• Archives of Pharmacal Research
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• v.13 no.2
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• pp.180-186
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• 1990

A bioequivalence study of ranitidine tablets was conducted according to the Korean Guidine for the Bioequivalence Test using twelve healthy male subjects. The plasma concentration-timecurves of ranitidine from the test and reference tablets showed profound multiple peak phenomenon in each subject as reported earlier. However, the area under the plasma concentration-time curve (AUC) and the maximum ploasma concentration at the first peak ($C_{max1}$) of the two preparations was proven to be equal when analyzed satistically according to the criteria of the guidline;i. e., statistical power (1-$\beta$)was calculated to be over 0.8 under the condition of $\alpha$ = 5% and $\Delta$(minimum detectable difference) = 20%, and the confidence interval of the difference in AUC at 95% confidence level was in the range of $\pm$ 20%, which statisfied the criteria of bioequivalence. Equivalence of the peak concentration of ranitidine at the second peak ($C_{max2}$), and the time to reach the first ($T_{max1}$) and second verify the bioequivalence of $c_{max2}$ , $T_{max1}$ and $T_{max2}$ between the two tablets. However, we conclude that the test and reference tablets are bioequivalent taking the therapeutic characteristics of the ranitidine preparations into consideration.

• Archives of Pharmacal Research
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• v.18 no.4
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• pp.237-242
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• 1995

For the vioequivalence study of two ceftriaxone injection formulations ($Rocephin{\circledR}$ ; Roche, and Triaxone ; Hanmi0, the HPLC analytical method for the analysis of ceftriaxone in plasma was used. Fourteen healthy volunteers completed the study and each subject were IM in jected signle doses (1 g) of the test and the reference formulations in a two-way crossover design with an one week drug free interval between doses. Following each administration, plasma concentrations of ceftrixone were monitored over a period of 24 h. Bioequivalence parameters $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT determined from the data obtained for the two formulations were examined by analyses of variance (ANOVA) and other criteria and tests for bioequivalence. Results of ANOVA and confidence limits of test/reference ratios of $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\pm}20%$) except for $T_{max}$ The mean of $T_{max}$ showed only 6. 9% difference from the reference but the detection limit was 22.5% which is slightly over the 20% criteria. No pharmacokinetic parameters including Ka, Kel, Vd and Cl indicated significant difference in between the two fomulations. It was concluded that the data yielded fro the two cefriaxone formulations demonstrated that they were bioequivalent.

• Journal of Biomedical Engineering Research
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• v.16 no.3
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• pp.271-278
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• 1995

An ECG data compression algorithM using max-min slope update is proposed and a real time 3 channel ECG transmission system is implemented using the proposed algorithm. In order to effectively compress ECG data, we compare a threshold value with the max-min slope difference (MMSD) which is updated at each sample values. If this MMSD value is smaller than the threshold value, then the data is compressed. Conversely, when the MMSD value is larger than threshold value, the data is transmitted after storing the value and the length between the data which is beyond previous threshold level. As a result, it can accurately compress both the region of QRS, P, and T wave that has fast-changing and the region of the base line that slope is changing slow. Therefore, it Is possible to enhance the compression rate and the percent roms difference. In addition, because of the simplicity, this algorithm is more suitable for real-time implementation.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.4
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• pp.339-345
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• 2014

PURPOSE: This study is to investigate the effect of 4 weeks of gym ball exercise on the pelvis and spine of women in 20s. METHODS: Randomly selected 10 of 20 subjects are allocated to experimental group who will practice gym-ball exercise while the rest 10 subjects are allocated to control group. Values for pelvic obliquity DL-DR, pelvic torsion DL-DR, pelvic rotation, kyphotic angle ICT-ITL (max), and lordotic angle ITL-ILS (max) were measured through recording using 3-dimensional image analyzer as a preliminary inspection. Gym-ball exercise was implemented 3 sessions a week for 4 weeks. Each session consisted of 10 minutes of warm up exercise, 30 minutes of main exercise, and 10 minutes of cool down exercise totaling 50 minutes. Post inspections were measured after exercise. RESULTS: Experimental group showed statistically significant difference in pelvic obliquity DL-DR, pelvic torsion DL-DR, and kyphotic angle ICT-ITL (max) (p<.05) and values of pelvic obliquity DL-DR showed statistically significant difference between two groups (p<.05). However pelvic rotation, lordotic angle ITL-ILS (max) did not show a significant difference. CONCLUSION: These results showed that gym-ball exercise has positive effect in the pelvic obliquity, torsion and spine kyphotic angle and expected to have positive effect on the body balance, body lineup, and coordination.

• Journal of the Korea Convergence Society
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• v.11 no.7
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• pp.289-295
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• 2020

As the importance of the beauty to pursue beauty comes to the fore, the market size of hairdressing industry including hair dyeing is getting bigger. In case of continuously applying an oxidative dyeing agent commonly used in hair salons, as hair damage is inevitable, we investigated morphological changes of hair treated with a neutral oxidative dyeing agent. In the experiment results, Between the control and the 6N-7N experimental groups, there was a significant difference in Max. modulus and Tangential modulus according to Max. load, Max. stress, Max. elongation, Break load, Break stress, Break elongation, and strain section. There were the highest values in Max. load, Max. stress, Max. elongation, Break load, Break stress and Break elongation in the control group, and there was no tendency to decrease significantly according to the treatment of the experimental group. Max. modulus and Tangential modulus according to the strain evaluation section did not show a tendency to increase or decrease constantly, although there was a difference between the control and experimental groups. This study attempts to provide basic data for the development of oxidative dyeing agent that minimizes hair damage and to establish the foundation for understanding the correlation between hair designers' oxidative dyeing agent and hair health.

• Journal of Technologic Dentistry
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• v.33 no.4
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• pp.313-321
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• 2011

Purpose: The purpose of this study was to compare color parameters of different fabrication method of Lava ceram powder, Lava DVS blocks, IPS e.max ceram and IPS e.max zirpress. Methods: The three available shades(A1, A2, A3.5) of Lava & Kavo zirconia blocks were examined. For each of three colors, three different thickness were tested, 5 times of measurement frequency. The measurements were made using a spectrophotometer equipped with an integrating sphere using the CIE $L^*$, $a^*$, $b^*$ colorimetric system. Results: Lava build-up group and Lava DVS group showed clinically perceived color difference, on the other hand IPS e.max build-up group and IPS e.max zirpress group did not show clinically perceived color difference to shade allowed on core. When the thickness of porcelain veneer increased from Lava and IPS e.max groups, color differences(${\Delta}E$) were decreased. Conclusion: All-ceramic system has color characteristics that clinicians have to consider when selecting materials. Also, manufacturers of different porcelain systems must make every effort to achieve color reproducibility.

• Journal of Pharmaceutical Investigation
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• v.29 no.2
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• pp.145-149
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• 1999

Bioequivalence of two cefixime capsules, test drug ($Cepirin^R$ capsule: Cheiljedang Corp.) and reference drug ($Suprax^R$ capsule: Dong A Pharm. Com.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 400 mg as cefixime in a $2{\times}2$ crossover study. There was a 1-week washout period between the administrations. Blood samples were taken at predetermined time intervals for 12 hour and the plasma concentration of cefixime was determined with a HPLC method. $AUC_{0-12hr}$ (area under the plasma concentration-time curve form time zero to 12 hour), $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were estimated from the plasma drug concentrationtime data. Analysis of variance (ANOVA) revealed no difference in $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences of these parameters between the formulations were less than 20% (i.e., 8.62, 11.10 and 0.00% for $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$,respectively). The powers $(1-{\beta})$ for $AUC_{0-12hr}$ $C_{max}$ and $T_{max}$ were over 0.9. Minimal detectable difference $({\Delta})$ at ${\alpha}=0.05$, $1-{\beta}=0.8$ were less than 20% (i.e., 12.84, 11.05 and 17.99% for $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$, respectively). The 90% confidence intervals $({\delta})$ for these parameters were also within ${\pm}20%$ (i.e., $-0.53{\le}{\delta}{\le}17.76$, $3.23{\le}{\delta}{\le}18.97$ and $-12.81{\le}{\delta}{\le}12.81$ for $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating the two formulations of cefixime were bioequivlent.

• The Journal of Korean Academy of Prosthodontics
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• v.47 no.1
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• pp.21-28
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• 2009

Purpose: The purpose of this study was to compare the wear characteristics of human enamel opposing 2 heat-pressed ceramics (e.max Press and Empress Esthetic), conventional feldspathic porcelain (Ceramco 3) and type III gold alloy. Material and methods: Intact cusps of extracted premolars were used for enamel specimens. Five disk samples were made for each of two heat-pressed ceramics groups, conventional feldspathic porcelain group and type III gold alloy group. Wear tests were conducted in distilled water using a pin-on-disk tribometer. The amount of enamel wear was determined by weighing the enamel specimens before and after wear tests, and the weight was converted to volumes by average density. The wear tracks were analyzed by scanning electron microscopy and surface profilometer to elucidate the wear characteristics. Results: 1. Ceramco 3 led to the greatest amount of enamel wear followed by Empress Esthetic, e.max Press and type III gold alloy. However, there was no significant difference between Ceramco 3 and Empress Esthetic (P>.05), and there were also no significant differences among Empress Esthetic, e.max Press and type III gold alloy (P>.05). 2. The average surface roughness of e.max Press after wear test was smallest followed by Empress Esthetic and Ceramco 3, but there was no significant difference between Empress Esthetic and Ceramco 3 (P>.05). 3. There were no significant differences among the depth of wear tracks of all the groups (P>.05). The group that showed the largest width of wear track was Ceramco 3 followed by Empress Esthetic, e.max Press and type III gold alloy. However, there was no significant difference between e.max Press and Empress Esthetic (P>.05), and there was also no significant difference between Empress Esthetic and Ceramco 3 (P>.05). Conclusion: Within the limits of this study, heat-pressed ceramics were not more abrasive than conventional feldspathic porcelain.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.4
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• pp.375-383
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• 2012

Together with the GPS-based approach, geolocation through mobile communication networks is a key technology for location-based service. Since the Mobile WiMAX system is considered as a candidate for fourth-generation mobile systems, it is important to investigate its location capability. The geolocation of Mobile WiMAX can be realized when the preamble symbols in the down-link channel are appropriately used for a TDOA (Time-Difference-of-Arrival) approach. However, the cellular structure of Mobile WiMAX inevitably generates co-channel interference, and it is difficult for the mobile terminal to acquire distance measurements from multiple base stations. Therefore, for geolocation via multilateration using the Mobile WiMAX network, it is very important to increase hearability. This paper proposes a geolocation method for Mobile WiMAX which employs interference cancellation and preamble signal overlapping for the enhancement of hearability. A novel interference cancellation strategy for complex-valued Mobile WiMAX signals is presented which has an iterative structure. Simulation results show that the proposed geolocation method provides the user's position with an accuracy of less than 20 m through the Mobile WiMAX cellular network if there is no multi-path or NLOS (None-Line-of-Sight).

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.6
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• pp.776-782
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• 2004

Generally, Max-Min CRI (Compositional Rule of Inference ) method by Zadeh and Mamdani is used in the conventional fuzzy inference. However, owing to the problems of Max-Min CRI method, the inference often results in significant error regions specifying the difference between the desired outputs and the inferred outputs. In this paper, I propose a New Max-Min CRI method which can solve some problems of the conventional Max-Min CRI method. And then this method is simulated in a D.C.series motor, which is a bench marking system in control systems, and showed that the new method performs better than the other fuzzy inference methods.