of Sweet BV (0.1, 100${\mu}g/m\ell$) at room temperature for four hours and refrigerated for 7 days all satisfied the criterion. 8. For the measurement of Quality control, QC samples measured on the first and eighth day all satisfied accuracy and precision criteria. Conclusion : Above experiment data satisfies validation and stability of concentration analysis method of Sweet BV.

• 대한기계학회논문집B
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• 제24권12호
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• pp.1625-1634
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• 2000

Verification of measurements is required for precise evaluation of turbine cycle performance in nuclear power plant. We assumed that initial acceptance data and design data of the plant could provide correlation information between performance data. The data can be used as sample sets for the correct estimation model of measurement value. The modeling was done practically by using regression model based on plant design data, plant acceptance data and verified plant performance data of domestic nuclear power plant. We can construct more robust performance analysis system for an operation nuclear power plant with this validation scheme.

• International Journal of Aeronautical and Space Sciences
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• 제5권1호
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• pp.46-56
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• 2004

The verification and improvement of the measurement uncertainty have beenperformed in the altitude test facility for small gas turbine engines, which was built atthe Korea Aerospace Research Institute (KARI) in October 1999. This test is performedwith a single spool turbojet engine at several flight conditions. This paper discussesthe evaluation and validation process for the measurement uncertainty improvements usedin the altitude test facility. The evaluation process, defined as tests before the facilitymodification, shows that the major contnbutors to the measurement uncertainty are theflow meter discharge coefficient, the inlet static and total pressures, the cell pressureand the fuel flow rate. The measurement uncertainty is focused on the primary parametersof the engine performance such as airflow rate, thrust and specific fuel consumption (SFC).The validation process, defined as tests after the facility modification, shows that themeasurement uncertainty, in seal level condition, is tmproved to the acceptable level throughthe facility modification. In altitude test conditions, the measurement uncertainties arenot improved as much as the uncertainty in sea level condition.

• Clinical and Experimental Pediatrics
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• 제65권2호
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• pp.73-80
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• 2022

A mercury sphygmomanometer (MS) has been the gold standard for pediatric blood pressure (BP) measurements, and diagnosing hypertension is critical. However, because of environmental issues, other alternatives are needed. Noninvasive BP measurement devices are largely divided into auscultatory and oscillometric types. The aneroid sphygmomanometer, the currently used auscultatory method, is inferior to MS in terms of limitations such as validation and regular calibration and difficult to apply to infants, in whom Korotkoff sounds are not audible. The oscillometric method uses an automatic device that eliminates errors caused by human observers and has the advantage of being easy to use; however, owing to its measurement accuracy issues, the development of an international validation protocol for children is important. The hybrid method, which combines the auscultatory and electronic methods, solves some of these problems by eliminating the observer bias of terminal digit preference while maintaining measurement accuracy; however, the auscultatory method remains limited. As the age-related characteristics of the pediatric group are heterogeneous, it is necessary to reconsider the appropriate BP measurement method suitable for this indication. In addition, the mobile application-based BP measurement market is growing rapidly with the development of smartphone applications. Although more research is still needed on their accuracy, many experts expect that mobile application-based BP measurement will effectively reduce medical costs due to increased ease of access and early BP management.

• 한국국방경영분석학회지
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• 제22권2호
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• pp.90-112
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• 1996

Research issues in software engineering in recent may be object oriented methodology and software quality. Since Halstead has proposed metric-software science in 1977, software quality area has been studied in steady but inactively until 1980s. As international standards such as ISO 9000-3, 9126 were enacted in 1990s early, interest in software quality is increased but many problems such as how to validate metric, measure quality or apply metric are remained. This paper proposes software quality metric methodology which software developer or project manager can use in measuring quality and validating metric during software development. The methodology is classified by several phases: establishment of quality requirement, identification of quality metric, data collection, metric implementation, metric validation. In order to show its applicability, test program, metrics and data are applied to each phase of the methodology. Consideration of this methodology as a methodology for software quality measurement similar to development methodology for software development is needed.

• 시스템엔지니어링학술지
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• 제14권2호
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• pp.49-57
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• 2018

The main objective of this paper is come up with methodology approach for FPGA-based system in verification and validation lifecycle regarding software reliability using system engineering approach. The steps of both reverse engineering and re-engineering are carried out to implement an FPGA-based of safety critical system in Nuclear Power Plant. The reverse engineering methodology is applied to elicit the requirements of the system as well as gain understanding of the current life cycle and V&V activities of FPGA based-system. The re-engineering method is carried out to get a new methodology approach of software reliability, particularly Software Reliability Growth Model. For measure the software reliability of a given FPGA-based system, the following steps are executed as; requirements definition and measurement, evaluation of candidate reliability model, and the validation of the selected system. As conclusion, a new methodology approach for software reliability measurement using software reliability growth model is developed.

• Journal of Cardiovascular Imaging
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• 제31권3호
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• pp.142-144
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• 2023

• 한국전자파학회논문지
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• 제24권10호
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• pp.1008-1016
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• 2013

한국전파법에서 휴대전화에만 적용되었던 전자파흡수율(SAR: Specific Absorption Rate) 측정 대상기기가 2012년 1월 이후 인체로부터 20 cm 이내에 위치하는 휴대용 송신 무선통신기기로 확대됨에 따라 150 MHz 대역의 무전기가 포함되어 이에 대한 SAR 적합성 평가를 위한 SAR 측정방법이 필요하다. 그러나 현재 SAR 측정방법에 대한 국제표준(IEC 62209-2)에서는 300 MHz 대역 이상의 주파수에 대해서 적용하고 있으며, 상용 SAR 측정시스템에서도 300 MHz 대역 이상의 주파수에 대해서만 측정이 가능하도록 되어 있는 실정이다. 본 논문에서는 150 MHz 대역의 SAR 측정 유효성 평가를 위한 기준 다이폴 안테나(복사체 길이: 760 mm, 반사 손실 : -25.48 dB) 및 평면형 모의인체의 크기($1,300 mm(L){\times}900 mm(W){\times}200 mm(H)$), 수치해석 SAR 목표값(1 g: 1.08 W/kg, 10 g: 0.77 W/kg)을 제시하였다. 제시된 기준 다이폴 안테나 및 평면형 모의인체를 제작하여 상용 SAR 측정시스템의 적합성 여부를 확인하였다. 측정된 1 g 및 10 g SAR 값은 각각 1.13 W/kg, 0.81 W/kg으로, IEC 국제 표준의 유효 범위인 ${\pm}10$ % 이내를 만족하였다. 본 연구를 통해 도출된 규격들은 국내 SAR 측정방법 및 IEC 국제 표준으로 반영될 수 있을 것으로 기대된다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 1999년도 Proceedings of International Symposium on Remote Sensing
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• pp.103-106
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• 1999

The Tropical Rainfall Measuring Mission(TRMM) is a United States-Japan project for rain measurement from space. The first spaceborne Precipitation Radar(PR) has been installed aboard the TRMM satellite. The ground based validation of the TRMM satellite observations was conducted by TRMM science team through a Global Validation Program(GVP) consisted of 10 or more ground validation sites throughout the tropics. However, TRMM radar should always be validated and assessed against reference data to be used in Korean Peninsula because the rainrates measured with satellite varies by time and space. We have analyzed errors in the comparison of rainrates measured with the TRMM/PR and the ground-based instrument i.e. Automatic Weather System(AWS) by means of statistical methods. Preliminary results show that the near surface rainrate of TRMM/PR are highly correlated with ground measurements especially for the very deep convective rain clouds, though the correlation is changed according to the type and amount of precipitating clouds. Results also show that TRMM/PR instrument is inclined to underestimate the rainrate on the whole over Korea than the AWS measurement for the cases of heavy rainfall.

• Nuclear Engineering and Technology
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• 제26권3호
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• pp.367-373
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• 1994

원전 계측제어계통의 설계구현에서는 알고리즘및 독립적 검토의 복잡성을 피하기 위해 되도록 간단한 신호검증방법이 일차적으로 요청된다. 본 논문은 다중채널측정 시스템의 채널간의 일치성검사를 기본으로 하여 개발된 신호검증 알고리즘을 제안한다. 이 방법은 간략화한 고정편차 추정법을 포함하며, 추정된 고정편차의 크기를 고려한 가중인자를 사용하여 가중평균을 구한다. 제시된 방법의 성능을 확인하기 위하여 가상의 다중입력 조건으로 실험하였다.