• Journal of The Korean Society of Integrative Medicine
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• v.10 no.4
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• pp.261-275
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• 2022

Purpose : According to the Korean Diabetes Association, the number of metabolic disease patients in Korea is approximately 14.97 million as of 2020;, the prevalence of diabetes among adults over 30 years old is 44.3 %, and the prevalence of diabetes in the elderly over 65 years old is 50.4%. These individuals exposed to the risk of complications. Therefore, the purpose of this study was to determine a distribution method for a customized fusion exercise marine healing program for metabolic disease patients. Methods : We have searched numerous papers concerning artificial intelligence (AI), virtual reality (VR), augmented reality (AR), and marine resources related to marine healing programs that can be introduced in marine healing centers for people with metabolic diseases Results : Through the production of various marine resources and evidence-based exercise programs, the provision of exercise programs using AI, and the development of exercise platforms using AR and VR, we were able to establish guidelines for how to operate marine healing programs at marine healing centers. Conclusion : Korea has much more diverse marine healing resources than other advanced countries in the marine healing industry. However, the development of these resources has only just begun. It is hoped that the studied marine healing program will be of great help to metabolic patients by creating contents that will be implemented in marine healing centers by using the cutting-edge technologies and various marine resources that Korea possesses.

• Journal of the Korean Association of Geographic Information Studies
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• v.22 no.4
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• pp.146-157
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• 2019

This study, as a pilot study to implement and extend the marine healing which has been rapidly extending oversea areas into the domestic market, has collected seven major marine healing resources such as ocean water, sand, salt, mud, seaweeds, forest, and weather targeting selected four pilot municipalities and established a GIS DB. Furthermore, web GIS based marine healing portal has been established to support the easier utilization of the GIS DB and various marine healing related contents, thereby facilitating expansion of related industry. The portal includes marine thematic maps as well as research papers, related therapy manuals, and various activities and programs of the pilot municipalities. It is expected that the portal would contribute to the expansion of the domestic marine healing industry significantly through the pilot operation of the portal, not to mention of the needs of subsequent studies for expansion of the marine GIS DB and securing more various contents.

• Journal of Wetlands Research
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• v.25 no.4
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• pp.386-393
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• 2023

The domestic marine healing industry is undergoing significant revitalization efforts, with a focus on understanding the efficacy and effectiveness of marine healing resources. This study establishes utilization and management standards through a detailed analysis of the active components within well-recognized marine healing mud materials. Samples of mud materials were collected from domestic tidal flats. These samples exhibited an average composition of 7.87% sand, 74.95% silt, and 17.17% clay, with a combined mud content (silt+clay)(silt+clay) consistently exceeding 90%. Notably, SiO₂ emerged as the most prevalent effective ingredient at 68.4%, followed by Al₂O₃ (13.3%)>Fe₂O₃ (4.0%)>K₂O (2.9%)>Na₂O (2.3%)>MgO (1.6%)>CaO (1.0%)>TiO₂ (0.7%), in terms of average content. Subsequently, through an analysis of effective ingredients, Si, Al, Fe, K, Na, Mg, and Ca were identified as elements demonstrating significant functionality. Among these, key indicator ingredients were selected for quality control, all of which were found to possess efficacious properties. Notably, K, Mg, and Ca exhibited particularly high concentrations. Based on these findings and referencing existing literature, it is recommended that domestic tidal flat mud resources earmarked for utilization as marine healing resources should possess a raw material mud content of no less than 70.0%. Moreover, the cumulative index components K₂O+MgO+CaO should meet or exceed a threshold of 5.0% for optimal effectiveness.

• Korean Journal of Agricultural Science
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• v.51 no.1
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• pp.9-23
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• 2024

This study investigates the physiological and psychological effects of a nature-based outdoor activity program in an environment reflecting the characteristics of forest and coastal areas on 30 firefighters (average age: 40.4 ± 9.8 years) who are frequently exposed to dangerous situations. Blood pressure, pulse pressure, and heart rate variability were used as physiological measurement indicators, and the Korean versions of PANAS (positive affect and negative affect schedule), WEMWBS (Warwick-Edinburgh mental well-being scale), and PRS (perceived restorativeness scale) were used as psychological measurement indicators. For four days and three nights, the participants experienced programs at Hallyeohaesang Nature Center and the surrounding mountains, seas, and islands, utilizing forest resources such as trekking on forest trails, walking barefoot, taking aromatic footbaths, meditating in forest oxygen domes, and lying on relaxation chairs, and programs utilizing marine resources such as taking a boat to an island, walking on forest trails with seascape views, and sailing on a yacht. Participants' systolic blood pressure and pulse pressure decreased, and participants' positive emotions increased and negative emotions decreased after the program. There was a statistically significant increase in mental well-being and perceived restorative environment. Through this study, it was found that nature-based outdoor activity programs based on forest and marine resources are effective in physiological and psychological stability of firefighters. It is hoped that the results of this study will be applied to other high-risk workers for PTSD, who have high stress levels, by combining forest healing and marine healing, and expanding the scope and diversity of programs in more diverse environments and conditions.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.3
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• pp.95-106
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• 2023

Korean healing research has developed over the past 20 years along with the growing social interest in healing. The field of healing research is diverse and includes legislated natural-based healing. In this study, abstracts of 2,202 academic journals, master's, and doctoral dissertations published in KCI and RISS were collected and analyzed. As for the research method, LDA topic modeling used to classify research topics, and time-series publication trends were examined. As a result of the study, it identified that the topic of Korean healing research was connected with 5 types and 4 mediators. The five were "Healing Tourism," "Mind and Art Healing," "Forest Therapy," "Healing Space," and "Youth Restoration and Healing," and the four mediators were "Forest," "Nature," "Culture", and "Education". In addition, only legalized healing studies extracted from Korean healing research and the topics were analyzed. As a result, legalized healing research classified into four. The four types were "Healing Spatial Environment Plan", "Healing Therapy Experiment", "Agricultural Education Experiential Healing", and "Healing Tourism Factor". Forest Therapy, which has the largest amount of research in legalized healing, Agro Healing and Garden Healing which operate similar programs through plants, and Marine Healing using marine resources also analyzed. As a result, topics that show the unique characteristics of individual healing studies and topics that are considered universal in all healing studies derived. This study is significant in that it identified the overall trend of research on Korean healing facilities and programs by utilizing LDA topic modeling.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.4
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• pp.121-136
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• 2022

Purpose : Marine therapy is an activity that promotes public health such as constitution improvement, immunity improvement, and anti-aging by utilizing marine therapeutic resources such as seawater, mud, seaweed, salt and sea climate. In Europe developed countries, the marine therapy industry has been developing for centuries, with France, Germany, and Israel leading the way. Currently, it has achieved great industrial achievements and is of great help in improving the human health. The purpose of this study is to investigate how marine therapeutic resources benefit to human health, as well as how to study and utilize their efficacy. We analyzed previous research articles related to the effects of marine therapeutic resources. Methods : The study included a total of 830 published literatures in the last 20 years from the Republic of Korea and other contries. PubMed and Google Scholar were utilized to collect the foreign source while the local scientific publications were accessed through the Korean Education and research Information Service (KERIS) and Korean studies Information Service System (KISS). The keywords used to search foreign literature were "marine therapy", "Thalassotherapy", "seawater", "deep seawater", "saline groundwater", "sand therapy", "mud therapy", "hydrotherapy", "seaweed", "Sun light", "sea salt", "marine animal", and "marine microorganisms" were combined, and for the domestic literature, the keywords were "marine therapy", "marine therapeutic resources", "seawater", and "sand". Results : A total of 830 research papers were found as a result of searching for domestic and international papers related to marine therapeutic resources. The collected documents were classified into 175 seawater resources, 259 marine mineral resources, 41 marine environment, and 355 marine organisms. The efficacy of each marine therapeutic resources was analyzed. By resources type, there were about 213 papers on the efficacy of seaweed, followed by about 175 papers on seawater, 142 on microorganisms, 124 on mud/peat, and sand, salt, minerals and others are appeared in order (Table 1). Conclusion : Korea has the highest marine biodiversity index, excellent tidal flats, four distinct seasons, and various sea environments of the East sea, Yellow sea, South sea and Jeju sea. For this reason, Korea has a much more diverse marine therapeutic resources than other advanced countries in the marine therapy industry. prebiously, we thought that the sea was only valuable as a shipping port and fishery industry. But now, it been shown that the ocean can become a new industrial field which can contribute to human health and well-being by providing healing and therapy to people through the gift of marine resources.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2018.05a
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• pp.17-18
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• 2018

19세기 이전부터 유럽에서는 해양치유자원을 이용한 치유요법인 탈라소테라피(Thalassotherapy)가 국민들의 건강을 지켜오고 있다. 탈라소테라피(Thalassotherapy)란 바다를 뜻하는 그리스어 'Thalassa'와 치료를 뜻하는 'Therapy'가 합쳐진 말로 해양치유자원을 이용해 신체적 정신적 건강을 증진시키는 활동을 뜻한다. 최근 우리나라에도 건강한 삶을 추구하는 인식의 변화 속에 다양한 해양치유자원을 이용하는 해양치유의 수요가 증가하고 있다. 본 논문에서는 해양치유산업의 활성화를 위한 해양치유자원의 현황 및 활용방안에 대해 연구하였다. 우리나라 해양치유자원의 분포를 확인하기 위해 동해, 서해, 남해, 제주도 등 4개의 권역으로 구분하여 전국을 대상으로 총괄도를 제작하였으며 국내외 해양치유자원을 이용해 작성된 문헌을 통해 해양치유자원의 이용현황에 대해 조사하였다. 또한 해양치유산업 선진국인 독일, 프랑스, 일본을 모델로 우리나라에 맞는 해양치유자원 적합기준을 연구하였다. 그 결과, 각 지역별 해양치유자원은 경기도:(머드, 염생식물, 염지하수, 해조류), 충청남도:(머드, 해조류, 천일염, 해조류), 전라북도:(머드, 염생식물, 해조류 해풍), 전라남도:(해조류, 해수, 천일염, 머드 해풍), 제주도:(용암해수, 염지하수, 태양광, 해수욕장), 강원도:(심층수, 태양광, 해조류, 해송림), 경상남도:(해조류, 해수욕장, 태양광, 해풍), 경상북도:(해조류, 태양광, 심층수, 염지하수, 해송림), 울산:(해조류, 태양광), 부산 :(해조류, 해수욕장, 태양광)이 있었으며 해양치유 자원을 이용해 작성된 국내외 논문은 265편(해수:101편, 머드:27편, 소금:12편, 해양환경:39편, 해양생물:18편, 해조류:68편)이 있었다. 해양치유자원 적합기준은 각 나라별 해양치유자원의 이용기준을 활용하여 자원별로 제시하였다.

• Mycobiology
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• v.49 no.6
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• pp.551-558
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• 2021

The Federated States of Micronesia (FSM) is an island country in the western Pacific and is a known biodiversity hotspot. However, a relatively small number of fungi (236 species) have been reported till July 2021. Since fungi play major ecological roles in ecosystems, we investigated the fungal diversity of FSM from various sources over 2016 and 2017 and constructed a local fungal inventory, which also included the previously reported species. Fruiting bodies were collected from various host trees and fungal strains were isolated from marine and terrestrial environments. A total of 99 species, of which 78 were newly reported in the FSM, were identified at the species level using a combination of molecular and morphological approaches. Many fungal species were specific to the environment, host, or source. Upon construction of the fungal inventory, 314 species were confirmed to reside in the FSM. This inventory will serve as an important basis for monitoring fungal diversity and identifying novel biological resources in FSM.

• Journal of Marine Bioscience and Biotechnology
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• v.7 no.2
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• pp.58-70
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• 2015

Injectable RGD-bioconjugated Mussel Adhesive Proteins (RGD-MAPs) composite hydroxypropyl methylcellulose (HPMC) hydrogels provide local periodontal tissue for bone filling in periodontal surgery. Previously we developed a novel type of injectable self-supported hydrogel (2 mg/ml of RGD-MAPs/HPMC) based porcine nano hydroxyapatite (MPH) for dental graft, which could good handling property, biodegradation or biocompatibility with the hydrogel disassembly and provided efficient cell adhesion activity and no inflammatory responses. Herein, the aim of this work was to evaluate bone formation following implantation of MPH and collagen membrane in rabbit calvarial defects. Eight male New Zealand rabbits were used and four circular calvarial defects were created on each animal. Defects were filled with different graft materials: 1) collagen membrane, 2) collagen membrane with MPH, 3) collagen membrane with bovine bone hydroxyapatite (BBH), and 4) control. The animals were sacrificed after 2 and 8 weeks of healing periods for histologic analysis. Both sites receiving MPH and BBH showed statistically increased augmented volume and new bone formation (p < 0.05). However, there was no statistical difference in new bone formation between the MPH, BBH and collagen membrane group at all healing periods. Within the limits of this study, collagen membrane with MPH was an effective material for bone formation and space maintaining in rabbit calvarial defects.

• Journal of Life Science
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• v.33 no.9
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• pp.703-712
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• 2023

Angiogenesis, the formation of blood vessels from pre-existing vessels, is a multistep process regulated by modulators of angiogenesis. It is essential for various physiological processes, such as embryonic development, chronic inflammation, and wound repair. Dysregulation of angiogenesis causes many diseases, such as cancer, autoimmune diseases, rheumatoid arthritis, cardiovascular disease, and delayed wound healing. However, the number of effective anti-angiogenic drugs is limited. Recent research has focused on identifying potential drug candidates from natural sources. For example, marine natural products have been shown to have anti-cancer, anti-oxidant, anti-inflammatory, antiviral, and wound-healing effects. Thus, this study aimed to describe the angiogenesis inhibitory effect of Hizikia fusiforms (brown algae) extract. The hexane extract of H. fusiformis has shown inhibitory effects on in vitro angiogenesis assays, such as cell migration, invasion, and tube formation in human umbilical vein endothelial cells (HUVECs). The hexane extract of H. fusiformis (HFH) inhibited in vivo angiogenesis in a mouse Matrigel gel plug assay. In addition, the protein expression of vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/extracellular signal kinase, and AKT serine/threonine kinase 1 decreased following treatment with H. fusiformis extracts. Our results demonstrated that the hexane extract of H. fusiformis (HFH) inhibits angiogenesis in vitro and in vivo.