• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5995-6000
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• 2013

Background: Nausea and vomiting after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) are common in clinical practice, but few studies have reported the incidence and risk factors of such events. Objective: The purpose of this study was to analyze the incidence and risk factors of nausea and vomiting after TACE for HCC. Methods: This study was a single-center retrospective analysis of a prospectively maintained database. Between May 2010 and October 2012, 150 patients with HCC were analyzed for incidence and preprocedural risk factors. Results: The incidence of postembolization nausea and vomiting was 38.8% and 20.9%, respectively, in patients with HCC. Patients who developed nausea had lower levels (<100 IU/L) of serum alkaline phosphatase (ALP) compared to those without nausea ($123.04{\pm}69.38$ vs. $167.41{\pm}138.95$, respectively, p=0.044). Female gender correlated to a higher incidence of nausea as well (p=0.024). Patients who developed vomiting, compared to those who did not, also had lower levels (<100 IU/L) of serum ALP ($112.52{\pm}62.63$ vs. $160.10{\pm}127.80$, respectively, p=0.010), and serum alanine transferase (ALT) ($35.61{\pm}22.87$ vs. $4.97{\pm}29.62$, respectively, p=0.045). There were no statistical significances in the incidences of nausea and vomiting between male patients over 50 years old and female patients who have entered menopause (p=0.051 and p=0.409, respectively). Multivariate analysis by logistic regression analysis demonstrated that female gender and ALP>100 IU/L were the most independent predictive factors of postembolization nausea (odds ratio (OR): 3.271, 95% CI: 1.176-9.103, p=0.023 and OR: 0.447, 95% CI: 0.216-0.927, p=0.030, respectively). ALP>100 IU/L was also the most independent predictive risk factor of postembolization vomiting (OR: 0.389, 95% CI: 0.159-0.952, p=0.039). Conclusions: Postembolizaiton nausea and vomiting are common in patients with HCC. Recognition of the risk factors presented above before TACE is important for early detection and proper management of postembolization nausea and vomiting. Nevertheless, future studies are required.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1153-1163
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• 2019

In women, obesity rises with menopause. By comparing the dose-dopendent effects of genistein on regulation of body weight and lipid levels with swimming exercise in female ovariectomized (OVX) mice, an animal model of postmenopausal women, the effective dose of genistein on obesity control was investigated. Ovariectomized female mice were divided into control group, swimming exercise group and genistein concentration (0.005%, 0.05%, 0.1% wt/wt) treatment group and all mice fed high-fat diet for 8 weeks. The three different genistein doses as well as swimming decreased body weight, white adipose tissue mass, plasma lipid levels and lipid accumulation in liver, compared with control OVX mice. These decrease effectiveness of genistein showed dose-dependent manner, and is most effective at 0.1% genistein concentration, and paralleled effects of swimming on body weight, white adipose tissue, plasma lipid levels and lipid accumulation in liver. This present findings indicate that optimal dose of genistein in feamle OVX mice have a similar effect to swimming exercise on improvement of obesity. Intake of dietary genistein supplements will help obesity prevention in postmenopausal women.

• Journal of dental hygiene science
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• v.13 no.4
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• pp.393-402
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• 2013

The purpose of this study was to examine the relationship between vitamin D and periodontal diseases based on the raw data of the 5th National Health & Nutrition Examination Survey of 2010. The subjects in this study were 1,327 people, and those whose data on major variables were missing and who suffered from diabetes and/or osteoporosis were excluded. As for data analysis, R2.15.1 program and PASW Statistics 18.0 were utilized. The findings of the study were as follows: 1. As for all the respondents aged 50 and up, there was no significant relationship between vitamin D and periodontal diseases. 2. As for the post-menopausal women including the women who underwent bilateral ovariectomy, the vitamin D-deficit group 1 (<10) were 6.66-fold more likely to suffer from periodontal diseases than the vitamin D-sufficient group (${\geq}30$) (OR, 6.66; 95% CI, 1.004~44.19). The above-mentioned findings ascertained that vitamin D had a significant negative correlation to periodontal diseases among the post-menopausal women including the women who underwent bilateral ovariectomy. This finding should be taken into account in terms of the prevention and management of periodontal diseases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.6
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• pp.2579-2588
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• 2012

The purpose of this study was to examine the relations between fatigue, family function and self-esteem among middle-aged women in menopausal periods. Data were collected through self-administered questionnaire survey form 133 middle-aged women. The data collection was done from March 2nd to April 10th, 2012. As a results, there were significant differences in fatigue by education level and menstrual status. And, there were significant differences in family function according to education level and marital status. Also, there were significant differences in self-esteem by education level, marital status and monthly income. Fatigue was negatively related to family function and self-esteem. And family function was positively related to self-esteem. These results suggest that nursing intervention should be developed to strengthen family function and self-esteem as a way to regulate fatigue for middle-aged women in menopausal periods. Especially, it is necessary to pay more attention to health management of middle-aged women belonging to menopausal transition, with low-income, low-education level.

• Journal of the Korea Convergence Society
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• v.9 no.5
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• pp.77-83
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• 2018

We investigated the age-related BMD, accumulated bone loss rate and peak BMD at Lumbar spine, total hip in Korean using data from KNHANES (the 1st(2010), 2nd(2011) and year at the 5th survey). We found that the cubic regression model was the best for describing age-related changes in BMD. Lumbar spine, total hip in bone mineral density difference were analyzed using ANOVA. This showed that the peak BMD was at the age of 20-24 years at lumbar spine, total hip and the bone loss rate was the highest in the lumbar spine at 75-79 years and the total hip was 80 years or older in the men. This showed that the peak BMD was at the age of 40-44 years at lumbar spine, total hip and the bone loss rate was the highest in the lumbar spine at 70 years or older and the total hip was 75-79 years older, 80 years old, 55-59 years old in the women. Therefore, in men, 75 years or older to increase the rate of osteoporosis screening, and women in their 50s and older menopause related management strategies to manage osteoporosis will be needed.

• Korean Journal of Psychosomatic Medicine
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• v.23 no.1
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• pp.57-65
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• 2015

Objectives:Within the normal reproductive cycles of women, dramatic fluctuations of sexual hormones occur in the premenstrual and menopausal periods. In both periods, women are vulnerable to mood disturbances and show several somatic complaints. Based on these common clinical profiles and physiological changes, a relationship between vasomotor symptoms and the premenstrual syndrome has been suggested. However, attempts to establish such a link have yielded inconclusive results. The purpose of this study was to investigate the association between histories of premenstrual syndrome and menopausal vasomotor symptoms within different menopausal stages. Methods:This cross-sectional study recruited Korean women aged 45-64 years who were perimenopausal and postmenopausal from 16 branch offices of the Korean Association of Health Promotion. All subjects completed self-report questionnaires that asked about a history of premenstrual syndromes, vasomotor symptoms, and several other variables. Results:A total of 1054 participants(361 perimenopausal women and 693 postmenopausal women) completed the study. Severity of premenstrual symptoms significantly correlated with postmenopausal vasomotor symptoms, only in late perimenopausal(r=0.213, p=0.010) and early postmenopausal women(r=0.246, p<0.001). After adjusting for several factors related to vasomotor symptoms, a history of premenstrual syndrome was a significant predictor of moderate to very severe vasomotor symptoms in late perimenopausal(OR=5.197, p=0.005) and early postmenopausal women(OR=3.017, p=0.010). Conclusions:This study suggests that a history of premenstrual syndrome/premenstrual dysphoric disorder is differentially associated with vasomotor symptoms in the menopausal stage. Prospective studies with larger population are needed to confirm these findings

• Journal of Nutrition and Health
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• v.51 no.3
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• pp.228-241
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• 2018

Purpose: The health risk of women increases after menopause. This study evaluated the effectiveness of a public health center-based nutrition education program for hypertension in women older than 50 years of age. Methods: The program included 8-week nutrition education and 8-week follow-up with keeping a health diary and nutrition counseling. The program was evaluated three times: before and after the nutrition education, and after the follow-up. The subjects were classified into hypertensives (n = 44) or normotensives (n = 71). Results: The rate of taking antihypertensive drugs in the hypertensive group was 86.4%. The systolic blood pressure decreased in the hypertensive and normotensive groups after nutrition education (p < 0.05). The body weight (p < 0.001), BMI (p < 0.001), waist circumference (p < 0.001), and percent body fat (p < 0.01) were also decreased after nutrition education in both groups. The hypertensive group showed an increase in HDL-cholesterol level (p < 0.001) and decreases in triglycerides (p < 0.01) and LDL-cholesterol (p < 0.05) levels after completion of the program. The normotensive group also displayed significant changes in HDL-cholesterol (p < 0.001) and triglycerides (p < 0.01). The dietary habits and nutrition knowledge on sodium and hypertension were improved in both groups (p < 0.001). The total score of dietary behavior related to the sodium intake was improved in the normotensive group (p < 0.001). The total score of the high sodium dish frequency questionnaire decreased in both groups after nutrition education and completion of the program compared to that before the program. Decreases in the consumption frequencies of noodles, pot stews and stews, Kimchi, and beverages were significant. The total self-efficacy score was increased in both groups by the program (p < 0.001). In particular, the hypertensive group showed improvement in all items. Conclusion: This public health center-based nutrition education program may contribute to the prevention and management of hypertension and chronic diseases in women over 50 years of age.

• Journal of radiological science and technology
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• v.39 no.4
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• pp.517-526
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• 2016

This study analyzed the correlation between BMD (bone mineral density) value calculated in the MDCT (multidetector computed tomography) and lifestyle, physical features and social characteristics. From July 15 2015 to June 6 2016, we converted from HU (hounsfield unit) value measured by using MDCT to T-score for BMD of 141 patients (male: 63, female: 78) in W medical center. We measured the 2nd, 3rd and 4th lumbar spine and analyzed the correlation between gender differences in BMD and lifestyle, physical features and social characteristics. Statistical significance was validated using independent sample T test with one way Anova. Gender BMD was confirmed that a statistically significant difference (p<0.05). BMD values decreased with increasing age but for the statistically men, there was no significant difference from 20s to 50s, it only showed a significant difference in 20s and 60s (p<0.001). For the statistically women, there was no significant difference from 20s to 40s. but since 50s BMD was decreased rapidly, which showed a significant difference (p<0.001). women showed significant differences for the menstruation and menopause, childbirth, alcohol, cereals and greasy food in bone mineral density (p<0.05) but there were no significant differences in men. The bone mineral density values calculated by the MDCT and lifestyle, physical features and social characteristics correlation analysis method is considered to be used as a basis for estimating the state in BMD and osteoporosis management.