• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.353-356
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• 2016

Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) for glassy cell carcinoma data to identify predictive models and potential disparities in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors. For risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. Area under the receiver operating characteristic curves (ROCs) were computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate modeling errors. Risk of glassy cell carcinoma death was computed for the predictors for comparison. Results: There were 79 patients included in this study. The mean follow up time (S.D.) was 37 (32.8) months. Female patients outnumbered males 4:1. The mean (S.D.) age was 54.4 (19.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.69). The risks of cause specific death were, respectively, 9.4% for localized, 16.7% for regional, 35% for the un-staged/others category, and 60% for distant disease. After optimization, separation between the regional and unstaged/others category was removed with a higher ROC area of 0.72. Several socio-economic factors had small but measurable effects on outcome. Radiotherapy had not been used in 90% of patients with regional disease. Conclusions: Optimized SEER stage was predictive and useful in treatment selection. Underuse of radiotherapy may have contributed to poor outcome.

• Journal of the korean Society of Automotive Engineers
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• v.10 no.6
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• pp.72-84
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• 1988

Engine performance is one of the main objectives specified at the beginning of a new engine design project. The cycle simulation for SI engine is based on the zero-dimensional gas exchange model and a heat release expression by Viebe. This program also requires minimum input data and takes only a short time to run. Heat transfer from cylinder transfer formula. The flow coefficient (effective area) is calculated from valve lift using the standard flow coefficient curve and engine friction is calculated from the Millington and Hartles' engine friction formula. The chemical species considered in burned gas are 6 species CO, CO, H$_{2}$, H$_{2}$O, $O_{2}$, N$_{2}$ and the cylinder pressure, homogeneous cylinder temperature, gas composition and burned fraction are calculated at each crank angle through the cycle. To check the validity and accuracy, experimental study was done with 3 engines for measuring cylinder pressure, indicated mean effective pressure, brake mean effective pressure and air flow rate, etc. Despite its simple assumptions, cycle simulation showes excellent breathing and performance correlation when compared with data of tested engines, and have been proved useful in engine design.

• International Journal of Automotive Technology
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• v.2 no.1
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• pp.9-16
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• 2001

The lifetime of power train components can be improved dramatically by finding crack initiation points with suitable software tools and optimization of the critical areas. With increasing capacities of computers the prediction of the lifetime for components by numerical methods gets more and more important. This paper discusses some applications of the outstanding fatigue simulation program FEMFAT supporting the assessment of uniaxially and multiaxially loaded components (as well as welding seams and spot joints). The theory applied in FEMFAT differs in some aspects from classical approaches like the nominal stress concept or the local one and can be characterized by the term "influence parameter method". The specimen S/N-curve is locally modified by different influence parameters as stress-gradient to take into account notch effects, mean-stress influence which is quantified by means of a Haigh-diagram, surface roughness and treatments, temperature, technological size, etc. It is possible to consider plastic deformations resulting in mean-stress rearrangements. The dynamic loading of power train components is very often multiaxial, e.g. the stress state at each time is not proportional to one single stress state. Hence, the directions of the principal axes vary with time. We will present the way how such complex load situations can be handled with FEMFAT by the examples of a crank case and a gear box.

• Archives of Pharmacal Research
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• v.17 no.2
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• pp.80-86
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• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).

• PNF and Movement
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• v.8 no.1
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• pp.67-77
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• 2010

Purpose : The purpose of this study was to investigate the usefulness of clinical balance tests through the correlation of balance evaluation using by forceplate in elderly. Methods : Thirty nine healthy elderly subjects (14 males, 25 females) participated in the study. The subjects were evaluated with clinical balance tests [(Berg balance scale (BBS), Functional reach test (FRT), Tinetti's performance oriented mobility assessment (POMA), and one leg standing (OLS)]. Static balance evaluation was assessed by using forceplate. Center of pressure (COP) parameters were obtained using it as total path distance, total sway area, X mean frequency and Y mean frequency for 20 seconds in the following conditions: (1) comfortable standing with eyes opened and closed, (2) uncomfortable standing with eyes opened and closed. After static balance evaluation tested, dynamic balance evaluation was assessed. COP parameters were error distance and area during sine curve trace. COP parameters were movement time, error distance, and maintained time in the circle during COP movement task. Results : Clinical balance tests showed statistically significant correlation between static and dynamic balance evaluations. Among the clinical balance tests, the BBS, POMA, and OLS showed significant correlation with to assess the balance ability of elderly in clinical setting both evaluations. Conclusion : Clinical balance tests can be recommended in clinical setting because of low costs and simplicity.

• Journal of Biomedical Engineering Research
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• v.27 no.3
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• pp.89-93
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• 2006

A simple algorithm that can be used to estimate a healthy person's blood pressure using pulse transit time is proposed in this paper. Fifty healthy students participated in the experiment that was conducted in line with the study. The subjects were asked to exercise on several exercise levels using a bicycle ergometer. Their blood pressures during the succeeding rest period were measured. A simple method was proposed to illustrate the relationship between blood pressure and pulse transit time. The systolic blood pressures as well as the heights and weights of the subjects were regarded as the proper parameters, and a second-order regression curve was produced to estimate the subjects' blood pressures. The mean error of estimation was less than 10 mmHg, which was the mean error of manual measurement. Although our estimation model is so simple, it can be used to estimate continuous blood pressure measurement for bicycle ergometer exercise. The electrocardiograms, photoplethysmograms, and blood pressures, however, could not be measured simultaneously As such, their estimation may be slightly different from the results taken from simultaneous measurements.

• Imaging Science in Dentistry
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• v.33 no.2
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• pp.91-95
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• 2003

Purpose : To compare the diagnostic accuracy of proximal caries detection between Kodak Insight film and the Biomedisys CDX2000HQ digital (CCD) sensor. Materials and Methods: 156 proximal surfaces of extracted teeth, 78 of which had chemical artificial caries, were used in this study. Four observers interpreted the radiographs using a five-point confidence rating scale to record their diagnoses. The results were analyzed by receiver operating characteristic curves, ANOVA and Kappa values. Result: Analysis using receiver operating characteristic curves revealed the areas under each curve which indicated a diagnostic accuracy of 0.951 in Insight and 0.952 in CDX2000HQ digital sensor. ANOVA revealed no significant differences between the two images with respect to caries detection. Kappa values indicated that the mean intra-observer agreement was 0.85 and inter-observer agreement 0.71 in conventional radiography. In digital radiography, the mean intra-observer agreement was 0.84 and inter-observer agreement 0.72. Conclusion: The results suggest that no significant difference exists between the two modalities for artificial caries detection and that CDX2000HQ was as good as Insight film for this purpose.

• Bulletin of the Korean Chemical Society
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• v.25 no.1
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• pp.115-118
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• 2004

We have examined the feasibility of using the specific interaction between mistletoe lectin I (ML I) and ${\beta}$-Dgalactose instead of the anti-ML I antibody in developing a homogeneous type competitive binding assay for ML I. We also have examined the feasibility of adapting the biotin/avidin mediated homogeneous assay for this system. Alkaline phosphatase (AKP) was employed as a single substrate enzyme label. The dose-response curve shows a detection range of 1-25 ${\mu}$g/mL and a linear response with a correlation coefficient of 0.99. To demonstrate the analytical utility of this method, 10 ${\mu}$g/mL of ML I was spiked into distilled water. The results show that the mean recovery was 10.03 ${\mu}$g/mL with an SD of 0.18. The difference between the spiked value and the mean recovery was 0.03 ${\mu}$g/mL, with a relative error of 0.3 and 1.6 % of RSD.

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.4
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• pp.363-370
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• 2020

In this study, pitching stability derivatives of the conical shell configuration is predicted using commercial CFD code. Unsteady flow analysis with forced harmonic motion of the model is performed using overset mesh. The test is conducted about Basic finner missile configuration. The static and dynamic stability derivatives are good agreement with available experimental data. As the same way, a conical shell is analyzed in Mach number 1.6 and various reduced frequency. The static and dynamic derivatives are obtained from the time-pitching moment coefficient histories in each of four cases of mean angle of attack. The variation of reduced frequency is not affected static and dynamic derivatives. Increasing the mean angle of attack, static derivatives are increased slowly. Comparison of the Cm curves at the steady and unsteady state results shows that the Cm curve including the damping effect is lower than otherwise case, approximately 9-18 %.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.63 no.10
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• pp.1455-1460
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• 2014

Wind turbine generators were designed on general regulations of wind condition. At real situations, it could be different from the design conditions. There are many control methods and definitions of transient region, because an efficient wind turbine generator control logic is the important matter in generator performance and annual energy production at real conditions. In this document, the power generation sensitivity for wind speed and turbulence intensities was defined to know the sensitive transient region. Wind conditions are applied for the ranges of 7~10m/s mean wind speed and 14~20% turbulence intensity. The sensibility of HR-D86 wind generator was increased in transient region(8~10m/s) on power curve diagram through a torque control to a pitch control. And then GH-bladed simulations was performed for performance analysis of the torque mode switching in transient region on 2MW direct drive wind generator(HR-D86) which is designed IEC class II for onshore. Through the sensitivity and performance analysis, the sensitivity for real wind condition could be the performance index for an wind generator. And the torque mode switching in transient region can increase the mean power generation on HR-D86 wind turbine generator.