• Title/Summary/Keyword: MSP20

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Plasmodium falciparum Genotype Diversity in Artemisinin Derivatives Treatment Failure Patients along the Thai-Myanmar Border

  • Congpuong, Kanungnit;Hoonchaiyapoom, Thirasak;Inorn, Kornnarin
    • Parasites, Hosts and Diseases
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    • v.52 no.6
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    • pp.631-637
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    • 2014
  • Genetic characteristics of Plasmodium falciparum may play a role in the treatment outcome of malaria infection. We have studied the association between diversity at the merozoite surface protein-1 (msp-1), msp-2, and glutamate-rich protein (glurp) loci and the treatment outcome of uncomplicated falciparum malaria patients along the Thai-Myanmar border who were treated with artemisinin derivatives combination therapy. P. falciparum isolates were collected prior to treatment from 3 groups of patients; 50 cases of treatment failures, 50 recrudescences, and 56 successful treatments. Genotyping of the 3 polymorphic markers was analyzed by nested PCR. The distribution of msp-1 alleles was significantly different among the 3 groups of patients but not the msp-2 and glurp alleles. The allelic frequencies of K1 and MAD20 alleles of msp1 gene were higher while RO33 allele was significantly lower in the successful treatment group. Treatment failure samples had a higher median number of alleles as compared to the successful treatment group. Specific genotypes of msp-1, msp-2, and glurp were significantly associated with the treatment outcomes. Three allelic size variants were significantly higher among the isolates from the treatment failure groups, i.e., $K1_{270-290}$, $3D7_{610-630}$, $G_{650-690}$, while 2 variants, $K1_{150-170}$, and $3D7_{670-690}$ were significantly lower. In conclusion, the present study reports the differences in multiplicity of infection and distribution of specific alleles of msp-1, msp-2, and glurp genes in P. falciparum isolates obtained from treatment failure and successful treatment patients following artemisinin derivatives combination therapy.

Allelic Diversity of MSP1 Gene in Plasmodium falciparum from Rural and Urban Areas of Gabon

  • Mawili-Mboumba, Denise Patricia;Mbondoukwe, Noe;Adande, Elvire;Bouyou-Akotet, Marielle Karine
    • Parasites, Hosts and Diseases
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    • v.53 no.4
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    • pp.413-419
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    • 2015
  • The present study determined and compared the genetic diversity of Plasmodium falciparum strains infecting children living in 2 areas from Gabon with different malaria endemicity. Blood samples were collected from febrile children from 2008 to 2009 in 2 health centres from rural (Oyem) and urban (Owendo) areas. Genetic diversity was determined in P. falciparum isolates by analyzing the merozoite surface protein-1 (msp1) gene polymorphism using nested-PCR. Overall, 168 children with mild falciparum malaria were included. K1, Ro33, and Mad20 alleles were found in 110 (65.5%), 94 (55.9%), and 35 (20.8%) isolates, respectively, without difference according to the site (P>0.05). Allelic families' frequencies were comparable between children less than 5 years old from the 2 sites; while among the older children the proportions of Ro33 and Mad20 alleles were 1.7 to 2.0 fold higher at Oyem. Thirty-three different alleles were detected, 16 (48.5%) were common to both sites, and 10 out of the 17 specific alleles were found at Oyem. Furthermore, multiple infection carriers were frequent at Oyem (57.7% vs 42.2% at Owendo; P=0.04) where the complexity of infection was of 1.88 (${\pm}0.95$) higher compared to that found at Owendo ($1.55{\pm}0.75$). Extended genetic diversity of P. falciparum strains infecting Gabonese symptomatic children and high multiplicity of infections were observed in rural area. Alleles common to the 2 sites were frequent; the site-specific alleles predominated in the rural area. Such distribution of the alleles should be taken into accounts when designing MSP1 or MSP2 malaria vaccine.

Comparison of three midsagittal planes for three-dimensional cone beam computed tomography head reorientation

  • Lee, Eon-Hwa;Yu, Hyung-Seog;Lee, Kee-Joon;Han, Sang-Sun;Jung, Hwi-Dong;Hwang, Chung-Ju
    • The korean journal of orthodontics
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    • v.50 no.1
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    • pp.3-12
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    • 2020
  • Objective: This study compared three prominent midsagittal planes (MSPs) to identify the MSP that best approximates the true symmetrical MSP. Methods: Forty-three patients (mean age, 23.0 ± 8.20 years) were grouped as follows: group 1 consisted of 10 patients with skeletal Class I and a menton (Me) deviation of < 2 mm; group 2, 11 patients with skeletal Class III and a Me deviation < 2 mm; group 3, nine patients with skeletal Class III and a Me deviation of 2 to less than 4 mm; and group 4, 13 patients with skeletal Class III and an Me deviation ≥ 4 mm. The candidate MSPs were established by three-dimensional (3D) cone beam computed tomography (CBCT) reorientation methods (RMs): (1) the MSP perpendicular to the Frankfort horizontal (FH) plane while passing through the crista galli and basion; (2) the MSP including the nasion, incisive foramen, and basion; (3) the MSP including the nasion, anterior nasal spine, and posterior nasal spine. The mean absolute distances (MADs) to the MSPs were calculated from the coordinates of 1,548 points on 129 CBCT images. The differences in the values of the 3D coordinates among RMs were compared. Results: The MADs of the three RMs showed significant differences (p < 0.05). Most of the differences in values of the coordinates were not significant among RMs. Conclusions: Although the differences in distance among the three MSPs were minor, the MSP perpendicular to the FH plane while passing through the crista galli and basion best approximated the true symmetrical MSP.

Mixed Carbon/Polypyrrole Electrodes Doped with 2-Naphthalenesulfonic Acid for Supercapacitor (2-Naphthalenesulfonic Acid로 도핑된 혼합카본/폴리피롤을 이용한 Supercapacitor용 전극)

  • Jang, In-Young;Kang, An-Soo
    • Korean Chemical Engineering Research
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    • v.43 no.3
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    • pp.425-431
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    • 2005
  • New type of supercapacitor using high surface area activated carbons mixed with high conductivity polypyrrole (Ppy) has been prepared in order to achieve low impedance and high energy density. Mixed carbons of BP-20 and MSP-20 were used as the active electrode material, and polypyrrole doped with 2-naphthalenesulfonic acid (2-NSA) and carbon black (Super P) as conducting agents were added to activated carbons in order to enhance good electric conductivity. Electrodes prepared with the activated electrode materials and the conducting agents were added to a solution of organic binder [P(VdF-co-HFP) / NMP]. The ratio of optimum electrode composition was 78 : 17 : 5 wt.% of (MSP20 : BP-20=1 : 1), (Super P : Ppy=10 : 7) and P(VdF-co-HFP) respectively. The performance of unit cell with addition of 7 wt% Ppy have shown specific capacitance of 28.02 F/g, DC-ESR of $1.34{\Omega}$, AC-ESR of $0.36{\Omega}$, specific energy of 19.87 Wh/kg and specific power of 9.77 kW/kg. With addition of Ppy, quick charge-discharge of unit cell was possible because of low ESR, low charge transfer resistance and quick reaction rate. And good stability up to 500 chargedischarge cycles were retained about 80% of their original capacity. It was concluded that the specific capacitance originated highly from compound phenomena of the pseudocapacitance by oxidation-reduction of polypyrrole and the nonfaradaic capacitance by adsorption-desorption of activated carbons.

The effect of multi-strain probiotics as feed additives on performance, immunity, expression of nutrient transporter genes and gut morphometry in broiler chickens

  • Biswas, Avishek;Dev, Kapil;Tyagi, Pramod K;Mandal, Asitbaran
    • Animal Bioscience
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    • v.35 no.1
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    • pp.64-74
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    • 2022
  • Objective: This study was conducted to investigate the effects of dietary multi-strain probiotic (MSP) (Bacillus coagulans Unique IS2 + Bacillus subtillis UBBS14 + Saccharomyces boulardii Unique 28) on performance, gut morphology and expression of nutrient transporter related genes in broiler chickens. Methods: A total of 256 (4×8×8) day-old CARIBRO Vishal commercial broiler chicks of uniform body weight were randomly distributed into four treatments with 8 replicates each and having eight chicks in each replicate. Four dietary treatments were T1 (negative control-basal diet), T2 (positive control-antibiotic bacitracin methylene disalicylate at 20 mg/kg diet), T3 (MSP at 107 colony-forming unit [CFU]/g feed), and T4 (MSP at 108 CFU/g feed). Results: During 3 to 6 weeks and 0 to 6 weeks, the body weight gain increased significantly (p<0.05) in T3 and T4 groups. The feed intake significantly (p<0.05) reduced from T1 to T3 during 0 to 3 weeks and the feed conversion ratio also significantly (p<0.05) improved in T3 and T4 during 0 to 6 weeks. The humoral and cell mediated immune response and the weight of immune organs were also significantly (p<0.05) improved in T3 and T4. However, significant (p<0.05) dietary effects were observed on intestinal histo-morphometry of ileum in T3 followed by T4 and T2. At 14 d post hatch, the relative gene expression of glucose transporter (GLUT5), sodium-dependent glucose transporter (SGLT1) and peptide transporter (PepT1) showed a significant (p<0.05) up-regulating pattern in T2, T3, and T4. Whereas, at 21 d post hatch, the gene expression of SGLT1 and PepT1 was significantly (p<0.05) downregulated in MSP supplemented treatments T3 and T4. Conclusion: The supplementation of MSP at 107 CFU/g diet showed significant effects with improved performance, immune response, gut morphology and expression of nutrient transporter genes. Thus, the MSP could be a suitable alternative to antibiotic growth promoters in chicken diets.

Psychosocial Factors and Musculoskeletal Pain Among Rural Hand-woven Carpet Weavers in Iran

  • Chaman, Reza;Aliyari, Roqayeh;Sadeghian, Farideh;Shoaa, Javad Vatani;Masoudi, Mahmood;Zahedi, Shiva;Bakhshi, Mohammad A.
    • Safety and Health at Work
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    • v.6 no.2
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    • pp.120-127
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    • 2015
  • Background: Musculoskeletal pain (MSP) is a common and disabling problem among carpet weavers and is linked to physical and psychosocial factors of work. This study aimed to determine the prevalence of MSP, its psychosocial risk factors, and association of pain in each pair of anatomical sites among carpet weavers. Methods: A cross-sectional study was performed among 546 hand-woven carpet weavers in rural small-scale workshops of Iran. Data were collected by using parts of a standardized CUPID (Cultural and Psychosocial Influences on Disability) questionnaire focused on MSP in 10 body sites, including the low-back, neck, both right and left shoulders, elbows, wrists/hands, individual, physical and psychosocial risk factors. Statistical analysis was performed applying logistic regression models. Results: Prevalence of MSP in at least one body sitewas 51.7% over the past month. The most common sites were low back and right shoulder pain 27.4% and 20.1%, respectively. A significant difference was found between the mean number of painful anatomical sites and the level of education, age, physical loading at work, time pressure, lack of support, and job dissatisfaction. In pairwise comparisons, strongest association was found between pain in each bilateral anatomical site (odds ratio = 11.6-35.3; p < 0.001). Conclusion: In home-based workshops of carpet weaving, psychosocial factors and physical loading were associated with MSP. This finding is consistent with studies conducted among other jobs. Considering the preventive programs, the same amount of attention should be paid to psychosocial risk factors and physical loading. Also, further longitudinal studies are needed to investigate the relationship of psychological factors.

Lightweight multiple scale-patch dehazing network for real-world hazy image

  • Wang, Juan;Ding, Chang;Wu, Minghu;Liu, Yuanyuan;Chen, Guanhai
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.15 no.12
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    • pp.4420-4438
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    • 2021
  • Image dehazing is an ill-posed problem which is far from being solved. Traditional image dehazing methods often yield mediocre effects and possess substandard processing speed, while modern deep learning methods perform best only in certain datasets. The haze removal effect when processed by said methods is unsatisfactory, meaning the generalization performance fails to meet the requirements. Concurrently, due to the limited processing speed, most dehazing algorithms cannot be employed in the industry. To alleviate said problems, a lightweight fast dehazing network based on a multiple scale-patch framework (MSP) is proposed in the present paper. Firstly, the multi-scale structure is employed as the backbone network and the multi-patch structure as the supplementary network. Dehazing through a single network causes problems, such as loss of object details and color in some image areas, the multi-patch structure was employed for MSP as an information supplement. In the algorithm image processing module, the image is segmented up and down for processed separately. Secondly, MSP generates a clear dehazing effect and significant robustness when targeting real-world homogeneous and nonhomogeneous hazy maps and different datasets. Compared with existing dehazing methods, MSP demonstrated a fast inference speed and the feasibility of real-time processing. The overall size and model parameters of the entire dehazing model are 20.75M and 6.8M, and the processing time for the single image is 0.026s. Experiments on NTIRE 2018 and NTIRE 2020 demonstrate that MSP can achieve superior performance among the state-of-the-art methods, such as PSNR, SSIM, LPIPS, and individual subjective evaluation.

Electrochemical Characteristics of $LiMn_2O_4$+Activated Carbon Electrode for Supercapacitor (Supercapacitor용 $LiMn_2O_4$+Activated Carbon 전극의 전기화학적 특성)

  • Jeon, Min-Je;Lee, Sun-Young;Kim, Ick-Jun;Moon, Seong-In;Im, Young-Tek;Lee, Sang-Hyun;Lee, Moon-Bae
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2005.07a
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    • pp.595-596
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    • 2005
  • This research which it sees adds $LiMn_2O_4$ in the activated carbon electrode the test against the effect which it follows is. Test cells, which were $LiMn_2O_4$fabricated with active mass composite consisted of (100-X)% of MSP-20 and (X)% of $LiMn_2O_4$ (X=20,40,60,80,100), exhibits the better specific capacitance than those of the cells fabricated with single active mass that is MSP-20. The enhanced properties of composite active mass could be caused by capability of $LiMn_2O_4$ powders. But the resistance was increase by proportionate in $LiMn_2O_4$ addition and when mixture ratio of the activated carbon and the $LiMn_2O_4$ being similar, to be low rather to the after where had become the maximum it came.

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Preparation and Electrochemical Performance of Carbon-PTFE Electrode for Electric Double Layer Capacitor (EDLC용 Carbon-PTFE 전극의 제조 및 전기화학적 특성)

  • Kim, Ick-Jun;Lee, Sun-Young;Moon, Seong-In
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.18 no.9
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    • pp.833-839
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    • 2005
  • This work describes the effect of the number of roll pressing and the composition of carbon black on the electric and mechanical properties of carbon-PTFE electrode, in which composition is MSP20 : carbon black : $PTFE\;=\;95-X\;:\;X\;:\;5wt.\%$. It was found that the best electric and mechanical properties were obtained for sheet electrode roll pressed about 15 times and for sheet electrode, in which composition is MSP20 : carton black $PTFE\;=\;80\;:\;15\;:\;5wt.\%$. These behaviors could be explained by the network structure of PTFE fibrils and conducting Paths linked with carbon blacks, respectively. On the other hand, cell capacitor using the sheet electrode with $15wt.\%$ of carbon black attached on aluminum current collector with the electric conductive adhesive, in composition is carbon black $CMC\;=\;70\;:\;30wt.\%$, has exhibited the best rate capability between $0.5\;mA/cm^2\~100\;mA/cm^2$ current density and the lowest ESR.

Study of Parameters on the Electrochemical Properties of Carbon-PTFE Electrode for Electric Double Layer Capacitor (EDLC용 Carbon-PTFE 전극의 전기화학적 특성에 미치는 변수 연구)

  • Kim, Ick-Jun;Yang, Sun-Hye;Jeon, Min-Je;Moon, Seong-In;Kim, Hyun-Soo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.11a
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    • pp.355-356
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    • 2006
  • This work describes the effect of the number of roll pressing and the composition of carbon black on the electric and mechanical properties of carbon-PTFE electrode, in which composition is MSP20 : carbon black: PTFE = 95-X : X : 5 wt.%. It was found that the best electric and mechanical properties were obtained for sheet electrode roll pressed about 15 times and for sheet electrode, in which composition is MSP20 carbon black : PTFE = 80 : 15 : 5 wt%. These behaviors could be explained by the network structure of PTFE fibrils and conducting paths linked with carbon blacks, respectively. On the other hand, cell capacitor using the sheet electrode with 15 wt.% of carbon black attached on aluminum current collector with the electric conductive adhesive, in composition is carbon black : CMC = 70 : 30 wt.%, has exhibited the best rate capability between 0.5 $mA/cm^2$ ~ 100 $mA/cm^2$ current density and the lowest ESR.

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