• Journal of Magnetics
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• 제19권4호
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• pp.353-356
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• 2014

The aim of the present study was to examine whether mental practice (MP) in conjunction with repetitive transcranial magnetic stimulation (rTMS) can improve the upper limb function of sub-acute stroke patients. This study was conducted with 32 subjects who were diagnosed with hemiparesis by stroke. The experimental group consisted of 16 members upon each of whom was performed MP in conjunction with rTMS, whreas the control group consisted of 16 members upon each of whom was performed MP and sham rTMS. Both groups received traditional physical therapy for 30 minutes a day, 5 days a week, for 6 weeks; additionally, they received mental practice for 15 minutes a day. The experimental group was instructed to perform rTMS, and the control group was instructed to apply sham rTMS for 15 minutes. A motor cortex excitability analysis was performed by motor evoked potentials (MEPs), and upper limb function was evaluated by Fugl-Meyer Assessment (FMA) and the Box and Block test (BBT). Results showed that the amplitude, latency, FMA, and BBT of the experimental group and the latency, FMA, and BBT of the control group were significantly improved after the experiment (p<0.05). Significant differences were found between the groups in amplitude and latency after the experiment (p<0.05). The results showed that MP in conjunction with rTMS is more effective in improving upper limb function than MP alone.

• Journal of Magnetics
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• 제19권1호
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• pp.28-31
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• 2014

The aim of the present study was to examine whether mirror therapy, in conjunction with repetitive transcranial magnetic stimulation (rTMS), can improve the upper extremity function of stroke patient. This study was conducted with 35 subjects, who were diagnosed as a hemiparesis by stroke. The Mirror plus rTMS group was of 12 members who undertook mirror therapy in conjunction with rTMS, the Mirror group was of 11 members who undertook mirror therapy, and the control group was of 12 members who undertook sham therapy. A motor cortex excitability was performed by motor evoked potential, and upper limb function was evaluated by Fugl-Meyer Assessment, and Box and Block Test. Significant difference was shown after the experiment, in comparison of the groups in terms of latency, and as the result of post hoc test, significant difference was shown between the Mirror plus rTMS group and control group, and between the Mirror group and control group, respectively. Significant difference was shown after the experiment in comparison of the groups in amplitude, and as the result of post hoc test, significant difference was shown between the Mirror plus rTMS group and Mirror group, and between the Mirror plus rTMS group and control group. Significant difference was shown after the experiment, in comparison of the groups in FMA and BBT, and as the result of post hoc test, significant difference was shown between the Mirror plus rTMS group and Mirror group, and between the Mirror group and control group. The study showed that mirror therapy in conjunction with rTMS is more effective to improve upper extremity function, than mirror therapy and sham therapy.

• 한국정보통신학회논문지
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• 제13권7호
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• pp.1399-1410
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• 2009

통증을 치료하기 위한 방법으로 약물요법, 신경차단법, 외과적 수술 등이 있으며, 대체물리요법으로 침구치료, 초음파, 전기 치료, 자기장 치료 등이 응용되고 있다. 이중 전기치료 요법이 많이 이용되고 있으나, 피부나 피하조직의 임피던스에 큰 영향을 받으며, 주로 경피자극이 주된 방법으로 효과가 매우 확률론적이다. 본 연구에서는 집속형 자기장을 이용하여 경혈이나 치료점에 대한 국소 부위를 비침습적으로 자극 할 수 있는 새로운 시스템을 개발하였다. 수기자극과 유사한 자극을 유도할 수 있는 새로운 자기장 침 전극(자기장 자극의 효율성을 고려하여 새로운 형태)을 설계하였다. 개발된 시스템의 임상적 유효성 및 신뢰성을 평가하기 위하여 수기자극과 자기장 자극에 대한 경락전위변화를 측정하여 비교하였다. 실험 결과 자기장 자극 시 수기자극을 할 때 나타나는 충전 방전 형태의 전위변화와 유사한 경락전위변화가 측정되었으며, 자극방식, 세기, 빈도를 조절함에 따라 다양한 반응특성이 나타남을 확인하였다. 또한, 전자기장 자극에 의해 경락전위변화를 유도할 수 있어 이를 이용한 새로운 경혈자극 및 통증치료기로써의 가능성을 확인하였다.

• Annals of Rehabilitation Medicine
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• 제42권6호
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• pp.788-797
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• 2018

Objective To investigate the effect of upper limb rehabilitation combining robot with low-frequency repetitive transcranial magnetic stimulation (rTMS) on unilateral spatial neglect in stroke patients. Methods Patients who had hemispatial neglect after right hemisphere stroke were randomly divided into rTMS only group, robot only group, and combined group. All groups received conventional neglect therapy and additional treatment for each group. rTMS group received rTMS therapy. Robot group received robot therapy, while combined group received both therapies. The effect of therapy was assessed with Motor-Free Visual Perception Test-3 (MVPT-3), line bisection test, star cancellation test, Catherine Bergego Scale (CBS), Mini-Mental State Examination (MMSE), and the Korean version of Modified Barthel Index (K-MBI). These measurements were evaluated before and after treatment. Results For each group, 10 patients were recruited. There were no significant differences in baseline characteristics or initial values among the three groups. Two weeks after the therapy, all groups showed significant improvement in MVPT-3, line bisection test, star cancellation test, CBS, MMSE, and K-MBI. However, changes in measurements showed no significant differences among groups. Conclusion Treatment effect of the combined therapy of robotic therapy and low-frequency rTMS therapy for hemispatial neglect was not statistically different from that of each single treatment. Results of this study did not prove the superiority of any of the three treatments. Further study with large number of patients is needed to evaluate the superiority of these treatments.

• 생물정신의학
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• 제23권3호
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• pp.89-101
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• 2016

Transcranial magnetic stimulation (TMS) is a safe, noninvasive and useful technique for exploring brain function. Especially, for the study of cognition, the technique can modulate a cognitive performance if the targeted area is engaged, because TMS has an effect on cortical network. The effect of TMS can vary depending on the frequency, intensity, and timing of stimulation. In this paper, we review the studies with TMS targeting various regions for evaluation of cognitive function. Cognitive functions, such as attention, working memory, semantic decision, discrimination and social cognition can be improved or deteriorated according to TMS stimulation protocols. Furthermore, potential therapeutic applications of TMS, including therapy in a variety of illness and research into cortical localization, are discussed.

• 한국정보통신학회논문지
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• 제14권5호
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• pp.1209-1216
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• 2010

당뇨 합병증 등으로 인한 말초혈류 및 신경장애, 수족냉증 및 손가락 관절염, 통증 질환이 증가하고 있으며, 이러한 문제를 개선할 수 있는 손가락 질환 전용 치료기기가 전무한 상태로 이와 관련된 치료기의 개발이 필요하다. 본 연구에서는 시변 미약자기장을 이용하여 비침습적으로 말초혈류/신경개선과 손가락 류마티스 치료를 위한 솔레노이드 원통형 코일을 제작하고, 다양한 치료목적에 사용하기 위해서 3가지 자극모드(N, S, N/S)와 자극주파수(0.25, 0.5, 1hz)를 선택할 수 있는 시스템을 설계하였다. 자속밀도 측정 프로브를 솔레노이드의 중심에서부터 거리를 0 ~ 3cm 단계로 자극방식과 주파수별로 자속밀도를 측정하였다. 자속밀도를 측정한 결과, 모든 자극방식과 주파수에서 솔레노이드 내부의 중심(0cm)에 근접할수록 자속밀도가 급격히 증가하였다. 솔레노이드 중심 자속밀도는 N자극 (294.3mT)과 S자극(293.8mT)에서는 1Hz, N/S자극(275.4mT)에서는 0.25Hz에서 가장 높게 측정되었다. 본 논문에서는 다양한 패턴과 강도의 자기장을 이용하여 다양한 손가락 질환을 치료할 수 있는 솔레노이드형 치료기기를 개발하였다. 솔레노이드 내부 자속밀도를 측정함으로써 손가락 말초질환 개선을 위한 미약자기장 시스템의 임상 적용 가능성을 확인하였다.

• 지역사회간호학회지
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• 제19권4호
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• pp.696-703
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• 2008

Purpose: To Perform a randomized comparative study investigating the effects of Pelvic Floor Muscle Exercise(PME) and Magnetic Stimulation Therapy(MST) and to identified the problems in each of PME & MST Method: Forty-nine patients with mild stress incontinence were randomly assigned to either of two treatment groups (24 patients in the PME group and 25 in the MST group). The PME group had a video exercising program for 40 times every day during 6 weeks. The MST group was treated with BioCon-2000TM, 2times/ week for six weeks. Pre-test and post-test were performed by Prineometer, 1-hour pad test. and Jackson's BFLUTS questionnaire of Jackson. Collected data were analysed using SAS 9.1 by frequency, Kolmogorov-Smirnov Z. Chi Square-test, t-test, Fisher Exact probability test, Paired t-test, and Wilcoxon's rank sum test. Results: In comparison between before and after PME and MST, statistically significant difference was observed in maximal vaginal pressure, duration of vaginal contraction, amount of urine, and symptom of urination. In the comparison of the effectiveness between PME & MST, only the maximal of vaginal pressure (Z=2.58, p= .010) was significantly different. Conclusion: The factor more effective in the MST group than in the PME group was high compliance.

• The Journal of Korean Physical Therapy
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• 제23권1호
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• pp.77-82
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• 2011

Purpose: Recently, many studies have demonstrated that application of external stimulation can modulate cortical excitability of the human brain. We attempted to observe cortical excitability using functional magnetic resonance imaging (fMRI) during the application of transcranial direct current stimulation (tDCS) or functional electrical stimulation (FES). Methods: We recruited two healthy subjects without a history of neurological or psychiatric problems. fMRI scanning was done during? each constant anodal tDCS and FES session, and each session was repeated three times. The tDCS session consisted of three successive phases (resting phase: 60sec dummy cycle: 10sec tDCS phase: 60sec). The FES session involved stimulation of wrist extensor muscles over two successive phase (resting phase: 15sec FES phase: 15sec). Results: The average map of the tDCS and FES analyses showed that the primary sensory-motor cortex area was activated in all subjects. Conclusion: Our findings show that cortical activation can be induced by constant anodal tDCS and FES. They suggest that the above stimuli have the potential for facilitating brain plasticity and modulating neural excitability if applied as specific therapeutic interventions for brain injured patients.

• The Journal of Korean Physical Therapy
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• 제22권1호
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• pp.67-73
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• 2010

Purpose: We tested whether repetitive transcranial magnetic stimulation (rTMS) improved recovery following spinal cord injury (SCI) in rats with transplantation of adipose tissue-derived stromal cells (ATSCs). Methods: Twenty Sprague-Dawley rats (200-250 g, female) were used. Moderate spinal cord injury was induced at the T9 level by a New York University (NYU) impactor. The rat ATSCs (approximately $5{\times}10^5$ cells) were injected into the perilesional area at 9 days after SCI. Starting four days after transplantation, rTMS (25 Hz, 0.1 Tesla, pulse width=$370{\mu}s$, on/off time=3 sec/3 sec) was applied daily for 7 weeks. Functional recovery was assessed using the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale as well as pain responses for thermal and cold stimuli. Results: Both groups showed similar, gradual improvement of locomotor function. rTMS stimulation decreased thermal and cold hyperalgesia after 7 weeks, but sham stimulation did not. Conclusion: rTMS after transplantation of ATSCs in an SCI model may reduce thermal hyperalgesia and cold allodynia, and may be an adjuvant therapeutic tool for pain control after stem cell therapy in SCI.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2006년도 하계종합학술대회
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• pp.855-856
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• 2006

Magnetic nerve stimulation treatment is much backward real condition than other field. Specially, successful medical treatment introduction of magnetic field (MF) can was refered long ago in Avicenna's work, and is thought as age of medicine magnetology development recently. These development is achieved through biologist and biophysicist and clinician's joint effort, but, new mountings and relationship air tassel are developed steadily. Magnetic nerve stimulation treatment field designs treatment system by each function during long wave high-amplitude (traditional magneto therapy of greatly great that strong that) short time that CMF, VMF, PMF field etc. are representative but are HPMT technology in this research and manufacture and special quality did comparative analysis.