• Journal of the Korean Chemical Society
• /
• v.40 no.9
• /
• pp.640-648
• /
• 1996

Crosslinked chitosan was prepared from chitin after reaction with epichlorohydrin followed by deacetylation at C2-position. Epidermal releasing polymeric matrix was prepared after swelling crosslinked chitosan with distilled water and adding silver sulfadiazine and glycerine as a plasticiser. The release behavior of silver sulfadiazine from polymeric matrix was studied in pH 7.4 phosphate buffer solution by varing the drug content, glycerine concentration, and the thickness of the matrix. The drug release time was delayed by increasing the content of silver sulfadiazine and the thickness of the matrix, whereas decreased as glycerine concentration increased. The apparent constant(K) of release rate was independent upon the matrix thickness, but was proportional to the content of drug or glycerine of crosslinked chitosan matrix. These results indicated that chitosan matrix showed some potential as a drug delivery system for transdermal therapeutic application.

• Polymer(Korea)
• /
• v.37 no.4
• /
• pp.442-448
• /
• 2013

In this study, we developed and optimized hydrophilic polymer-based solid dispersion formulations (SDs) using a spray drying method for improving the aqueous solubility of eprosartan, one of poorly soluble drugs that has been broadly used for the treatment of high blood pressure. Hydroxylpropylcellulose (HPC) and poly(vinyl pyrrolidone) (PVP) were used as hydrophilic polymer matrices and poloxamer 407 (P407) added as a polymeric surfactant. Various kinds of solid dispersions with different drug/polymer compositions were prepared and their physico-chemical properties were compared. As the polymer content increased, the drug crystallinity in the SDs significantly decreased and the dissolution properties were enhanced. The PVP based SDs were observed to have relatively reduced crystallinity and an enhanced dissolution rate than HPC-based SDs, due to better miscibility between drug and polymer matrix. For PVP based SDs, the drug crystallinity almost disappeared and the dissolution properties significantly increased by more than 3~7 times.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.10 no.2
• /
• pp.128-135
• /
• 2005

Mixed-mode hydrophobic/ionic matrices exhibit a salt-tolerant property for adsorbing target protein from high-ionic strength feedstock, which allows the application of undiluted feedstock via an expanded bed process. In the present work, a new type of mixed-mode adsorbent designed for expanded bed adsorption, Fastline $PRO^{\circledR}$, was challenged for the capture of nattokinase from the high ionic fermentation broth of Bacillus subtilis. Two important factors, pH and ion concentration, were investigated with regard to the performance of nattokinase ad-sorption. Under initial fermentation broth conditions (pH 6.6 and conductivity of 10 mS/cm) the adsorption capacity of nattokinase with Fastline PRO was high, with a maximum capacity of 5,350 U/mL adsorbent. The elution behaviors were investigated using packed bed adsorption experiments, which demonstrated that the effective desorption of nattokinase could be achieved by effecting a pH of 9.5. The biomass pulse response experiments were carried out in order to evaluate the biomass/adsorbent interactions between Bacillus subtilis cells and Fastline PRO, and to demonstrate a stable expanded bed in the feedstock containing Bacillus subtilis cells. Finally, an EBA process, utilizing mixed-mode Fastline PRO adsorbent, was optimized to capture nattokinase directly from the fermentation broth. The purification factor reached 12.3, thereby demonstrating the advantages of the mixed-mode EBA in enzyme separation.

• Research in Community and Public Health Nursing
• /
• v.29 no.2
• /
• pp.244-256
• /
• 2018

Purpose: This study tried to understand discourses of life-sustaining treatments in general daily and healthcare newspapers. Methods: A text-network analysis was conducted using the NetMiner program. Firstly, 572 articles from 11 daily newspapers and 258 articles from 8 healthcare newspapers were collected, which were published from August 2013 to October 2016. Secondly, keywords (semantic morphemes) were extracted from the articles and rearranged by removing stop-words, refining similar words, excluding non-relevant words, and defining meaningful phrases. Finally, co-occurrence matrices of the keywords with a frequency of 30 times or higher were developed and statistical measures-indices of degree and betweenness centrality, ego-networks, and clustering-were obtained. Results: In the general daily and healthcare newspapers, the top eight core keywords were common: "patients," "death," "LST (life-sustaining treatments)," "hospice palliative care," "hospitals," "family," "opinion," and "withdrawal." There were also common subtopics shared by the general daily and healthcare newspapers: withdrawal of LST, hospice palliative care, National Bioethics Review Committee, and self-determination and proxy decision of patients and family. Additionally, the general daily newspapers included diverse social interest or events like well-dying, euthanasia, and the death of farmer Baek Nam-ki, whereas the healthcare newspapers discussed problems of the relevant laws, and insufficient infrastructure and low reimbursement for hospice-palliative care. Conclusion: The discourse that withdrawal of futile LST should be allowed according to the patient's will was consistent in the newspapers. Given that newspaper articles influence knowledge and attitudes of the public, RNs are recommended to participate actively in public communication on LST.

• Journal of the Korea Concrete Institute
• /
• v.13 no.2
• /
• pp.175-183
• /
• 2001

Immersion tests with artificial seawater were carried out to investigate the resistance to seawater attack of 5 types of cement matrices. From the results of compressive strength and length change, it was found that blended cement mortars due to mineral admixtures, were superior to portland cement mortars with respect to the resistance to seawater attack. Moreover, XRD analysis indicated that the peak intensity ratio of low heat portland cement(LHC) paste, in portland cement pastes, had better results, and so did that of blended cement Paste. Pore volume of pastes by mercury intrusion porosimetry method demonstrated that total pore volume of ordinary portland cement(OPC) paste had a remarkable increase comparing with that of other pastes. In case of immersion of artificial seawater, the use of ground granulated blast-furnace slag and fly ash, however, showed the beneficial effects of 56% and 32% in reduction of total pore volume, respectively.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.26 no.11A
• /
• pp.1820-1826
• /
• 2001

In this paper, we present a modeling scheme for the already-installed two-wire home phone lines with arbitrary topologies and show that the inter-symbol interference due to the topology can be removed using an adaptive equalizer. The transmission characteristics of the arbitrary-configured two-wire home phone lines can be analyzed through the ABCD matrices. The simulation result shows that the impedance mismatch due to the branch lines renders nulls in the frequency response or delayed pulses in the impulse response. These nulls or delayed pulses cause inter-symbol interference that inhibits correct signal detection. An adaptive equalizer is shown to be effective in eliminating the interference. Also, the simulation result shows that the equalizer converges in 1.5 ms at a data rate of 1 Msps at signal-to-noise ratios greater than 15 dB. In addition, from the result of relation between E$\_$b//N$\_$and BER(Bit Error Rate), we can see that E$\_$b//N$\_$o/ more than 19 dB is required for the data communication with a BER less than 10$\^$-5/.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
• /
• v.6 no.3
• /
• pp.80-90
• /
• 1995

The scattering parameters of a microstrip single line, a right-angle bend and a coupled line are calculated using the multiport network model for the frequency range from 1 to 18 GHz. The single line is analyzed using the planar waveguide model. The right-angle bend is broken into two rectangular segments, and each segment is analyzed in a similar fashion as the single line. Impedance matrices corresponding to the two segments are combined by the segmentation method. In the analysis of elec- tromagnetic coupling of the coupled line, a new method is employed resulting in much less computation time than those previous methods involving Green's functions. A good agreement between the numerical results for the three structures and those from SuperCompact reveals the usefulness of the multiport network medel in analyzing complicated mirostrip single and coupled line discontinuities.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.29 no.2
• /
• pp.128-137
• /
• 2018

In this paper, we propose a novel class separability measure for radar signals. To reduce the sensitivity of the relative aspect angle between a target and radar, to evaluate the discriminatory power of radar signals, the proposed method first calculates the correlation coefficients between two radar cross sections (RCSs) or linearly shifts one-dimensional (1D) radar signals (i.e., high-resolution range profiles (HRRPs)), or rotates two 2D radar signals (i.e., inverse synthetic aperture radar (ISAR) images). Then, it uses the maximum correlation coefficient when two radar signals are best aligned. Next, the proposed method obtains new correlation-based discriminant matrices (CDM) using maximum correlation coefficients. Finally, the cumulative distribution function (CDF) in the CDM and the value corresponding to the specific probability in the CDF are obtained, and this value represents the discriminatory power of the radar signal. Experimental results show that the proposed method can accurately measure the target separability.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.22 no.4
• /
• pp.602-610
• /
• 2018

The model predictive control is an effective method to optimize the current control input that predicts the current control state and the future error using the predictive model of the control system when the reference trajectory is known. Since the control input can not have a physically infinitely large value, a predictive controller design with constraints should be considered. In addition, the reference model $A_r$ and the weight matrices Q, R that determine the control performance of the predictive controller are not optimized as arbitrarily designated should be considered in the controller design. In this study, we construct a predictive controller of a mobile robot by transforming it into a quadratic programming problem with constraints, The control performance of the mobile robot can be improved by optimizing the control parameters of the predictive controller that determines the control performance of the mobile robot using genetic algorithm. Through the computer simulation, the superiority of the proposed method is confirmed by comparing with the existing method.

• Journal of Pharmaceutical Investigation
• /
• v.26 no.4
• /
• pp.281-289
• /
• 1996

In our previous work, we have studied the effect of lactose and sodium alginate (SA) on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) matrix. These hydrophilic additives promoted the rate of 5-FU release and the increase in rate was larger when SA was used. Both additives showed better ability to increase the rate than 5-FU itself. In this paper, we extended our study to another hydrophilic additive, Carbopol 940 (CP). Compared to SA or lactose, CP increased the rate of 5-FU release markedly. Release rate increased as the loading amount and the pH of the release medium increased. After release experiment, matrix volume increased up to 15 times of that before release experiment, depending on the amount of CP dispersed in the matrix and the pH of the release medium. On the other hand, the volume of the matrix containing lactose or SA decreased. The weight changes of the dry matrix before and after release experiment imply that CP is not released out of the matrix, to the contrary of lactose and SA. Scanning electron microscope study clearly showed that large cavities and pores are generated on the surface and the inside of the matrix. These results indicate that the mechanism by which CP increases the release rate is quite different from that of monomeric additives such as lactose or SA.