• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.279-288
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• 2002

This research investigates the effect of the Crataegus pinnatifida BGE. var. major N.E. BR(CPVM) on Alzheimer's disease. The CPVM extract suppressed the expression of IL-1 β, IL-6, APP, AChE mRNA in PC-12 cells treated with CT105. The CPVM extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT105. The CPVM extract group showed a significant inhibitory effect on the memory deficit for the mice with Alzheimer's disease induced by CT105 in the Morris water maze experiment. The CPVM extract suppressed the over-expression of IL-1 β, TNF- α and ROS in the mice with Alzheimer's disease induced by CT105. This study suggests that CPVM may be effective for the prevention and treatment of Alzheimer's disease.

• Journal of Preventive Medicine and Public Health
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• v.31 no.2 s.61
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• pp.167-182
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• 1998

The purpose of this study was to identify the major health components and measurements to be conducted in National Health Examination Survey(KNHES). The prevalence and severity of disease, acceptability of population and the possibility of standardization of measurement were considered as guideline for selecting the components. On the base of magnitude and severity of disease, chronic liver disease, hepatic cancer, gastric ulcer, stomach cancer, essential hypertension, cerebrovascular disease, ischemic heart disease, pulmonary tuberculosis, lung cancer, DM, breast cancer, cervical cancer, arthritis and intervertebral disc disorder were selected as the preliminary target diseases. Questionnaire survey for 648 persons in 'K' city and medical specialists in five clinical societies were conducted for evaluation the acceptability of general population for the measurements and the possibility of standardization for the procedures. In conclusion, the major target diseases were chronic liver disease, hypertension and DM and the total cholesterol, high density lipoprotein, triglyceride, total protein, albumin, hemoglobulin, hematocrit, platlet count, anti-HBs, HBsAg, height and weight were selected for basic physical components.

• Journal of the Korean Society of Tobacco Science
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• v.15 no.1
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• pp.15-25
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• 1993

The severities of major tobacco diseases had been surveyed throughout northern Kyeongbuk, a major flue-cured tobacco growing district in Korea, in relation to the actual control method used by the farmers in 1992. At seedling stage, anthracnose caused by Colletotrichum nicotianae was major disease of the plant due to poor damage of the temporary transplanting pots. Mosaic caused by tobacco mosaic virus(TMV) was very severe in certain of greenhouses. Although viral disease caused by TMV, cucumber mosaic virus(CMV) and by potato virus Y(PVY) were severe in fields, but mosaic by TMV was major of the diseases. Potato virus Y was found later than that in Honam district. The late occurrence of the disease might be caused the difference between cultivating method of potato plants in northern Kyeongbuk and that in Honam district. In fields suffered from hail disaster, the damage of tobacco plants by angular leaf spot was severe. Most of tobacco growers had wrong information about the practical methods not only of milk treatment for the protection of the plants from TMV, but also of fungicide applications for the control of other major diseases. It suggested that education on the methods to the farmers must be very important for control of the diseases.

• The Journal of Internal Korean Medicine
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• v.41 no.4
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• pp.658-667
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• 2020

Objectives: The purpose of this study was to analyze trends in Korean-Western Collaborative Medicine studies by disease group. Methods: Articles published until May 2020 were searched in domestic databases (NDSL, RISS, KISS, DBPIA, and KoreanTK) using the keywords '한양방', '양한방', '협진', '협의진료', '의한의', '의·한의', and '통합의학'. The articles were analyzed according to the publication year, journal type, research methodology, and disease group using the major and intermediate classifications of the Korean Standard Classification of Diseases (KCD-7). Results: In total, 112 articles were selected. The most frequent major disease groups were disease codes G, C (D), I, and M, in that order. The medium disease groups numbered 41 and most commonly involved collaborative studies on cerebrovascular diseases. Among the three top KCD-7 major group diseases, publications on Group C (D) were increasing significantly, publications on Group G were slightly increasing, but, publications on Group I decreased in the 2010s compared to the 2000s. Conclusions: In this study, we analyzed the frequent disease groups treated with domestic Korean-Western medicine in collaborative studies using the major and medium classifications of KCD-7. Well-designed clinical trials and economic evaluation research are needed, and this study can provide directions for future collaborative studies using Korean-Western medicine.

• Herbal Formula Science
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• v.21 no.2
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• pp.72-80
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• 2013

Objectives : Ontology is a good tool to represent the knowledge and has developed for Traditional Korean Medicine(TKM) in Korea Institute of Oriental Medicine. There are a lot of TKM terms, which have a complex meaning, especially major indication terms of medicinal treatment and terms of symptom and disease. These complex meaning terms result in the low linkage between major indication terms of medicinal treatment and terms of symptom and disease in TKM ontology. We studied to enhance the percentage of the linkage among those data in TKM ontology. Methods : We disassembled major indication terms of medicinal treatment into minimum meaning units and then linked them to enhance the percentage of the linkage among medicinal material, formula and disease ontology based on Traditional Korean Medicine. To retain objectivity, several experts of Korean Medicine used a web-based tool that supports users in refining terms and disassembling them into the minimum meaning efficiently. Results : The outcome shows that the percentage of the linkage among medicinal material, formula and disease ontology increased. By linking disassembled major indication terms to symptoms and diseases, the amount of information for medicinal materials and formulas also increased quantitatively in comparison with given formula for diseases in disease ontology. Conclusions : By this study, disassembled data increases the percentage of linkage between diseases and medicinal treatments. And the applicability of TKM ontology is also increased.

• Journal of Nutrition and Health
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• v.26 no.9
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• pp.1071-1084
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• 1993

This study was performed to investigate the relationships between obese index and major risk factors of cardiovascular disease in CVD patients. Anthropometry, food intake patterns, blood pressure, serum lipids and hematological values were analyzed in 550 patients from June, 1991 to August, 1992. The results are as follows: Total food intakes, especially total vegetable food and alcohol intakes were significantly related with obese index, so that the heavier patients tended to consume more carbohydrate and less fat. The blood pressure were observed to have positive correlation with obese index in man but not in women. However, both in men and women, blood levels of TG, TC, and VLDL tended to be related to obese index positively, while HDL and HDL-C were shown to be oppositive. So, it seems that as the degree of obesity is higher the blood pressure and blood lipids patterns worse. Therefore, these results suggest that obesity is one of the major risk factors of CVD, and for prevention & treatment of the disease, controlling body weight by nutritionally adequate diet along with alcohol restriction is necessary.

• Journal of Preventive Medicine and Public Health
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• v.34 no.4
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• pp.372-378
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• 2001

Objectives : This study introduced the healthy life-year(HeaLY), a composite indicator of disease burden, and used it to estimate the burden of major cancers in Korea. Methods : We collected data from the national death certificate database, the national health insurance claims database and the abridged life table. This data was used to create a spreadsheet and estimate the burden of major cancers by sex in terms of HeaLYs. Results : The burden of 10 major cancers for males was 2,248.97 person-year in terms of HeaLYs. Stomach cancer, liver cancer, and lung cancer were responsible for 75.2% of the burden of 10 major cancers. The disease burden of 10 major cancers for females was estimated to be 1,567.58 person-years. About two thirds of HeaLYs lost were from stomach cancer, liver cancer, lung cancer, colorectal cancer, and breast cancer. The rankings among 10 major cancers were somewhat different in terms of both HeaLYs and deaths as the HeaLY method considers both mortality and morbidity. Conclusions : Despite the limitations of the data sources, we conclude that HeaLY can aid in setting policy priorities concerning major cancers by estimating the disease burden of these cancers. Time-series analysis of the disease burden using HeaLY and DALY will elucidate the strengths and weaknesses of both methods.

• International Journal of Industrial Entomology and Biomaterials
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• v.18 no.1
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• pp.8-12
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• 2009

A study has been made to know the effect of a phytoecdysteroid 'Sampoorna' on uniform maturation of silkworms during spinning and its effect on diseased silkworms infected by major silkworm disease viruses, Bombyx mori nuclear polyhedrosis virus (BmNPV) and Bombyx mori infectious flacherie virus (BmIFV). In the present investigation, the effect of the phytoecdysteroid "Sampoorna" on Grasserie disease caused by BmNPV have shown an average cocoon melting of 11.91% with a disease incidence of 5.83%. The values of 't' test for different treatments of BmNPV indicated low survival rate and cocoon traits were drastically reduced. Another major disease Flacherie caused by BmIFV has shown considerable levels of larval disease incidence (22-32%) and cocoon melting (3-7.67%) with an average melting of 12.95% and 20.24% disease incidence. There is a drastic reduction in survival rate, cocoon yield and other economic traits. The control batches were indicated negligible values for disease incidence and cocoon melting with Sapoorna application and without the inoculation of the two disease-causing viruses. The application of Sampoorna on already infected batches with major pathogens triggered high mortality and disease incidence and melting percentage was also significantly increased with reduced economic traits. Hence, it is suggested that application of Sampoorna in infected batches should be done only in the extreme conditions of rearing. Application of Sampoorna on healthy batches led to uniform maturation and improvement in productivity with the added advantage of better quality cocoons and labour saving.

• Korean Journal Plant Pathology
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• v.11 no.3
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• pp.224-229
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• 1995

Occurrence and incidences of major diseases of peach (Prunus persicae pv. vulgaris), leaf curl caused by Taphrina deformans, bacterial shot hole caused by Xanthomonas campestris pv. pruni, brown rot caused by Monilinia fructicola, and anthracnose caused by Glomerella cingulata in peach orchards in Cheongdo and Kyungsan areas of Gyeongbuk province, Korea, were investigated for four years from 1990 to 1993. In leaf curl and bacterial shot hole which mainly occurred on leaves, frist disease occurrences were dated from late April to early May. The maximum leaf curl incidence was dated in mid May, while dates of the maximum bacterial shot hole incidence varied from mid May to mid August depending on the years surveyed. In brown rot and anthracnose on fruit, the first disease occurrence dates ranged from early June to early August; however, the maximum disease incidences for both were invariably dated in late August. The disease incidences on the dates of the maximum incidences differed year by year, and the averages for the 4 years were 13.2%, 10.5%, 10.9% and 3.8% for leaf curl, bacterial shot hole, brown rot and anthracnose, respectively. Especially in the leaf curl disease, the first disease occurrence dates and the maximum disease incidences matched with the amounts of precipitation of rain up to April, suggesting that the disease occurrence may be related to the precipitation during the early season. The occurrence of leaf curl was somewhat higher in cultivar“Baekmi”than other cultivars. All of the major disease occurred more in hilly orchards than in plain ones.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.964-968
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• 2009

The purpose of this study is to select the major pulse indicators and evaluate their significance in discriminating the subtypes of Pattern Identifications (PI) from stroke patients. Decision tree analysis was carried out using clinical data collected from 835 stroke patients with the same subtypes diagnosed identically by two experts with more than 3 year clinical experiences. Among the 10 pulse indicators, 6 major pulse indicators (slow, rapid, strong, weak, slippery, and fine pulse) were selected by decision tree analysis. The accumulated distributions of six pulse indicators in each PI showed that strong was major pulse indicator in Fire-Heat pattern, slippery in Dampness Phlegm pattern, weak in Qi Deficiency pattern. But there were two major combinations in Yin deficiency pattern, weak or fine with rapid pulse and weak or fine without rapid pulse. Therefore, it is suggested that 6 pulse indicators can be used for discrimination of PI in stroke patients, though the combination studies between these pulse indicators and the other PI indicators are left for further study.