• 대한한의학회지
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• 제25권3호
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• pp.55-66
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• 2004

Objectives : This study was aimed to evaluate the anti-starvation stress effect of Atractylodis Macrocephalae Rhizoma on mice. Methods : First, we divided the mice into 6 groups: Normal Group (group with no starvation), Control Group (administered normal saline 6 times before starting 36 hours starvation), Sample A Group (administered Atractylodis Macrocephalae Rhizoma 0.25g/kg 6 times before starting 36 hours starvation), Sample B Group (administered Atractylodis Mocrocephalae Rhizoma 0.5g/kg 6 times before starting 36 hours starvation), Sample C Group (administered Atractylodis Macrocephalae Rhizoma 1.0g/kg 6 times before starting 36 hours starvation), and Sample D Group (administered Atractylodis Macrocephalae Rhizoma 3.0g/kg 6 times before starting 36 hours starvation). Blood was collected from the retro-orbital plexus and then we measured the plasma corticosterone level from the blood. Rectal temperature was measured right after the blood collection. Results : 1. The plasma corticosterone level in Sample A. B, C, and D Groups decreased compared with the Control Group. Sample A and Sample B Groups showed significant differences (p<0.05, p<0.01) compared with the Control Group. 2. The rectal temperature in Sample A, B, C, and D Groups increased compared with the Control Group. Sample A, B. C, and D Groups showed significant differences (p<0.001, p<0.001, p<0.01, p<0.001) compared with the Control Group. Conclusions : Based on the above results, it might be recognized that Atractylodis Macrocephalae Rhizoma has anti-starvation stress effect, and that further study is needed from various viewpoints.

• 대한한의학방제학회지
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• 제18권1호
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• pp.13-21
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• 2010

Low Back Pain Prescriptions of Jin, sa tak are peculiar to using Atractylodis Macrocephalae Rhizoma(AMR). All low back pain prescriptions which are enlisted in Byunjeunggimoon, Byunjeungrok and Byunjeungokham include AMR. Whereas low back pain prescriptions which is enlisted in Seoksilbirok are 7 of 10. Preexistence of low back pain prescriptions are not necessarily used AMR. But Jin, sa tak who lived at Ming and Ching era presented AMR in low back pain treatment. AMR is able to get rid of dampness between the kidney functional area and umbilicus. The results are as follows : It is made much of the malicious dampness which is in the kidney. There are not used cold but warm and eliminating dampness herbs to invigorate kidney. It shows that Jin, sa tak who was a Taoist used invigorating and warming kidney herbs. Atractylodis Macrocephalae Rhizoma is mainly used in treating low back pain from Jin, sa tak. Jin, sa tak shows concrete prognosis to treat a disease.

• 동의생리병리학회지
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• 제22권1호
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• pp.89-95
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• 2008

This experimental study was designed to investigate the effects of Ijin-tang add Atractylodis rhizoma and Atratcylodis macrocephalae rhizoma (IJTAA) on the change of weight and serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, free fatty acid, total lipid and phospholipid level in obese mice induced by high fat diet. Experimental groups were as follows ; Normal group was fed normal diet and administered distilled water during 7 weeks, Control group was fed high fat diet and administered distilled water during 7 weeks, Sample A group was fed high fat diet and administered IJTAA 500 ㎎/㎏/day/mouse during 7 weeks, Sample B group was fed high fat diet and administered IJTAA 700 ㎎/㎏/day/mouse during 7 weeks. The results were as follows ; 1. In Sample A group and Sample B group, There were significantly decreased in body weight, serum total cholesterol level, serum triglyceride level, serum free fatty acid level, serum total lipid level and serum phospholipid level in comparison with Control group. 2. In Sample A group and Sample B group, There were significantly increased in serum HDL-cholesterol level in comparison with Control group. 3. In Sample A group and Sample B group, There were decreased in serum LDL-cholesterol level in comparison with Control group. According to above results, I suggest IJTAA is able to be used for managing obesity by controllong body weight, serum total cholesterol level, serum triglyceride level, serum free fatty acid level, serum total lipid level and serum phospholipid level.

• 식물분류학회지
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• 제33권3호
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• pp.227-253
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• 2003

한국산 사초속(Carex Linn$\acute{e}$) 괭이사초아속(subgen. Vignea Nees), 통보리사초절(sect. Macrocephalae K$\ddot{u}$k.), 나도벌사초절(sect. Gibbae K$\ddot{u}$k.), 겹개구리사초절(sect. Stellulatae Kunth), 충실사초절(sect. Elongatae Kunth)과 타래사초절(sect. Ovales Kunth) 식물 각각 1종과 산사초절(sect. Heleonastes Kunth) 식물 2종을 대상으로 외부형태학적 형질을 재검토하고, 광학현미경과 주사전자현미경을 사용하여 과낭, 수과와 잎의 표피형을 비교 분석하였다. 그 결과 얻어진 정량적 형질(줄기, 잎, 이삭, 비늘조각, 총포, 과낭과 수과의 길이와 너비, 총포의수, 잎의 기공복합체의 크기와 빈도, 기본세포줄, 기공줄의 수), 정성적 형질(암 수이삭, 비늘조각, 과낭과 수과, 줄기의 단면모양과 비늘조각 윗부분의 모양, 과낭과 수과의 표피세포, 잎의 표피구성요소; 기본표피 세포의 모양, 세포벽의 굴곡, 규소체의 모양, 부세포의 모양)과 잎의 앞 뒷면의 유두돌기, 가시돌기와 털의 유 무등이 종을 동정하고 식별하는데 유용하였다. 그 결과 괭이사초아속에 속하는 6절의 식물 중에는 자웅이주로 암꽃 이삭화서와 수꽃 이삭화서가 다른 개체로 된 통보리사초절과 자웅동주이나 수꽃이 아래부분에 암꽃이 윗부분에 배열되는 양성화 이삭화서로 자웅형이삭(gynecandrus) 형태를 이루는 나도벌사초절, 겹개구리사초절, 충실사초절, 타래사초절, 산사초절로 크게 나눌 수 있었고, 과낭의 가장자리의 날개모양과 부리모양, 과낭 표피의 맥의 유 무, 잎의 앞 뒷면의 유두돌기와 가시돌기의 유 무가 괭이사초 아속에 속하는 절과 종을 구별하는 유용한 형질로 확인 되었다.

• 동의생리병리학회지
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• 제22권2호
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• pp.277-281
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• 2008

The objectives of this study lie in theoretical establishment of Bobee-tang for curing the asthenic syndrome of spleen through analyzing the component medicines and combination principles of Hyeongok's Bobee-tang, and furthermore, maximizing the clinical use of Bobee-tang. This study analyzed the component medicines and combination principles of Hyeongok's Bobee-tang based on the theory for properties and tastes of herbal medicines from the ${\ulcorner}$Yellow Emperor's Canon of Internal Medicine${\lrcorner}$, the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's Bobee-tang is an odd prescription, composed of 7 kinds of ingredients : No.1 Radix Ginseng (2don;7.5 g), No.2 Rhizoma Atractylodis Macrocephalae (1don;3.75 g), No.3 Carapax Et Plastrumtestudinis (1don), No.4 Concha Ostreae (1don), No.5 Cortex Cinnamomi (1don), No.6 Rhizoma Zingiberis Praeparatae (1don), and No.7 Radix Glycyrrhizae (1don). First, to cure the asthenic syndrome of the spleen, the methods of invigorating the spleen and the heart, and purging the liver should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's Bobee-tang is combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

• 대한예방한의학회지
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• 제3권1호
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• pp.101-123
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• 1999

To investigate the documental records of the medi-alcohol theraphy on the Gastrointestinal disease, the 33 kinds of medical books editioned from the old to the present were used. the results were followed Many herbs used on the Gastrointestinal disease were sequently Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma, Ginseng Radix. The herbs of invigorating and warming body, regulating the flow of qi etc. were many occupied(used) in treating the Gastrointestinal disease. In analyzing treatment symptom as medi-alcohol theraphy were sequently many used abdominal pain, inappetence, gastrointestinal cancer, indigestion, fatigue, vomiting, diarrhea, abdominal dropsy. The kinds of using medi-alcohol on the Gastrointestinal disease were totally 120 ones.

• 대한한방내과학회지
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• 제21권4호
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• pp.677-682
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• 2000

Idopathic thrombocytopenic purpura(ITP) is the most common autoimmune hematologic disorder. The use of glucocorticoids and splenectomy have been the mainstays of treatment of ITP Some studies have shown that chinese herbal medicine treatment increase platelet count level of ITP patients. However, there is a lack of research considering oriental herbal medicine with ITP, in korea. A 33-year-old female who had diagnosed ITP on Mar 1999, was treated herbal medicine for decreased platelet count level$(34000/{\mu}l)$ that was identified on regular follow-up. this patient's platelet count level was get to normal$(139000/{\mu}l)$ by BuQiSheXue(補氣攝血) pattern herbal medicine that composed with Radix Astragali(黃?), Herba Agrimoniae(仙鶴草), Rhizoma Atractylodis Macrocephalae(白朮), Radix codonopsis(黨參), etc. I report the case with a review of literature.

• 대한한의학방제학회지
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• 제11권2호
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• pp.147-158
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• 2003

This study aimed to investigate the effect of each constituent-herb of Sagoonja-Tang on the plasma corticosterone level in mice exposed to heat stress. Each formula(0.5g/kg, 1.0g/kg) was injected intragastrically to mice exposed to forced hot water swimming(42$^{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 15 minutes after the heat stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group didn't show significant changes. 3. Atractylodis group showed significant decrease at 0.5g/kg dose(P<0.05). But it showed slightly increase at 1.0g/kg dose. 4. Poria group didn't show significant changes. 5. Glycyrrhizae group showed slightly increase, but insignificant. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level in mice exposed to heat stress.

• 대한한의학방제학회지
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• 제11권2호
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• pp.83-94
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• 2003

This study aimed to investigate the effects of each constituent-herb of Sagoonja- Tang on the plasma corticosterone level in mice exposed to cold stress. Sagoonja-Tang is composed of Ginseng Radix, Atractylodis Radix, Poria, and Glycyrrhizae Radix. Each constisuent-herb(0.5g/kg, 1.0g/kg) was administered intragastrically to mice 1hr prior to expose to forced cold water swimming($4{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 30 minutes after the cold stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group(PGR group) didn't show any significant changes. 3. Atractylodis group(AR group) showed significant decrease at 0.5g/kg dose (P<0.01). But it didn't show significant changes at 1.0g／kg dose. 4. Poria group(P group) didn't show significant changes. But it showed slightly increase at 1.0g/kg dose. 5. Glycyrrhizae group(GR group) didn't show significant changes. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level and the dose of herbs had a different effect on the plasma corticosterone level in mice exposed to cold stress.

• 동의생리병리학회지
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• 제24권6호
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• pp.903-906
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• 2010

The spleen is the source of gi, blood, body fluid and plays a vital role in maintaining life. The function of the spleen is to transform food nutrients and water, and to transport them to the heart and the lung. The movement of splenic gi is marked by elevation. The spleen governs the activity of elevating the lucid. The function of transportation and transformation is usually disturbed in the state of Gi deficiency of the spleen. The main clinical manifestations of gi deficiency of the spleen can be divided into as followers: anorexia, loose stool if the digesting and absorbing functions are disturbed; phlegm and edema if dampness and water are retained due to unhealthy water metabolism. Sagunja-tang can be applied for gi deficiency syndrome of the spleen. Ingredient bakchul(Rhizoma Atractylodis Macrocephalae) and bokryeung(Poria) can be used as monarch drug to eliminate dampness and strengthen the spleen.