• 대한소아치과학회지
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• 제34권4호
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• pp.551-559
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• 2007

하악골 성장을 평가하는 데 경추골 성숙도가 수완부골 성숙도만큼 유용한가 규명하고자 본 연구를 시행하였다. 정상교합을 가진 만 8세$\sim$만 16세 여성 292명을 연구대상으로 하여 진단석고모형, 측모두부규격방사선사진, 그리고 수완부방사선사진을 이용하여 경추 및 수완부의 골성숙도를 비교하여 다음과 같은 결과를 얻었다. 1. 연령 증가에 따라 경추 및 수완부의 골성숙도가 일정하게 증가하였다. 2. 경추골 성숙도가 증가할수록 Ar-Go, Go-Me, N-Go, S-Gn, N-Me이 일정하게 증가하였다. 3. 수완부골 성숙도가 증가할수록 Ar-Go, Go-Me, N-Go, S-Gn이 일정하게 증가하였다. 4. 경추골 성숙도 3단계와 4단계 사이에서 Ar-Go, Go-Me, N-Go, S-Gn이 크게 증가하였고, 수완부골 성숙도 6단계와 7단계 사이에서 Go-Me, S-Gn이 크게 증가하였다. 5. Ar-Go, Go-Me, N-Go, S-Gn, N-Me은 경추 및 수완부 골성숙도와 각각 유의 한 상관성을 보였다. 이상의 결과는 하악골 성장을 평가하는 데에 경추골 성숙도가 수완부골 성숙도처럼 유용하게 사용될 수 있음을 시사한다.

• 대한치과교정학회지
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• 제53권4호
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• pp.232-240
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• 2023

Objective: This study aimed to evaluate the zygomaticotemporal suture (ZTS) maturation, analyze the age distribution patterns of ZTS maturation stages, and investigate the relationship between ZTS and cervical vertebral maturation (CVM). Methods: A total of 261 patients who underwent cone-beam computed tomography (112 males, mean age, 13.1 ± 3.3 years; 149 females, mean age, 13.7 ± 3.1 years) were examined to evaluate the ZTS stages. The ZTS stages were defined based on a modified method from previous studies on zygomaticomaxillary sutures. Differences between groups and correlations between indicators were analyzed using the Spearman correlation test, intraclass coefficient of correlation (ICC), one-way analysis of variance and rank sum test. Statistical significance was set at p < 0.05. The diagnostic value of CVM stages in identifying ZTS maturation stages was evaluated using positive likelihood ratios (LRs). Results: A positive relationship was found between the ZTS and CVM stage (r = 0.747, ICC = 0.621, p < 0.01) and between the ZTS stage and chronological age (r = 0.727, ICC = 0.330, p < 0.01). Positive LRs > 10 were found for several cervical stages (CSs), including CS1 and CS2 for the diagnosis of stage B, CS1 to CS3 for the diagnosis of stages B and C, and CS6 for the diagnosis of stages D and E. Conclusions: The ZTS maturation stage may be more relevant to the CVM stage than to the chronological age. The CVM stages can be good indicators for clinical decisions regarding maxillary protraction, except for CS4 and CS5.

• Journal of Nutrition and Health
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• 제40권1호
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• pp.58-68
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• 2007

The associations between dietary, body composition and sexual maturation were investigated among Korean girls of pubertal age in this study. Dietary intakes were collected by 3 day food records, body compositions were measured by bio-impedence analyzer and sexual maturation stages were determined with a self-administrated questionnaire using Tanner stages in 1,114 girls 9-13 years of age. Girls were divided into early maturation (EM) and late maturation (LM), based on the comparative maturation stages of breast and pubic hair among the same age groups by months. Subjects were excluded if their stage of maturation could not be divided into early and late groups. EM and LM groups consisted of 42.8% and 38.9% of subjects by breast stage and 67.4% and 22.8% by pubic hair stage. Girls in LM group had significantly lower in height, weight and bone mineral contents (p < 0.05). When nutrient densities of average daily intake of the two groups were compared, folate density was significantly higher among the LM group of breast stages (p < 0.01), and Ca, P, K, Vit. $B_1$, Vit. $B_2$ and folate densities were significantly higher among the LM group of pubic hair stages (p < 0.05). These results show that intakes of some micronutrients differ between children with faster and slower sexual maturation velocities at early pubertal stages. More longitudinal studies are needed to confirm whether such differences are consistent throughout the pubertal period.

• Journal of Ginseng Research
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• 제44권3호
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• pp.413-423
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• 2020

Background: Ginseng berries (GBs) show temporal metabolic variations among different maturation stages, determining their organoleptic and functional properties. Methods: We analyzed metabolic variations concomitant to five different maturation stages of GBs including immature green (IG), mature green (MG), partially red (PR), fully red (FR), and overmature red (OR) using mass spectrometry (MS)-based metabolomic profiling and multivariate analyses. Results: The partial least squares discriminant analysis score plot based on gas chromatography-MS datasets highlighted metabolic disparity between preharvest (IG and MG) and harvest/postharvest (PR, FR, and OR) GB extracts along PLS1 (34.9%) with MG distinctly segregated across PLS2 (18.2%). Forty-three significantly discriminant primary metabolites were identified encompassing five developmental stages (variable importance in projection > 1.0, p < 0.05). Among them, most amino acids, organic acids, 5-C sugars, ethanolamines, purines, and palmitic acid were detected in preharvest GB extracts, whereas 6-C sugars, phenolic acid, and oleamide levels were distinctly higher during later maturation stages. Similarly, the partial least squares discriminant analysis based on liquid chromatography-MS datasets displayed preharvest and harvest/postharvest stages clustered across PLS1 (11.1 %); however, MG and PR were separated from IG, FR, and OR along PLS2 (5.6 %). Overall, 24 secondary metabolites were observed significantly discriminant (variable importance in projection > 1.0, p < 0.05), with most displaying higher relative abundance during preharvest stages excluding ginsenosides Rg1 and Re. Furthermore, we observed strong positive correlations between total flavonoid and phenolic metabolite contents in GB extracts and antioxidant activity. Conclusion: Comprehending the dynamic metabolic variations associated with GB maturation stages rationalize their optimal harvest time per se the related agroeconomic traits.

• 대한소아치과학회지
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• 제46권2호
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• pp.139-146
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• 2019

본 연구는 7세부터 15세사이의 소아청소년을 대상으로 촬영하여 획득한 Cone beam computed tomography(CBCT) 영상을 이용하여 정중구개봉합의 성숙도를 평가하고 골 성숙도 및 연령과의 연관성을 분석하여 Rapid maxillary expansion(RME) 적용 시 적절한 치료계획 수립의 참고자료로 활용하고자 하였다. 남아 240명, 여아 240명, 총 480명의 CBCT 수평면 영상에서 정중구개봉합의 성숙도를 5단계로 평가하였고 수집된 자료를 경추골 성숙도 측정법에 의해 평가된 골 성숙도 및 연령에 따라 통계분석을 시행하였다. 정중구개봉합 성숙도와 골 성숙도는 0.602의 강한 상관관계를 보였으며, 특히 정중구개봉합 성숙도 A - C단계의 예측을 위한 경추골 성숙도 1 - 3단계의 양성 검정우도비는 44.79로서 예측을 위한 타당한 지표임을 나타내었다. 정중구개봉합 성숙도와 연령의 상관관계는 남아에서 0.499, 여아에서 0.560으로 나타나 경추골 성숙도 보다는 낮으나 비교적 높은 상관관계를 보였다. 따라서 경추골 성숙도 측정법은 정중구개봉합의 성숙도 예측을 위한 신뢰할 만한 지표라고 할 수 있으며, 연령은 경추골 성숙도 측정이 어려운 경우에 한하여 임상에서 간편하고 직관적인 지표로 쓰일 수 있다. 연구 결과를 종합해보면 RME 사용 시 골격성 효과를 충분히 얻을 수 있는 것으로 기대 할 수 있는 시기는 경추골 성숙도 1 - 3단계, 남녀 모두 연령 12세 이하이며 경추골 성숙도 4단계 혹은 여아 연령 13세 및 남아 연령 15세까지는 conventional RME의 사용은 가능하나 골격성 효과는 감소하고 치성 효과가 증가할 것으로 예상된다. 경추골 성숙도 5, 6단계 혹은 여아 연령 14세 이상에서는 RME 필요 시 사용 형태를 결정하기 위해 정중구개봉합 성숙 단계 평가 시 CBCT 촬영이 고려되어야 한다.

• 대한소아치과학회지
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• 제48권1호
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• pp.31-41
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• 2021

연구의 목적은 7세부터 15세 사이 소아청소년을 대상으로 정중구개봉합의 성숙도와 SMI 및 MP3 방법으로 평가된 골 성숙도와의 연관성을 분석하고 수완부 골 성숙도와 중지의 중절골 성숙도가 정중구개봉합 성숙 단계를 예측할 수 있는 지표로 사용될 수 있는지 알아보기 위함이다. 이번 연구 대상은 무작위로 선택된 7세부터 15세 사이 남자 132명과 여자 135명으로 교정 치료 전 교정 진단을 위해 촬영 되었던 CBCT 수평면 영상 이용하여 정중구개봉합의 성숙도를 5단계로 평가하였고 수완부 방사선 사진을 이용하여 골 성숙도를 평가하였다. 정중구개봉합 성숙도와 SMI 방법으로 평가된 골 성숙도는0.905, MP3 방법으로 평가된 골 성숙도는 0.830으로 강한 상관관계를 보였다. 정중구개봉합 성숙도와 연령의 상관관계는 0.868으로 나타나 비교적 높은 상관관계를 보였다. 이번 후향적 연구를 통해 골 성숙도 평가를 위한 SMI와 MP3 방법은 정중구개봉합 성숙도를 예측할 수 있는 지표로 사용될 수 있음이 증명 되었으며 SMI 방법이 MP3 방법보다 더 나은 신뢰성을 보였다. 따라서 정중구개봉합 성숙도 평가가 필요한 모든 소아환자들을 대상으로 CBCT촬영하는 것은 불필요할 수 있으며 CBCT와 대체 가능한 SMI 와 MP3 방법은 최소의 방사선 피폭으로 간단하게 성장기 아동의 악정형 장치의 최적의 치료 시기 결정의 참고자료로 활용될 수 있을 것이다.

• Imaging Science in Dentistry
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• 제52권1호
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• pp.83-91
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• 2022

Purpose: This study assessed the associations between chronological age, dental maturation (DM), cervical vertebrae maturation (CVM), and hand-wrist maturation (HWM) in individuals aged 9-19 years. In addition, this study aimed to derive practical methods to evaluate the skeletal age using DM, CVM, or HWM for orthodontic, medical, and forensic purposes and to compare which of these 3 developmental parameters is more accurate for estimating the age of individuals in a Turkish population. Materials and Methods: Panoramic, lateral cephalometric, and hand-wrist radiographs of 284 patients aged 9-19 years were used in this study. The DM, CVM, and HWM stages were determined. The Kolmogorov-Smirnov, kappa, Wilcoxon, Kruskal-Wallis, chi-square, and Spearman correlation tests and simple linear regression analysis were used for statistical analysis. The significance level was 0.05. Results: Statistically significant differences were found between chronological age and DM, chronological age and CVM, and chronological age and HWM in both sexes (P<0.05). DM did not show statistically significant differences according to sex (P>0.05), but CVM and HWM were statistically different between males and females (P<0.05). The DM-estimated age yielded more accurate values than the other methods. Conclusion: All correlations between skeletal and dental stages were statistically significant. Our results showed that there was no statistically significant difference between chronological age and DM-estimated age. Therefore, it can be concluded that DM stages have the potential to be used for legal purposes.

• Journal of Korean Dental Science
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• 제11권1호
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• pp.1-4
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• 2018

Purpose: The aim of this study was to evaluate the ossification and maturation of the midpalatal suture in young Koreans using cone-beam computed tomography (CBCT). Materials and Methods: The study sample consisted of 40 patients with ages from 8.2 to 23.6 years who visited the Department of Orthodontics, Chung-Ang University Dental Hospital. CBCT images were taken for diagnosis. From the CBCT image, morphological stages and Hounsfield units (HU) of midpalatal suture were obtained to evaluate the midpalatal suture maturation. Spearman's correlation coefficients were calculated to analyze relationships between chronological age, morphological stage, and HU. Result: There was a wide variation in the morphology of the midpalatal suture in each age group. It showed a modest relationship between the chronological age and the degree of morphological stages. Also there was a modest relationship between the chronological age and HU. In contrast, there was a significant relationship between morphological stages and HU of midpalatal suture (P<0.01). Conclusion: CBCT images can be used for the evaluation of midpalatal suture maturation. For the estimation of the prognosis of rapid maxillary expansion, CBCT may be reliable for the assessment of the maturation of the midpalatal suture.

• 대한치과교정학회지
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• 제46권5호
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• pp.323-330
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• 2016

Objective: The purpose of this study was to determine whether the results of fractal analysis can be used as criteria for midpalatal suture maturation evaluation. Methods: The study included 131 subjects aged over 18 years of age (range 18.1-53.4 years) who underwent cone-beam computed tomography. Skeletonized images of the midpalatal suture were obtained via image processing software and used to calculate fractal dimensions. Correlations between maturation stage and fractal dimensions were calculated using Spearman's correlation coefficient. Optimal fractal dimension cut-off values were determined using a receiver operating characteristic curve. Results: The distribution of maturation stages of the midpalatal suture according to the cervical vertebrae maturation index was highly variable, and there was a strong negative correlation between maturation stage and fractal dimension (-0.623, p < 0.001). Fractal dimension was a statistically significant indicator of dichotomous results with regard to maturation stage (area under curve = 0.794, p < 0.001). A test in which fractal dimension was used to predict the resulting variable that splits maturation stages into ABC and D or E yielded an optimal fractal dimension cut-off value of 1.0235. Conclusions: There was a strong negative correlation between fractal dimension and midpalatal suture maturation. Fractal analysis is an objective quantitative method, and therefore we suggest that it may be useful for the evaluation of midpalatal suture maturation.

• 농업과학연구
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• 제35권2호
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• pp.167-176
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• 2008

Supplementation of serum and estrogen in in vitro maturation(IVM) medium was shown to improve embryo development and quality in several species. This study investigates the effect of ovarian estrus stage on canine oocyte quality and supplementation of medium with canine serum or estrogen on IVM of canine oocytes. As results, in experimental 1, IVM oocytes collected from follicular stage ovaries to MII stages($10.2{\pm}1.5%$) was higher (p<0.05) with 10% canine estrus stage serum than control($1.3{\pm}1.6%$), anoestrus stage serum($4.0{\pm}1.6%$), luteal stage serum($2.7{\pm}1.7%$) and 10% FBS($1.3{\pm}1.6$). In experimental 2, 10% canine estrus stage serum supplementation has highest maturation rate to MII stages($10.0{\pm}1.8%$) and there were significant differences(P<0.05) with another treatment in follicular stages group. In order to investigate the synergic effect of estrous serum and estrogen supplementation, different estrous stage groups of oocytes were cultured with 2 ug/ml estrogen plus various concentrations of different reproductive stage serum and FBS(experimental 3). As results, the rate of maturation to metaphase II(MII) stage was significantly higher(p<0.05) in oocytes from the follicular stage supplemented with estrogen and 10% canine estrus stage serum(11.5%) compared to the other groups(6.0 - 8.8%). The present study was demonstrated that canine serum and the estrus cycle of the bitch affect the meiotic competence of oocytes. Hormonal influences within the follicle may be one of the factors responsible for the greater proportion of maturation of oocyte to MII from bitches at the follicular phase.