• 제목/요약/키워드: Mace

검색결과 76건 처리시간 0.018초

CT-Based Leiden Score Outperforms Confirm Score in Predicting Major Adverse Cardiovascular Events for Diabetic Patients with Suspected Coronary Artery Disease

  • Zinuan Liu;Yipu Ding;Guanhua Dou;Xi Wang;Dongkai Shan;Bai He;Jing Jing;Yundai Chen;Junjie Yang
    • Korean Journal of Radiology
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    • 제23권10호
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    • pp.939-948
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    • 2022
  • Objective: Evidence supports the efficacy of coronary computed tomography angiography (CCTA)-based risk scores in cardiovascular risk stratification of patients with suspected coronary artery disease (CAD). We aimed to compare two CCTA-based risk score algorithms, Leiden and Confirm scores, in patients with diabetes mellitus (DM) and suspected CAD. Materials and Methods: This single-center prospective cohort study consecutively included 1241 DM patients (54.1% male, 60.2 ± 10.4 years) referred for CCTA for suspected CAD in 2015-2017. Leiden and Confirm scores were calculated and stratified as < 5 (reference), 5-20, and > 20 for Leiden and < 14.3 (reference), 14.3-19.5, and > 19.5 for Confirm. Major adverse cardiovascular events (MACE) were defined as the composite outcomes of cardiovascular death, nonfatal myocardial infarction (MI), stroke, and unstable angina requiring hospitalization. The Cox model and Kaplan-Meier method were used to evaluate the effect size of the risk scores on MACE. The area under the curve (AUC) at the median follow-up time was also compared between score algorithms. Results: During a median follow-up of 31 months (interquartile range, 27.6-37.3 months), 131 of MACE were recorded, including 17 cardiovascular deaths, 28 nonfatal MIs, 64 unstable anginas requiring hospitalization, and 22 strokes. An incremental incidence of MACE was observed in both Leiden and Confirm scores, with an increase in the scores (log-rank p < 0.001). In the multivariable analysis, compared with Leiden score < 5, the hazard ratios for Leiden scores of 5-20 and > 20 were 2.37 (95% confidence interval [CI]: 1.53-3.69; p < 0.001) and 4.39 (95% CI: 2.40-8.01; p < 0.001), respectively, while the Confirm score did not demonstrate a statistically significant association with the risk of MACE. The Leiden score showed a greater AUC of 0.840 compared to 0.777 for the Confirm score (p < 0.001). Conclusion: CCTA-based risk score algorithms could be used as reliable cardiovascular risk predictors in patients with DM and suspected CAD, among which the Leiden score outperformed the Confirm score in predicting MACE.

Evaluation of the Ostium in Anomalous Origin of the Right Coronary Artery with an Interarterial Course Using Dynamic Cardiac CT and Implications of Ostial Findings

  • Jin-Young Kim;Yoo Jin Hong;Kyunghwa Han;Suji Lee;Young Jin Kim;Byoung Wook Choi;Hye-Jeong Lee
    • Korean Journal of Radiology
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    • 제23권2호
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    • pp.172-179
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    • 2022
  • Objective: We aimed to evaluate the ostium of right coronary artery of anomalous origin from the left coronary sinus (AORL) with an interarterial course throughout the cardiac cycle on CT and analyze the clinical significance of the ostial findings. Materials and Methods: From January 2011 to December 2015, 68 patients (41 male, 57.3 ± 12.1 years) with AORL with an interarterial course and retrospective cardiac CT data were included. AORL was classified as high or low ostial location based on the pulmonary annulus in the diastolic and systolic phases on cardiac CT. In addition, the height, width, height/width ratio, area, and angle of the ostium were measured in both cardiac phases. After cardiac CT, patients were followed until December 31, 2020 for major adverse cardiac events (MACE). Clinical and CT characteristics associated with MACE were explored using Cox regression analysis. Results: During a median follow-up period of 2071 days (interquartile range, 1180.5-2747.3 days), 13 patients experienced MACE (19.1%, 13/68). Seven (10.3%, 7/68) had the ostial location change from high in the diastolic phase to low in the systolic phase. In the univariable analysis, younger age (hazard ratio [HR] = 0.918, p < 0.001), high ostial location (HR = 4.008, p = 0.036), larger height/width ratio (HR = 5.621, p = 0.049), and smaller ostial angle (HR = 0.846, p = 0.048) in the systolic phase were significant predictors of MACE. In multivariable cox regression analysis, younger age (adjusted HR = 0.917, p = 0.002) and high ostial location in the systolic phase (adjusted HR = 4.345, p = 0.026) were independent predictors of MACE. Conclusion: The ostial location of AORL with an interarterial course can change during the cardiac cycle, and high ostial location in the systolic phase was an independent predictor of MACE.

Prognostic Value of Coronary CT Angiography for Predicting Poor Cardiac Outcome in Stroke Patients without Known Cardiac Disease or Chest Pain: The Assessment of Coronary Artery Disease in Stroke Patients Study

  • Sung Hyun Yoon;Eunhee Kim;Yongho Jeon;Sang Yoon Yi;Hee-Joon Bae;Ik-Kyung Jang;Joo Myung Lee;Seung Min Yoo;Charles S. White;Eun Ju Chun
    • Korean Journal of Radiology
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    • 제21권9호
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    • pp.1055-1064
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    • 2020
  • Objective: To assess the incremental prognostic value of coronary computed tomography angiography (CCTA) in comparison to a clinical risk model (Framingham risk score, FRS) and coronary artery calcium score (CACS) for future cardiac events in ischemic stroke patients without chest pain. Materials and Methods: This retrospective study included 1418 patients with acute stroke who had no previous cardiac disease and underwent CCTA, including CACS. Stenosis degree and plaque types (high-risk, non-calcified, mixed, or calcified plaques) were assessed as CCTA variables. High-risk plaque was defined when at least two of the following characteristics were observed: low-density plaque, positive remodeling, spotty calcification, or napkin-ring sign. We compared the incremental prognostic value of CCTA for major adverse cardiovascular events (MACE) over CACS and FRS. Results: The prevalence of any plaque and obstructive coronary artery disease (CAD) (stenosis ≥ 50%) were 70.7% and 30.2%, respectively. During the median follow-up period of 48 months, 108 patients (7.6%) experienced MACE. Increasing FRS, CACS, and stenosis degree were positively associated with MACE (all p < 0.05). Patients with high-risk plaque type showed the highest incidence of MACE, followed by non-calcified, mixed, and calcified plaque, respectively (log-rank p < 0.001). Among the prediction models for MACE, adding stenosis degree to FRS showed better discrimination and risk reclassification compared to FRS or the FRS + CACS model (all p < 0.05). Furthermore, incorporating plaque type in the prediction model significantly improved reclassification (integrated discrimination improvement, 0.08; p = 0.023) and showed the highest discrimination index (C-statistics, 0.85). However, the addition of CACS on CCTA with FRS did not add to the prediction ability for MACE (p > 0.05). Conclusion: Assessment of stenosis degree and plaque type using CCTA provided additional prognostic value over CACS and FRS to risk stratify stroke patients without prior history of CAD better.

개인신원정보 보호를 위한 광 보호 시스템 (Optical security system for protection of personal identification information)

  • 윤종수;도양회
    • 한국광학회지
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    • 제14권4호
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    • pp.383-391
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    • 2003
  • 개인의 신원정보 보호를 위하여 새로운 광 정보보호 시스템을 제안하였다. 개인 신원정보의 확인과 인증을 위하여 얼굴영상과 개인식별번호로 구성된 신원정보를 사용하였다. 영상 암호화는 4-f 광상관기의 입력과 푸리에영역에서 랜덤위상패턴을 사용하는 위상암호화 기술을 사용하였다. 그렇지만 암호화된 영상을 복원하는 과정에서 개인의 신원정보가 유출될 가능성이 있다. 이에 대처하기 위하여 신원확인 과정에서 영상을 복원하지 않고 암호화된 영상을 그대로 사용하였다. 암호화된 개인식별번호는 제안된 MMACE_p 필터를 사용하여 분류ㆍ인식하였고, 개인정보의 인증은 OWMF를 사용하여 얼굴영상의 상관치를 구하여 확인하였다. 제안된 MMACE_p 필터는 10개의 암호화된 숫자를 한꺼번에 인식할 수 있도록 4개의 MACE_p필터를 다중화하여 합성하였고, OWMF는 얼굴영상의 분리인식 능력과 SNR을 향상시킬 수 있도록 하였다. 컴퓨터 시뮤레이션을 통하여 제안된 정보보호기술이 개인신원정보 보호에 적용될 수 있음을 보였다.

관상동맥 약물 용출 스텐트 삽입 후 항혈소판제제 3제요법과 2제요법의 임상적 효과 비교 (Effect of Triple Compared to Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Percutaneous Coronary Intervention)

  • 예경남;김정태;이숙향
    • 한국임상약학회지
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    • 제22권2호
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    • pp.113-122
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    • 2012
  • ACC/AHA/SCAI Guideline recommends for administration dual antiplatelet therapy after drug-eluting stent (DES) to prevent restenosis and stent thrombosis in patients with percutaneous coronary intervention (PCI). Recently triple antiplatelet therapy including cilostazol is known to reduce restenosis and stent thrombosis significantly after DES implantation. However, there is lack of data providing the efficacy of triple antiplatelet therapy. The purpose of this study is to evaluate the clinical effects of the triple therapy after DES implantation compared with the dual therapy. This retrospective study collected data from medical charts of 251 patients who received DES implantation between Jul 2006 and Jun 2008. They received either dual antiplatelet therapy (N = 154 clopidogrel and aspirin; Dual group) or triple antiplatelet therapy (N = 97 cliostazol, clopidogrel and aspirin; Triple group). Major adverse cardiac event rates (MACE, included total death, myocardial infarction, target lesion revascularization) at 12 months, 24 months, stent thrombosis, rates of bleeding complications and adverse drug reactions were compared between these two groups. Compared with the dual group, the triple group had a similar incidence of the MACE rates at 24months (12.3% vs. 12.4%, p = 0.99). There is no difference in overall stent thrombosis between two groups (Dual group 2.6% vs. Triple group 4.1%, p = 0.5). Subgroup analysis showed that diabetic patients got more benefit in reducing MACE rates but, there is no statistical difference. Bleeding complications and adverse drug effects were not different significantly. As compared with dual antiplatelet therapy, triple antiplatelet therapy did not reduce the 12-months, 24-months MACE rates and stent thrombosis. Bleeding complications and adverse drug effects were not different.

인쇄체 한글의 광학적 인식을 위한 다중 MACE 필터의 합성 (Synthesis of Multiplexed MACE Filter for Optical Korean Character Recognition)

  • 김정우;김철수;배장근;도양회;김수중
    • 한국통신학회논문지
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    • 제19권12호
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    • pp.2364-2375
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    • 1994
  • 효율적인 인쇄체 한글 인식을 위하여 다중 최소평균 상관 에너지 필터를 제안하였다. 제안된 방법은 기존의 나무구조 알고리듬의 단점인 인식시스템의 방대함과 인식방법의 복잡함을 해결하였다. 오직 하나의 자음 MMACE 필터와 모음 MMACE 필터를 사용하여 완전한 한글을 인식하였다. 각 MMACE 필터는 24개의 자모음으로 합성된 4개의 K-tuple MACE 필터를 이용하여 다중화시켰다. 따라서 제안된 MMACE 필터의 필터평면과 상관분포 평면은 4개의 부평면으로 나누어 진다. 각 상관분포 부평면으로 한글 인식을 위한 코드를 얻었다. 얻어진 코드와 컴퓨터에 내장된 자모음을 인식하기 위한 진리표와 비교하였다. 일치하는 코드의 해당자모음을 찾아 출력상관평면상의 상관첨두 위치에 치환하면 완전한 한글을 인식할 수 있다. 컴퓨터 시뮬레이션과 광 실험을 통하여 제안된 MMACE 필터를 이용한 한글 인식 시스템의 높은 변별력을 확인하였다.

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Solvent Extraction, Preconcentration and Determination of Thorium with Monoaza 18-Crown-6 Derivative

  • Dolak, I.;Karakaplan, M.;Ziyadanogullar, B.;Ziyadanogullari, R.
    • Bulletin of the Korean Chemical Society
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    • 제32권5호
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    • pp.1564-1568
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    • 2011
  • A solvent extraction separation, preconcentration and determination of thorium with a new crown, 2-ethyl-N-benzyl-4,7,10,13,16-pentaoxa-1-azacyclooctadecane (MACE), is described in the study. The amount of thorium in the aqueous phase and organic phase was determined by Inductively Coupled Plasma-Optical Emission Spectroscopy and Ultraviolet-Visible, respectively. Thorium loaded organic phase was quantitatively stripped in a stage by using 1.0 M $HNO_3$. Thorium was effectively extracted with MACE in the pH range of 6-7 to produce a 3:2 complex ratio in the chloroform. A highly sensitive and rapid spectrophotometric method was described for determination of trace amounts of thorium with MACE. The effective molar absorption coefficient at 281 nm is $1.98{\times}10^3\;mol^{-1}cm^{-1}$, and the system complies with Beer's law in the range from 0.464 to 2.32 ${\mu}gm\;L^{-1}$ of thorium. Thorium was also determined in standard and environmental samples.

우리나라의 낙농단지규모에 알맞는 사료가공시설의 모델개발(II) -TMR 지원시설의 모델 개발- (Development of Farm Size Dairy Feedmill System in Korea(II) -Development of the TMR Main Center-)

  • 김태욱;박경규
    • Journal of Biosystems Engineering
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    • 제19권4호
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    • pp.343-357
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    • 1994
  • Current commercial dairy feed has various problems in low feed productivity, inadequate formulation and higher feeding cost due to excessive capital investment and non-specialized system for the end product. To solve those problems, 6 TMR terminal models were developed in this study. The developed TMR terminal system consists of TMR terminal, TMR main center and combined system linked TMR terminal and TMR main center. 15 TMR main center models were developed to support 10, 20, 30, 40, 50 TMR terminal(30 ton/day basis) by 3 different types, and evaluated for capital investment and operation cost by the analysis of the newly developed computer program. Optimum model size is analyzed and suggested for each model. Followings are summary of this study : 1. The capital investment costs of TMR main centers were 1,600 to 3,800 million won for type 1, 2,200 to 4,500 million won for type 2 and 2,200 to 4,800 million won for type 3. Also model MACE30 or bigger were justified as the economical models. 2. The feed production costs of TMR main center models were 3,166 to 4,824 won/ton for type 1, 3,816 to 6,182 won/ton for type 2 and 3,990 to 6,263 won/ton for type 3. So feed production cost range was 3,166 to 6,263 won/ton. 3. The bigger production capacity, the less TMR main center production cost. The feed production cost of the biggest model MACE50 was 62~65% of smallest model MACE10.

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Poly(dimethylsiloxane) Mini-disk Extraction

  • Cha, Eun-Ju;Lee, Dong-Sun
    • Bulletin of the Korean Chemical Society
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    • 제32권10호
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    • pp.3603-3609
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    • 2011
  • A novel sampling method of the headspace poly(dimethylsiloxane) (PDMS) mini-disk extraction (HS-PDE) was developed, optimized, validated and applied for the GC/MS analysis of spices flavors. A prototype PDMS mini-disk (8 mm outer diameter, 0.157 mm thickness, 9.4 mg weight) has been designed and fabricated as a sorption device. The technique uses a small PDMS mini-disk and very small volume of organic solvent and less sample size than the solvent extraction. This new HS-PDE method is very simple to use, inexpensive, rapid, requires less labor. Linearities of calibration curves for ${\alpha}$-pinene, ${\beta}$-pinene, limonene and ${\gamma}$-terpinene by HS-PDE combined with GC/MS were excellent having $r^2$ values greater than 0.99 at the dynamic range of 6.06~3500 ng/mL. The limit of detection (LOD) and the limit of quantitation (LOQ) showed very low values. This method exhibited good precision and accuracy. The overall extraction efficiency of this method was evaluated by using partition coefficients ($K_p$) and concentration factors (CF) for several characteristic components from nutmeg and mace. Partition coefficients were in the range from $2.04{\times}10^4$ to $4.42{\times}10^5$, while CF values were 0.88-15.03. HS-PDE was applied successfully for the analysis of flavors compositions from nutmeg, mace and cumin. The HS-PDE method is a very promising sampling technique for the characterization of volatile flavors.

지리산 남악제(南岳祭) 제례복식(祭禮服飾)에 관한 제언 (A Study about Historical Research on Jebok(ritual robes) of Jirisan Namakje)

  • 이영주;이상은
    • 한국의상디자인학회지
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    • 제16권4호
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    • pp.49-62
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    • 2014
  • This study is intended to historical research the Jebok(ritual robes) of Jirisan Namakje. Joseon Dynasty established Five Manners as a country-ruling policy on the basis of Confucianism, the religious clothes-wearing method has been established through Sejong Silok Five Manners and the ritual robes system of all the government officials has been handed down to the end of Joseon Dynasty. The ritual robes of all the government officials was worn at the timed of the religious ceremony included ritual manners, and ritual robes are composed of Yanggwan, Ui, Sang, Jungdan, Peasul, Hwan, Wu(a cord, a leather belt, a belt, jade, a mace, Bangsimgokryeong, Mal, Ri, etc., and the rank was classified by the number of the veritical line of Ynaggwan, a leather belt, Hwan, Wu and jade and typeof a mace. "Jongmyouigwe" during the reign of king Sukjong described exactly the Uicha and textile of the ritual robes at that time, the textile Ui used Heukju as same as "Jegiakgidogamuigwe", and jade was used only in case of the first rank ritual official and other government officials did not wear jase. Also, it was revealed that all officials used a wooden mace, and in case of Husu, the first rank ritual official used Jikseong and other official used a picture.

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