• 한국항해항만학회지
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• 제40권6호
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• pp.469-476
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• 2016

본 연구는 조선기자재 수출입 기업체를 대상으로 설문조사를 실시하여 수출입 물류에 관한 일반사항과 물류실태, 화물정보 제공, 화물 식별 및 분류, 화물 오배송 및 손상 등의 화물관리 상의 애로요인과 개선방안을 조사, 분석하여 조선기자재 수출입 물류에 있어서 화물관리의 문제점과 해결방안을 제시하였다. 조선기자재 수출입 물류가 원할히 이루어지기 위해서는 수출입 업체와 물류관련 업체 간의 화물상태와 위치에 관한 정보가 실시간으로 제공되어야 할 것이다. 그리고 수출입 화물의 지연과 소실 및 오배송을 줄이고 물류효율성을 제고하기 위해서는 표준 화물 분류시스템과 인식시스템의 제정이 시급히 이루어져야 할 것이다. 또한 조선기자재 전문 포워더의 육성과 전문성 강화가 필요하며, 이를 위해 포워더 담당자들에 대한 역량배양 교육을 수출입 업체와 물류업체가 공동으로 참여하여 조선기자재 제품 특성과 물류 특성을 모두 반영하여 수행하여야 할 것이다.

• Journal of Pharmaceutical Investigation
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• 제36권2호
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• pp.109-114
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• 2006

Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles were developed for sustained delivery of water-soluble macromolecules. PLGA nanoparticles were fabricated by spontaneous emulsification solvent diffusion method generating negatively charged particles and heterogeneous size distribution. As a model drug, blue dextran was encapsulated in PLGA nanoparticles. In addition, nanoparticles were also prepared with varying ratio of poloxamer 188 (P188) and poloxamer 407 (P407), and coating with poly(vinyl alcohol) (PVA). Then, the particle size, zeta potential and encapsulation efficiency of nanoparticles containing blue dextran were studied. In vitro release of blue dextran from nanoparticles was also investigated. The surface and morphology of nanoparticles were characterized by scanning electron microscopy (SEM). In case of nanoparticles prepared with PLGA, P407, and different organic solvents, particle size was in the range of $230{\sim}320\;nm$ and zeta potentials of nanoparticles were negative. The SEM images showed that ethyl acetate is suitable for the formulation of PLGA nanoparticles with good appearance. Moreover, ethyl acetate showed higher encapsulation efficiency than other solvents. The addition of P188 to formulation did not affect the particle size of PLGA nanoparticles but altered the release patterns of blue dextran from nanoparticles. However, PVA, as a coating material, altered the particle size with increasing the PVA concentration. The nanoparticles were physically stable in the change of particle size during long-term storage. From the results, the PLGA nanoparticles prepared with various contents of poloxamers and PVA, could modulate the particles size of nanoparticles, in vitro release pattern, and encapsulation of water-soluble macromolecules.

• Journal of Pharmaceutical Investigation
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• 제41권2호
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• pp.95-102
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• 2011

An amphiphilic cationic branched methoxy poly (ethylene glycol)-branched polyethylenimine - poly(L-phenylalanine) (mPEG-bPEI-pPhe) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of L-phenylalanine (Phe-NCA) with mPEG-bPEI for the preparation of more stable polyelectrolyte complex (PEC) included a hydrophobic interaction. mPEG-bPEI was firstly prepared by the coupling of mPEG and bPEI using hexamethylene diisocyanate (HMDI). The structural properties of mPEG-bPEI-pPhe copolymers were confirmed by $^1H$ NMR. The copolymers exhibited a self-assemble behavior in water above critical aggregate concentration (CAC) in the range of 0.01-0.14 g/L. The CAC of copolymers obviously depended on the hydrophobic block content in the copolymers (the value decreased with the increase of the pPhe block content). The cationic copolymers have the ability to form multi-interaction complex (MIC) with bovine serum albumin (BSA) and plasmid DNA through multi-interaction (electrostatic and hydrophobic interaction). The physicochemical characterization of the complex was carried out by the measurement of zeta potential and particle size. Their zeta-potentials were positive (approximately +10 mV) and their sizes decreased with increasing pPhe contents in the copolymers (PPF/BSA wt% ratio = 2). The complex showed good stability at high ionic strength. Therefore, mPEG-bPEI-pPhe block copolymer was considered as a potential material to enhance the stability of complex including biotherapuetic drugs.

• 한국도서관정보학회지
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• 제30권2호
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• pp.1-28
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• 1999

캠퍼스에는 물리적으로 참석하지 않는 학생들에게 전자적 매체를 통하여 교육을 제공함으로써 급변하고 있는 정보화 사회에서의 정규 교육, 계속적인 전문성 개발, 그리고 고용자의 재훈련의 해결 방안이 되고 있는 원격 교육 또는 혹은 가상 대학은 계속적인 성장 산업이 될 것이며 이를 지원하기 위한 도서관의 역할과 서비스에 대한 인식이 확산되어야 한다. 본 연구는 이 인식의 재고를 위하여 가상 대학의 개념, 발전 및 문제점들을 검토하였으며 원격 교육을 위한 도서관 서비스의 발잔 이용자 조사에 근거한 도서관 서비스의 유형 개발, 그리고 미래의 도서관 서비스 방향들을 살펴보았고 앞으로 가상 대학 지원을 위한 도서관 역할 정립을 위한 기초 자료를 제공하고자 하였다.

• 한국통신학회논문지
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• 제40권6호
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• pp.1166-1174
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• 2015

단순 바코드 또는 포장 내용물 단위의 이력추적, 농 식품의 저장 창고나 배송차량의 일부 정보 추적, 직감에 의한 원격 환경 조정 등을 통해 농 식품의 위해인자를 차단하려는 노력들이 있었다. 그러나 이러한 시도는 선택적인 정보수집 및 불충분한 정보량, 현실과 수집 시점 간 시간차에 따른 정보 왜곡의 문제점 및 각 유통 기업의 자체 독립적인 정보망으로 인하여 생산지로부터 소비자까지의 총체적인 위해인자 차단이 어렵다. 본 논문에서는 농 식품의 생산지뿐만 아니라 전주기상의 주요 유통 거점, 소비지까지 정형, 반 정형, 비정형의 다양하고 대규모의 농 식품 유통 정보를 이용하여, 위해인자 발생의 실시간 상황이나 예측, 추적을 통하여, 위해인자 파급 차단과 예방을 위한 농 식품의 위해인자 신속 관리 방법을 제안한다. 제안방법은 빅 데이터 클러스터 기반, 실시간으로 정보를 수집하고, 위해인자 상황인지, 위해인자 발생 예측, 위해인자 발생지 추적 분석을 통해 위해인자를 차단하고 파급을 예측하며, 그 결과를 가시화하여 신속하게 위해인자를 관리 할 수 있도록 한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권4호
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• pp.316-322
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• 2004

A low molecular weight component named bone morphogenetic protein(BMP) chemically isolated from the organic matrix of bone, induce postfetal connective tissue cells surrounding small blood vessels to differentiate into cartilage and bone. The end product of BMP is a spherical ossicle of lamella bone filled with red bone marrow for the functional loading. This is a important point that the graft material is embedded the defect site during the implant surgery. Because present knowledge of the relationship between BMP and bone regeneration arises mainly from studies of induced bone formation in heterotopic sites, it would be helpful to determine whether BMP plays any part in the process of bone healing. The BMPs have been shown to play crucial roles in normal skeletal development as well as bone healing and are able to activate transcription of genes involved in cellular migration, proliferation, and differentiation. The delivery of BMP on matrices has been efficacious in the treatment of defect bone in implant surgery. The purpose of the histologic study was to evaluate the effect of DLB(demineralized lyophilized bone) coated with purified human BMP(hBMP-I) in immediate implant surgery with bony defect to obtain the functional structure of implant asap. The ability of a graft of hBMP-I to accelerate bony defect repair provides a rationale for its use in immediate implant surgery that have large bone defect in edentulous area.

• 아태비즈니스연구
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• 제3권1호
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• pp.39-47
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• 2012

Organizations pursue a CRM strategy for the purpose of increasing business performance and value. However, firms face a multitude of organizational challenges associated with this endeavor. To reduce their risk of failure, it is suggested that firms undertake a deep analysis of organizational readiness prior to committing to a CRM initiative. Insurance sector is no exception to this fact. There is an increased need to concentrate on the various challenges thrown open by the public insurance firms in implementing CRM. Many insurance firms have invested into customer driven CRM but research indicates varying outcomes (Schmith 2004). While it is clear that there are significant issues involved in the CRM implementation and success and environment faced by the public sector. It is clear that business should have an easier time in applying CRM systems is the strategic value for public sector. With customers demanding more service and accessibility from administrators, public sector CRM software technologies have to offer best solutions for achieving process and cost objectives (Souder 2001). With results which go far beyond improved service delivery and include sustained cost reductions, increased customer knowledge and better employee morale, CRM software implementation and post product environments offer great upside value. Although there are material differences in public sector use of CRM strategy, they share at least one glaring similarity - they have much to gain from proven CRM software technology. As business methods cross over in the public sector, many government bodies are investigating how they can adopt and adapt various CRM models (Bleyer 2003). There is a need to understand the similarities and differences in public sector CRM to foster shared knowledge, business processes and planning functions to integrate disparate technologies and software platforms and then, of course, the organizational culture to support knowledge sharing (Peters 1997). For the public sector, there are clearly identified CRM processes which have resulted in increased profits and improved efficiency. These have focused on sales, marketing and customer service activities, which often operate along fundamentally different lines in various public sector insurance companies. Thus the present research paper makes an attempt to explore how public sector CRM methods can be adopted and subsequently adapted.

• The Plant Pathology Journal
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• 제24권1호
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• pp.67-73
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• 2008

Seedling damping-off and bottom rot caused by Rhizoctonia solani are yield limiting diseases of crisphead lettuce. To provide biocontrol measure in the management of the diseases, biocontrol strain Pseudomonas aeruginosa LY-11 was isolated from lettuce rhizosphere and introduced into crisphead lettuce rhizosphere by the seed coating delivery method. Alginate was used as a coating material to generate beads containing $10^6-10^{6.5}$ colony-forming units (CFUs) of viable bacterial cells of LY-11. When seeds germinated from the alginate beads containing the strain LY-11, the bacteria established mostly in plant rhizosphere to maintain at least $10^4$ CFU per gram of plant tissues. Crisphead lettuce seedlings germinated from the entrapped seeds were less affected from damping-off and bottom rot with disease control values of 70.4% and 85.4% respectively. Although P. aeruginosa LY-11 colonized plant rhizosphere and not phyllosphere, the result indicated that bottom rot caused by the foliar inoculation of R. solani was effectively reduced by the rhizobacteria. All data suggested that immobilized rhizobacterial application in seeds by alginate coating could control damping-off and induce induced systemic resistance of crisphead lettuce to reduce bottom rot.

• 접착 및 계면
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• 제9권2호
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• pp.8-15
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• 2008

마이크로캡슐은 다양한 기능성 물질의 약물 전달 시스템으로서 화장품과 제약 분야에서 널리 적용되고 있다. 키토산은 천연에 풍부하게 존재하는 생체고분자로 생체적합성이 우수하며 무독성이다. 본 연구에서는 키토산 마이크로캡슐을 글루타르알데히드를 가교제로 사용하여 W/O 형태의 유화법으로 제조하였다. 유화제로는 span80을 사용하였으며 가교가 시행되는 bath상의 물질은 mineral oil을 사용하였다. 제조된 키토산 마이크로캡슐은 완벽한 구의 형태로 평균 $2{\sim}10{\mu}m$ 크기를 보였으며, 교반속도와 유화제의 농도에 따른 캡슐의 직경 및 형태 변화를 관찰하였다. 마이크로캡슐의 방출실험을 하기 위하여 가교제, 키토산, 그리고 유화제의 양을 변화시키면서 방출 속도를 측정하였다. Riboflavin의 방출속도는 키토산의 가교 정도와 사용한 유화제의 양에 따라 크게 변하였다.

• Nuclear Engineering and Technology
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• 제32권4호
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• pp.395-409
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• 2000

Parametric studies were performed to assess the sensitivity in determining the maximum in-vessel heat removal capability from the core material relocated into the lower plenum of the reactor pressure vessel (RPV）during a core melt accident. A fraction of the sensible heat can be removed during the molten jet delivery from the core to the lower plenum, while the remaining sensible heat and the decay heat can be transported by rather complex mechanisms of the counter-current flow limitation (CCFL) and the critical heat flux (CHF）through the irregular, hemispherical gap that may be formed between the freezing oxidic debris and the overheated metallic RPV wall. It is shown that under the pressurized condition of 10MPa with the sensible heat loss being 50% for the reactors considered in this study, i.e. TMI-2, KORI-2 like, YGN-3&4 like and KNGR like reactors, the heat removal through the gap cooling mechanism was capable of ensuring the RPV integrity as much as 30% to 40% of the total core mass was relocated to the lower plenum. The sensitivity analysis indicated that the cooling rate of debris coupled with the sensible heat loss was a significant factor The newly proposed heat removal capability map (HRCM) clearly displays the critical factors in estimating the maximum heat removal from the debris in the lower plenum. This map can be used as a first-principle engineering tool to assess the RPV thermal integrity during a core melt accident. The predictive model also provided ith a reasonable explanation for the non-failure of the test vessel in the LAVA experiments performed at the Korea Atomic Energy Research Institute (KAERI), which apparently indicated a cooling effect of water ingression through the debris-to-vessel gap and the intra-debris pores and crevices.