• Asian-Australasian Journal of Animal Sciences
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• 제16권4호
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• pp.473-480
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• 2003

In order to control the genetic background noise in QTL mapping, cofactor markers were incorporated in single marker analysis (SMACO) and interval mapping (CIM). A simulation was performed to see how effective the cofactors were by the number of QTL, the number and the type of markers, and the marker spacing. The results of QTL mapping for the simulated data showed that the use of cofactors was slightly effective when detecting a single QTL. On the other hand, a considerable improvement was observed when dealing with more than one QTL. Genetic background noise was efficiently absorbed with linked markers rather than unlinked markers. Furthermore, the efficiency was different in QTL mapping depending on the type of linked markers. Well-chosen markers in both SMACO and CIM made the range of linkage position for a significant QTL narrow and the estimates of QTL effects accurate. Generally, 3 to 5 cofactors offered accurate results. Over-fitting was a problem with many regressor variables when the heritability was small. Various marker spacing from 4 to 20 cM did not change greatly the detection of multiple QTLs, but they were less efficient when the marker spacing exceeded 30 cM. Likelihood ratio increased with a large heritability, and the threshold heritability for QTL detection was between 0.30 and 0.05.

• Molecules and Cells
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• 제20권2호
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• pp.201-209
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• 2005

We have constructed an AFLP-based linkage map of Japanese red pine (Pinus densiflora Siebold et Zucc.) using haploid DNA samples of 96 megagametophytes from a single maternal tree, selection clone Kyungbuk 4. Twenty-eight primer pairs generated a total of 5,780 AFLP fragments. Five hundreds and thirteen fragments were verified as genetic markers with two alleles by their Mendelian segregation. At the linkage criteria LOD 4.0 and maximum recombination fraction 0.25(${\theta}$), a total of 152 markers constituted 25 framework maps for 19 major linkage groups. The maps spanned a total length of 2,341 cM with an average framework marker spacing of 18.4 cM. The estimated genome size was 2,662 cM. With an assumption of equal marker density, 82.2% of the estimated genome would be within 10 cM of one of the 230 linked markers, and 68.1% would be within 10 cM of one of the 152 framework markers. We evaluated map completeness in terms of LOD value, marker density, genome length, and map coverage. The resulting map will provide crucial information for future genomic studies of the Japanese red pine, in particular for QTL mapping of economically important breeding target traits.

• 한국해양공학회지
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• 제20권4호
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• pp.31-36
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• 2006

Numerical schemes for spacing and time are tested to accurately simulate the wave propagation. The tested numerical schemesinclude 2nd-order central differencing, l-order upwind scheme, 2nd-order Leith scheme, 3rd-order MUSCLE, QUICK and QUICKEST schemes in spacing and the Euler and 4th-order Runge-Kutta(R-K) schemes in time. It is seen that more accurate results are expected when the higher-order schemes, especially the schemes combined with a TVD control limiter, are used for solving the wave equation. The 3rd-order upwind scheme with limiter and the 4th-order R-K scheme in tim￡ are finally applied to the wave-making simulation in a digital wave tank.

• 대한조선학회논문집
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• 제29권3호
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• pp.117-124
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• 1992

시리즈 60과 실제 선형주위의 파도를 MAC(Marker And Cell) 법에 의해 격자간격이 변화하는 Staggered좌표계에서 계산하였다. 지배방정식으로는 오일러(Euler) 방정식을 채택하였다. 계산된 파고는 계측된 파고와 잘 일치하고 있어 MAC 법이 유효함을 보여주고 있다. 한편, 비점성 불안정성 해석에 의해 유도된 Sub-breaking파 출현의 임계조건이 비대선수주위의 계산된 결과에 적용되었다. 이 유도된 임계조건이 Sub-breaking파의 출현을 잘 탐지하는 것을 확인하였다.

• Genomics & Informatics
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• 제7권3호
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• pp.152-158
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• 2009

Although the genetic basis for bone mineral density (BMD) has been studied by many groups so far, genes responsible for this complex trait has not been completely revealed. In order to localize quantitative trait loci (QTLs) for BMD variation in Asian population, the study was designed using a group of Mongolian population, a genetically closed population with a homogeneous lifestyle. BMD was measured at the left and right wrists and ankles using DEXA in 1,082 participants from 142 families. Genotyping of 13 polymorphic microsatellite markers on chromosome 13 (average spacing 8-9 cM) and two-point and multipoint linkage analysis were performed. In two-point linkage analysis, we identified two markers, D13S175 (6.03 cM) and D13S265 (68.73 cM) that had LOD scores greater than 1 for left ankle (LOD=2.09, LOD=1.49, respectively). We also found a marker D13S175 (6.03 cM) with a high LOD for left wrist (LOD=1.49) and the markers D13S265 (68.73 cM) and D13S217 (17.21 cM) for the right wrist (LOD= 1.82, LOD= 1.62, respectively). Among these significant marker regions, only two regions at 17 cM (13p11) and 65 cM (13q21) for the right wrist overlapped with major QTLs reported in following multipoint linkage analysis (LOD= 1.7549, LOD=1.4462, respectively). This study provides the possible evidence of the presence of QTLs affecting right wrist BMD in Mongolian populations on 13p11 and 13q21. Modest evidence was also found for genes affecting left ankle and left wrist BMD on 13p13.

• 한국과학교육학회지
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• 제35권4호
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• pp.649-663
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• 2015

과학교육 논문의 글쓰기 실태를 한국어 기초 문법과 번역투의 측면에서 조사하고 그 개선점을 찾아보았다. 과학교육 연구는 사회과학과 자연과학의 특성을 모두 나타내며 양적 연구를 더 많이 하는 특징이 있어 논문 글쓰기 방식에 영향을 미칠 수 있다. 이 연구에서 번역투는 순수한 한국어가 아닌 외국어에서 유래한 상투적 표현을 말한다. 한국어 기초 문법은 호응의 문제, 맞춤법 띄어쓰기 문장 부호의 문제, 사동표현의 문제, 무분별한 영어 사용의 문제로 정리하였고, 번역투는 영어번역의 문제, 일본어 번역의 문제, 영어와 일본어 번역의 문제로 구분하였다. 이에 따라 한국과학교육학회지 한 호에 실린 논문 9편의 글쓰기 중에서 한국어 기초 문법에 어긋나는 사례와 번역투에 해당하는 사례를 찾아 문제를 논의하고 대안을 제시하였다. 빈도가 높은 문제사례는 '~적', '영어 사용', '복수 표현', '하다류 피동', '~고 있는', '~을 통하여', '~에 대하여', '가지다', '관형격조사 ~의', '사물주어 수동태', '사동(시키다)' 등이었다. 연구 결과에 기초하여 과학교육 소논문의 글쓰기 특징을 '양적 연구의 글쓰기', '학술 연구의 객관적 글쓰기', '외국에서 유래한 연구의 글쓰기' 세 가지로 정리하였다. 과학교육 논문 글쓰기에 나타나는 문제를 개선하기 위해 과학교육 연구자는 한국어 기초 문법과 번역투에 관심을 기울이고, 구체적인 사례와 내용을 숙지할 필요가 있다. 이 연구의 결과는 한국어 글쓰기 교육과 문법 교육에 활용할 수 있다.