• Land and Housing Review
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• v.10 no.2
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• pp.1-13
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• 2019

This study suggests that the system improvement priority of the Natural Conservation Zone of the Metropolitan Area Maintenance Planning Law, which was enacted for about 37 years. First of all, through the precedent research and the consultation meeting, the improvement plan was divided into the short term and the mid(or long) term. Important findings and implications are as follows. The short-term priority results were 'Improve water quality regulation', 'Strengthen individual location regulations of factories and induce multi-use plan position', and 'Improvement of waterfront area regulation', which were both critical and urgent. The mid-term(or Long-term) priority results were 'To integrate development and environmental duplication regulations', 'Abolition and unification of environmental laws', and 'Adjustment and resetting of natural conservation areas', which were both critical and urgent. On the other hand, 76.4% of the residents and 64.5% of the experts are concerned about the necessity of improvement of the Natural Conservation Zone system. Both residents and experts seem to be aware of the necessity. Opinions about Improvement and mitigation of regulations on Natural Conservation Zone that were constantly raised. In the past, there was a temporary and fragmented institutional mitigation of the government. However, with the rapid development of eco-friendly technologies since 2010, Our Country Conditions is in a transition period. This study has significant implications for the improvement and mitigation of metropolitan area regulations.

• Molecules and Cells
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• v.37 no.5
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• pp.357-364
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• 2014

Medulloblastoma, the most common malignant brain tumor in children, is a disease whose mechanisms are now beginning to be uncovered by high-throughput studies of somatic mutations, mRNA expression patterns, and epigenetic profiles of patient tumors. One emerging theme from studies that sequenced the tumor genomes of large cohorts of medulloblastoma patients is frequent mutation of RNA binding proteins. Proteins which bind multiple RNA targets can act as master regulators of gene expression at the post-transcriptional level to co-ordinate cellular processes and alter the phenotype of the cell. Identification of the target genes of RNA binding proteins may highlight essential pathways of medulloblastomagenesis that cannot be detected by study of transcriptomics alone. Furthermore, a subset of RNA binding proteins are attractive drug targets. For example, compounds that are under development as anti-viral targets due to their ability to inhibit RNA helicases could also be tested in novel approaches to medulloblastoma therapy by targeting key RNA binding proteins. In this review, we discuss a number of RNA binding proteins, including Musashi1 (MSI1), DEAD (Asp-Glu-Ala-Asp) box helicase 3 X-linked (DDX3X), DDX31, and cell division cycle and apoptosis regulator 1 (CCAR1), which play potentially critical roles in the growth and/or maintenance of medulloblastoma.

• Journal of the Korean Society of Safety
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• v.34 no.5
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• pp.153-158
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• 2019

It is estimated that about 2,515 persons have been injured by conveyor for the past five years(2013 ~ 2017). Conveyors used in various industrial sites for transporting iron ore, coal, courier goods, etc., have various incidents such as a worker putting on or pulling a part of the body or work clothes on the driving part during maintenance. It is necessary for preventing similar accidents to conduct various researches. In order to propose the basis for revising laws and standards for the safety standards of the full cord switch to prevent conveyor accidents, this study compares Korea's Industrial Safety and Health Law (KISHL) with those of IEC, EN, Canada, and Australia. In addition, surveys of conveyor use plant and full cord switch domestic and foreign manufacturers was conducted. In this study, domestic and overseas related laws and technical standards compare and analyze to prevent conveyor accidents. In addition, we propose extension of safety certification for full code switch, establishment of safety inspection standard, and improvement of working method regulation through actual working condition investigation. It can be used as a basis for revising the occupational safety and health regulation and related notices, and thus contributing to enhancing the safe atmosphere of the conveyor business and improving the safety consciousness of the concerned persons.

• BMB Reports
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• v.51 no.2
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• pp.92-97
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• 2018

B cell leukemia/lymphoma 3 (Bcl3) plays a pivotal role in immune homeostasis, cellular proliferation, and cell survival, as a co-activator or co-repressor of transcription of the $NF-{\kappa}B$ family. Recently, it was reported that Bcl3 positively regulates pluripotency genes, including Oct4, in mouse embryonic stem cells (mESCs). However, the role of Bcl3 in the maintenance of pluripotency and self-renewal activity is not fully established. Here, we report the dynamic regulation of the proliferation, pluripotency, and self-renewal of mESCs by Bcl3 via an influence on Nanog transcriptional activity. Bcl3 expression is predominantly observed in immature mESCs, but significantly decreased during cell differentiation by LIF depletion and in mESC-derived EBs. Importantly, the knockdown of Bcl3 resulted in the loss of self-renewal ability and decreased cell proliferation. Similarly, the ectopic expression of Bcl3 also resulted in a significant reduction of proliferation, and the self-renewal of mESCs was demonstrated by alkaline phosphatase staining and clonogenic single cell-derived colony assay. We further examined that Bcl3-mediated regulation of Nanog transcriptional activity in mESCs, which indicated that Bcl3 acts as a transcriptional repressor of Nanog expression in mESCs. In conclusion, we demonstrated that a sufficient concentration of Bcl3 in mESCs plays a critical role in the maintenance of pluripotency and the self-renewal of mESCs via the regulation of Nanog transcriptional activity.

• BMB Reports
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• v.53 no.9
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• pp.472-477
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• 2020

Osteoclasts are hematopoietic-derived cells that resorb bone. They are required to maintain proper bone homeostasis and skeletal strength. Although osteoclast differentiation depends on receptor activator of NF-κB ligand (RANKL) stimulation, additional molecules further contribute to osteoclast maturation. Here, we demonstrate that protocadherin-7 (Pcdh7) regulates formation of multinucleated osteoclasts and contributes to maintenance of bone homeostasis. We found that Pcdh7 expression is induced by RANKL stimulation, and that RNAi-mediated knockdown of Pcdh7 resulted in impaired formation of osteoclasts. We generated Pcdh7-deficient mice and found increased bone mass due to decreased bone resorption but without any defect in bone formation. Using an in vitro culture system, it was revealed that formation of multinucleated osteoclasts is impaired in Pcdh7-deficient cultures, while no apparent defects were observed in differentiation and function of Pcdh7-deficient osteoblasts. Taken together, these results reveal an osteoclast cell-intrinsic role for Pcdh7 in maintaining bone homeostasis.

• Journal of the Korean Institute of Rural Architecture
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• v.20 no.2
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• pp.1-9
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• 2018

The purpose of this study was to develop guidelines for sustainability of back-to-farm community village in 4 aspects; social environment, maintenance and management, regional environment, and economic environment. These 4 aspects, which count for sustainability, based on the comprehensive comparative analysis about items that field survey and literature suggested. Conclusions of guideline are of the following. The guidelines on social environment are developed by 3 items; resident participation and activity, village leader, decision making in village and person in charge of operation. The guidelines on maintenance and management are developed by 5 items; village operation system, village regulation, transparency of management, village operation expenses, and management type. The guidelines on regional environment are developed by 2 items; support by central and local government, and area projects and connection to regional resources. The guideline on economic environment is not developed due to low demands of based production facilities and income increase facilities.

• Journal of Korean Academy of Nursing Administration
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• v.12 no.4
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• pp.574-586
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• 2006

Purpose: This paper is intended to provide a clauses of scope of nursing practice with nursing act. Method: This was a planning study. The provision of scope of nursing practice is constructed through critical review of literatures and regulations. The validity of the legal definition was tested through expert and staffs in affiliates of Korean Nurses Association review. Result: 'Nursing is an activity that assesses and diagnoses the reaction of an individual, family, and community for health promotion and maintenance, illness prevention and rehabilitation and to provide intervention and evaluate the results. This practices are done through nursing knowledge and skills. The nursing practices include basic nursing services (general hygiene, environment and safety control, emotional and physical comfort, examination and surgery related care, systematic observation and reporting about patients, activity and organ function maintenance), practice of doctor's regimen, consulting and education to patients, reference, collaboration and management with other health personnel, public health activity by regulation. And nursing standards are set by a separate code. Conclusions: The result of this study can be used to offer for nursing act. So, This legal definition will be constantly discussed and extended to reflect actual nursing practice.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.2
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• pp.109-116
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• 2007

The purpose of this paper is to evaluate the fire resistant performances of load-bearing wall using both composite and steel stud panel infilled with light-weight formed mortar under axial loading according to KS F 2257(1999). The minimum requirement of 2 hours fire resistant rating is needed for the residential and commercial buildings under the fire regulation of Korea. From test results, it is found that two types of specimen composed of the hybrid stud and steel stud panel filled with light-weight formed mortar fited in with the requirement of 2 hours fire resisting rate for the load-bearing wall. In the conclusions, the specimen with hybrid stud shows predominating fire-resistant performance on the adiabatic effects rather than that of the steel stud specimen.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.2
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• pp.163-175
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• 2011

This study is a bibliographic search about completion and maintenance of pregnancy. In oriental medicine, there is a proper temper and appearance that encourages optimal pregnancy. Invigoration of sperm is important for males to have descendants, and regulation of menstrual disturbances is necessary for female to have descendants. It is not good for both male and female to engage in sexual intercourse too often. Male and female shall have sexual intercourse. When they feel the connection, mind and body are sound, weather is fine, and they take position at ease. Previous studies on pregnancy describe minutely process of fetus's growth until the fifth month, and suggest the rules of fetus's health according to fetal development. Therefore, it is important to prevent acquiring diseases during pregnancy. Female needs to be careful and restful in the early stage of pregnancy. In the late period of pregnancy, she needs to be active.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.521-525
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• 2011

Although the Korean construction industry has risen rapidly, the quality of the buildings is not met with the industry standard compared to the potential of the technology development and the cost of maintenance has been increased. The user's request for quality have been increased, but in the current building construction, the contractors only follow the specifications of design, material and technology, and their main concern is whether they are in right track with the specification or not. Thus, the necessity of developing technology has been ignored and sufficient opportunities for the development have not been provided as well. In the developed countries, in contrast, the quality assurance and the payment regulation system has been utilized for the active response to the changes of users' request. As a result of this, the maintenance cost has been decreased and the development of construction technology has been improved. Therefore the pay adjustment system is needed to create the improvement of the quality of the buildings by the contractors' earnest building construction. In order to introduce the pay adjustment system suitable to the Korean construction industry, this study presented the logical method of adjusting the construction cost and making payment with the pay adjustment index that is created based on the result of the performance test, after making a set of the indicators of the building performance standard and applied them to the targeted building.