• 제목/요약/키워드: Mean response

검색결과 2,317건 처리시간 0.027초

Monitoring Response to Neoadjuvant Chemotherapy of Primary Osteosarcoma Using Diffusion Kurtosis Magnetic Resonance Imaging: Initial Findings

  • Chenglei Liu;Yan Xi;Mei Li;Qiong Jiao;Huizhen Zhang;Qingcheng Yang;Weiwu Yao
    • Korean Journal of Radiology
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    • 제20권5호
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    • pp.801-811
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    • 2019
  • Objective: To determine whether diffusion kurtosis imaging (DKI) is effective in monitoring tumor response to neoadjuvant chemotherapy in patients with osteosarcoma. Materials and Methods: Twenty-nine osteosarcoma patients (20 men and 9 women; mean age, 17.6 ± 7.8 years) who had undergone magnetic resonance imaging (MRI) and DKI before and after neoadjuvant chemotherapy were included. Tumor volume, apparent diffusion coefficient (ADC), mean diffusivity (MD), mean kurtosis (MK), and change ratio (ΔX) between pre-and post-treatment were calculated. Based on histologic response, the patients were divided into those with good response (≥ 90% necrosis, n = 12) and those with poor response (< 90% necrosis, n = 17). Several MRI parameters between the groups were compared using Student's t test. The correlation between image indexes and tumor necrosis was determined using Pearson's correlation, and diagnostic performance was compared using receiver operating characteristic curves. Results: In good responders, MDpost, ADCpost, and MKpost values were significantly higher than in poor responders (p < 0.001, p < 0.001, and p = 0.042, respectively). The ΔMD and ΔADC were also significantly higher in good responders than in poor responders (p < 0.001 and p = 0.01, respectively). However, no significant difference was observed in ΔMK (p = 0.092). MDpost and ΔMD showed high correlations with tumor necrosis rate (r = 0.669 and r = 0.622, respectively), and MDpost had higher diagnostic performance than ADCpost (p = 0.037) and MKpost (p = 0.011). Similarly, ΔMD also showed higher diagnostic performance than ΔADC (p = 0.033) and ΔMK (p = 0.037). Conclusion: MD is a promising biomarker for monitoring tumor response to preoperative chemotherapy in patients with osteosarcoma.

The role of inhaled and/or nasal corticosteroids on the bronchodilator response

  • Lee, Ju-Kyung;Suh, Dong-In;Koh, Young-Yull
    • Clinical and Experimental Pediatrics
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    • 제53권11호
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    • pp.951-956
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    • 2010
  • Purpose: To compare the profiles of the bronchodilator response (BDR) among children with asthma and/or allergic rhinitis (AR) and to determine whether BDR in these children is reduced by treatment with inhaled and/or nasal corticosteroid. Methods: Sixty-eight children with asthma (mean age, 10.9 years), 45 children with comorbid asthma and AR (mean age, 10.5 years), and 44 children with AR alone (mean age, 10.2 years) were investigated. After a 2-week baseline period, all children were treated with inhaled fluticasone propionate (either 100 or $250{\mu}g$ b.i.d., tailored to asthma severity) or nasal fluticasone propionate (one spray b.i.d. in each nostril) or both, according to the condition. Before and 2 weeks after starting treatment, all children were evaluated with spirometry and bronchodilator testing. BDR was calculated as a percent change from the forced expiratory volume in 1 second ($FEV_1$) at baseline. Results: The mean BDR was 10.3% [95% confidence interval (CI) 8.3-12.4%] in children with asthma, 9.0% (95% CI 7.3-10.9%) in subjects with asthma and AR, and 5.0% (95% CI 4.1-5.9%) in children with AR alone ($P$<0.001). After treatment, the mean BDR was reduced to 5.2% (95% CI 4.2-6.3%) ($P$<0.001) in children with asthma and to 4.5% (95% CI 3.5-5.5%) ($P$<0.001) in children with asthma and AR. However, children with rhinitis showed no significant change in BDR after treatment, with the mean value being 4.7% (95% CI 3.7-5.8%) ($P$=0.597). Conclusion: The findings of this study imply that an elevated BDR in children with AR cannot be attributed to nasal inflammation alone and highlights the close relationship between the upper and lower airways.

간호인력의 배치에 영향을 미치는 간호사의 간호행위 인지정도에 관한 연구 (A Study on the perception Level of Nursing Activities of Staffing the Nursing Unit)

  • 박청자;이경희
    • 기본간호학회지
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    • 제1권2호
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    • pp.193-205
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    • 1994
  • The Study was carried out for the purpose of investigating the degree of perception in nursing activities. The data of this study were collected by self-reported questionnaire composed of 5 point rating scale measure the ideal level and the performance level of nurses activity. For the analysis of the data, percentage, MANOVA and ANOVA were 231 nurses in 3 general hospitals in Taegu. Data was administrated from October 4 through 14, 1994. The results were as follow : 1. The average mean score for the ideal level was 4.19 with a maximum possible score 5points. The highest mean score was Infection Controll and the lowest mean score was nutrition The average mean score for the performance level was 3.75, the highest mean score was fluid and electrolyte, the lowest mean score was nutrition. In the desirable nursing pergormance, Education was found the highest response above charge nurse, Medication was found the highest response above General nurse, environment was found the highest response above aide. 2. In the analysis of the relationship between the ideal level and th performance level, significant defference was found in age, position, career, marital status, occupation satisfaction, Nursing unit, parent. 3. In the analysis of the relationship between the ideal level and the performance level and the general characteristics, significant difference was found in marital status in the ideal level of direct nursing care, significant difference was found in age, position, marital status, nursing unit in the ideal level of indirect nursing care, significant difference was found in age, position, career, marital status, occupation satisfaction, nursing unit in the performance level of direct nursing care. significant difference was found in age (25-29) and above 30 career(4-7 and 7), occupation satisfaction(good and moderate, good and poor) in scheffe test of the performance level of direct nursing care.

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유무선 인터넷 환경에서 TCP와 SCTP의 성능 비교 (Performance Comparison of TCP and SCTP in Wired and Wireless Internet Environment)

  • ;서태정;이용진
    • 대한공업교육학회지
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    • 제33권2호
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    • pp.287-299
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    • 2008
  • HTTP는 월드 와이드 웹에서 가장 널리 사용되는 프로토콜의 하나로 신뢰성을 제공하기 위해 전송 계층 프로토콜로 TCP를 사용한다. HTTP는 개별적인 파일 요청에 대해 분리된 TCP 연결을 사용하기 때문에 파일 수신에 있어서 불필요한 오버헤드인 헤드-오브-라인 (head-of-line) 블로킹을 유발시킨다. 웹 응용은 일반적으로 전송되는 크기가 작기 때문에 무선 환경에서는 TCP로 인한 핸드오버의 지연이 증가한다. 이에 비해 최근에 제안된 SCTP(stream control transmission protocol)는 멀티-스트리밍과 멀티-호밍과 같은 매력적인 기능을 갖고 있다. SCTP의 이러한 기능들은 TCP의 헤드-오브-라인 블로킹을 제거하고, 무선 환경에서 TCP의 핸드오버 지연을 줄이는 것으로 기대되고 있다. 평균 응답 시간은 대부분의 웹 응용에 있어서 중요한 측정 요소이다. 본 논문에서는 NS-2 시뮬레이터를 이용하여 유무선 인터넷 환경에서 SCTP와 TCP의 평균 응답 시간을 비교하였다. 이를 위해, 유선 환경에서는 패킷 손실률, 대역폭, RTT(Round Trip Time) 및 웹 객체의 개수의 변화에 따른 평균 응답 시간이 비교되었고, 무선 환경에서는 이동속도 및 반경의 크기에 따른 평균 응답 시간과 패킷 손실률이 비교되었다. 시뮬레이션 결과는 SCTP가 TCP의 평균 응답 시간을 감소시키는 것으로 나타났다.

정신과 병동 간호사와 일반병동 간호사의 스트레스 반응양상에 대한 비교연구 (Comparative Study on the Stress Response of Nurses Working on Pscychiatric Wards to that of Nurses Working on General Wards)

  • 김영자
    • 대한간호학회지
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    • 제25권3호
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    • pp.399-418
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    • 1995
  • The purpose of this study was to investigate the stress response of nurses working on psychiatric wards (psychiatric nurses) compared with that of nurses working on general wards (general nurses) in order to provide assessment data for intervention of the stress response. The Symptoms of Stress Inventory was used to measure the stress response. Data were collected by a direct survey method using a questionnaire and were collected from March first to March 30, 1995. A sample of 200 nurses working in three psychiatric hospitals and psychiatric wards in four university hospitals in Seoul and Kangwon province were selected and 200 nurses working on general wards from two general hospitals in Seoul were also selected for a total sample of 400 nurses. Nurses who had experienced more than one of the major life events in the last two years were excluded from the total number in the samples, so the final sample was 161 psychiatric nurses, and 169 general nurses. The Scores for the total stress response, scores of the SOS subscales, stress response by sociodemographic characteristics of the nurses working on the psychiatric wards were compared with those of nurses working on the general ward. The results of this investigation are as follows 1. The mean total SOS score for the psychiatric nurse was 0.81 (SD=0.48) and that of the general nurses was 0.90(SD=0.53). 2. The Mean score for peripheral manifestation, con tral-neurological symptoms, gastrointestinal symptoms, muscle tension, habitual patterns, de-pression, anxiety, anger and cognitive disorganization for the general nurses showed a tendency to be higher than those of the psychiatric nurses. Mean score for cardiopulmonary symptoms for the general nurses was significantly higher than that of the psychiatric nurses. 3. The mean scores for the sixteen SOS items for the general nurses was significantly higher than for the psychiatric nurses. The 16 items were flushing of the face, sweating excessively even in cold weather, thumping of the heart, rapid breathing, dry mouth, a choking lump in the throat, hoarseness, muscle tension in hands or arm, muscle tension in leg, working tiring one out completely, severe aches a핀 Pain make it diffi-cult to do the work, severe nervous exhaustion, worrying about health, feeling weak and faint, so upset that one wants to hit something, unable to keep thoughts from running through one's mind. The mean score of only 505 item were significantly higher for the psychiatric nurses. 4. Stress responses between psychiatric nurses and general nurses were significantly different according to the following demographic characteristics : marriage, duration of work, position, accommodation, planning to move into another working site, working ward, education in psychiatric nursing.

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빗 형태 패턴을 가지는 OFDM 시스템을 위한 파일럿 심볼 기반 채널 주파수 응답의 추정 (Pilot Assisted Channel Frequency Response Estimation for an OFDM System with a Comb-Type Pilot Pattern)

  • 김영웅;김남훈;윤은철
    • 한국통신학회논문지
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    • 제39A권6호
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    • pp.333-342
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    • 2014
  • 본 논문은 OFDM 블록에 파일럿 심볼들이 빗 형태의 패턴에 따라 배치된 경우, 가상 부반송파를 가지는 OFDM 시스템의 channel frequency response (CFR)를 추정하는 여러 방식들을 서로 비교한다. 채널 임펄스 응답을 먼저 예측하는 것이 목적인 minimum mean square error (MMSE) 기반의 채널추정 방식과 누설현상의 억제가 목적인 MMSE 기반의 채널추정 방식이 지금까지 비교되지 않았기 때문에, 본 논문에서는 후자 방식과 전자 방식의 mean square error (MSE) 값들의 차이가 양수가 됨을 유도함으로써 전자 방식의 우수성을 논리적으로 증명한다. 아울러 본 논문에서는 파일럿 수의 변화가 MMSE 기반 채널추정 방식과 least-square (LS) 기반 채널 추정 방식의 성능에 미치는 영향을 조사한다. 컴퓨터 시뮬레이션을 통해 채널추정 방식들의 성능을 정량적으로 확인한다.

웹 서비스 환경에서 평균 응답 시간의 제약조건을 만족하는 최대 객체 크기의 추정 (Estimation of maximum object size satisfying mean response time constraint in web service environment)

  • 이용진
    • 사물인터넷융복합논문지
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    • 제9권3호
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    • pp.1-6
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    • 2023
  • 웹 서비스 환경에서 사용자가 원하는 서비스 품질을 만족하는 경제적인 방법의 하나는 객체의 크기를 조절하는 것이다. 이를 위해 본 연구에서는 서비스 품질로 평균 응답 시간이 임의의 임계값 이하로 주어질 때, 이 제약 조건을 만족하는 최대 객체의 크기를 구한다. 시스템이 정상 상태일 때, 라운드-로빈을 사용하는 결정 모델의 평균 응답 시간은 일반 분포를 따르는 큐잉 모델에서의 평균 응답 시간과 같아질 것으로 추론할 수 있다. 이를 기반으로 최대 객체 크기를 발견하기 위한 해석적 수식과 절차를 수립한다. 웹 트래픽은 서비스 분포로 Pareto 분포가 적합하므로 M/G(Pareto)/1 모델과 지수 분포를 사용한 M/G/1/PS를 적용하여 최대 객체의 크기를 구한다. 수치 계산을 통한 성능평가는 Pareto 분포의 형상 파라미터(shaping parameter)가 커짐에 따라 M/G(Pareto)/1 모델과 M/G/1/PS 모델의 최대 객체 크기가 같아짐을 보여준다. 본 연구의 결과는 경제적인 웹 서비스 제어를 위해 객체의 크기를 조절하는 환경에 사용될 수 있다.

목표스펙트럼의 평균과 분산을 고려한 지반운동 선정과 배율조정계수 결정방법 (An Accurate and Efficient Method for Selecting and Scaling Ground Motions Considering Target Response Spectrum Mean and Variance)

  • 하성진;박미영;한상환
    • 한국지진공학회논문집
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    • 제20권5호
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    • pp.331-340
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    • 2016
  • It is important to select proper ground motions for obtaining accurate results from response history analyses. The purpose of this study is to propose an accurate and efficient method that does not require excessive computation for selecting and scaling ground motions to match target response spectrum mean and variance. The proposed method is conceptually simple and straightforward, and it does not use a simulation algorithm that requires a sophisticated subroutine program. In this method, the desired number of ground motions are sequentially scaled and selected from a ground motion library. The proposed method gives the best selection results using Sum of Square Error and has the smallest value(=0.14). Also, The accuracy and consistency of the proposed method are verified by comparing the selection results of the proposed method with those of existing methods.

그레디언트 행렬 고유치의 기하 평균을 이용한 특징점 검출 (Feature Detection using Geometric Mean of Eigenvalues of Gradient Matrix)

  • 예철수
    • 대한원격탐사학회지
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    • 제30권6호
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    • pp.769-776
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    • 2014
  • 동일 대상에 대한 두 영상의 등록을 위해서는 두 영상에 공통적으로 존재하는 특징점을 검출하고 검출된 특징점 간의 대응관계를 찾는 과정이 필수적이다. 본 논문에서는 화소의 밝기 변화를 측정할 수 있는 그레디언트 행렬의 고유치 기하평균에 기반한 새로운 특징점 검출기를 제안한다. 제안하는 특징점 검출기는 그레디언트 행렬의 두 고유치의 기하평균 크기에 비례하고 기하 평균 크기가 동일한 경유 두 고유치의 상대적인 차이에 비례하여 가변적으로 변하는 특성을 가진다. 제안한 특징점 검출기의 성능 평가를 위해 다양한 종류의 코너가 존재하는 합성 영상과 항공 영상을 기준 영상으로 사용하여 코너 검출의 위치 오차를 분석하였다. 제안한 검출기의 위치 오차는 Gaussian smoothing scale 조건하에서 대표적인 코너 검출기인 Harris detector의 위치 오차보다 작은 결과가 얻어졌다.

Influence of second order wave excitation loads on coupled response of an offshore floating wind turbine

  • Chuang, Zhenju;Liu, Shewen;Lu, Yu
    • International Journal of Naval Architecture and Ocean Engineering
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    • 제12권1호
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    • pp.367-375
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    • 2020
  • This paper presents an integrated analysis about dynamic performance of a Floating Offshore Wind Turbine (FOWT) OC4 DeepCwind with semi-submersible platform under real sea environment. The emphasis of this paper is to investigate how the wave mean drift force and slow-drift wave excitation load (Quadratic transfer function, namely QTF) influence the platform motions, mooring line tension and tower base bending moments. Second order potential theory is being used for computing linear and nonlinear wave effects, including first order wave force, mean drift force and slow-drift excitation loads. Morison model is utilized to account the viscous effect from fluid. This approach considers floating wind turbine as an integrated coupled system. Two time-domain solvers, SIMA (SIMO/RIFLEX/AERODYN) and FAST are being chosen to analyze the global response of the integrated coupled system under small, moderate and severe sea condition. Results show that second order mean drift force and slow-drift force will drift the floater away along wave propagation direction. At the same time, slow-drift force has larger effect than mean drift force. Also tension of the mooring line at fairlead and tower base loads are increased accordingly in all sea conditions under investigation.