• Nutrition Research and Practice
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• v.10 no.1
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• pp.115-124
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• 2016

BACKGROUND/OBJECTIVES: This is the first study to identify common genetic factors associated with the basal metabolic rate (BMR) and body mass index (BMI) in obese Korean women including overweight. This will be a basic study for future research of obese gene-BMR interaction. SUBJECTS/METHODS: The experimental design was 2 by 2 with variables of BMR and BMI. A genome-wide association study (GWAS) of single nucleotide polymorphisms (SNPs) was conducted in the overweight and obesity (BMI > $23kg/m^2$) compared to the normality, and in women with low BMR (< 1426.3 kcal/day) compared to high BMR. A total of 140 SNPs reached formal genome-wide statistical significance in this study (P < $1{\times}10^{-4}$). Surveys to estimate energy intake using 24-h recall method for three days and questionnaires for family history, a medical examination, and physical activities were conducted. RESULTS: We found that two NRG3 gene SNPs in the 10q23.1 chromosomal region were highly associated with BMR (rs10786764; $P=8.0{\times}10^{-7}$, rs1040675; $2.3{\times}10^{-6}$) and BMI (rs10786764; $P=2.5{\times}10^{-5}$, rs10786764; $6.57{\times}10^{-5}$). The other genes related to BMI (HSD52, TMA16, MARCH1, NRG1, NRXN3, and STK4) yielded P < $10{\times}10^{-4}$. Five new loci associated with BMR and BMI, including NRG3, OR8U8, BCL2L2-PABPN1, PABPN1, and SLC22A17 were identified in obese Korean women (P < $1{\times}10^{-4}$). In the questionnaire investigation, significant differences were found in the number of starvation periods per week, family history of stomach cancer, coffee intake, and trial of weight control in each group. CONCLUSION: We discovered several common BMR- and BMI-related genes using GWAS. Although most of these newly established loci were not previously associated with obesity, they may provide new insights into body weight regulation. Our findings of five common genes associated with BMR and BMI in Koreans will serve as a reference for replication and validation of future studies on the metabolic rate.

• Korean Journal of Soil Science and Fertilizer
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• v.4 no.1
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• pp.55-66
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• 1971

A method for the identification of and measurement of beta activity due to $^{40}K$ have been developed in this institute. The method is based on the principle of : $$G(t)=\frac{A}{A_{\infty}}=1-e^{-{\eta}t}$$ where: G(t)=fraction of maximum activity A = counting rate of thickness $A_{\infty}$= saturation activity ${\eta}$= mass absorption coefficient of $^{40}K$ By this technique, total beta activity in 92 Korean paddy soil samples collected from various part of the country, have been determined and the results of this analysis reported in this paper. Most of the beta activity in soils have been accounted for to be due to $^{40}K$.

• Journal of the Korean Applied Science and Technology
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• v.38 no.4
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• pp.1117-1128
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• 2021

The purpose of the current study was to investigate the effects of 4-week health promotion intervention program consisting of high-intensity aerobic exercise to improve energy consumption and cardiorespiratory capacity, circuit training to strengthen muscular strength and endurance and education for lifestyle changes on the obesity level, physical fitness, insulin resistance and metabolic syndrome among overweight or obese elementary school students. Twenty three overweight or obese children as obese group and 15 normal body weight children as normal group were recruited. The health promotion program consisted of two exercise sessions and one education session, 3days/week in 4-week. Obesity level(body mass index, waist circumference, %body fat), physical fitness(muscular strength, muscular endurance, flexibility, cardiopulmonary fitness), insulin resistance(homeostasis model assessment of insulin resistance) and metabolic syndrome risk factors(blood pressure, fasting glucose, triglycerides, high density lipoprotein cholesterol) were measured. There was not significant decrease in obesity level; however, there were significant improvement in physical fitness, insulin resistance and metabolic syndrome risk factors after program participation among obese children. As a result, through participation in the summer camp consisting mainly of exercise, the improvement of the physical fitness level and the decrease of insulin resistance had an effect on the reduction of the metabolic syndrome frequency.

• Nuclear Engineering and Technology
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• v.52 no.12
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• pp.2860-2866
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• 2020

Oxide dispersion-strengthened materials W-1wt%Pr₂O₃ and W-1wt%La₂O₃ were synthesized by wet chemical method and spark plasma sintering. The field emission scanning electron microscopy (FE-SEM) analysis, XRD and Vickers microhardness measurements were conducted to characterize the samples. The irradiations were carried out with a 5 keV helium ion beam to fluences up to 5.0 × 10²¹ ions/m² under 600 ℃ using the low-energy ion irradiation system. Transmission electron microscopy (TEM) study was performed to investigate the microstructural evolution in W-1wt%Pr₂O₃ and W-1wt%La₂O₃. At 1.0 × 10²⁰ He⁺/m², the average loops size of the W-1wt%Pr₂O₃ was 4.3 nm, much lower than W-1wt% La₂O₃ of 8.5 nm. However, helium bubbles were not observed throughout in both doped W materials. The effects of pre-irradiation with 1.0 × 10²¹ He⁺/m² on trapping of injected deuterium in doped W was studied by thermal desorption spectrometry (TDS) technique using quadrupole mass spectrometer. Compared with the samples without He⁺ pre-irradiation, deuterium (D) retention of doped W materials increased after He⁺ irradiation, whose retention was unsaturated at the damage level of 1.0 × 10²²D₂⁺/m². The present results implied that irradiation effect of He⁺ ions must be taken into account to evaluate the deuterium retention in fusion material applications.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.409-418
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• 2019

Debris flows occur in mountainous areas due to heavy rains resulting from climate change and result in disasters in the downstream area. The purpose of this study is to estimate the impact force of a debris flow when a check dam according is installed in various locations in the channel of a highly mountainous area. A Finite Differential Element Method (FDM) model was used to simulate the erosion and deposition based on the equation for the mass conservation and momentum conservation while considering the continuity of the fluid. The peak impact force from the debris flow occurred at 0 to 5 sec and 15 to 20 sec. When the supplied water discharge was increased, greater peak impact force was generated at 16 to 19 sec. This means that when increasing the water supply, the velocity of the debris flow became faster, which results in increased energy of the consolidation between the particles of the water and the sediment made. If a number of check dams were to be set up, it would be necessary to investigate the impact force at each location of the check dam. The results of this study could provide useful information in predicting the impact force of the debris flow and in installing the check dams in appropriate locations.

• Korean Journal of Agricultural and Forest Meteorology
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• v.20 no.4
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• pp.366-375
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• 2018

Evapotranspiration (ET) information is needed for many applications in agricultural and environmental resource management because crop yields, plant growth and physiological characteristics are primarily water limited. This study was conducted to evaluate the diurnal change of ET using electronic weighing lysimeter and to determine whether the ET of Cnidium officinale Makino could be manipulated through meteorological factors such as solar radiation, windy conditions and air temperature etc., Pot has a diameter of 35 cm and an height of 38 cm. A disturbed soil of sandy loam (coarse, mixed, mesic family of Dystric Fluventic Eutroudepts) within lysimeter has a mass of approximately 40.0 kg. In 2017, 10-minute recordings of data were used for measuring actual ET, and also evaluating a relationship between ET and meteorological factors during from 2 Aug. to 6 Aug. The maximum daily ET of Cnidium officinale was $44.04{\pm}3.949g$ per hour in lysimetric measurements. Diurnal changes of ET was highly correlated with solar radiation ($r^2=0.7778$) and followed by wind speed ($r^2=0.6400$). But on the other hand, air temperature was not consistent with ET ($r^2=0.2260$). This results imply that ET of Cnidium officinaele seems to be mainly governed by radiation energy in clear days, and approximately 40% of solar radiation is likely to be converted into ET. Therefore, weighing lysimeter can be used to accurately estimate actual ET and is expected to attract a great deal of attention to reliable application of water management in agriculture.

• Journal of Life Science
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• v.28 no.12
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• pp.1455-1460
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• 2018

Due to a rapidly expanding aging population, the incidence of degenerative bone disease has increased, and efforts to handle the issue using regenerative medicine have become more important. In order to control various bone diseases such as osteoarthritis and osteoporosis, regenerative medicine utilizing adult stem cells has been extensively studied. And it is now clear that the mitochondrial energy metabolism, oxidative phosphorylation, is important for the process of stem cell differentiation. Interestingly, a recent study reported that salicylate promotes mitochondrial biogenesis by regulating the expression of $PGC-1{\alpha}$ in murine cells. However, the possible effects of salicylate on osteogenic differentiation through increased mitochondrial biogenesis in stem cells remain unknown. Thus, here we investigated whether salicylate could influence osteogenic differentiation and mitochondrial biogenesis of periosteum-derived mesenchymal stem cells (POMSCs). We found that salicylate treatments of POMSCs undergoing osteogenic differentiation increased the activity of alkaline phosphatase, a well-known early marker of bone cell differentiation. In addition, we observed that mitochondrial mass was increased by salicylate treatments in POMSCs. Together, these results indicate that salicylate can enhance osteogenic differentiation and mitochondrial biogenesis in POMSCs. Therefore, the findings in this study suggest that small molecules augmenting mitochondrial function such as salicylate can be a novel modulator for osteogenic differentiation and regenerative medicine.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.1
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• pp.127-136
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• 2019

Tunnel construction by TBMs should be supported by the performance of a screw conveyor in order to obtain the optimum penetration rate, so studies related to the screw conveyor performance have been being conducted. Compared to the study on the performance of the screw conveyor for the soil, however, the research on the performance of the screw conveyor for the rock is insufficient. Considering the domestic tunnel sites with more rock layers than soil layers, simulation of discharge of 6 types of rock chips by the screw conveyor was conducted using DEM. Regardless of the shape and volume of the rock chips, the discharge rates of the rock chips by the parallel placed screw conveyor at a speed of 10 RPM in the same rock mass were about 20% (standard deviation: 1.3%) of the maximum volume of discharge rate by the screw conveyor. It is expected that this study can be used as a reference material for screw conveyor design and operation in TBM excavations in rock masses.

• Clean Technology
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• v.27 no.3
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• pp.269-274
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• 2021

Bioenergy is generally considered to be one of the options for pursuing carbon neutrality. However, for a period of time, combustion of harvested plant biomass inevitably causes more carbon dioxide in the atmosphere than combustion of fossil fuels. This paper proposes a method that predicts and minimizes the total amount and payback period of this carbon debt. As a case study, a carbon cycle impact assessment was performed for immediate switching of the currently used fossil fuels to biomass. This work points out a fundamental vulnerability in the concept of carbon neutrality. As an action plan for the sustainability of bioenergy, formulas for afforestation proportional to the decrease in the forest area and surplus harvest proportional to the increase in the forest mass are proposed. The results of optimization indicate that the carbon debt payback period is about 70 years, and the carbon dioxide in the atmosphere increases by more than 50% at a maximum and 3% at a steady state. These are theoretically predicted best results, which are expected to be worse in reality. Therefore, biomass is not truly carbon neutral, and it is inappropriate as an energy source alternative to fossil fuels. The method proposed in this work is expected to be able to contribute to the approach to carbon neutrality by minimizing present and future carbon debt of the bioenergy that is already in use.

• (The)Study of the Eastern Classic
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• no.55
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• pp.59-84
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• 2014

This research is an attempt to newly interpret his academic evaluation and understand Seo Kye Bak Se-Dang's Sa Byeun Rok The Doctrine of the Mean. In academic world, his academic Characteristic was considered as anti-Neo-confucianism, out of Jung Ju Hak, out of Seong Ri Hak, and Sil Hak. His understanding of The Doctrine of the Mean was pretty critical, because he had unique academic characteristic to interpret Chinese classics rather than anti-Neo-confucianism, out of Jung Ju Hak, out of Seong Ri Hak, and Sil Hak. Especially, he took practical study with six Chinese classics as the central figure and it was a creative thing with philosophical method. He tried to find out original meaning which was essential thought of Confucianism, and pointed out disharmony for consistency about meaning of The Doctrine of the Mean when Jung Ja and Ju Ja interpreted The Doctrine of the Mean. It appeared as an effort of trying agreement between name and its duty, and role and function in things and act. In addition, he thought The Doctrine of the Mean as trying to follow nature, and it was the way of people to practice in bright side of mind. It is different from Ju Ja's thought which explains principle about people and things, and it has strong reality which is foundation of practice and allows dynamic energy of human life. Therefore, practice style of The Doctrine of the Mean develops filial duty as center of mass and appears manifestation of human's independence through how people pracice it. To sum up, he traced The Doctrine of the Mean as reality, practice, and physical science rather than ideal, theoretical, and metaphysical philosophy. It developed the spirit of study as understanding world as the center of human, thinking over the way of people, and studying the essence of Confucianism with practice of thought.