• Computers and Concrete
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• v.10 no.4
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• pp.331-347
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• 2012

This paper describes the varying material model, the analysis method and the software development for reinforced concrete circular columns confined by spiral or hoop transverse steel reinforcement and subjected to eccentric loading. The widely used Mander model of concentric loading is adapted here to eccentric loading by developing an auto-adjustable stress-strain curve based on the eccentricity of the axial load or the size of the compression zone to generate more accurate interaction diagrams. The prediction of the ultimate unconfined capacity is straight forward. On the other hand, the prediction of the actual ultimate capacity of confined concrete columns requires specialized nonlinear analysis. This nonlinear procedure is programmed using C-Sharp to build efficient software that can be used for design, analysis, extreme event evaluation and forensic engineering. The software is equipped with an elegant graphics interface that assimilates input data, detail drawings, capacity diagrams and demand point mapping in a single sheet. Options for preliminary design, section and reinforcement selection are seamlessly integrated as well. Improvements to KDOT Bridge Design Manual using this software with reference to AASHTO LRFD are made.

• Earthquakes and Structures
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• v.7 no.4
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• pp.463-484
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• 2014

Solid piers with a rounded rectangular cross-section are widely used in railway bridges for high-speed trains in China. Compared to highway bridge piers, these railway bridge piers have a larger crosssection and less steel reinforcement. Existing material models cannot accurately predict the seismic behavior of this kind of railway bridge piers. This is because only a few parameters, such as axial load, longitudinal and transverse reinforcement, are taken into account. To enable a better understanding of the seismic behavior of this type of bridge pier, a simultaneous influence of the various parameters, i.e. ratio of height to thickness, axial load to concrete compressive strength ratio and longitudinal to transverse reinforcements, on the failure characteristics, hysteresis, skeleton curves, and displacement ductility were investigated. In total, nine model piers were tested under cyclic loading. The hysteretic response obtained from the experiments is compared with that obtained from numerical studies using existing material models. The experimental data shows that the hysteresis curves have significantly pinched characteristics that are associated with small longitudinal reinforcement ratios. The displacement ductility reduces with an increase in ratio of axial load to concrete compressive strength and longitudinal reinforcement ratio. The experimental results are largely in agreement with the numerical results obtained using Chang-Mander concrete model.

• Structural Engineering and Mechanics
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• v.10 no.6
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• pp.589-601
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• 2000

A simplified analysis procedure utilizing the strut-tie modeling technique is developed to take a close look into the post-elastic deformation capacity of beam-column connections in ductile reinforced concrete frame structures. Particular emphasis is given to the effect of concrete strength decay and quantity and arrangement of joint shear steel. For this a fan-shaped crack pattern is postulated through the joints. A series of hypothetical rigid nodes are assumed through which struts, ties and boundaries are connected to each other. The equilibrium consideration enables all forces in struts, ties and boundaries to be related through the nodes. The boundary condition surrounding the joints is obtained by the mechanism analysis of the frame structures. In order to avoid a complexity from the indeterminacy of the truss model, it is assumed that all shear steel yielded. It is noted from the previous research that the capacity of struts is limited by the principal tensile strain of the joint panel for which the strain of the transverse diagonal is taken. The post-yield deformation of joint steel is taken to be the only source of the joint shear deformation beyond the elastic range. Both deformations are related by the energy consideration. The analysis is then performed by iteration for a given shear strain. The analysis results indicate that concentrating most of the joint steel near the center of the joint along with higher strength concrete may enhance the post-elastic joint performance.

• Journal of Korean Society of Steel Construction
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• v.15 no.1
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• pp.1-8
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• 2003

In locations where the cost of concrete is relatively high or in situations where the weight of concrete members has to be kept to a minimum, it may be more economical to use hollow reinforced concrete vertic al members. Hollow reinforced concrete colun-ms with a low axial load, a moderate longitudinal steel percentage and a reasonably thick wall were found to perform in a ductile manner at the flexural strength, similar to solid columns. Hollow reinforced concrete columns with a high axial load, a high longitudinal steel percentage, and a thin wall were found, however, to behave in a brittle manner at the flexural strength, since the neutral axis is forced to occur away from the inside face of the tube towards the section centroid and, as a result, crushing of concrete occurs near the unconfined inside face of the section. If, however, a steel tube is placed near the inside face of a circular hollow column, the column can be expected not to fail in a brittle manner through the disintegration of the concrete in the compression zone. A design recommendation and example through the moment-curvature analysis program for curvature ductility are herein presented. A theoretical moment-curvature analysis for reinforced concrete columns, indicating the available flexural strength and ductility, can be conducted, providing that the stress-strain relation for the concrete and steel are known. In this paper, a unified stress-stain model for confined concrete by Mander is developed foi members with circular sections.

• Proceedings of the KSR Conference
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• 2002.05a
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• pp.183-188
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• 2002

In locations where the cost or concrete is relatively high, or in situations where the weight or concrete members is to be kept to a minimum, it may be economical to use hollow reinforced concrete vertical members. Hollow reinforced concrete columns with low axial load, moderate longitudinal steel percentage, and a reasonably thick wall were found to perform in a ductile manner at the flexural strength, similar to solid columns. However, hollow reinforced concrete columns with high axial load, high longitudinal steel percentage, and a thin wall were found to behave in a brittle manner at the flexural strength, since the neutral axis is forced to occur away from the inside face of the tube towards the section centroid and, as a result, crushing of concrete occurs near the unconfined inside face of the section. If, however, a steel tube is placed near the inside face of a circular hollow column, the column can be expected not to fail in a brittle manner by disintegration of the concrete in the compression zone. Design recommendation and example by moment-curvature analysis program for curvature ductility are presented. Theoretical moment-curvature analysis for reinforced concrete columns, indicating the available flexural strength and ductility, can be conducted providing the stress-strain relation for the concrete and steel are known. In this paper, a unified stress-stain model for confined concrete by Mander is developed for members with circular sections.

• Journal of Korean Society of Steel Construction
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• v.19 no.1
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• pp.43-52
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• 2007

There is a growing range of applications for concrete-filled steel tube (CFT) member because of its superior performance. But a CFT member may be uneconomical or has weight problems because it is fully filled with concrete. In this study, a new type of member, called internally confined hollow (ICH) CFT member, was developed to solve the high cost and weight problems of the CFT member. To determine stress-strain model of the concrete in an ICH CFT column, possible failure modes of an ICH CFT column were suggested and confining pressure was derived from equilibriums for each failure mode. From the derived equations, a computer program was coded and parametric studies were performed for some examples. Analytical results showed that internally confined concrete has enhanced strength and ductility compared with those of unconfined or biaxially confined concrete.

• International Journal of Concrete Structures and Materials
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• v.11 no.1
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• pp.135-149
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• 2017

The prediction of the actual ultimate capacity of confined concrete columns requires partial confinement utilization under eccentric loading. This is attributed to the reduction in compression zone compared to columns under pure axial compression. Modern codes and standards are introducing the need to perform extreme event analysis under static loads. There has been a number of studies that focused on the analysis and testing of concentric columns. On the other hand, the augmentation of compressive strength due to partial confinement has not been treated before. The higher eccentricity causes smaller confined concrete region in compression yielding smaller increase in strength of concrete. Accordingly, the ultimate eccentric confined strength is gradually reduced from the fully confined value $f_{cc}$ (at zero eccentricity) to the unconfined value $f^{\prime}_c$ (at infinite eccentricity) as a function of the ratio of compression area to total area of each eccentricity. This approach is used to implement an adaptive Mander model for analyzing eccentrically loaded columns. Generalization of the 3D moment of area approach is implemented based on proportional loading, fiber model and the secant stiffness approach, in an incremental-iterative numerical procedure to achieve the equilibrium path of $P-{\varepsilon}$ and $M-{\varphi}$ response up to failure. This numerical analysis is adapted to assess the confining effect in rectangular columns confined with conventional lateral steel. This analysis is validated against experimental data found in the literature showing good correlation to the partial confinement model while rendering the full confinement treatment unsafe.

• Journal of the Korea Concrete Institute
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• v.14 no.4
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• pp.578-588
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• 2002

An experimental study was conducted to investigate the effectiveness of transverse reinforcement in reinforced concrete tied columns subjected to monotonically increasing axial compression. Eighteen large-scale columns(260$\times$260$\times$1200 mm) were tested. Effects of main variables such as the concrete compressive strength, the tie configuration, the transverse reinforcement ratio, the tie spacing, and the spatting of the concrete cover were considered. High-strength concrete columns under concentric axial loads show extremely brittle behavior unless the columns are confined with transverse reinforcement that can provide sufficiently high lateral confinement pressure There is a consistent decrease in deformability of column specimen with increasing concrete strength. Test results were compared with the previous confinement model such as modified Kent-Park, Sheikh-Uzumeri, Mander, and Saatcioglu-Razvi model. The comparison indicates that many previous models for confined concrete overestimate or underestimate the ductility of confined concrete.

• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.331-341
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• 2021

Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer arises in the context of hepatic inflammation, such as hepatitis B virus and hepatitis C virus infection. Despite significant improvements in the therapeutic modalities for liver cancer, patient prognosis is not satisfactory due to the limited efficacy of current drug therapies in anti-metastatic activity. Therefore, developing new effective anti-cancer agents with anti-metastatic activity is important for the treatment of liver cancer. In this study, SP-8356, a verbenone derivative with anti-inflammatory activity, was investigated for its effect on the growth and migration of liver cancer cells. Our findings demonstrated that SP-8356 inhibits the proliferation of liver cancer cells by inducing apoptosis and suppressing the mobility and invasion ability of liver cancer cells. Functional studies revealed that SP-8356 inhibits the mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways, which are related to cell proliferation and metastasis, resulting in the downregulation of metastasis-related genes. Moreover, using an orthotopic liver cancer model, tumor growth was significantly decreased following treatment with SP-8356. Thus, this study suggests that SP-8356 may be a potential agent for the treatment of liver cancer with multimodal regulation.