• 제목/요약/키워드: McKrae

검색결과 1건 처리시간 0.013초

Development of Zosteriform Models in Skin and Vagina of Mice using Herpes simplex Virus Strain McKrae

  • 이형환;차성철;어홍선;조재경;이준근;장동준;김수영
    • 대한바이러스학회지
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    • 제29권4호
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    • pp.283-288
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    • 1999
  • Zosteriform lesions, occurring after left flank and intravaginal inoculations of Balb/c mice with the Herpes simplex virus type 1 strain McKrae, developed in clinically normal skin via nerve endings. The developments of zosteriforms were standardized in 5 phases with the following references; formation of small vesicles (phase 1); occurrence of erosion and ulceration of local lesions (phase 2); occurrence of ulcerations (phase 3); occurrence of severe ulcerations (phase 4); and death (phase 5). These results provide two valuable zosteriform models to further investigate and analyze the pathological symptoms in susceptible animals infected with HSV-1 or HSV-2 and DNA vaccines.

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