• YAKHAK HOEJI
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• v.54 no.4
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• pp.316-321
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• 2010

Adefovir dipivoxil which was originally developed by Gilead Sciences has been used as treatments of HIV and HBV, especially a therapeutics for HBeAg positive and negative chronic patients. We developed highly efficient purification method using reverse phase column chromatography for mass production and a stable amorphous Adefovir dipivoxil using solid dispersion method. Reverse phase column chromatography led to highly pure product, more than 99.7% by HPLC and can be used for mass production compared with normal column chromatography. Solid dispersion method containing watersoluble polymer and Isomalt showed improved stability of amorphous Adefovir dipivoxil against heat and moisture.

• Journal of IKEEE
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• v.26 no.4
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• pp.560-567
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• 2022

This paper proposed an application of agile management method to resolve the electrical system issues identified during the mass production phase of aged aircraft performance improvement. The proposed method was applied from issue analysis to on-site verification and testing stage, before the formal configuration control process. At this time, the project was carried out by setting a sprint period to complete the verification according to requirements through daily scrum and sprint review. As a result, It was verified that the wiring installation of the aircraft, which was the output of the sprint, met requirements within the defined sprint period.

• Animal Bioscience
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• v.34 no.5
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• pp.886-894
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• 2021

Objective: An experiment was conducted to study the effect of graded concentration of digestible lysine (dLys) on performance of layers fed diets containing sub-optimal level of protein. Methods: Five diets were formulated to contain graded concentrations of dLys (0.700%, 0.665%, 0.630%, 0.593%, and 0.563%), but similar levels of crude protein (15% CP), energy (10.25 MJ ME/kg) and other nutrients. A total of 3,520 hens (26 wk of age) with mean body weight of 1,215+12.65 g were randomly divided into 40 replicate groups of 88 birds in each and housed in an open sided colony cage house. Each diet was offered ad libitum to eight replicates from 27 to 74 wk of age. The performance was compiled at every 28 d and the data for each parameter were grouped into three phases, that is early laying phase (27 to 38 wk), mid laying phase (39 to 58 wk), and late laying phase (59 to 74 wk of age) for statistical analysis. Results: Egg production, egg mass and feed efficiency (feed required to produce an egg) were significantly improved by the dLys level during the early and mid laying phases but not during the late phase. Whereas feed intake was significantly reduced by dLys concentration during mid and late laying phases but not during early laying phase. The egg weight was not affected by dLys concentration in any of the three phases. Conclusion: Based on best fitted statistical models, dietary requirements of dLys worked out to be 0.685%, 0.640%, and 0.586% during early phase, mid phase, and late egg laying phase, respectively. The calculated requirement of dLys for the respective production phases are 727 mg/b/d during the early and mid laying phases and 684 mg/b/d during the late laying phase in diets containing 15% CP.

• Transactions of Materials Processing
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• v.11 no.2
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• pp.123-131
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• 2002

The rheology process is net shape manufaturing technology to high of automobile part and improve the mechanical properties. For the rheology forming process, Phase and globular microstructure are very important. The equipments to make a rheology alloys with slurry statement have been introduced. Therefore, the Problems to Produce a rheology alloyas with continuous process had also been investigated to make Production in industries. The validity of the introduced rheology Process is investigated by comparing the reported thixoforming results. Therefore, the many advantage of rheology process to be reduced the reheating Process and billet fabrication method has been expressed in terms of mass production, in the future.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.4
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• pp.617-624
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• 2020

Due to the rapid development of science technology and the main characteristics of the defense industry, such as long development period, design complexity, high possibility of discontinuing parts due to long life cycle, and small quantity production, it can cause increasing of the inflow possibility of counterfeit electronic parts and deteriorating the reliability of weapons systems. This paper presents the specific criteria for the identification of electronic parts to be verified for mass produced weapons systems after the development is completed, and the identification and verification methods for the inflow of counterfeit electronic components.

• Nuclear Engineering and Technology
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• v.27 no.2
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• pp.216-225
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• 1995

Simulation for a dynamic analysis of the electrolytic preparation of U(IV) in two-phases system, which consisted of mass transfer of U(VI) from TBP phase into HNO$_3$ solution and electrolytic re-duction of U(VI) to U(IV) at a cathode in aqueous phase, was carried out in order to establish the most suitable operating condition and best electrode area as basic design data for the system. It was found that maintaining an appropriate mass transfer rate was more significant rather than enlarging the surface area of the cathode for more effective production yield of U(IV). The electrode area and the operation time affected deeply the production composition of U(IV) in the resulting aqueous phase. And optimal electrode areas ore evaluated to meet production criteria of U(IV) of resulting solution in several system conditions. Though about 0.37M HNO$_3$ was preferable to prepare the solution of U(IV), nitric acid concentration should be higher than 0.5M to prevent a hydrolysis of U(IV) in the aqueous phase.

• Journal of Microbiology and Biotechnology
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• v.19 no.12
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• pp.1603-1611
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• 2009

High-cell-density cultivation of yeast was investigated using the agricultural waste products corn steep liquor (CSL) and molasses. The Saccharomyces cerevisiae KV-25 cell mass was significantly dependent on the ratio between C and N sources. The concentrations of molasses and CSL in the culture medium were statistically optimized at 10.25% (v/v) and 16.87% (v/v), respectively, by response surface methodology (RSM). Batch culture in a 5-l stirred tank reactor using the optimized medium resulted in a cell mass production of 36.5 g/l. In the fed-batch culture, the feed phase was preceded by a batch phase using the optimized medium, and a very high dried-cell-mass yield of 187.63 g/l was successfully attained by feeding a mixture of 20% (v/v) molasses and 80% (v/v) CSL at a rate of 22 ml/h. In this system, the production of cell mass depended mainly on the agitation speed, the composition of the feed medium, and the glucose level in the medium, but only slightly on the aeration rate.

• The Korean Journal of Mycology
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• v.42 no.4
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• pp.328-332
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• 2014

For mass production of entomopathogenic fungus Beauveria bassiana 149, isolated from moth larva, by two-phase fermentation, we performed selection of carbon and nitrogen sources for liquid culture and examined solid fermentation on carrier, ingredient, temperature, and water content. Spore production with rice powder, corn powder, and starch from sweet potato was higher than that of sucrose and dissolvable starch for liquid fermentation as first-phase fermentation. As a nitrogen source, addition of peptone and yeast powder showed higher spore production than $NaNO_3$, fish powder, and soybean powder. The isolate produced more conidia in sawdust + wheat bran + corn powder, sawdust + wheat bran and rice shell + wheat bran as carrier and ingredient than vermiculite as carrier. Conidia production of B. bassiana 149 in solid-phase fermentation was twice higher at 30 than 20. Conidia yield was higher at 60% and 70% water content ($26.9{\times}10^8$ and $38.6{\times}10^8conidia/g$) than 40% and 50% ($13.9{times}10^8 $and $11.6{\times}10^8conidia/g$), respectively.

• Journal of Microbiology and Biotechnology
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• v.21 no.6
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• pp.652-658
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• 2011

The growth kinetics of Streptomyces noursei NRRL 5126 was investigated under different aeration and agitation combinations in a 5.0 l stirred tank fermenter. Poly-${\varepsilon}$-lysine biosynthesis, cell mass formation, and glycerol utilization rates were affected markedly by both aeration and agitation. An agitation speed of 300 rpm and aeration rate at 2.0 vvm supported better yields of 1,622.81 mg/l with highest specific productivity of 15 mg/l.h. Fermentation kinetics performed under different aeration and agitation conditions showed poly- ${\varepsilon}$-lysine fermentation to be a growth-associated production. A constant DO at 40% in the growth phase and 20% in the production phase increased the poly-${\varepsilon}$-lysine yield as well as cell mass to their maximum values of 1,992.35 mg/l and 20.73 g/l, respectively. The oxygen transfer rate (OTR), oxygen utilization rate (OUR), and specific oxygen uptake rates ($qO_2$) in the fermentation broth increased in the growth phase and remained unchanged in the stationary phase.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.4
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• pp.669-676
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• 2012

In this paper, The method to improve the mass production method of the radar sensor is suggested by using the temperature compensation circuit which is composed with the thermister. The mass production became easier by decreasing the adjustment time for the exact oscillation frequency with the temperature compensation circuit that can support the proper gate bias voltage for the FET after the dielectric resonator is removed from the DRO(Dielectric Resonator Oscillator) of the radar sensor. Radar sensor with the proposed method has 15.67MHz oscillator frequency variation in the temperature range of $-20^{\circ}C-+55^{\circ}C$, 0.65dB magnitude variation, -105.47dBc phase noise characteristics at 1MHz which are better or similar temperature characteristics with the DRO whose oscillator frequency variation is 25MHz, magnitude variation is 0.42dB and phase noise is -107.40dBc in the same temperature range.