• Journal of Microbiology and Biotechnology
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• v.33 no.1
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• pp.114-122
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• 2023

A family of signal transduction pathways known as wingless type (Wnt) signaling pathways is essential to developmental processes like cell division and proliferation. Mutation in Wnt signaling results in a variety of diseases, including cancers of the breast, colon, and skin, metabolic disease, and neurodegenerative disease; thus, the Wnt signaling pathways have been attractive targets for disease treatment. However, the complicatedness and large involveness of the pathway often hampers pinpointing the specific targets of the metabolic process. In our current study, we investigated the differential metabolic regulation by the overexpression of the Wnt signaling pathway in a timely-resolved manner by applying high-throughput and un-targeted metabolite profiling. We have detected and annotated 321 metabolite peaks from a total of 36 human embryonic kidney (HEK) 293 cells using GC-TOF MS and LC-Orbitrap MS. The un-targeted metabolomic analysis identified the radical reprogramming of a range of central carbon/nitrogen metabolism pathways, including glycolysis, TCA cycle, and glutaminolysis, and fatty acid pathways. The investigation, combined with targeted mRNA profiles, elucidated an explicit understanding of activated fatty acid metabolism (β-oxidation and biosynthesis). The findings proposed detailed mechanistic biochemical dynamics in response to Wnt-driven metabolic changes, which may help design precise therapeutic targets for Wnt-related diseases.

• International journal of advanced smart convergence
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• v.12 no.1
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• pp.220-229
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• 2023

The development of logistics technology due to the 4th Industrial Revolution and logistics 4.0 has changed the logistics environment from offline to online, and the growth of the online market has accelerated due to the recent increase in non-face-to-face delivery due to COVID-19. Such growth in the online market has expanded the logistics market for delivery, and contributes to creating an advanced logistics ecosystem as last mile services and logistics technologies begin to grow together. As traffic and environmental problems arise as a result, interest in transportation means of cargo increases, and changes to cargo electric vehicles and delivery cycles are being considered. However, since mass transportation of transportation focused on terminal delivery such as cargo electric vehicles and delivery cycles is limited in handling large quantities in urban areas, methods for efficiently transporting cargo while considering the environment are being devised. In order to solve such environmental problems and increase the efficiency of logistics delivery in urban areas, technologies using underground spaces based on existing urban railroads are being developed. In this study, a study was conducted on the establishment of evaluation criteria for selecting a test bed, which is a space for applying the system.

• Geomechanics and Engineering
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• v.28 no.2
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• pp.145-155
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• 2022

Safety is a most important parameters in underground railway transportation; Also stability of underground tunnel is very important in tunneling engineering. Design of a reliable support system requires an evaluation of both ground demand and support capacity. Iran's traditional railway tunnels are mainly supported with masonry structures or unsupported in high quality rock masses. A decrease in rock mass quality due to changes in groundwater regime creep and fatigue in rock and similar phenomena causes tunnel safety to decrease during time. The case study is an old tunnel in Iran, called "Keshvar"; it is more than 50 years old railway organization. In operating this Tunnel, until the several problems came up based on stability and leaking water. The goal of study is evaluation of the various reinforcement systems for supporting of the tunnel. The optimal selection of the reinforcement system is examined using TOPSIS Fuzzy method in light of the looming and available uncertainties. Several factors such as; the tunnel span, maintenance, drainage, sealing, ventilation, cost and safety were based to choose the method and system of designing. Therefore, by identifying these parameters, an optimal reinforcement system was selected and introduced. Based on optimization system for analysis, it is revealed that the systematic rock bolts and shotcrete protection had a most appropriate result for these kind of tunnel in Iran.

• The Korean Journal of Food & Health Convergence
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• v.8 no.1
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• pp.1-7
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• 2022

This study classified subjects aged 30 to 64 into normal group, impaired fasting glucose group, and diabetes mellitus patient group based on data from the 6th period of the National Health and Nutrition Examination Survey (2013-2015). Skipping breakfast, lack of physical activity, inadequate sleep time, inadequate weight, excessive drinking, and current smoking are classified as a low health risk group when three or less items are present, and a high health risk group when three or more items are included. By classification, each item included in the physical measurement and biochemical analysis factors and health risk behavior factors was comparatively analyzed. As a result, in the normal group, impaired fasting glucose group, and diabetes group, the average age was higher in the group with high health risk factors than the group with low risk factors, and the male ratio was higher. Body mass index, waist circumference, blood pressure, triglyceride showed a significantly higher result. In the normal group, the fasting blood glucose level and total cholesterol level were also higher in group 2. Therefore, it is thought that it is necessary to control health risk behaviors through lifestyle changes in the normal group, fasting glucose disorder group, and diabetes group.

• Current Optics and Photonics
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• v.7 no.4
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• pp.435-442
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• 2023

These days, the size of a reflective telescope has been increasing for astronomical observation. An additional optical system usually assists a large ground telescope for image analysis or the compensation of air turbulence. To guide collimated light to the external optical system through a designated path, a coudé mirror is usually adopted. Including a collimator, a coudé mirror of a ground telescope is affected by gravity, depending on the telescope's pointing direction. The mirror surface is deformed by the weight of the mirror itself and its mount, which deteriorates the optical performance. In this research, we propose an optimization method for the coudé mirror assembly for a 1-m class ground telescope that minimizes the gravitational surface error (SFE). Here the mirror support positions and the sizes of the mount structure are optimized using finite element analysis and the response surface optimization method in both the horizontal and vertical directions, considering the telescope's altitude angle. Throughout the whole design process, the coefficients of the Zernike polynomials are calculated and their amplitude changes are monitored to determine the optimal design parameters. At the same time, the design budgets for the thermal SFE and the mass and size of the mount are reflected in the study.

• Journal of the Korean Society of Food Culture
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• v.21 no.1
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• pp.17-30
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• 2006

This survey was conducted to find out the familiarity and preference of Chinese residing in Korea on Korean food. They were composed of Chinese students studying in Korea and Chinese staffs working at the Chinese Embassy in Seoul. About 65.60% of the respondents liked Korean food while 28.00% disliked it. The reason for liking Korean food was its taste. The frequency of having Korean food a week was 46.80%, which meant Chinese had Korean food quite often. Their interest in Korean food was derived from their own personal taste and food programs of mass communication media. The most familiar food was kimchi (90.40%), followed by bulgogi (89.60%), samketang, chicken stew with ginseng (75.60%) and bibimbap, rice with vegetables (74.80%). The the most favored dish was bulgogi (64.40%), which showed that bulgogi was the most representative dish to them among Korean dishes. The area where Korean food needed innovation, Chinese pointed out, was some changes in cooking. That is, traditional Korean food needs, although maintaining its original tastes, to change its preparation of spices catering to foreigners' taste.

• Educational Technology International
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• v.13 no.1
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• pp.27-48
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• 2012

In this paper we are comparing how the OER (open educational resources) are developed in Higher Education in Finland and South Korea. We also present a comparison model for further studies. Essential findings based on our comparison are that in both countries there are many best practices of use of the OER and open learning. Open educational resources have great potential and their use can ensure quality teaching and learning. The activity has not inspired the great mass of higher education teachers in Finland and Korea. Traditionally, a teacher's job is working alone, and so a new operational culture is required. Our comparison indicates that numerous questions, fears and problems and cultural differences are also related to the thematic. There is an evident need for a new kind of strategic leadership, a new kind of teaching and learning culture and a doing together and production ideology for the method to spread. Based on our study the following interlinked elements of OER seem to be pivotal: changes to pedagogies, technology and operational culture; educational policy intention; and attitude to culture. Lastly, comparison frame by OER practice model is developed.

• Steel and Composite Structures
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• v.49 no.4
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• pp.407-417
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• 2023

After a disaster like the catastrophic earthquake, the government have to use rapid assessment of the condition (or damage) of bridges, buildings and other infrastructures is mandatory for rapid feedbacks, rescue and post-event management. Many domain schemes based on the measured vibration computations, including least squares estimation and neural fuzzy logic control, have been studied and found to be effective for online/offline monitoring of structural damage. Traditional strategies require all external stimulus data (input data) which have been measured available, but this may not be the generalized for all structures. In this article, a new method with unknown inputs (excitations) is provided to identify structural matrix such as stiffness, mass, damping and other nonlinear parts, unknown disturbances for example. An analytical solution is thus constructed and presented because the solution in the existing literature has not been available. The goals of this paper are towards access to adequate, safe and affordable housing and basic services, promotion of inclusive and sustainable urbanization and participation, implementation of sustainable and disaster-resilient buildings, sustainable human settlement planning and manage. Simulation results of linear and nonlinear structures show that the proposed method is able to identify structural parameters and their changes due to damage and unknown excitations. Therefore, the goal is believed to achieved in the near future by the ongoing development of AI and control theory.

• Korean Journal of Plant Resources
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• v.36 no.6
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• pp.580-587
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• 2023

Androsace septentrionalis is a grass species restricted to North Korea; however, it is at the brink of extinction due to habitat loss and environmental changes caused by natural disasters and anthropogenic activities. This study was conducted to characterize the dormancy conditions of A. septentrionalis in an effort to conserve this North Korean plant resource. For this purpose, the morphological characteristics and vigor of A. septentrionalis seeds were examined, and its germination characteristics under different temperature conditions (15/6℃ and 25/15℃ ), low-temperature stratification, and gibberellin (GA₃) treatment were determined. The results revealed that A. septentrionalis exhibits non-deep type morpho-physiological dormancy, and low-temperature stratification treatment was not effective in breaking the dormancy of A. septentrionalis seeds. Meanwhile, GA₃ treatment significantly increased the mean germination time, rate, and speed of the seeds. The optimal conditions for the germination of A. septentrionalis seeds were 25/15℃ fluctuating temperature and 500 mg·L¹ GA₃ treatment. The results of this study are useful for the mass propagation of A. septentrionalis.

• Journal of Korean Traditional Oncology
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• v.28 no.1
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• pp.45-53
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• 2023

Objectives: To report the reduction of adverse effects of chemotherapy and improvement in the quality of life in recurrent liver metastasis by Korean medicine treatments. Methods: In 2018, a 75-year-old male patient underwent surgery for primary cancer in the ampulla of Vater. In 2021, he was diagnosed with recurrent liver metastasis. Following the failure of tumor treatment with gemcitabine/cisplatin and the development of severe side effects, he decided to discontinue chemotherapy. Subsequently, with a significantly enlarged liver tumor, he resumed capecitabine/oxaliplatin treatment, alongside moxibustion, acupuncture, and herbal prescriptions from August 2021 to August 2023. The changes of chief complaints, abdominal CT, and laboratory findings were investigated. Results: After combined treatment of Korean traditional medicine and chemotherapy, the mass was decreased. Laboratory findings, and chief complaints of hand-foot syndrome, fatigue, abdominal distension, nausea and anorexia were improved. Conclustions: This case study suggests that Korean traditional medicine is effective in enhancing anticancer effects, suppressing the side effects of chemotherapy, and improving general conditions.