• Proceedings of the KSR Conference
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• 2008.06a
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• pp.659-664
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• 2008

The Railroad Safety Act's regulation reads as follows. "The Minister of Construction and Transportation may qualify and authorize the product to guarantee performance and safety of parts, machine, and device used in Railway fields." Another regulation reads as follows."“The guidelines about targets, standards, and procedures of Quality and Authority in first provision are decided as Ministry of Construction and Transportation Decree." The software used in rail cars and facilities is considered as a railway product. Therefore, it is qualified and authorized for acquiring the safety of rail cars and facilities. The software businesses shall again a Quality and Authority for applying a software to the rail cars and facilities. This paper regulates some guidelines that are needed to develop a software. The procedures that a software developer performs are divided by plan, requirement, design, implementation, and maintenance. The procedures that a software verification person performs are classified by verification plan, requirement verification, design verification, implementation verification, testing verification, maintenance verification, and safety activity. The entire processes and detailed activities to develope and verify a software are described as new guidelines.

• Molecules and Cells
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• v.43 no.2
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• pp.198-202
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• 2020

Comprehensive inhibition of RUNX1, RUNX2, and RUNX3 led to marked cell suppression compared with inhibition of RUNX1 alone, clarifying that the RUNX family members are important for proliferation and maintenance of diverse cancers, and "cluster regulation of RUNX (CROX)" is a very effective strategy to suppress cancer cells. Recent studies reported by us and other groups suggested that wild-type RUNX1 is needed for survival and proliferation of certain types of leukemia, lung cancer, gastric cancer, etc. and for their one of metastatic target sites such as born marrow endothelial niche, suggesting that RUNX1 often functions oncogenic manners in cancer cells. In this review, we describe the significance and paradoxical requirement of RUNX1 tumor suppressor in leukemia and even solid cancers based on recent our findings such as "genetic compensation of RUNX family transcription factors (the compensation mechanism for the total level of RUNX family protein expression)", "RUNX1 inhibition-induced inhibitory effects on leukemia cells and on solid cancers through p53 activation", and "autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells". Taken together, these findings identify a crucial role for the RUNX cluster in the maintenance and progression of cancers and suggest that modulation of the RUNX cluster using the pyrrole-imidazole polyamide gene-switch technology is a potential novel therapeutic approach to control cancers.

• Journal of the Korean Society of Industry Convergence
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• v.26 no.4_2
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• pp.649-656
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• 2023

Recently, global warming has become severe, and regulation is established for carbon savings each field. its regulation is applied to various fields using IC engine such as automobile, ship, agricultural machine. Therefore engine block applied Common Rail Direct Injection(CRDI) technology, that carry out thermal-structure analysis to examine design. The thermal load about 900℃ by explosion was applied in cylinder. And pressure about 9 MPa(90 Bar) was applied to structure analysis. As a result, it was the highest at 185.99℃ at the top of cylinder. Static-structure analysis applied thermal load, that was shown maximum equivalent stress at 142.59 Mpa and Maximum principal stress 145.03 MPa, Minimum principal stress -149 MPa. When compare analysis results to material property, it design is safety structurally.

• Journal of the Korea Institute of Building Construction
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• v.22 no.6
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• pp.673-680
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• 2022

Modular construction is recognized as a construction method with various advantages, such as shortening the construction duration, achieving quality control through factory production, ease of maintenance, and reduced construction costs due to reduced weight of materials. However, despite efforts by the modular industry and government to activate modular construction, it has rarely been established in the domestic market. Currently, there are technical limitations to the modular construction fire resisting technology applied to general buildings. The lack of access to modular construction fire resistance regulation is considered a major factor. In this study, the current status and problems with modular construction fire resistance regulation, a significant hindrance factor, were considered to activate modular construction. This study is intended to present a direction for institutional improvement in modular construction fire resistance and a direction for research and development.

• Journal of Animal Reproduction and Biotechnology
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• v.38 no.3
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• pp.89-98
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• 2023

Background: The regulation of maternal immunity is critical for the establishment and maintenance of successful pregnancy. Among many cell types regulating the immune system, innate lymphoid cells (ILCs) are known to play an important role in innate immunity. Although some reports show that ILCs are present at the maternalconceptus interface in humans and mice, the expression and function of ILCs in the endometrium have not been studied in pigs. Methods: Thus, we determined the expression, localization, and regulation of ILC markers, CD127 (a common marker for ILCs), BCL11B (a ILC2 marker), and RORC (a ILC3 marker) at the maternal-conceptus interface in pigs. Results: The expression of BCL11B and RORC, but not CD127, in the endometrium changed during pregnancy in a stage-specific manner and the expression of CD127, BCL11B, and RORC was greatest on Day 15 during pregnancy. CD127, BCL11B, and RORC were also expressed in conceptus tissues during early pregnancy and in chorioallantoic tissues during the later stage of pregnancy. BCL11B and RORC proteins were localized to specific cells in endometrial stroma. The expression of CD127 and BCL11B, but not RORC, was increased by the increasing doses of interferon-γ (IFNG) in endometrial explants. Conclusions: These results suggest that ILCs present at the maternal-conceptus interface may play a role in the establishment and maintenance of pregnancy by regulating the innate immunity in pigs.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.30 no.4
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• pp.33-44
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• 2022

As the majority of Korean MRO demand is outsourced overseas, AMO by major foreign authorities is required to promote the Korean MRO industry to keep Korean MRO demand on shore. This study aims to promote consulting for AMO (obtaining repair station certification) by U.S. Federal Aviation Administration (FAA) for Korean maintenance companies. We analyzed AMO process, studied various industry cases, developed a model for AMO consulting, and identified core competencies for consultants. We suggested a five-step modified Milan model to apply AMO consulting process. We identified seven core competencies (ethics, communications, problem-solving, technical, relationship, resource management, organizational understanding) both social and technical for consultants. Additionally, we text analyzed more than 260 FAA AMO consultant resumes on Linkedin and interpreted frequent words (airline, audit, inspector, DER, regulation, ISO, system) to their competencies. This study contributes to promote consulting for the Korean MRO industry to be recognized by FAA and to develop the Korean MRO industry.

• Journal of Korean Medicine for Obesity Research
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• v.19 no.2
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• pp.119-136
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• 2019

Objectives: People often fail to maintain their weight even though they have succeeded in weight loss. The purpose of this study was to review previously published study results with regards to the predictive factors associated with weight loss maintenance after successful weight loss. Methods: The authors searched for the articles related to weight loss maintenance after successful weight loss, published up until June 2019 on PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, Research Information Sharing Service (RISS), and Koreanstudies Information Service System (KISS). A total of 76 articles were finally selected. From the study results, changeable and unchangeable predictors were extracted, and these predictors were examined according to detailed categories. Results: The changeable predictors of weight loss maintenance included behavioral factors, psychological factors and treatment process-related factors, whereas the unchangeable predictors included genetic and physiological factors, demographic factors, history of treatment on obesity-related factors. The main factors of weight loss maintenance were changeable predictors such as healthy eating habits, dietary intake control, binge eating control, regular exercise and physical activity, depression and stress control, social supports, self-regulation, self-weighing and initial weight loss and unchangeable predictors such as low initial weight and maximum lifetime weight. Conclusions: The results of our review results suggest that changeable and unchangeable predictors of weight loss maintenance should be carefully examined during treatments of obesity.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.6
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• pp.1901-1910
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• 2014

Current domestic and overseas BIM practice and research efforts show very few examples that design and construction BIM data could be successfully used for efficient operation and maintenance (O&M) of infrastructure in particular. This study takes public wastewater treatment plant requiring an enhancement of operation and maintenance capability into account to develop a prototype BIM-based maintenance management system. The system is designed and implemented following a typical system development procedure and validated by the system outputs per four scenarios being considered to be main maintenance activities: The research results are expected to contribute to the upgrade of current wastewater treatment plant maintenance level, which is more demanded as water-related regulation and policy direction changes to region-based large scale O&M and asset management adoption, and overseas market participation.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.1092-1096
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• 2011

The "standard regulation" of the vehicles from "urban transit law" are being adopted to electric multiple unit in domestic. In the standard regulation, there are two types for EMU. One is heavy EMU for Seoul. The other is large EMU for Pusan, Daegu, Gwangju, Daejeon, Incheon. Korea Railroad Research Institute, with the assistance of the Ministry of Land, Transport and Maritime Affairs, "advanced EMU development project" are progressed, and 6th year started at September, one unit to six cars is completed. Now "urban transit vehicle performance tests are on the current progress. The main characteristics of AUTS(Advanced Urban Transit System) are as follows. One inverter control one motor, DDM(Dircet Drive Motor), no driving gear, plug door and steps, mounting and maintenance costs down, passenger convenience improvement. This paper describes the key features the next generation EMU, and performance test results, and the commercial success method of national R&D business.

• Korean Journal of Child Studies
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• v.22 no.3
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• pp.31-48
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• 2001

This study was designed to examine various patterns of developmental change in children's recall, strategic behaviors, and meta-memory with a sort-recall task in relation to utilization deficiencies. Memory tasks consisting of 18 pictures were presented individually to 48 seven-year-old children in each of 7 sessions. Sessions 1 and 2 were baseline; Sessions 3 and 4 were for strategy training, including the organization group, the self-regulation group, the organization/self-regulation group and control group. Sessions 5, 6, and 7 were unprompted tests of strategy maintenance. Results showed significant differences between the 4 groups in their recall, strategy repertories and strategy evaluation. Findings were discussed in terms of the analysis of memory strategy and memory development.