• Reproductive and Developmental Biology
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• v.36 no.1
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• pp.39-47
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• 2012

Ovarian cancer is the most lethal gynecological malignancy, and specific biomarkers are important needed to improve diagnosis, prognosis, and to forecast and monitor treatment efficiency. There are a lot of pathological factors, including reactive oxygen species (ROS), involved in the process of cancer initiation and progression. The oxidative modification of proteins by ROS is implicated in the etiology or progression of disorders and diseases. In this study, a labeling experiment with the thiol-modifying reagent biotinylated iodoacetamide (BIAM) revealed that a variety of proteins were differentially oxidized between normal and tumor tissues of ovarian cancer patients. To identify cysteine oxidation-sensitive proteins in ovarian cancer patients, we performed comparative analysis by nano-UPLC-$MS^E$ shotgun proteomics. We found oxidation-sensitive 22 proteins from 41 peptides containing cysteine oxidation. Using Ingenuity program, these proteins identified were established with canonical network related to cytoskeletal network, cellular organization and maintenance, and metabolism. Among oxidation-sensitive proteins, the modification pattern of Collagen alpha-1(VI) chain (COL6A1) was firstly confirmed between normal and tumor tissues of patients by 2-DE western blotting. This result suggested that COL6A1 might have cysteine oxidative modification in tumor tissue of ovarian cancer patients.

• Journal of Microbiology and Biotechnology
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• v.23 no.2
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• pp.184-188
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• 2013

In the continued search for inhibitors of enoyl-acyl carrier protein (ACP) reductase, we found that four acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761 potently inhibited bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis. Their structures were identified as panosialins A, B, wA, and wB by MS and NMR data. They showed stronger inhibition against S. aureus FabI and S. pneumoniae FabK with $IC_{50}$ of 3-5 ${\mu}M$ than M. tuberculosis InhA with $IC_{50}$ of 9-12 ${\mu}M$. They also exhibited a stronger antibacterial spectrum on S. aureus and S. pneumoniae than M. tuberculosis. In addition, the higher inhibitory activity of panosialin wB than panosialin B on fatty acid biosynthesis was consistent with that on bacterial growth, suggesting that they could exert their antibacterial activity by inhibiting fatty acid synthesis.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.694-697
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• 2008

A retaining wall system suitable for a construction project is selected on the basis of subsoil conditions. If the decision-maker selects an improper system, it has a negative effect on the cost and schedule of the construction project. There have been many studies related to the models and processes for selecting optimal retaining wall systems. However, engineers who are not familiar with formal analysis methods could not easily utilize the formal methods proposed by previous studies. In order to overcome this problem, we developed a web-based decision support system called Dr. Underground, which is both physically and technically easily accessible by engineers. Dr. Underground was developed based on a selection method developed from a precedent research project. It was developed using a server-side web language ASP.NET and MS Access as a database. Decision-makers can input data about the building's condition, construction site conditions and adjacent site conditions in this system. Based on the input data, Dr. Underground recommends an optimal retaining wall system for the inputted conditions and provides detail information on the system.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.21 no.1
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• pp.89-97
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• 2003

This study is aimed at standardizing the process of spatial database construction and developing a software tool for process management. Knowhow of five GIS firms and provisions of NGI(National Geography Institute) was analyzed. In this study, the process of spatial database construction was standardized. The system from this study has the capability to manage the process of construction database using GIS and to deal with the metadata of unit map, generated from the process, systematically and continuously. The process was also shown by using either Gantt chart or PERT chart after developing an interface for "MS Project". A software "Visual Basic for Application" was used for this study.

• Journal of electromagnetic engineering and science
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• v.3 no.1
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• pp.50-56
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• 2003

This paper proposes a coding scheme of control channel for mobile packet communication to maximize the minimum Hamming distance, which is based on shifting of basis vectors of Reed Muller code with optimized dynamic puncturing and/or(partial) sequence repetition. Since the maximum likelihood decoding can be performed using the extremely simple FHT(Fast Hadamard Transformation), it is suitable for real time optimum decoding of control channel information with very little complexity. We show applications of the proposed coding method to TFCI(Transport Format Combination Indicator) code in split and normal modes of 3GPP W-CDMA system. We also discuss how this method can reduce rate indication error over AWGN(Additive White Gaussian Noise) as well as fading channels when the proposed coding scheme is applied to 1xEV-DV system of $3^{rd}$TEX> generation partnership project 2(3GPP2) to indicate the data rate transmitted on the reverse traffic channel by a Mobile Station(MS).

• 한국정보통신설비학회:학술대회논문집
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• 2007.08a
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• pp.264-268
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• 2007

This article presents the performance evaluation case study of circuit-switched WCDMA R5MSC(Mobile Switching Center) Server and CS-MGW(Circuit Switched Media Gateway) in 3'rd generation mobile telecommunication (UMTS : Universal Mobile Telecommunication System). The presented work adopted circuit switching scenarios recommended by 3GPP(Third Generation Partnership Project) and terrestrial spectrum calculation parameters and its values defined in ITU-R M.2023 and M.1390 to do the case study on performance evaluation of circuit switched system (R5 MSC Server and CS-MGW) in WCDMA core network. This paper describes test results by using simulator which substitutes for wireless section (MS, Node-B, RNC).

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2003.04a
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• pp.285-290
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• 2003

This study is aimed at standardizing the process of spatial database construction and developing a software tool for process management. Knowhow of five GIS firms and provisions of NGI(National Geography Institute) were analyzed. In this study, the process of spatial database construction was standardize. The system from this study has the capability to manage the process of construction database using GIS and to deal with the metadata of unit map, generated from the process, systematically and continuously The process was also shown by using either Gantt chart or PERT chart after developing an interface for "MS Project". A software "Visual Basic for Application" was used for this study.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2004.11a
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• pp.355-360
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• 2004

This study is aimed at developing the system to manage the process and metadata of spatial data construction. The process of spatial data construction is standardized by analyzing knowhow of major firms and the provisions of MOCT(Ministry of the Construction and Transportation), and by appling the development methodology of information system. The system from this study has the capability to manage efficiently the process and metadata of spatial data construction. The process is shown by using index map. Also, it is shown by using Gantt chart and PERT chat after developing the interface for MS Project. The metadata is generated from the process, and managed systematically.

• 보존과학연구
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• s.28
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• pp.149-168
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• 2007

This project aims to develop a partnership between France and Korea; the field of paper conservation with two mains objectives. The first object is to study the possibilities of implementing the use of traditional Korean paper in conservation workshops in France and Europe. The second one is to establish a long term collaborative research program to investigate the degradation mechanisms of ancient papers and particularly early waxed manuscripts founded in Korea and France which are now brittle and fallen into parts. This problem deserves an investigation using analytical tools such as SEC/MALS, GC/MS to understand the interactions between wax and cellulose during the ageing process and to recommend proper conservation treatment. A research plan could be establish for both institution in order to facilities an exchange of visiting scholars (scientist, post-doc) to implement and share knowledge and for carrying out the research.

• Journal of Conservation Science
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• v.36 no.3
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• pp.213-224
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• 2020

This research conducted a component analysis and conservation treatment of "Sangryangmun," a material which had been written in 1965 and was discovered during the repair project for "Jinnamgwan" in Yeosu. The "Sangryangmun" has been stored in a cylindrical metal storage; however, defects, discolorations, hardening, and damages caused by pollutants were found. Based on the XRF analysis, rust in the cylindrical metal storage, which was made of Cu, was stuck on the surface of the "Sangryangmun". Using FT-IR and Pyrolysis-GC/MS analyses, carbonyl and compounds of fatty acids were detected; the organic material on the surface of the "Sangryangmun" was identified to have belonged to oil-based components. Therefore, it was presumed that the bast fibers of a mulberry was used in the paper. To determine the conservation materials, component analysis, condition survey, and preliminary test on adhesives were conducted. Moreover, the missing parts and partial linings were filled using mulberry-fiber paper, methyl cellulose, etc.