• 대한한의학회지
• /
• 제39권4호
• /
• pp.183-192
• /
• 2018

Objectives: The purpose of this study is to report effectiveness of MY1-Hwan(MYH) on wart patients. Methods: Seven wart patients who wanted to treat wart with Korean medicine took MYH 2~3 times a day for 2~4 months without external treatments. Results: Nodules or papules of wart were vanished from seven patients' lesion. Specific side effect was not shown. Conclusions: MYH was effective to treat seven wart cases. However, seven cases are not enough to figure out the various effects of MYH and the effectiveness on other kind of wart. So follow-up studies are needed based on this study.

• Communications for Statistical Applications and Methods
• /
• 제15권1호
• /
• pp.51-64
• /
• 2008

일반적으로 R 언어는 작은 크기의 자료분석에 적당하다. 이 연구에서 데이터베이스에 저장된 대용량의 자료를 R 언어를 통해서 접근하는 방법에 대해서 알아보았다. 실제 자료를 사용하여 MySQL, Oracle 또는 PostgreSQL 데이터베이스 서버에 저장된 자료에 접근하는 예를 제공하였다.

• 인문언어
• /
• 제2권2호
• /
• pp.301-319
• /
• 2002

In a recent paper, I have proposed an analysis concerning propositions and 'that'-clauses as a solution to Kripke's puzzle and other similar puzzles, which I now call 'the Indefinite Description Analysis of Belief Ascription Sentences.' I have listed some of the major advantages of this analysis besides its merit as a solution to the puzzles: it is amenable to the direct-reference theory of proper names; it does not nevertheless need to introduce Russellian (singular) propositions or any other new entities. David Lewis has constructed an interesting argument to refute this analysis. His argument seems to show that my analysis has an unwelcome consequence: if someone believes any proposition, then he or she should, ipso facto, believe any necessary (mathematical or logical) proposition (such as the proposition that 1 succeeds 0). In this paper, I argue that Lewis's argument does not pose a real threat to my analysis. All his argument shows is that we should not accept the assumption called 'the equivalence thesis': if two sentences are equivalent, then they express the same proposition. I argue that this thesis is already in trouble for independent reasons. Especially, I argue that if we accept the equivalence thesis then, even without my analysis, we can derive a sentence like 'Fred believes that 1 succeeds 0 and snow is white' from a sentence like 'Fred believes that snow is white.' The consequence mentioned above is not worse than this consequence.

• Communications for Statistical Applications and Methods
• /
• 제10권1호
• /
• pp.39-48
• /
• 2003

Quality in agriculture statistics at the international level is very important to all countries in the world. We investigate international organizations which produce worldwide agricultural statistics. The UN-FAO is one of the most important organization in agricultural statistics fields. We first introduce the Statistics division in FAO and present some considerations like production, reliability, quality of the agriculture data from my own experience as a consultant in FAO and Ministry of Agriculture and Forestry in Korea.

• 한국자원식물학회지
• /
• 제36권1호
• /
• pp.15-25
• /
• 2023

이삭물수세미는 민간에서는 전초를 고름, 염증 등에 약용으로 사용하였으나, 염증에 대한 연구가 미비한 상황이다. 이에 본 연구에서는 이삭물수세미 추출물(EMS)의 항산화 효능과 항염증 효능을 분석하였다. 항산화 효능은 DPPH 라디칼 소거능과 환원력을 통해 산화적 스트레스를 통해 염증을 유발시킬 수 있는 ROS (Hong et al., 2020; Snezhkina et al., 2019)를 억제하는지 확인하였고, 항염증 효능은 염증 발현 인자인 LPS를 이용하여 RAW 264.7 대식세포에 염증을 유도한 뒤 pro-inflammatory cytokine (TNF-α, IL-1β)과 염증 매개체(NO, PGE₂)의 억제 및 TLR4/Myd88/NF-κB signaling pathway 발현 억제를 통해 확인하였다. 연구 결과, 항산화 효능에 있어서는 DPPH 라디칼 소거능과 Fe³⁺를 Fe²⁺로 환원시키는 환원력이 농도 의존적으로 증가함을 확인하였다. 무독성 상태에서 실험하기 위해 LPS와 EMS를 처리한 RAW 264.7 대식세포에서 90% 이상의 생존율을 나타내는 조건에서 실험을 진행하였다. LPS로 염증이 유도된 RAW 264.7 세포에서 EMS는 염증 매개 인자의 발현 및 생성 억제(iNOS에 의한 NO 생성 및 COX-2에 의한 PGE₂ 생성억제)와 pro-inflammatory cytokine (TNF-α 및 IL-1β)의 생성 또한 억제하였다. 특이적으로 COX-2에 의한 PGE₂ 생성 억제에서는 고농도에서 작용함을 확인하였고, IL-1β에서는 약한 억제력을 보였다. 이후 signaling pathway에서 염증 전사인자 경로를 확인하기 위하여 TLR4/MyD88의 활성을 확인하였고, EMS 처리에 따라 농도 의존적으로 억제되는 것을 확인하였다. 이에 따라 염증 초기 단계에서 NF-κB p65가 nuclear로 들어가는 것을 억제하는지 확인하기 위해 early time (LPS 처리 후 30, 60 min) 조건으로 nuclear에서 p65 인산화를 확인하였다. 그 결과, LPS 자극으로 인해 증가된 p65 인산화가 EMS에 의해 부분적으로 억제됨을 확인하였다. 이상의 결과를 통해 LPS로 염증이 유도된 RAW 264.7 대식세포에서 EMS가 COX-2에 의한 PGE₂ 생성 억제와 IL-1β의 생성에 있어 낮은 억제력을 가진 반면, iNOS에 의한 NO과 TNF-α 생성 및 TLR4/MyD88 singnaling pathway에 있어 강한 억제력을 가짐을 확인하였다. 결론적으로 EMS가 ROS를 제거하고 TLR4/MyD88/NF-κB signaling pathway를 억제함으로써 염증 인자들의 전사를 억제하고, 염증 인자 부분에서는 iNOS에 의한 NO 생성과 TNF-α 생성을 강하게 억제하여 RAW 264.7 대식세포에서 LPS로 자극된 염증을 억제하는 것으로 판단된다. 또한 TLR4/Myd88/NF-κB signaling pathway를 통한 pro-inflammatory cytokine과 염증 매개체와의 연관성에 대한 기초자료로 활용할 수 있는 근거 자료가 될 수 있을 것으로 생각된다.

• 대한한방내과학회지
• /
• 제21권5호
• /
• pp.889-895
• /
• 2000

I experienced a case of a patient with clinical features of cerebellar dysfunction in the intracranial hemorrhage which encroached the basis of lower pontine and all parts of pontine tegmentum. So I report this case with bibliographical inquiry. In addition, I applied the treatment of Oriental medicine to sequelae of intracranial hemorrhage like disorders of eye movement, central dizziness, cerebellar tremor and ataxias but the effect did not meet my expectation. I anticipate more clinical studies and reports on this hereafter.

• Design & Manufacturing
• /
• 제7권1호
• /
• pp.40-44
• /
• 2013

My company develops, manufactures injection mold and produces thin-walled cosmetics and food containers. Without high quality and low production cost, it is hard to compete in the market. To be competitive, a company has to utilize mold with as many cavities as possible to lower manufacturing cost. Eject plate abrasion and deformation cut down mold lifespan, troubles during injection lower productivity and foreign substances in molds cause abrasion. This study focuses on how to improve mold life and productivity, and to slow down mold abrasion.

• 대한청각학회지
• /
• 제24권2호
• /
• pp.99-102
• /
• 2020

Trichofolliculoma (TF) is a follicular hamartoma in which hairs protruding out of single orifice. To the best of my knowledge, only two auricular TF has been reported in the English literature. Moreover, clinically TF have been described to mimic malignancy. I present a case of an adult female with mass at the intertragal notch of the left auricle for several years. The clinical diagnosis was thought to be epidermoid cyst, accessory tragus, and other benign skin adnexal tumor. To prevent recurrence, the wide local excision of the mass was performed. The final diagnosis of TF was made. No recurrence was noted during the follow-up of 1 year. It is important for otologists to be familiar with the clinical and pathologic characterization of TF, to make the correct diagnosis.

• Journal of Audiology & Otology
• /
• 제24권2호
• /
• pp.99-102
• /
• 2020

Trichofolliculoma (TF) is a follicular hamartoma in which hairs protruding out of single orifice. To the best of my knowledge, only two auricular TF has been reported in the English literature. Moreover, clinically TF have been described to mimic malignancy. I present a case of an adult female with mass at the intertragal notch of the left auricle for several years. The clinical diagnosis was thought to be epidermoid cyst, accessory tragus, and other benign skin adnexal tumor. To prevent recurrence, the wide local excision of the mass was performed. The final diagnosis of TF was made. No recurrence was noted during the follow-up of 1 year. It is important for otologists to be familiar with the clinical and pathologic characterization of TF, to make the correct diagnosis.

• 대한관절경학회지
• /
• 제1권1호
• /
• pp.102-107
• /
• 1997

Discoid meniscus has been well known to a frequent anomaly of meniscus and much reported in diagnosis and treatment. But, associated X-ray findings have not been known well. We reported its significance of X-ray findings in discoid meniscus. From May 1995 to May 1997, 31 cases of discoid meniscus were compared with 51 cases of nondiseoid meniscus both confirmed by arthroscopy, with simple X-my findings. Both groups were evaluated by X-ray findings in view of lateral joint space widening, peripheral spur of lateral joint space, sclerotic change of lateral tibial plateau, concave lateral tibial plateau, flattening of lateral femoral condyle, hypoplasia of lateral femoral condyle and high riding fibula. The results of analysis were as follows: 1. Widening of lateral joint space, sclerotic change of lateral tibial plateau and cupping of lateral tibial plateau were statistically significant in discoid meniscus. 2. X-ray findings in discoid meniscus were not associated with patient's injury history and symptom duration. 3. Other X-ray findings were not related in discoid meniscus significantly. X-ray findings with patient's history and physical examination arc helpful in the diagnosis of discoid meniscus.