• Molecules and Cells
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• 제38권9호
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• pp.750-758
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• 2015

Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.

• 대한간호학회지
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• 제46권5호
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• pp.687-696
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• 2016

Purpose: The purpose of this study was to define and clarify the concept of volition for health behavior. Methods: For this study the process of Walker & Avant's concept analysis was used. Seventeen studies from electronic data basses met criteria for selection. Results: Volition can be defined by the following attributes: 1) planning, 2) maintenance of self-efficacy, and 3) self regulation. The antecedents of volition consisted of: 1) risk awareness, 2) outcome expectation, 3) perceived self-efficacy, and 4) social support. The consequences occurring as a result of volition were: 1) prevention of disability and complications, 2) improvement of functional ability, and 3) enhencement of quailty of life. Conclusion: Definition and attributes of volition identified by this results can be applied to develop measurements and intervention programs for chronic patients health behavior.

• 에너지공학
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• 제24권3호
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• pp.34-39
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• 2015

Recently, Air pollution is gradually increasing which are coming from the exhaust of the ICE vehicles in the world. ICE vehicle exhaust gas and $CO_2$ are widely suspected of contributing to the called greenhouse effect, fueling fears of global warming. Therefore, many countries are striving to decrease the vehicle exhaust gas and have developed a variety of policies as air pollution regulation plans. To comply with the regulations, automotive industry has developed hybrid vehicles, which have features of both ICE vehicles and electric vehicles. Hybrid car is eco-friendly and has lowered exhausting gases and improved fuel efficiency. This research has been written to show that break down cases with EGR valve in hybrid cars, steadily increasing in use, and to help with on-site maintenance.

• 전기학회논문지P
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• 제58권4호
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• pp.546-551
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• 2009

In this paper, we studied insulation characteristics of LED lamps for load and street lighting. LED lamps can be divided into internal type and external type according to converter type. In this study, we analyzed technology standard, K(Electrical Appliances Safety Standards) and KS(Korean Industrial Standards) about insulation resistance for LED lamps for load and street lighting, and measured insulation resistances for each measured point. Mostly, insulation resistances were measured high more than regulation value but some measured points were measured badly. We expect that the results of these experiments would be helpful for electrical safety of LED lighting installation, manufacture, construction and maintenance.

• Clinical and Experimental Reproductive Medicine
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• 제39권1호
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• pp.10-14
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• 2012

The ovarian follicles develop initially from primordial follicles. The majority of ovarian primordial follicles are maintained quiescently as a reserve for the reproductive life span. Only a few of them are activated and develop to an advanced follicular stage. The maintenance of dormancy and activation of primordial follicles are controlled by coordinated actions of a suppressor/activator with close communications with somatic cells and intra-oocyte signaling pathways. Many growth factors and signaling pathways have been identified and the transforming growth factor-beta superfamily plays important roles in early folliculogenesis. However, the mechanism of maintaining the dormancy and survival of primordial follicles has remained unknown for decades. Recently, since the first finding that all primordial follicles are activated prematurely in mice deficient forkhead box O3a, phosphatidylinositol 3 kinase/phosphatase and tensin homolog (PTEN) signaling pathway was reported to be important in the regulation of dormancy and initial follicular activation. With these informations on early folliculogenesis, clinical application can be expected such as in vitro maturation of immature oocytes or in vitro activation of follicles by PTEN inhibitor in cryopreserved ovarian cortical tissues for fertility preservation.

• Molecules and Cells
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• 제37권2호
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• pp.89-94
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• 2014

Fission and fusion of mitochondrial tubules are the main processes determining mitochondrial shape and size in cells. As more evidence is found for the involvement of mitochondrial morphology in human pathology, it is important to elucidate the mechanisms of mitochondrial fission and fusion. Mitochondrial morphology is highly sensitive to changing environmental conditions, indicating the involvement of cellular signaling pathways. In addition, the well-established structural connection between the endoplasmic reticulum (ER) and mitochondria has recently been found to play a role in mitochondrial fission. This minireview describes the latest advancements in understanding the regulatory mechanisms controlling mitochondrial morphology, as well as the ER-mediated structural maintenance of mitochondria, with a specific emphasis on mitochondrial fission.

• BMB Reports
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• 제48권11호
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• pp.599-608
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• 2015

Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.

• 한국생산제조학회지
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• 제20권5호
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• pp.598-604
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• 2011

In guard rail crashes, the development of guard rail structure to ensure the maintenance of safety for passengers is very important. So, this paper focuses on understanding the possibility of efficient structural development considering crash strength of guard rail through computer simulation using the commercial code, LS-DYNA3D at the initial stage of guard rail development. For this study, guard rail structure was modeled using shell elements to represent major structural members and passenger car was modeled using plate elements of simple shape to do not have the drawing, and impact boundary conditions required by regulation was applied. In order to confirm the validity of the computational results, they were compared with the test results.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1789-1795
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• 2007

Railroad, the structure maintenance and restoration project was increased and widely performed in concrete pavement road and airport, building at downtown area, bridge abutment, and other concrete structures. Especially, the ground reinforcement technique by quick-reaction expansible resins is the most effective countermeasures against differential settlement and undesired deformation of structure. In this paper, the unconfined compressive strength and some environmental related tests were conducted to evaluate compressive strength and environmental effect of quick-reaction expansive resins and soil mixtures. Also, three case histories of concrete structure and railroad restoration project are presented. Based on the laboratory test, the quick-reaction expansible resins and soil mixture represent the sufficient compressive strength and the leachate material is satisfied the environmental regulation limits. As a result of this study, the structure restoration technology using quick-reaction expansible resins is very effective for restoration of differential settlement and deformation, and it is environmentally sustainable technology.

• KIEAE Journal
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• 제6권4호
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• pp.17-24
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• 2006

The application of photovoltaics into building as integrated building components has been paid more attention worldwide. Photovoltaics or solar electric modules are solid state devices, directly converting solar radiation into electricity; the process does not require fuel and any moving parts, and produce no pollutants. And the prefab building method is very effective because the pre- manufactured building components is simply assembled to making up buildings in the construction fields especially the sandwich panel. Architecture considerations for the integration of PV module to building envelope such as building structure, construction type, safety, regulation, maintenance etc. have been carefully refelected from the early stage of BIPV module design. Trial product of BIPV module are manufactured and sample construction details for demonstration building are purposed. Therefore, this paper intends to advanced its practical use by proposing how to get integrated PV system which can be applied to prefab building material, and how to apply it.