• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.35 no.2
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• pp.55-65
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• 2009

Purpose: We determined the therapeutic effects of blockade of epidermal growth factor(EGF) and vascular endothelial growth factor(VEGF) receptor tyrosine kinases on the growth of oral squamous cell carcinoma(OSCC) xenografted in athymic nude mice. Experimental Design: We investigated the in vivo antitumor effects of a tyrosine kinase inhibitor for EGFR and VEGFR-2, AEE788 in a mouth floor(orthotopic) tumor model. Nude mice with orthotopic tumors were randomized to receive AEE788, paclitaxel, a combination of AEE788 and paclitaxel, or control. Antitumor mechanisms of AEE788 were determined by immunohistochemical/immunofluorescent and apoptosis assays. Results: Tumors of mice treated with AEE788 demonstrated down-regulation of phosphorylated EGFR, phosphorylated VEGFR and their downstream mediators(pMAPK and pAkt), decreased proliferative index, decreased microvessel density(MVD). As a result, growth of the primary tumor and nodal metastatic potentials were inhibited by AEE788. Conclusion: These data show that EGFR and VEGFR can be molecular targets for the treatment of OSCC.

• Journal of Korean Neurosurgical Society
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• v.47 no.4
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• pp.271-277
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• 2010

Objective : The purpose of this study is to evaluate the clinical characteristics and surgical outcome of cerebellopontine angle (CPA) epidermoids presenting with trigeminal neuralgia. Methods : Between 1996 and 2004, 10 patients with typical symptoms of trigeminal neuralgia were found to have cerebellopontine angle epidermoids and treated surgically at our hospital. We retrospectively analyzed the clinico-radiological records of the patients. Results : Total resection was done in 6 patients (60%). Surgical removal of tumor and microvascular decompression of the trigeminal nerve were performed simultaneously in one case. One patient died due to postoperative aseptic meningitis. The others showed total relief from pain. During follow-up, no patients experienced recurrence of their trigeminal neuralgia (TN). Conclusion : The clinical features of TN from CPA epidermoids are characterized by symptom onset at a younger age compared to TN from vascular causes. In addition to removal of the tumor, the possibility of vascular compression at the root entry zone of the trigeminal nerve should be kept in mind. If it exists, a microvascular decompression (MVD) should be performed. Recurrence of tumor is rare in both total and subtotal removal cases, but long-term follow-up is required.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.4
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• pp.1128-1139
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• 2012

With the development of three-dimensional display and related technologies, depth video coding becomes a new topic and attracts great attention from industries and research institutes. Because (1) the depth video is not a sequence of images for final viewing by end users but an aid for rendering, and (2) depth video is simpler than the corresponding color video, fast algorithm for depth video is necessary and possible to reduce the computational burden of the encoder. This paper proposes a fast mode decision algorithm for depth video coding based on depth segmentation. Firstly, based on depth perception, the depth video is segmented into three regions: edge, foreground and background. Then, different mode candidates are searched to decide the encoding macroblock mode. Finally, encoding time, bit rate and video quality of virtual view of the proposed algorithm are tested. Experimental results show that the proposed algorithm save encoding time ranging from 82.49% to 93.21% with negligible quality degradation of rendered virtual view image and bit rate increment.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.04a
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• pp.358-361
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• 2007

Most aircraft cruise in the stratosphere at which temperature is below $-50^{\circ}C$ md, as a result, the surface of aircraft can be iced up. Ice on the wing can change aerodynamic characteristic and results in the deterioration of its performance. Ice on the engine inlet increases the possibility of compressor blade damage and affects the performance and safety of the engine. This paper focused on the development of icing simulation device for analyzing effect of icing on engine performance. Icing simulation tests were conducted with a liquid air system and a icing simulation device and results show that icing could be simulated with this system.

• Journal of the Korean Magnetic Resonance Society
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• v.23 no.1
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• pp.12-19
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• 2019

A former study has shown that the spin-lattice relaxation time ($T_1$) in cancerous prostate tissue had enhanced contrast at an ultra-low magnetic field, $132{\mu}T$. To study the field dependence and the origin of the contrast we measured $T_1$ in pairs of ex-vivo prostate tissues at the Earth's magnetic field. A portable and coil-based nuclear magnetic resonance (NMR) system was adopted for $T_1$ measurements at $40{\mu}T$. The $T_1$ contrast, ${\delta}=1-T_1$ (more cancer)/$T_1$(less cancer), was calculated from each pair. Additionally, we performed pathological examinations such as Gleason's score, cell proliferation index, and micro-vessel density (MVD), to quantify correlations between the pathological parameters and $T_1$ of the cancerous prostate tissues.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.9
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• pp.4587-4605
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• 2019

High Efficiency Video Coding (HEVC) suffers from high computational complexity due to its quad-tree structure in motion estimation (ME). This paper exposes an adaptive search range decision algorithm for accelerating HEVC integer-pel ME on GPU which estimates the optimal search range (SR) using a MAP (Maximum A Posteriori) estimator. There are three main contributions; First, we define the motion feature as the standard deviation of motion vector difference values in a CTU. Second, a MAP estimator is proposed, which theoretically estimates the motion feature of the current CTU using the motion feature of a temporally adjacent CTU and its SR without any data dependency. Thus, the SR for the current CTU is parallelly determined. Finally, the values of the prior distribution and the likelihood for each discretized motion feature are computed in advance and stored at a look-up table to further save the computational complexity. Experimental results show in conventional HEVC test sequences that the proposed algorithm can achieves high average time reductions without any subjective quality loss as well as with little BD-bitrate increase.

• Journal of KIBIM
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• v.13 no.2
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• pp.37-46
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• 2023

The main objective of this study is to propose a method to enhance building safety using the Industry Foundation Classes (IFC) schema in Building Information Modeling (BIM). To achieve this goal, a fire object relationship diagram is created by using the Model View Definition (MVD) and Property Set (Pset) methodology, as well as the Work Breakdown Structure (WBS) based object relationship analysis. The proposed method illustrates how to represent objects and tasks related to fire prevention and human safety during a building fire, including variables that are relevant to these aspects. Furthermore, the proposed method offers the advantage of considering both the IFC object hierarchy and the project work hierarchy when creating new objects, thereby expanding the attribute information for fire safety and maintenance. However, upon confirmation via an IFC viewer after development, a problem with the accuracy of mapping between attributes and objects arises due to the issue of proxy representation of related object information and newly added object information in standard IFC. Therefore, in future research, a mapping method for fire safety objects will be developed to ensure accurate representation, and the scope of utilization of the fire safety object diagram will be expanded. Furthermore, efforts will be made to enhance the accuracy of object and task representation. This research is expected to contribute significantly to the technological development of building safety and fire facility design in the future.

• BMB Reports
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• v.46 no.5
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• pp.252-257
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• 2013

Fibroblast activation protein (FAP) is a specific serine protease expressed in tumor stroma proven to be a stimulatory factor in the progression of some cancers. The purpose of this study was to investigate the effects of FAP knockdown on tumor growth and the tumor microenvironment. Mice bearing 4T1 subcutaneous tumors were treated with liposome-shRNA complexes targeting FAP. Tumor volumes and weights were monitored, and FAP, collagen, microvessel density (MVD), and apoptosis were measured. Our studies showed that shRNA targeting of FAP in murine breast cancer reduces FAP expression, inhibits tumor growth, promotes collagen accumulation (38%), and suppresses angiogenesis (71.7%), as well as promoting apoptosis (by threefold). We suggest that FAP plays a role in tumor growth and in altering the tumor microenvironment. Targeting FAP may therefore represent a supplementary therapy for breast cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.4
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• pp.1730-1747
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• 2018

Multi-view video plus depth (MVD) is a mainstream format of 3D scene representation in free viewpoint video systems. The advanced 3D extension of the high efficiency video coding (3D-HEVC) standard introduces new prediction tools to improve the coding performance of depth video. However, the depth video in 3D-HEVC is time consuming. To reduce the complexity of the depth video inter coding, we propose a fast coding unit (CU) size and mode decision algorithm. First, an off-line trained Bayesian model is built which the feature vector contains the depth levels of the corresponding spatial, temporal, and inter-component (texture-depth) neighboring largest CUs (LCUs). Then, the model is used to predict the depth level of the current LCU, and terminate the CU recursive splitting process. Finally, the CU mode search process is early terminated by making use of the mode correlation of spatial, inter-component (texture-depth), and inter-view neighboring CUs. Compared to the 3D-HEVC reference software HTM-10.0, the proposed algorithm reduces the encoding time of depth video and the total encoding time by 65.03% and 41.04% on average, respectively, with negligible quality degradation of the synthesized virtual view.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.12
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• pp.2530-2538
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• 2015

The pixel value of depth image is depth value so that different objects which are placed on nearby position have similar pixel value. Moreover, the pixels of depth image have distinct pixel values compared to adjacent pixels while those of color image has very similar values. Accordingly distorted depth image of multiview video plus depth (MVD) needs proper error concealment methods considering the characteristics of depth image when transmission errors are happened. In this paper, classifying regions of depth image to consider edge directions and then applying adaptive error concealment methods to each region are proposed. Recovered depth images utilize with multiview video data to synthesize intermediate-view point video. The synthesized view is evaluated by objective quality metrics to demonstrate proposed method performance.