• Journal of Life Science
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• 제10권2호
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• pp.33-38
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• 2000

Maekmoondong-Tang is prescription recorded on Zang‘s ${ulcorner}$Synopsis of the Golden Chamber${\lrcorner}$ for the first time. It can be used in abnormal rising of qi, asthma, swelling throat ect. So it is observed influence of Maekmoondong-Tang on respiratory aspect of allergic asthma patient, we have significant result and report it. We used egg-white and ovalbmuin (OVA) to induce asthma in experimental animals for observe what maekmoondong-Tang have an effect on asthma. And it is observed respiratory aspect and obtained next conclusions. 1. Number of total respiration in group that is prescribed Maekmoondong-Tang slightly increased than in control group. 2. Number of abnormal respiration in group that is prescribed Maekmoondong-Tang decreased than in control group significantly.

• 대한한의학회지
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• 제23권1호
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• pp.37-49
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• 2002

Objectives: Maekmoondong-tang and Jeongcheonhwadamgangki-tang are herbal decoctions which have been used as traditional therapeutic agents for asthma. This study was performed to investigate the effects of Maekmoondong-tang and Jeongcheonhwadamgangki-tang on immune Cell & serum OA-specific 19B in broncho-alveolar lavage fluid (BALF) in rat asthma model. Methods: Rats were sensitized with ovalbumin (OA); at day I the sensitized group and Maekmoondong-tang and Jeongcheonhwadamgangki-tang groups were systemically immunized by subcutaneous injection of 1mg OA and 300mg of $Al(OH)_3$ in a total volume of 2ml. At the same time, 1ml of 0.9% saline containing $6{\times}10^9$ B. pertussis bacilli was injected by i.p. for 14 days. After systemic immunization, the rats received local immunization by inhaling 0.9% saline aerosol containing 2% (wt/vol) OA. A day after local immunization, BAL fluid was collected from the rats. A day after local immunization, rats were orally administered with each of Maekmoondong-tang and Jeongcheonhwadamgangki-tang extract for 14 days. Lymphocyte, CD4+T-cell CD8+ T-cell counts, CD4+/CD8+ ratio in BALF, change of serum OA-specific IgE level, and CD4+T-cell CD8+T-cell percentage in the peripheral blood were measured and evaluated. Results: Maekmoondong-tang and Jeongcheonhwadamgangki-tang showed a suppressive effect on the rat asthma model. Maekmoondong-tang decreased total cell, lymphocyte, CD4+T-cell, CD8+T-cell in BALF, and serum OA specific 19B level as compared with the control group, whereas Maekmoondong-tang decreased CD4+/CD8+ ratio in BALF with statistical nonsignificance as compared with the control group. 1 decreased total cell, CD4+T-cell, CD4+/CD8+ ratio in BALF, and serum OA specific IgE level, whereas Jeongcheonhwadamgangki-tang decreased ymphocyte, and CD8+T-cell in BALF with statistical nonsignificance as compared with the control group. CD4+T-cell and CD8+ T-cell percentage in peripheral blood were not changed significantly in all the experimental groups. Conclusions: This study shows that Maekmoondong-tang and Jeongcheonhwadamgangki-tang have a suppressive effect on asthma. Maekmooruiong-tang and Jeongcheonhwadamgangki-tang would be useful asthma treatment agents.

• 동의생리병리학회지
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• 제17권4호
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• pp.946-951
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• 2003

The purpose of this research was to investigate the effect of Maekmoondong-tang(MMDT) on the activity of immune cell. The addition of MMDT(10 ㎍/㎖) enhanced the proliferation of cultured-splenocytes and thymocytes. And administration of MMDT(250, 500 ㎎/㎏) accelerated subpopulation of splenic T lymphocytes in BALB/c mice. In contrast, the treatment of the high concentration (500 ㎎/㎏)of MMDT were decreased thymic T lymphocytes. Administration of MMDT(250, 500 ㎎/㎏) eminently enhanced the production of IFN-γ. And MMDT did not affect the cell viability of Jurkat leukemia cells. These results suggest that MMDT have a immunoregulatory effect via enhanced cell mediated immunity

• Journal of Applied Biological Chemistry
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• 제61권3호
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• pp.283-290
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• 2018

맥문동탕 열수추출물의 용매분획물을 이용하여 1-1-diphenyl-2-picryl-hydrazyl radical scavenge, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenge, elastase, tyrosinase 억제 효과를 검증하였고 그 결과 에틸아세테이트 분획물(MW-EA)에서 가장 우수한 저해활성을 보여주었다. 세포를 이용한 활성 검증에서는 MW-EA를 처리하였을 때 ROS 저해활성에서 34% ($100{\mu}g/mL$), MMPs 저해 50% ($100{\mu}g/mL$) 이상, 미백 활성에서는 tyrosinase를 25% ($50{\mu}g/mL$) 억제하는 것을 확인 하였다. 따라서 맥문동탕은 피부개선 소재로서 개발 가능성이 높다고 사료된다.

• 대한한방내과학회지
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• 제42권5호
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• pp.1148-1159
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• 2021

Objectives: This study investigated the effect of combined Korean medical treatment and antibiotics on a patient diagnosed with nontuberculous mycobacterial lung disease. Methods: The patient had been treated with antibiotics since July 2020 concurrently with Maekmoondong-tang, Banhasasim-tang, Gwakhyangjunggi-san and Bojungikgi-tang. The improvement of symptoms was evaluated using scores for the numerical rating scale (NRS), the Medical Research Council (MRC) dyspnea scale, C-reactive protein (CRP) levels, and computed tomography (CT). Results: Following treatment, the NRS, MRC dyspnea scale and CT images significantly improved. Also, CRP levels remained in the normal range during treatment. Conclusions: Traditional Korean medical treatment combined with antibiotics could be effective for treating patients with nontuberculous mycobacterial lung disease.

• 대한한방내과학회지
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• 제40권1호
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• pp.117-125
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• 2019

Objective: This study investigated the effect of Yin deficiency medicine on halitosis patients and the relationship between subjective recognition and objective symptoms of oral malodor. Methods: We administered Yin deficiency medicine, such as Jaeumganghwa-tang, and conducted the Halitosis Associated Life-quality Test (HALT) and $OralChroma^{TM}$. Subjective recognition of halitosis was evaluated using HALT. Objective symptoms of halitosis were evaluated using $OralChroma^{TM}$. In addition, before and after administering medicine, we determined the halitosis according to percentages at the patient's word. Results: The total gas and HALT were not related to each other after Maekmoondong-tang or Saengmaek-san were administered to 10 halitosis patients. Conclusion: Yin deficiency medicine is effective in treating halitosis. Moreover, the subjective recognition and objective symptoms of halitosis are not related to each other.

• 대한본초학회지
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• 제24권3호
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• pp.161-167
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• 2009

Objectives : Maekmoondong-tang (MMDT), a Korean herbal medicine, has been used to treat severe dry cough in patients with bronchitis and pharyngitis. MMDT has been reported to have anti-inflammatory, anti-allergic, immunomodulatory, secretory-modulating, and metabolic regulatory actions. However, there are no evidence in regard to the effects of MMDT on carcinogenesis and metastasis. Here, we investigated the effects of 70% ethanol extract of MMDT on cell viability, apoptosis, and motility in human hepatocarcinoma HepG2 cells. Methods : Cell viability was measured using the CCK-8 assay, and the apoptosis induction was evaluated by caspase-3 activity. To detect apoptotic features, the cells treated with MMDT were stained with 4'-6-diamidino-2-phenylindole (DAPI). Cell motility was examined by Boyden chamber assay and Real-time Cell Index of Migration assay. Gelatin zymography also performed to measure matrix metalloproteinase (MMP)-2/9 activity. Results : We found that MMDT significantly inhibited cell proliferation and increased caspase-3 activity in a dose-dependent manner in HepG2 cells. Apoptotic features such as chromatin condensation and apoptotic bodies were observed in MMDT-treated cells by DAPI staining. MMDT also suppressed PMA-induced cell motility and activities of MMP-2/9. Conclusions : Our results exhibited that MMDT possess the anti-carcinogenetic and anti-metastatic activities via caspase-3 activation and down-regulation of cell motility and invasion in HepG2 cells. Therefore, these findings suggest that MMDT could be potentially applied to the prevention and treatment of cancer.

• 한국약용작물학회지
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• 제3권1호
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• pp.56-60
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• 1995

맥문동(麥門冬)의 괴근비대기간중(塊根肥大期間中)의 괴근비대양상(塊根肥大樣相), 수량(收量)및 성분변이(成分變異)를 조사(調査)하기 위하여 맥문동 1호를 공시(供試)하여 '92년 .4월 10일에 $30{\times}10cm$로 정식(定植)해서 다음해 1월 15일부터 4월 15일까지 15일 간격(間隔)으로 수확하여 수량관련형질(收量關聯形質) 및 성분변이(成分變異)를 조사한 결과를 요약(要約)하면 다음과 같다. 1. 맥문동의 지상부 생육은 월동중(越冬中)에도 계속 증가(增加)하였고 괴근(塊根)의 형성(形成)은 1월 15일 이전에 결정(決定)되는 것으로 판단(判斷)되었다. 2. 괴근의 비대(肥大)는 월동중(越冬中)에 진행(進行)되며 2월 28일 이후에 완료(完了)되는 것으로 나타났다. 그리고 괴근수량은 3월 15일에서 387kg/10a로 최고수량(最高收量)을 보여 수확적기(收穫適期)로 판단(判斷)되었다. 3. 괴근의 전당함량(全糖含量)은 1월 30일에 가장 높았고, 그 이후 점차(漸次) 감소(減少)하여 3월 15일에 가장 낮으며, 전당함량(全糖含量)과 수량(收量)과는 고도(高度)의 부(負)의 유의상관(有意相關)(-0.788**)을 보였다.

• 한국약용작물학회지
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• 제2권2호
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• pp.110-113
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• 1994

맥문동(麥門冬) 재식밀도(栽植密度)에 따른 생육(生育) 및 수양성(收量性)을 구명(究明)코자 맥문동(麥門冬) 1호(號)를 공시(供試)하여 재식밀도(栽植密度)는 조간(條間) $20cm{\times}$ 주간(株間) 10cm, $30{\times}10cm$, $30{\times}30cm$의 4수준(水準)으로 하고 주당본수(株當本數)는 2,4,6본(本)으로 4월(月) 10일(日)에 정식(定植)하여 시험(試驗)을 실시(實施)한 결과(結果)를 요약(要約)하면 다음과 같다. 1. 시험포장(試驗圃場) 토양(土壤)의 이화학적(理化學的) 특성(特性)은 중점토(重點土)로 유기물(有機物), 유효린산(有效隣酸), Ca, Mg는 전국치(全國値)보다 낮은 반면, K, C.E.C.함량(含量)은 높았다. 2. 재식밀도(栽植密度)에 다른 맥문동(麥門冬)의 지토부(地土部) 생육(生育)은 밀치(密値)에 비하여 소치(疎値)할수록, 잎은 크고, 분얼수(分蘖數)도 많았으며, 경엽중(莖葉重)은 무거운 경향(傾向)이었다. 재식밀도별(栽植密度別) 지토부(地土部)의 수양구성요소(收量構成要素) 및 수양성(收量性)은 재식거리(栽植距離) $\30{\times}10$ 재식본수(栽植本數) 6본(本)으로 정식(定植)한 것이 괴근수(塊根數)가 43개(個)로서 많았고, 건근수률도 372kg /10a로 높았다. 4. 각형질간(各形質間)의 상관관계(相關關係)를 보면 분얼수(分蘖數) 뿌리무게, 괴근수간(塊根數間)에 유혜성(有蕙性)이 있었고, 괴근수(傀根數)와 수양간(收量間)에도 고도(高度)의 정(正)의 상관(相關)을 보였다.